TWAS hub - EXOSC9

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0470	0.0210	1.1e-02	0.046	0.008	0.018	0.014	0.032	2.3e-06	2.9e-02	2.8e-03	6.4e-03	7.1e-05
2	GTEx	Adipose Subcutaneous	0.0690	0.0320	7.3e-03	-0.003	NA	-0.001	NA	-0.001	7.6e-01	NA	4.6e-01	NA	4.5e-01
3	GTEx	Cells EBV-transformed lymphocytes	0.2930	0.0700	1.8e-05	0.173	NA	0.156	NA	0.160	2.8e-06	NA	8.7e-06	NA	6.7e-06
4	GTEx	Testis	0.1660	0.0550	3.1e-04	0.071	NA	0.053	NA	0.104	4.6e-04	NA	2.2e-03	NA	2.5e-05
5	NTR	Blood	0.0223	0.0089	1.2e-03	0.000	0.003	0.001	0.004	0.000	3.1e-01	2.1e-02	1.7e-01	1.7e-02	3.5e-01
6	ROSMAP	Brain Pre-frontal Cortex	0.0500	0.0213	5.8e-03	0.023	0.018	0.016	0.020	0.023	4.8e-04	1.9e-03	3.0e-03	1.0e-03	5.3e-04
7	YFS	Blood	0.0577	0.0117	0.0e+00	0.092	0.083	0.084	0.090	0.088	2.3e-28	1.0e-25	4.6e-26	7.0e-28	2.0e-27
8	TCGA	Breast Invasive Carcinoma	0.0257	0.0112	7.5e-08	0.039	0.036	0.038	NA	0.036	1.5e-08	6.3e-08	2.7e-08	NA	5.1e-08
9	TCGA	Lung Squamous Cell Carcinoma	0.0277	0.0167	2.2e-03	0.020	0.023	0.022	NA	0.023	2.4e-03	1.1e-03	1.3e-03	NA	1.0e-03
10	TCGA	Prostate Adenocarcinoma	0.0328	0.0222	8.9e-03	0.002	0.016	0.002	NA	0.003	1.7e-01	8.0e-03	1.8e-01	NA	1.5e-01
11	TCGA	Thyroid Carcinoma	0.0370	0.0190	1.8e-04	0.053	0.039	0.015	NA	0.041	7.2e-06	1.1e-04	1.2e-02	NA	7.1e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Number of full sisters	9.8	11.9	21.8	-0.9	-2.5	-4.5	-3.7	-1.0	-2.2	-4.7	-4.3	-4.4	-2.4	-4.3
Height	7.3	140.7	210.2	-0.0	10.5	14.2	13.9	3.7	12.2	14.0	14.5	13.9	8.4	14.5
Trunk fat-free mass	7.3	42.0	65.9	-1.0	5.7	7.7	7.8	1.0	6.0	7.6	8.0	8.0	4.4	8.1
Trunk predicted mass	7.3	41.7	65.9	-1.0	5.8	7.7	7.7	1.0	5.9	7.6	8.0	7.9	4.4	8.1
Basal metabolic rate	7.3	40.1	65.1	-0.6	5.3	7.5	7.5	1.3	5.8	7.4	8.0	7.6	4.8	8.1
Whole body water mass	7.2	41.1	65.9	-0.8	5.6	7.6	7.7	1.2	5.9	7.5	8.0	7.7	4.7	8.1
Arm predicted mass (left)	7.2	36.8	60.7	-0.9	5.4	7.3	7.3	1.0	5.4	7.1	7.5	7.2	4.2	7.8
Arm fat-free mass (left)	7.0	35.3	57.8	-0.6	4.9	7.2	6.9	1.3	5.5	7.0	7.5	7.2	4.3	7.6
Whole body fat-free mass	6.9	39.6	63.4	-0.7	5.4	7.5	7.5	1.1	5.8	7.4	7.9	7.5	4.7	8.0
Arm predicted mass (right)	6.8	34.9	56.4	-0.5	5.0	7.1	6.9	1.1	5.5	7.0	7.3	7.0	4.5	7.5
Leg predicted mass (right)	6.7	35.6	58.4	-0.5	5.0	7.1	7.2	1.1	5.6	6.9	7.5	6.9	4.7	7.6
Leg fat-free mass (right)	6.6	35.2	57.8	-0.6	5.0	7.0	7.2	1.1	5.5	6.9	7.5	6.8	4.7	7.6
Leg fat-free mass (left)	6.4	33.7	54.5	-0.7	5.0	6.8	7.0	1.1	5.5	6.7	7.3	6.7	4.5	7.4
