[Hub]/) : Traits : Comparative height size at age 10 :

chr4:305,291-2,437,290

Best TWAS P=7.63e-23 · Best GWAS P=5.06e-19 conditioned to 0.823

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CRIPAK 0.31 0.15 enet 34 0.26 1.2e-31 -4.2 -6.4 1.3e-10 0.04 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex TMEM129 0.11 0.07 enet 6 0.07 3.7e-09 -8.0 5.6 1.8e-08 0.35 0.85 0.15 TRUE
3 GTEx Adipose Visceral Omentum CRIPAK 0.47 0.24 lasso 12 0.31 1.3e-16 -4.2 -5.5 3.8e-08 0.02 1.00 0.00 FALSE
4 GTEx Artery Aorta UVSSA 0.33 0.06 enet 30 0.28 7.2e-16 -4.3 -5.6 2.5e-08 0.01 0.95 0.00 FALSE
5 GTEx Artery Tibial CRIPAK 0.42 0.09 enet 50 0.34 1.3e-27 1.5 -5.4 7.6e-08 0.02 1.00 0.00 FALSE
6 GTEx Brain Cortex TACC3 0.26 0.13 lasso 4 0.17 1.7e-05 -8.1 5.7 9.3e-09 0.52 0.25 0.27 FALSE
7 GTEx Brain Cortex CRIPAK 0.34 0.10 lasso 6 0.18 9.5e-06 -4.2 -5.9 3.8e-09 0.03 0.20 0.06 FALSE
8 GTEx Brain Hippocampus CRIPAK 0.48 0.22 lasso 4 0.23 4.0e-06 -4.1 -6.1 1.3e-09 0.00 0.18 0.12 FALSE
9 GTEx Brain Hypothalamus CRIPAK 0.22 0.00 lasso 5 0.01 2.1e-01 -4.3 -5.2 2.2e-07 0.02 0.06 0.08 FALSE
10 GTEx Brain Nucleus accumbens basal ganglia CRIPAK 0.34 0.13 lasso 6 0.25 2.7e-07 -4.2 -5.3 1.1e-07 0.05 0.21 0.04 FALSE
11 GTEx Breast Mammary Tissue CRIPAK 0.42 0.12 enet 35 0.39 5.2e-21 -4.2 -5.8 7.3e-09 0.02 1.00 0.00 FALSE
12 GTEx Breast Mammary Tissue (Female) CRIPAK 0.32 0.17 enet 29 0.26 2.7e-08 -4.0 -6.0 2.0e-09 0.01 0.54 0.02 FALSE
13 GTEx Cells EBV-transformed lymphocytes CRIPAK 0.49 0.27 lasso 8 0.35 2.9e-12 -4.2 -5.3 1.1e-07 0.05 0.84 0.01 FALSE
14 GTEx Cells Transformed fibroblasts TMEM129 0.14 0.02 lasso 3 0.02 6.0e-03 -7.3 -7.7 1.0e-14 -0.54 0.25 0.15 FALSE
15 GTEx Colon Transverse TMEM129 0.23 0.05 lasso 4 0.03 1.8e-02 -8.1 6.2 4.5e-10 0.51 0.08 0.10 FALSE
16 GTEx Colon Transverse CRIPAK 0.33 0.10 enet 22 0.24 5.8e-12 -4.1 -5.4 6.1e-08 0.03 0.97 0.00 FALSE
17 GTEx Colon Transverse RP11-20I20.4 0.17 0.05 lasso 3 0.05 2.3e-03 -4.9 -5.1 2.7e-07 0.01 0.30 0.30 FALSE
18 GTEx Esophagus Gastroesophageal Junction UVSSA 0.30 0.00 enet 23 0.08 1.1e-03 -4.2 -5.3 1.2e-07 0.09 0.28 0.04 FALSE
