Best TWAS P=7.63e-23 · Best GWAS P=5.06e-19 conditioned to 0.823
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CRIPAK | 0.31 | 0.15 | enet | 34 | 0.26 | 1.2e-31 | -4.2 | -6.4 | 1.3e-10 | 0.04 | 1.00 | 0.00 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | TMEM129 | 0.11 | 0.07 | enet | 6 | 0.07 | 3.7e-09 | -8.0 | 5.6 | 1.8e-08 | 0.35 | 0.85 | 0.15 | TRUE |
3 | GTEx | Adipose Visceral Omentum | CRIPAK | 0.47 | 0.24 | lasso | 12 | 0.31 | 1.3e-16 | -4.2 | -5.5 | 3.8e-08 | 0.02 | 1.00 | 0.00 | FALSE |
4 | GTEx | Artery Aorta | UVSSA | 0.33 | 0.06 | enet | 30 | 0.28 | 7.2e-16 | -4.3 | -5.6 | 2.5e-08 | 0.01 | 0.95 | 0.00 | FALSE |
5 | GTEx | Artery Tibial | CRIPAK | 0.42 | 0.09 | enet | 50 | 0.34 | 1.3e-27 | 1.5 | -5.4 | 7.6e-08 | 0.02 | 1.00 | 0.00 | FALSE |
6 | GTEx | Brain Cortex | TACC3 | 0.26 | 0.13 | lasso | 4 | 0.17 | 1.7e-05 | -8.1 | 5.7 | 9.3e-09 | 0.52 | 0.25 | 0.27 | FALSE |
7 | GTEx | Brain Cortex | CRIPAK | 0.34 | 0.10 | lasso | 6 | 0.18 | 9.5e-06 | -4.2 | -5.9 | 3.8e-09 | 0.03 | 0.20 | 0.06 | FALSE |
8 | GTEx | Brain Hippocampus | CRIPAK | 0.48 | 0.22 | lasso | 4 | 0.23 | 4.0e-06 | -4.1 | -6.1 | 1.3e-09 | 0.00 | 0.18 | 0.12 | FALSE |
9 | GTEx | Brain Hypothalamus | CRIPAK | 0.22 | 0.00 | lasso | 5 | 0.01 | 2.1e-01 | -4.3 | -5.2 | 2.2e-07 | 0.02 | 0.06 | 0.08 | FALSE |
10 | GTEx | Brain Nucleus accumbens basal ganglia | CRIPAK | 0.34 | 0.13 | lasso | 6 | 0.25 | 2.7e-07 | -4.2 | -5.3 | 1.1e-07 | 0.05 | 0.21 | 0.04 | FALSE |
11 | GTEx | Breast Mammary Tissue | CRIPAK | 0.42 | 0.12 | enet | 35 | 0.39 | 5.2e-21 | -4.2 | -5.8 | 7.3e-09 | 0.02 | 1.00 | 0.00 | FALSE |
12 | GTEx | Breast Mammary Tissue (Female) | CRIPAK | 0.32 | 0.17 | enet | 29 | 0.26 | 2.7e-08 | -4.0 | -6.0 | 2.0e-09 | 0.01 | 0.54 | 0.02 | FALSE |
13 | GTEx | Cells EBV-transformed lymphocytes | CRIPAK | 0.49 | 0.27 | lasso | 8 | 0.35 | 2.9e-12 | -4.2 | -5.3 | 1.1e-07 | 0.05 | 0.84 | 0.01 | FALSE |
14 | GTEx | Cells Transformed fibroblasts | TMEM129 | 0.14 | 0.02 | lasso | 3 | 0.02 | 6.0e-03 | -7.3 | -7.7 | 1.0e-14 | -0.54 | 0.25 | 0.15 | FALSE |
15 | GTEx | Colon Transverse | TMEM129 | 0.23 | 0.05 | lasso | 4 | 0.03 | 1.8e-02 | -8.1 | 6.2 | 4.5e-10 | 0.51 | 0.08 | 0.10 | FALSE |
16 | GTEx | Colon Transverse | CRIPAK | 0.33 | 0.10 | enet | 22 | 0.24 | 5.8e-12 | -4.1 | -5.4 | 6.1e-08 | 0.03 | 0.97 | 0.00 | FALSE |
17 | GTEx | Colon Transverse | RP11-20I20.4 | 0.17 | 0.05 | lasso | 3 | 0.05 | 2.3e-03 | -4.9 | -5.1 | 2.7e-07 | 0.01 | 0.30 | 0.30 | FALSE |
18 | GTEx | Esophagus Gastroesophageal Junction | UVSSA | 0.30 | 0.00 | enet | 23 | 0.08 | 1.1e-03 | -4.2 | -5.3 | 1.2e-07 | 0.09 | 0.28 | 0.04 | FALSE |
19 | GTEx | Esophagus Gastroesophageal Junction | CRIPAK | 0.33 | 0.20 | lasso | 5 | 0.30 | 1.4e-11 | -4.2 | -5.1 | 3.0e-07 | 0.02 | 0.99 | 0.00 | FALSE |