Arm fat-free mass (right)	6.3	32.1	52.2	-0.7	4.8	6.7	6.7	1.0	5.2	6.7	7.0	6.7	4.3	7.2
Leg predicted mass (left)	6.2	33.0	53.1	-0.6	5.0	6.8	7.0	1.1	5.4	6.6	7.2	6.6	4.6	7.3
Weight	5.6	27.7	47.6	-0.3	4.2	6.3	6.3	1.2	4.8	6.0	6.7	6.1	4.2	6.9
Hip circumference	5.5	23.7	41.1	0.5	3.7	5.7	5.8	1.9	4.3	5.4	6.3	5.6	4.2	6.4
Number of self-reported non-cancer illnesses	4.5	7.8	10.7	0.2	2.1	3.0	3.1	3.2	2.8	2.9	3.2	2.9	2.6	3.3
Standing height	4.4	43.6	65.6	-1.5	6.0	7.9	7.8	2.1	6.9	7.4	8.1	8.0	4.2	7.9
Comparative height size at age 10	4.4	24.0	39.4	-1.4	4.8	5.8	6.1	0.8	4.5	5.5	6.1	5.8	2.8	6.3
Health satisfaction	3.8	4.9	7.7	-0.1	1.9	2.5	2.6	0.4	1.8	2.7	2.8	2.6	2.0	2.8
Medication: Blood pressure	3.8	7.2	11.6	0.0	2.6	3.0	3.3	1.4	3.1	2.8	3.3	3.4	1.4	2.9
Blood Red Count	3.6	35.0	61.3	-3.0	6.7	6.2	7.8	2.1	6.3	6.0	6.8	6.7	2.9	7.3
Medication: Gliclazide	3.6	4.1	8.4	-0.6	-1.2	-2.0	-2.0	-2.0	-2.9	-2.0	-2.2	-2.0	-2.2	-2.3
LDL Cholesterol	3.5	5.5	8.8	-1.2	-1.7	-2.6	-2.5	-0.7	-2.0	-2.7	-2.8	-2.6	-2.8	-3.0
Ever had hysterectomy (womb removed)	3.5	4.0	10.2	0.5	1.1	2.4	1.8	3.2	2.4	1.9	2.1	1.8	1.4	2.1
Waist circumference	3.5	12.7	21.7	0.9	2.1	4.2	4.0	2.2	3.0	3.8	4.6	4.0	3.7	4.7
Noisy workplace	3.4	4.2	6.3	0.6	-2.1	-2.2	-2.5	-2.3	-2.2	-2.0	-2.2	-2.2	-1.2	-2.2
Severe depression (siblings)	3.3	3.6	5.6	-0.1	-1.7	-1.9	-2.1	-1.2	-2.3	-1.9	-2.2	-2.4	-2.1	-2.1
High blood pressure (mother)	3.3	4.7	8.0	0.6	1.9	2.7	2.5	0.9	1.9	2.5	2.5	2.8	1.8	2.4
Arm fat mass (right)	3.3	13.7	23.6	0.3	2.4	4.3	4.4	1.4	3.5	4.0	4.8	4.2	3.6	4.9
Birth weight of first child	3.3	6.0	8.6	0.7	2.3	2.9	2.9	1.7	2.2	2.6	2.9	2.9	2.0	2.8
Eye problems/disorders: Cataract	3.3	3.9	12.0	2.5	-0.7	1.5	0.9	2.9	1.4	1.7	1.6	1.0	3.5	1.9
Arm fat mass (left)	3.3	13.6	23.2	0.3	2.5	4.3	4.3	1.1	3.4	4.1	4.7	4.2	3.6	4.8
Hayfever/allergic rhinitis (self-reported)	3.2	4.2	7.5	0.7	1.6	2.7	2.1	2.5	1.0	2.3	2.4	2.2	1.6	2.3
Breastfed as a baby	3.2	4.0	6.6	-0.3	-1.8	-2.0	-2.4	-0.4	-1.8	-2.1	-2.6	-2.2	-2.6	-2.4
Emphysema/chronic bronchitis	3.2	3.5	10.3	0.9	1.1	1.9	1.8	3.2	1.2	2.1	2.0	1.8	1.8	1.9
Chronotype (morning person)	3.1	7.2	13.2	-0.1	-2.0	-3.1	-3.3	-1.5	-2.5	-2.6	-3.3	-2.5	-3.0	-3.6
Trunk fat mass	3.1	13.3	23.2	0.7	2.3	4.3	4.3	1.7	3.4	3.9	4.7	3.8	3.8	4.8
Whole body fat mass	3.1	12.8	22.3	0.8	1.9	4.3	4.0	1.5	3.4	3.9	4.7	3.9	3.7	4.7
Major Depression (MDD)	2.9	3.5	8.6	-0.3	2.9	1.8	2.9	0.9	0.9	1.5	2.1	1.4	1.2	2.6
