Best TWAS P=1.47e-11 · Best GWAS P=2.17e-10 conditioned to 0.121
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | BBS7 | 0.19 | 0.21 | bslmm | 423 | 0.23 | 1.8e-27 | -6.3 | -6.0 | 2.5e-09 | 0.93 | 0.00 | 1.00 | FALSE |
2 | GTEx | Brain Cerebellar Hemisphere | BBS7 | 0.27 | 0.05 | lasso | 3 | 0.08 | 4.7e-03 | -5.0 | -6.0 | 2.3e-09 | 0.61 | 0.08 | 0.35 | FALSE |
3 | GTEx | Cells EBV-transformed lymphocytes | EXOSC9 | 0.29 | 0.17 | lasso | 7 | 0.16 | 6.6e-06 | 5.2 | 5.8 | 8.8e-09 | -0.68 | 0.43 | 0.52 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | BBS7 | 0.16 | 0.09 | lasso | 7 | 0.16 | 2.9e-12 | -6.3 | -6.5 | 8.2e-11 | 0.91 | 0.00 | 1.00 | FALSE |
5 | GTEx | Testis | EXOSC9 | 0.17 | 0.07 | lasso | 8 | 0.10 | 2.5e-05 | -5.0 | 6.1 | 1.3e-09 | -0.87 | 0.01 | 0.98 | FALSE |
6 | YFS | Blood | EXOSC9 | 0.06 | 0.09 | bslmm | 401 | 0.09 | 7.0e-28 | 5.2 | 5.5 | 3.5e-08 | -0.63 | 0.76 | 0.24 | FALSE |
7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EXOSC9 | 0.03 | 0.04 | enet | 9 | 0.04 | 2.8e-08 | 5.4 | 6.1 | 9.9e-10 | -0.70 | 0.62 | 0.38 | FALSE |
8 | The Cancer Genome Atlas | Colon Adenocarcinoma | BBS7 | 0.05 | 0.00 | blup | 47 | 0.02 | 1.9e-02 | 5.4 | -5.3 | 1.2e-07 | 0.56 | 0.02 | 0.12 | FALSE |
9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CCNA2 | 0.03 | 0.01 | blup | 34 | 0.02 | 1.5e-03 | -6.3 | 6.8 | 1.5e-11 | -0.80 | 0.00 | 0.97 | TRUE |
10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | BBS7 | 0.04 | 0.04 | lasso | 2 | 0.03 | 6.1e-04 | -6.3 | -6.3 | 2.6e-10 | 1.00 | 0.00 | 1.00 | FALSE |
11 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | EXOSC9 | 0.03 | 0.02 | lasso | 2 | 0.02 | 1.0e-03 | 5.1 | 5.8 | 8.5e-09 | -0.66 | 0.09 | 0.28 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | EXOSC9 | 0.04 | 0.05 | lasso | 2 | 0.04 | 7.1e-05 | 5.4 | 6.3 | 3.5e-10 | -0.78 | 0.03 | 0.94 | FALSE |