19 GTEx Esophagus Gastroesophageal Junction CRIPAK 0.33 0.20 lasso 5 0.30 1.4e-11 -4.2 -5.1 3.0e-07 0.02 0.99 0.00 FALSE
20 GTEx Esophagus Mucosa CRIPAK 0.49 0.14 enet 28 0.40 6.8e-29 -4.2 -5.3 1.3e-07 0.00 1.00 0.00 FALSE
21 GTEx Lung CRIPAK 0.61 0.22 enet 46 0.41 1.1e-33 -4.2 -6.2 5.4e-10 0.02 1.00 0.00 FALSE
22 GTEx Lung RP11-20I20.4 0.07 0.00 lasso 3 0.01 6.0e-02 -4.9 -5.5 4.1e-08 0.03 0.13 0.06 FALSE
23 GTEx Muscle Skeletal FGFRL1 0.14 0.08 lasso 4 0.06 3.7e-06 -5.6 5.3 9.6e-08 0.01 0.00 1.00 FALSE
24 GTEx Muscle Skeletal SLBP 0.08 0.06 lasso 4 0.04 5.0e-05 -7.6 -7.2 6.0e-13 -0.35 0.92 0.01 FALSE
25 GTEx Muscle Skeletal CRIPAK 0.25 0.11 enet 32 0.18 7.6e-18 -4.2 -5.3 1.2e-07 0.03 1.00 0.00 FALSE
26 GTEx Nerve Tibial CRIPAK 0.50 0.11 enet 76 0.38 1.1e-28 -4.1 -6.1 1.2e-09 -0.08 1.00 0.00 FALSE
27 GTEx Ovary UVSSA 0.33 0.10 enet 12 0.32 1.5e-08 -4.3 -5.4 8.2e-08 0.02 0.11 0.05 FALSE
28 GTEx Ovary CRIPAK 0.43 0.27 enet 19 0.32 9.0e-09 -4.2 -6.0 2.7e-09 0.03 0.47 0.04 FALSE
29 GTEx Pancreas TMEM129 0.20 0.19 lasso 3 0.14 1.5e-06 -8.1 7.6 2.7e-14 0.58 0.76 0.17 FALSE
30 GTEx Pancreas CRIPAK 0.34 0.13 lasso 6 0.27 1.0e-11 -4.1 -5.4 6.1e-08 0.01 0.84 0.01 FALSE
31 GTEx Pituitary TACC3 0.37 0.17 lasso 2 0.26 4.3e-07 -8.1 5.3 9.1e-08 0.23 0.33 0.09 FALSE
32 GTEx Skin Sun Exposed Lower leg CRIPAK 0.36 0.09 enet 40 0.35 8.7e-30 -4.2 -5.3 9.4e-08 0.03 1.00 0.00 FALSE
33 GTEx Spleen AC016773.1 0.42 0.21 lasso 7 0.16 8.6e-05 -8.0 6.6 4.9e-11 0.50 0.11 0.14 FALSE
34 GTEx Testis TACC3 0.17 0.03 lasso 6 0.04 5.2e-03 -8.0 -5.1 2.8e-07 -0.21 0.20 0.07 FALSE
35 GTEx Thyroid AC016773.1 0.11 0.07 enet 7 0.06 3.9e-05 -8.0 6.2 6.0e-10 0.52 0.61 0.12 FALSE
36 GTEx Whole Blood TACC3 0.11 0.05 enet 7 0.06 2.8e-06 -7.6 8.2 3.5e-16 0.59 0.89 0.08 FALSE
37 GTEx Whole Blood CRIPAK 0.38 0.17 lasso 9 0.28 3.4e-26 -4.1 -5.7 1.4e-08 0.02 1.00 0.00 FALSE
38 GTEx Whole Blood AC016773.1 0.27 0.21 enet 8 0.22 1.2e-19 -8.1 7.2 6.4e-13 0.53 0.83 0.17 FALSE
39 METSIM Adipose CRIPAK 0.28 0.16 bslmm 335 0.25 2.7e-37 -3.6 -5.7 1.2e-08 -0.01 1.00 0.00 FALSE
40 METSIM Adipose TMEM129 0.11 0.09 lasso 8 0.09 3.3e-13 -8.0 7.3 2.5e-13 0.57 0.86 0.14 FALSE