Sitting height	2.9	20.8	31.0	-1.7	4.2	5.4	5.6	0.2	5.0	5.0	5.5	5.5	2.9	5.4
Long-standing illness, disability or infirmity	2.9	4.5	9.3	1.3	1.4	2.3	2.1	3.0	1.5	2.0	2.3	1.6	2.6	2.4
Supplements: Calcium	2.9	3.2	6.8	1.7	0.1	1.6	1.3	2.2	1.7	1.6	2.0	1.5	2.6	2.1
Heart attack	2.8	3.5	10.3	0.8	-3.2	-2.1	-2.5	0.4	-0.5	-2.6	-1.8	-1.6	0.2	-2.2
Peak expiratory flow (PEF)	2.8	6.5	12.8	-1.9	3.4	2.8	3.6	0.2	1.5	2.7	2.9	2.5	0.6	3.4
Ever taken oral contraceptive pill	2.8	3.1	4.9	-1.3	-1.7	-2.1	-2.0	-1.3	-0.9	-2.2	-1.9	-1.4	-2.0	-2.0
Deep venous thrombosis (DVT) (self-reported)	2.8	3.5	8.4	0.1	2.9	1.5	2.7	2.1	1.9	1.7	1.6	1.4	1.5	1.8
Other serious medical condition/disability diagnosed by doctor	2.7	3.5	7.9	2.8	-0.2	1.9	0.8	2.8	0.8	1.9	1.8	1.6	2.5	1.5
Risk taking	2.7	4.0	6.7	-2.0	0.3	-2.4	-1.0	-1.0	-2.6	-2.6	-2.3	-2.3	-2.1	-1.9
Ever had bowel cancer screening	2.6	3.1	6.4	0.3	1.5	2.2	2.2	0.9	1.1	2.1	2.1	1.7	1.2	2.5
Impedance of whole body	2.6	13.0	22.9	0.2	-3.0	-4.2	-4.3	0.3	-3.2	-4.5	-4.5	-4.1	-2.8	-4.8
Leg fat mass (left)	2.6	10.1	18.6	0.6	1.7	3.8	3.5	0.8	2.9	3.6	4.2	3.6	3.1	4.3
Impedance of leg (right)	2.5	12.0	21.3	0.2	-2.7	-4.0	-4.1	0.1	-3.2	-4.2	-4.4	-3.8	-3.0	-4.6
Mouth/teeth dental problems: Bleeding gums	2.5	3.2	5.3	-0.8	-0.8	-2.0	-1.5	-1.0	-1.7	-2.3	-2.2	-2.2	-2.1	-2.0
Medication for cholesterol	2.5	3.9	6.5	0.3	-1.9	-2.2	-2.5	-0.4	-2.3	-2.0	-2.5	-2.6	-1.0	-2.1
Impedance of leg (left)	2.4	11.6	19.2	0.2	-2.9	-3.8	-4.1	-0.2	-3.3	-4.1	-4.3	-3.7	-3.0	-4.4
Leg fat mass (right)	2.4	9.2	16.2	0.7	1.7	3.6	3.4	0.9	2.8	3.5	3.9	3.4	3.1	4.0
Heart attack/myocardial infarction (self-reported)	2.2	2.9	9.5	0.8	-3.1	-1.8	-2.3	0.4	-0.2	-2.3	-1.5	-1.2	0.3	-1.9
Lung FEV1/FVC ratio	2.1	10.6	17.0	-0.5	3.2	3.7	4.1	0.8	3.0	3.6	4.1	4.1	1.9	4.0
Number of incorrect matches in round	2.1	3.5	10.2	2.8	-1.4	1.2	0.0	2.3	2.6	1.5	1.4	0.5	3.2	1.0
Depression (self-reported)	2.1	2.5	4.6	-0.8	-0.8	-1.7	-1.2	-2.1	-1.5	-1.8	-1.7	-2.0	-1.3	-1.7
Prospective memory result	2.1	2.6	9.9	1.4	0.8	1.2	1.1	3.1	2.0	1.1	1.3	1.6	1.9	0.8
Impedance of arm (left)	2.1	9.5	17.1	-0.0	-2.5	-3.7	-3.6	0.5	-2.6	-3.9	-3.8	-3.6	-2.2	-4.1
Blood clot in the leg (DVT)	2.1	2.7	6.7	0.3	2.6	1.2	2.4	2.0	1.6	1.4	1.4	1.1	1.5	1.5
Glaucoma (self-reported)	2.1	2.5	4.3	1.9	-0.1	1.8	0.6	1.5	1.3	2.1	1.6	1.9	2.0	1.3
Basal cell carcinoma (self-reported)	2.1	2.5	5.2	1.4	-2.0	-1.3	-2.3	1.2	-1.4	-1.6	-1.6	-1.5	-0.5	-1.9
Breast Cancer	2.0	4.8	12.6	-2.8	3.5	1.6	3.2	-1.1	1.9	1.8	1.8	1.9	-0.2	2.3