20 | GTEx | Esophagus Mucosa | CRIPAK | 0.49 | 0.14 | enet | 28 | 0.40 | 6.8e-29 | -4.2 | -5.3 | 1.3e-07 | 0.00 | 1.00 | 0.00 | FALSE |
21 | GTEx | Lung | CRIPAK | 0.61 | 0.22 | enet | 46 | 0.41 | 1.1e-33 | -4.2 | -6.2 | 5.4e-10 | 0.02 | 1.00 | 0.00 | FALSE |
22 | GTEx | Lung | RP11-20I20.4 | 0.07 | 0.00 | lasso | 3 | 0.01 | 6.0e-02 | -4.9 | -5.5 | 4.1e-08 | 0.03 | 0.13 | 0.06 | FALSE |
23 | GTEx | Muscle Skeletal | FGFRL1 | 0.14 | 0.08 | lasso | 4 | 0.06 | 3.7e-06 | -5.6 | 5.3 | 9.6e-08 | 0.01 | 0.00 | 1.00 | FALSE |
24 | GTEx | Muscle Skeletal | SLBP | 0.08 | 0.06 | lasso | 4 | 0.04 | 5.0e-05 | -7.6 | -7.2 | 6.0e-13 | -0.35 | 0.92 | 0.01 | FALSE |
25 | GTEx | Muscle Skeletal | CRIPAK | 0.25 | 0.11 | enet | 32 | 0.18 | 7.6e-18 | -4.2 | -5.3 | 1.2e-07 | 0.03 | 1.00 | 0.00 | FALSE |
26 | GTEx | Nerve Tibial | CRIPAK | 0.50 | 0.11 | enet | 76 | 0.38 | 1.1e-28 | -4.1 | -6.1 | 1.2e-09 | -0.08 | 1.00 | 0.00 | FALSE |
27 | GTEx | Ovary | UVSSA | 0.33 | 0.10 | enet | 12 | 0.32 | 1.5e-08 | -4.3 | -5.4 | 8.2e-08 | 0.02 | 0.11 | 0.05 | FALSE |
28 | GTEx | Ovary | CRIPAK | 0.43 | 0.27 | enet | 19 | 0.32 | 9.0e-09 | -4.2 | -6.0 | 2.7e-09 | 0.03 | 0.47 | 0.04 | FALSE |
29 | GTEx | Pancreas | TMEM129 | 0.20 | 0.19 | lasso | 3 | 0.14 | 1.5e-06 | -8.1 | 7.6 | 2.7e-14 | 0.58 | 0.76 | 0.17 | FALSE |
30 | GTEx | Pancreas | CRIPAK | 0.34 | 0.13 | lasso | 6 | 0.27 | 1.0e-11 | -4.1 | -5.4 | 6.1e-08 | 0.01 | 0.84 | 0.01 | FALSE |
31 | GTEx | Pituitary | TACC3 | 0.37 | 0.17 | lasso | 2 | 0.26 | 4.3e-07 | -8.1 | 5.3 | 9.1e-08 | 0.23 | 0.33 | 0.09 | FALSE |
32 | GTEx | Skin Sun Exposed Lower leg | CRIPAK | 0.36 | 0.09 | enet | 40 | 0.35 | 8.7e-30 | -4.2 | -5.3 | 9.4e-08 | 0.03 | 1.00 | 0.00 | FALSE |
33 | GTEx | Spleen | AC016773.1 | 0.42 | 0.21 | lasso | 7 | 0.16 | 8.6e-05 | -8.0 | 6.6 | 4.9e-11 | 0.50 | 0.11 | 0.14 | FALSE |
34 | GTEx | Testis | TACC3 | 0.17 | 0.03 | lasso | 6 | 0.04 | 5.2e-03 | -8.0 | -5.1 | 2.8e-07 | -0.21 | 0.20 | 0.07 | FALSE |
35 | GTEx | Thyroid | AC016773.1 | 0.11 | 0.07 | enet | 7 | 0.06 | 3.9e-05 | -8.0 | 6.2 | 6.0e-10 | 0.52 | 0.61 | 0.12 | FALSE |
36 | GTEx | Whole Blood | TACC3 | 0.11 | 0.05 | enet | 7 | 0.06 | 2.8e-06 | -7.6 | 8.2 | 3.5e-16 | 0.59 | 0.89 | 0.08 | FALSE |
37 | GTEx | Whole Blood | CRIPAK | 0.38 | 0.17 | lasso | 9 | 0.28 | 3.4e-26 | -4.1 | -5.7 | 1.4e-08 | 0.02 | 1.00 | 0.00 | FALSE |
38 | GTEx | Whole Blood | AC016773.1 | 0.27 | 0.21 | enet | 8 | 0.22 | 1.2e-19 | -8.1 | 7.2 | 6.4e-13 | 0.53 | 0.83 | 0.17 | FALSE |
39 | METSIM | Adipose | CRIPAK | 0.28 | 0.16 | bslmm | 335 | 0.25 | 2.7e-37 | -3.6 | -5.7 | 1.2e-08 | -0.01 | 1.00 | 0.00 | FALSE |
40 | METSIM | Adipose | TMEM129 | 0.11 | 0.09 | lasso | 8 | 0.09 | 3.3e-13 | -8.0 | 7.3 | 2.5e-13 | 0.57 | 0.86 | 0.14 | FALSE |