41 NTR Blood CRIPAK 0.13 0.09 enet 31 0.15 1.5e-46 -4.2 -7.5 9.1e-14 0.00 1.00 0.00 TRUE
42 NTR Blood KIAA1530 0.19 0.04 blup 345 0.10 9.1e-32 -4.3 -6.5 1.0e-10 0.08 1.00 0.00 FALSE
43 NTR Blood SLBP 0.04 0.02 lasso 5 0.02 2.8e-08 -8.0 9.7 2.9e-22 0.82 0.02 0.98 FALSE
44 NTR Blood TACC3 0.05 0.03 lasso 9 0.04 2.7e-13 -8.0 9.8 7.6e-23 0.71 0.47 0.53 TRUE
45 ROSMAP Brain Pre-frontal Cortex AC016773.1 0.12 0.06 lasso 3 0.10 3.0e-12 -8.0 5.7 1.5e-08 0.52 0.93 0.07 FALSE
46 YFS Blood CRIPAK 0.35 0.27 bslmm 301 0.33 6.0e-112 -4.1 -5.7 1.4e-08 -0.03 1.00 0.00 FALSE
47 YFS Blood SLBP 0.10 0.12 lasso 3 0.12 1.2e-35 -8.0 8.1 8.6e-16 0.60 0.87 0.13 FALSE
48 YFS Blood TACC3 0.22 0.24 lasso 11 0.27 1.4e-87 -8.1 6.3 3.3e-10 0.34 0.86 0.14 FALSE
49 The Cancer Genome Atlas Breast Invasive Carcinoma CRIPAK 0.22 0.11 blup 28 0.14 5.6e-28 -4.1 -5.4 5.9e-08 0.01 0.01 0.84 FALSE
50 The Cancer Genome Atlas Colon Adenocarcinoma CRIPAK 0.38 0.16 blup 28 0.21 2.8e-12 -4.1 -5.4 5.7e-08 0.01 0.01 0.84 FALSE
51 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma CRIPAK 0.28 0.16 blup 28 0.19 3.2e-21 -4.1 -5.7 1.1e-08 0.03 0.01 0.84 FALSE
52 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma TMEM129 0.04 0.02 blup 47 0.02 3.0e-03 6.7 -6.4 1.9e-10 -0.70 0.03 0.43 FALSE
53 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CRIPAK 0.21 0.10 enet 9 0.15 1.3e-16 -4.1 -5.2 1.7e-07 0.00 0.01 0.82 FALSE
54 The Cancer Genome Atlas Lung Squamous Cell Carcinoma TMEM129 0.05 0.03 lasso 4 0.02 8.5e-04 6.7 -7.8 7.5e-15 -0.69 0.13 0.46 FALSE
55 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma TACC3 0.09 0.08 enet 7 0.11 2.7e-05 -8.0 5.8 7.6e-09 0.52 0.13 0.23 FALSE
56 The Cancer Genome Atlas Soft Tissue Sarcoma TMEM129 0.09 0.04 lasso 2 0.03 3.8e-03 -7.6 -8.0 1.5e-15 -0.51 0.02 0.30 FALSE
57 The Cancer Genome Atlas Thyroid Carcinoma CRIPAK 0.38 0.22 enet 12 0.25 5.4e-24 -4.1 -5.5 4.0e-08 0.01 0.01 0.84 FALSE
58 The Cancer Genome Atlas Thyroid Carcinoma FAM53A 0.05 0.03 blup 56 0.04 1.8e-04 5.1 5.9 3.0e-09 0.79 0.01 0.95 FALSE
59 The Cancer Genome Atlas Thyroid Carcinoma TMEM129 0.20 0.21 lasso 5 0.24 3.5e-23 -1.7 5.2 2.0e-07 0.49 1.00 0.00 FALSE