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	4.9	-0.1	2.1	1.8	2.2	0.5	1.2	1.7	1.6	1.2	0.7	1.9
High blood pressure	2.0	5.6	9.7	-1.2	3.0	2.7	3.1	1.4	1.4	2.5	2.8	3.0	0.4	2.6
Commuting to job workplace: Car/motor vehicle	2.0	2.3	3.3	-0.7	-1.5	-1.6	-1.8	-1.1	-1.5	-1.2	-1.7	-1.4	-1.8	-1.7
Age started oral contraceptive pill	2.0	2.5	4.3	1.6	-0.4	2.1	0.7	0.9	2.0	1.9	1.9	1.4	1.7	1.8
Mouth/teeth dental problems: Loose teeth	1.9	2.3	4.5	0.6	-2.1	-1.7	-1.9	-0.6	-1.5	-1.8	-1.6	-1.8	-0.8	-1.3
Shortness of breath walking on level ground	1.8	2.2	3.7	0.4	0.6	1.6	1.4	1.0	1.8	1.8	1.7	1.3	1.8	1.9
Osteoarthritis (self-reported)	1.8	2.3	8.6	0.9	-2.9	-1.5	-2.1	-1.4	-1.2	-1.3	-1.0	-1.3	0.3	-1.3
Medication: Bendroflumethiazide	1.8	2.7	4.5	-0.2	1.5	1.8	2.1	1.2	1.8	1.6	2.0	1.6	1.5	1.9
Medication: Co-codamol	1.7	1.9	6.5	1.9	0.1	1.0	1.1	1.3	1.6	0.8	1.3	1.0	2.5	1.2
Medication: Ramipril	1.7	2.2	3.8	1.2	-0.4	1.7	0.8	0.5	1.0	1.9	1.9	2.0	2.0	1.8
Impedance of arm (right)	1.7	7.8	14.4	0.1	-2.4	-3.3	-3.3	0.4	-2.4	-3.6	-3.4	-3.1	-2.1	-3.8
Medication: Seretide 50 evohaler	1.7	2.0	3.7	1.1	1.0	1.6	1.3	1.5	1.4	1.9	1.4	1.5	1.6	1.1
Eye problems/disorders: Glaucoma	1.7	2.1	3.7	1.2	0.2	1.7	0.8	1.7	1.3	1.9	1.4	1.6	1.8	1.3
Vascular/heart problems diagnosed by doctor	1.7	4.5	7.9	1.0	-2.5	-2.4	-2.8	-1.6	-1.3	-2.2	-2.6	-2.6	-0.7	-2.5
Alzheimer’s Disease (in father)	1.6	1.7	6.2	-2.5	1.3	0.8	0.9	-2.2	0.1	0.5	0.5	0.9	-1.6	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	5.8	0.0	0.2	-1.6	-0.7	0.5	-1.8	-2.0	-1.9	-2.4	-0.9	-1.4
Breast cancer (self-reported)	1.6	1.9	5.0	1.1	1.3	1.2	1.5	2.2	1.7	1.0	1.2	0.5	1.5	1.4
Number of treatments/medications taken	1.5	2.6	8.5	1.4	-0.1	1.4	1.0	2.9	1.1	1.3	1.6	1.0	2.4	1.6
Body mass index (BMI)	1.5	6.6	13.2	0.3	1.8	3.0	3.2	0.3	2.0	2.9	3.3	2.7	2.5	3.6
Hair/balding pattern: Pattern 2	1.5	1.9	3.0	-1.3	-0.3	-1.5	-1.1	-1.7	-1.7	-1.1	-1.6	-1.6	-1.5	-1.1
Illnesses of mother	1.5	1.8	3.5	1.0	-1.4	-1.4	-1.8	-0.2	-1.9	-1.1	-1.5	-1.6	-0.4	-1.6
Hypertension (Self-reported)	1.5	4.2	7.2	-0.8	2.3	2.5	2.5	1.6	1.0	2.3	2.5	2.7	0.5	2.3
Bipolar Disorder (2011)	1.4	1.4	5.1	1.4	0.6	1.1	1.0	2.3	0.7	0.9	0.9	1.1	1.3	0.8
Alcohol intake versus 10 years previously	1.4	2.1	4.1	-0.2	1.1	1.6	1.8	0.7	1.8	1.1	1.9	1.7	1.0	2.0
Qualifications: A levels/AS levels or equivalent	1.4	3.0	8.6	-0.1	-1.0	-1.6	-1.9	-0.5	-2.9	-1.7	-1.9	-1.6	-2.0	-2.0
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	3.8	0.2	-1.0	-1.3	-1.5	-1.0	-2.0	-1.4	-1.3	-1.9	-1.0	-1.2
