Best TWAS P=4.34e-10 · Best GWAS P=8.55e-18 conditioned to 6.67e-20
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ECE2 | 0.24 | 0.20 | bslmm | 542 | 0.19 | 1.6e-22 | 5.5 | 5.7 | 9.7e-09 | 0.04 | 0.93 | 0.07 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | SENP2 | 0.21 | 0.18 | enet | 33 | 0.19 | 4.2e-22 | -5.7 | 6.2 | 6.7e-10 | -0.11 | 1.00 | 0.00 | TRUE |
| 3 | GTEx | Artery Tibial | PSMD2 | 0.13 | 0.09 | lasso | 5 | 0.08 | 1.3e-06 | -5.1 | 5.2 | 1.5e-07 | 0.03 | 0.79 | 0.12 | FALSE |
| 4 | GTEx | Brain Cerebellum | MAP6D1 | 0.38 | 0.27 | enet | 38 | 0.34 | 1.0e-10 | 3.3 | -5.2 | 1.7e-07 | 0.02 | 0.98 | 0.00 | TRUE |
| 5 | GTEx | Skin Sun Exposed Lower leg | PSMD2 | 0.13 | 0.14 | lasso | 4 | 0.15 | 1.4e-12 | -5.1 | 5.2 | 2.0e-07 | 0.04 | 1.00 | 0.00 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ECE2 | 0.04 | 0.02 | blup | 61 | 0.03 | 3.5e-04 | 5.6 | 6.2 | 6.6e-10 | 0.02 | 0.04 | 0.93 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | PSMD2 | 0.09 | 0.02 | blup | 50 | 0.05 | 1.2e-06 | -5.7 | 6.2 | 4.3e-10 | 0.06 | 0.14 | 0.30 | TRUE |
| 8 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | VWA5B2 | 0.10 | 0.04 | blup | 51 | 0.04 | 1.8e-02 | 4.2 | -5.7 | 1.1e-08 | -0.04 | 0.04 | 0.24 | FALSE |