41 | NTR | Blood | CRIPAK | 0.13 | 0.09 | enet | 31 | 0.15 | 1.5e-46 | -4.2 | -7.5 | 9.1e-14 | 0.00 | 1.00 | 0.00 | TRUE |
42 | NTR | Blood | KIAA1530 | 0.19 | 0.04 | blup | 345 | 0.10 | 9.1e-32 | -4.3 | -6.5 | 1.0e-10 | 0.08 | 1.00 | 0.00 | FALSE |
43 | NTR | Blood | SLBP | 0.04 | 0.02 | lasso | 5 | 0.02 | 2.8e-08 | -8.0 | 9.7 | 2.9e-22 | 0.82 | 0.02 | 0.98 | FALSE |
44 | NTR | Blood | TACC3 | 0.05 | 0.03 | lasso | 9 | 0.04 | 2.7e-13 | -8.0 | 9.8 | 7.6e-23 | 0.71 | 0.47 | 0.53 | TRUE |
45 | ROSMAP | Brain Pre-frontal Cortex | AC016773.1 | 0.12 | 0.06 | lasso | 3 | 0.10 | 3.0e-12 | -8.0 | 5.7 | 1.5e-08 | 0.52 | 0.93 | 0.07 | FALSE |
46 | YFS | Blood | CRIPAK | 0.35 | 0.27 | bslmm | 301 | 0.33 | 6.0e-112 | -4.1 | -5.7 | 1.4e-08 | -0.03 | 1.00 | 0.00 | FALSE |
47 | YFS | Blood | SLBP | 0.10 | 0.12 | lasso | 3 | 0.12 | 1.2e-35 | -8.0 | 8.1 | 8.6e-16 | 0.60 | 0.87 | 0.13 | FALSE |
48 | YFS | Blood | TACC3 | 0.22 | 0.24 | lasso | 11 | 0.27 | 1.4e-87 | -8.1 | 6.3 | 3.3e-10 | 0.34 | 0.86 | 0.14 | FALSE |
49 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CRIPAK | 0.22 | 0.11 | blup | 28 | 0.14 | 5.6e-28 | -4.1 | -5.4 | 5.9e-08 | 0.01 | 0.01 | 0.84 | FALSE |
50 | The Cancer Genome Atlas | Colon Adenocarcinoma | CRIPAK | 0.38 | 0.16 | blup | 28 | 0.21 | 2.8e-12 | -4.1 | -5.4 | 5.7e-08 | 0.01 | 0.01 | 0.84 | FALSE |
51 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CRIPAK | 0.28 | 0.16 | blup | 28 | 0.19 | 3.2e-21 | -4.1 | -5.7 | 1.1e-08 | 0.03 | 0.01 | 0.84 | FALSE |
52 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TMEM129 | 0.04 | 0.02 | blup | 47 | 0.02 | 3.0e-03 | 6.7 | -6.4 | 1.9e-10 | -0.70 | 0.03 | 0.43 | FALSE |
53 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CRIPAK | 0.21 | 0.10 | enet | 9 | 0.15 | 1.3e-16 | -4.1 | -5.2 | 1.7e-07 | 0.00 | 0.01 | 0.82 | FALSE |
54 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TMEM129 | 0.05 | 0.03 | lasso | 4 | 0.02 | 8.5e-04 | 6.7 | -7.8 | 7.5e-15 | -0.69 | 0.13 | 0.46 | FALSE |
55 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | TACC3 | 0.09 | 0.08 | enet | 7 | 0.11 | 2.7e-05 | -8.0 | 5.8 | 7.6e-09 | 0.52 | 0.13 | 0.23 | FALSE |
56 | The Cancer Genome Atlas | Soft Tissue Sarcoma | TMEM129 | 0.09 | 0.04 | lasso | 2 | 0.03 | 3.8e-03 | -7.6 | -8.0 | 1.5e-15 | -0.51 | 0.02 | 0.30 | FALSE |
57 | The Cancer Genome Atlas | Thyroid Carcinoma | CRIPAK | 0.38 | 0.22 | enet | 12 | 0.25 | 5.4e-24 | -4.1 | -5.5 | 4.0e-08 | 0.01 | 0.01 | 0.84 | FALSE |
58 | The Cancer Genome Atlas | Thyroid Carcinoma | FAM53A | 0.05 | 0.03 | blup | 56 | 0.04 | 1.8e-04 | 5.1 | 5.9 | 3.0e-09 | 0.79 | 0.01 | 0.95 | FALSE |
59 | The Cancer Genome Atlas | Thyroid Carcinoma | TMEM129 | 0.20 | 0.21 | lasso | 5 | 0.24 | 3.5e-23 | -1.7 | 5.2 | 2.0e-07 | 0.49 | 1.00 | 0.00 | FALSE |