Medication: Ventolin 100micrograms inhaler	1.4	1.8	3.0	0.3	0.9	1.5	1.6	1.1	1.2	1.7	1.3	1.1	1.6	1.7
Illnesses of siblings: Diabetes	1.4	1.8	3.7	-1.5	-0.8	-1.8	-0.8	-1.9	-0.5	-1.8	-1.3	-1.1	-1.0	-1.3
Schizophrenia (2018)	1.3	2.8	5.7	1.8	0.3	1.4	1.0	2.4	1.5	1.8	1.6	2.1	2.3	1.1
Body Mass Index (BMI) (2010)	1.3	1.7	3.4	0.2	1.8	1.6	1.7	1.0	0.3	1.2	1.5	1.9	0.2	1.4
Medication for hormone replacement therapy	1.3	1.5	2.2	0.2	1.4	1.4	1.5	0.3	1.0	1.4	1.5	1.5	1.2	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	5.6	1.2	0.3	1.3	1.2	0.8	0.8	1.3	1.4	0.9	2.4	1.6
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.9	5.2	0.5	1.5	1.7	1.9	1.8	1.3	1.9	1.8	1.1	2.3	2.1
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	4.6	-0.7	2.0	1.6	2.2	-0.1	1.2	1.1	1.5	1.3	1.1	1.8
Prostate Cancer	1.2	1.6	7.6	-2.8	1.1	-0.2	0.7	-1.7	1.9	0.0	-0.2	0.4	-1.4	-0.1
Trunk fat percentage	1.2	4.9	9.0	0.8	1.1	2.5	2.5	1.6	2.0	2.1	2.8	1.9	2.8	3.0
Hearing difficulty/problems with background noise	1.2	2.0	5.5	-2.3	1.2	-1.0	0.3	-1.8	-2.1	-0.7	-0.7	-0.8	-2.2	-0.3
Allergy	1.2	2.7	8.5	0.8	-2.1	-1.5	-2.3	-2.9	-1.0	-1.3	-1.2	-1.4	-0.7	-1.5
Arm fat percentage (right)	1.2	4.7	8.2	0.9	0.7	2.3	2.3	1.0	1.9	2.2	2.9	2.3	2.8	2.8
Time employed in main current job	1.2	1.4	6.6	-2.6	1.5	0.2	1.2	-1.3	0.5	-0.2	0.5	0.4	-1.4	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	3.6	-0.9	0.7	-1.3	-0.2	-0.3	-1.9	-1.3	-1.4	-1.3	-1.5	-1.0
Arm fat percentage (left)	1.2	4.7	8.7	1.0	0.7	2.3	2.3	1.2	1.9	2.2	2.9	2.2	3.0	2.8
Commuting to job workplace: Walk	1.2	1.3	3.1	1.8	-0.0	1.3	0.2	1.7	0.8	1.4	0.9	1.0	1.6	0.5
Diastolic blood pressure, automated reading	1.2	3.7	7.4	-1.6	2.3	1.9	2.7	0.1	1.4	2.0	2.1	2.3	0.4	2.4
Schizophrenia (2014)	1.1	2.5	5.1	2.0	0.2	1.4	1.0	2.3	0.9	1.5	1.6	1.8	2.2	1.2
Asthma	1.1	2.1	7.4	0.7	0.7	1.4	1.5	2.7	1.1	1.5	1.1	1.3	1.5	1.3
Medication: Lansoprazole	1.1	1.2	4.7	0.8	-1.1	-1.0	-1.1	0.1	-2.2	-1.0	-1.0	-1.3	-0.3	-1.0
Pulse wave Arterial Stiffness index	1.1	1.3	2.7	0.6	0.9	1.2	1.5	-0.5	1.4	1.3	1.2	0.6	1.3	1.6
Body fat percentage	1.1	4.2	7.6	1.1	0.5	2.3	2.1	1.5	1.8	2.0	2.6	1.9	2.7	2.8
Eye problems/disorders: None of the above	1.1	1.3	5.8	-1.5	0.2	-0.7	-0.7	-1.0	-0.7	-1.2	-0.7	-0.7	-2.4	-1.1
Overall health rating	1.1	2.3	4.2	0.2	0.9	1.7	1.7	0.2	1.1	1.7	2.1	1.9	1.7	2.1
Supplements: Vitamin C	1.1	1.3	4.4	0.9	-2.1	-1.1	-1.6	-0.4	0.1	-1.3	-1.1	-1.1	-0.0	-1.3
Ever depressed for a whole week	1.1	1.4	3.5	-0.3	-0.4	-1.8	-0.8	-0.1	-0.3	-1.5	-1.6	-1.9	-0.2	-1.4
Alzheimer’s Disease (including proxy)	1.0	1.5	6.5	-2.5	1.7	0.2	1.2	-1.7	0.5	0.2	0.4	0.6	-1.2	0.5
Blood Platelet Count	1.0	12.0	22.4	-2.2	3.9	3.7	4.7	1.9	3.1	3.5	3.9	3.6	1.9	4.4
Maternal smoking around birth	1.0	1.5	3.7	0.8	0.6	1.2	1.1	1.2	0.6	1.4	1.3	1.3	1.9	1.2
Fed-up feelings	1.0	1.8	4.6	1.0	1.6	1.3	1.9	0.5	0.4	1.0	1.2	0.7	2.1	1.6
Taking other prescription medications	1.0	1.5	2.7	-0.3	1.0	1.3	1.6	1.5	0.7	1.1	1.4	1.3	1.1	1.6
Medication: Paracetamol	1.0	1.7	4.7	0.8	-2.2	-1.4	-1.8	0.2	-0.8	-1.4	-1.3	-1.4	0.2	-1.3
Illnesses of father: Heart disease	1.0	1.3	2.9	-0.9	-0.6	-1.0	-0.9	-1.7	-1.7	-1.1	-1.0	-1.2	-1.3	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	5.4	-0.7	2.3	1.5	2.0	0.4	1.2	1.4	1.4	1.4	0.4	1.4
Mineral and other dietary supplements	1.0	1.3	3.5	-1.5	1.5	-0.8	0.2	-1.2	-1.4	-0.7	-1.1	-0.9	-1.9	-0.7
Asthma (self-reported)	1.0	2.0	6.4	0.4	0.9	1.4	1.6	2.5	1.1	1.5	1.1	1.2	1.4	1.4
Leg fat percentage (left)	1.0	3.7	7.3	1.1	0.5	2.3	2.0	0.5	1.5	2.2	2.6	2.2	2.1	2.7
Bipolar Disorder or Schizophrenia	0.9	2.2	7.4	1.9	0.2	1.2	0.7	2.7	1.1	1.5	1.1	1.3	2.0	0.8
Neuroticism (2016)	0.9	1.3	4.8	1.5	0.9	0.7	1.4	0.7	1.1	0.4	1.0	0.5	2.2	1.0
Type 2 Diabetes (T2D) (2012)	0.9	1.1	2.0	0.3	0.9	1.2	1.4	1.1	0.9	0.4	1.4	1.0	1.0	1.1
BMI	0.9	5.3	10.4	-0.3	2.3	2.3	3.2	-0.4	1.6	2.4	2.8	2.4	2.1	3.2
Stomach or abdominal pain in last month	0.9	1.1	2.1	-0.1	0.9	1.1	1.1	-0.6	1.3	1.1	1.3	1.5	0.9	0.9
Medication: Levothyroxine sodium	0.9	1.5	4.5	2.1	-0.2	1.3	0.5	1.4	0.6	0.6	1.2	0.8	2.0	0.9
Past tobacco smoking	0.9	1.6	2.9	-0.6	1.2	1.4	1.4	-1.3	1.0	1.1	1.5	1.7	0.4	1.5
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.0	-1.4	0.3	-1.3	-0.2	-1.0	-0.6	-1.2	-1.2	-1.7	-0.6	-0.8
Happiness	0.9	1.1	2.7	0.2	0.5	1.4	0.9	-0.3	0.3	1.6	1.3	1.1	1.0	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	3.5	0.5	-1.9	-0.4	-1.5	-0.8	-1.9	-0.5	-0.6	-0.5	-0.7	-0.4
Medication: Cholesterol lowering	0.9	1.5	4.0	1.4	-2.0	-0.9	-1.5	0.8	-1.7	-0.9	-0.8	-1.2	0.5	-0.7
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	7.2	2.7	-1.2	0.5	-0.3	1.9	0.5	-0.0	0.6	0.4	2.3	0.3
Leg fat percentage (right)	0.9	3.1	5.5	1.3	0.5	2.0	1.8	0.8	1.4	2.0	2.3	1.9	2.2	2.3
Friendships satisfaction	0.9	1.2	3.4	1.8	-1.0	0.8	-0.2	1.8	0.4	0.9	0.6	0.4	1.7	0.7
Average weekly champagne plus white wine intake	0.9	1.3	2.6	-0.3	0.8	1.3	1.1	0.3	1.6	1.5	1.2	1.2	1.2	1.0
Alcohol drinker status: Never	0.9	1.1	3.3	-1.8	1.6	0.1	1.0	-1.8	1.0	0.2	0.5	0.2	-0.6	0.4
Average weekly beer plus cider intake	0.9	1.4	2.8	1.4	-0.5	1.2	0.4	-0.5	0.9	1.7	1.4	1.1	1.5	1.4
Triglycerides	0.8	1.3	2.9	0.1	-1.7	-0.9	-1.3	-1.3	-1.4	-1.3	-0.9	-0.8	-0.9	-1.0
Waist Hip Ratio (WHR)	0.8	3.7	9.0	2.2	-3.0	-1.3	-2.4	2.6	-1.3	-1.4	-1.2	-1.4	1.5	-1.7
Respiratory disease	0.8	1.7	10.3	0.6	0.7	1.1	1.3	3.2	0.7	0.9	0.8	0.5	1.2	1.0
Type 2 Diabetes (T2D) (2018)	0.8	1.4	5.3	-2.3	0.6	-0.8	-0.1	-1.4	-1.1	-1.3	-0.7	-0.9	-1.8	-0.5
Frequency of depressed mood in last 2 weeks	0.8	1.2	3.1	0.6	0.5	1.0	1.1	1.3	0.9	0.9	1.1	1.0	1.8	1.2
Supplements: Zinc	0.8	0.9	1.5	-0.9	0.9	0.9	1.2	-0.4	1.2	0.8	1.2	0.7	0.8	1.1
Pack years adult smoking proportion	0.8	1.2	2.4	-0.1	-1.1	-1.4	-1.3	-0.5	-1.0	-0.9	-1.6	-1.5	-0.9	-1.1
Qualifications: CSEs or equivalent	0.8	1.0	4.0	1.5	0.6	0.6	0.8	1.7	0.1	0.4	0.5	0.5	2.0	0.4
Mouth/teeth dental problems: Dentures	0.8	1.3	4.1	2.0	-1.3	0.0	-0.3	2.0	0.4	0.1	0.5	-0.1	2.0	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	4.8	-2.2	1.6	1.6	1.7	-1.3	0.7	1.9	1.7	2.0	-0.5	1.7
Worry too long after embarrassment	0.8	1.3	2.2	1.5	-0.9	1.4	-0.0	1.3	0.4	1.3	1.2	1.1	1.5	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.2	0.8	0.1	1.1	0.8	1.2	0.6	0.9	0.9	0.7	1.5	1.1
Guilty feelings	0.8	1.2	2.9	1.4	-0.0	1.2	0.6	1.7	-0.8	1.0	1.0	0.7	1.4	1.0
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.9	-1.7	0.9	0.6	1.1	-1.5	0.7	0.4	0.7	0.7	-0.7	0.7
Alzheimer’s Disease (in mother)	0.7	0.8	2.6	-1.4	1.6	0.3	1.4	-0.1	1.3	0.3	0.4	0.3	-0.1	0.8
Age at First Birth	0.7	1.0	3.3	1.0	-0.3	0.3	0.1	1.8	1.8	0.9	0.2	0.5	1.6	0.2
Blood White Count	0.7	5.2	9.1	0.4	-2.5	-3.0	-2.7	-1.2	-2.6	-2.5	-2.6	-2.6	-0.3	-2.5
Multivitamins +/- minerals	0.7	0.9	1.9	0.3	0.7	0.8	1.2	0.8	1.2	0.6	1.2	1.0	1.4	0.8
Chronic bronchitis/emphysema (father)	0.7	0.8	2.9	0.6	-1.7	-0.7	-1.5	0.3	-0.2	-0.8	-0.7	-0.9	0.4	-1.0
Had other major operations	0.7	0.9	2.3	-0.7	1.1	1.1	1.3	1.0	0.4	0.7	0.9	0.8	-0.4	1.5
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	7.1	-2.7	2.0	1.2	1.8	-1.6	0.2	1.3	1.3	1.3	-0.7	1.7
Length of working week for main job	0.7	0.8	1.9	-0.9	0.6	-0.6	-0.5	-0.4	-1.2	-0.7	-1.0	-0.7	-1.4	-1.0
Forced vital capacity (FVC), Best measure	0.7	2.6	4.8	-1.4	1.3	1.9	1.6	-0.5	1.0	2.2	2.0	2.2	0.4	1.9
Number of children fathered	0.7	0.8	3.4	-1.5	1.9	-0.0	1.2	-0.9	-0.4	0.3	-0.1	-0.3	-0.6	0.5
Heart disease (mother)	0.7	0.8	1.6	-1.3	-0.1	-0.9	-0.6	-0.9	-1.0	-1.0	-1.0	-0.9	-1.0	-0.7
Pulse rate, automated reading	0.7	2.2	3.7	1.7	-1.9	-1.4	-1.9	-0.5	-0.9	-1.3	-1.4	-1.8	1.2	-1.7
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	2.4	0.6	-1.1	-0.8	-1.1	-0.2	-1.5	-0.8	-0.8	-1.0	-0.7	-0.6
Smoking status: Previous	0.7	1.0	1.8	0.6	-0.8	-1.1	-1.1	1.0	-0.7	-0.9	-1.3	-1.3	-0.5	-1.4
Back pain experienced in last month	0.7	1.1	3.7	-1.4	1.9	0.6	1.8	-0.2	0.4	0.6	0.7	0.5	0.1	1.1
Illnesses of father: None of the above (group 1)	0.7	0.9	3.3	1.0	-0.0	0.4	0.5	1.0	1.4	0.5	0.8	0.6	1.8	0.7
Wears glasses or contact lenses	0.7	0.8	2.2	-0.1	-1.5	-0.9	-1.1	0.0	0.2	-1.1	-0.9	-1.2	-0.5	-0.8
Illnesses of father: High blood pressure	0.7	0.9	3.3	-0.4	1.8	1.0	1.5	0.7	0.3	0.9	0.7	0.5	-0.2	1.0
Alcohol drinker status: Previous	0.7	0.9	1.5	1.2	-0.1	1.2	0.5	0.9	1.0	0.9	1.1	1.0	0.9	0.8
Pack years of smoking	0.7	1.0	2.0	0.3	-1.3	-1.3	-1.2	-0.1	-0.6	-0.8	-1.4	-1.4	-0.5	-1.0
Reaction Time	0.6	1.1	3.3	-1.4	0.4	0.5	1.0	-0.2	1.8	0.8	1.3	1.5	0.7	0.8
Verbal and Numeric Reasoning (VNR)	0.6	1.3	6.1	2.0	-0.8	0.2	-1.0	1.4	-2.5	0.0	-0.4	-0.8	-0.0	-0.0
Mean Putamen Volume	0.6	0.7	2.9	-0.6	0.6	-0.9	-0.3	-0.7	-1.7	-0.8	-0.7	-0.5	-1.0	-0.6
Fasting Glucose	0.6	0.8	1.5	-1.0	1.2	0.7	1.1	-0.8	0.6	1.1	0.7	1.0	-0.2	0.7
Rheumatoid Arthritis	0.6	0.8	4.3	0.2	0.3	0.2	0.8	0.4	2.1	0.3	0.6	0.7	1.4	0.5
Systolic Blood Pressure	0.6	2.9	6.2	0.7	1.1	1.7	1.8	2.5	0.7	1.7	1.9	2.2	1.8	1.8
Hearing difficulty/problems: Yes	0.6	0.8	2.4	-0.4	-0.0	-1.0	-0.7	-0.8	-1.5	-0.9	-0.9	-0.8	-1.2	-1.0
Diabetes (father)	0.6	0.7	2.4	-1.5	1.0	0.2	0.4	-0.8	-1.0	0.3	-0.1	0.2	-1.6	0.3
Diverticular disease/diverticulitis (self-reported)	0.6	0.8	3.3	1.8	-0.5	0.5	-0.1	1.4	0.8	0.6	0.3	0.5	1.1	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	2.2	-0.3	1.0	1.1	1.3	1.3	0.7	1.2	1.4	0.9	1.4	1.5
Qualifications: None of the above	0.6	1.3	5.3	0.5	-0.6	0.6	0.6	0.8	2.3	0.1	1.2	0.7	2.0	1.1
Mouth/teeth dental problems	0.6	0.9	2.2	-0.2	1.0	1.4	0.9	-0.6	0.4	1.5	0.9	1.1	0.3	0.9
Tense / ‘highly strung’	0.6	1.1	2.0	-0.5	-0.8	-1.1	-1.2	0.5	-1.0	-0.8	-1.3	-1.4	-1.1	-1.1
Ever highly irritable/argumentative for 2 days	0.6	0.7	1.9	1.4	0.1	0.8	0.4	1.0	0.2	0.8	0.8	0.8	1.4	0.7
Qualifications: O levels/GCSEs or equivalent	0.6	1.0	3.3	-1.4	0.9	-0.5	0.1	-0.5	-1.3	-0.8	-0.8	-1.0	-1.8	-0.4
High blood pressure (siblings)	0.6	0.9	2.9	-1.0	0.7	0.6	1.4	0.0	1.7	0.2	1.1	0.9	0.5	1.1
Wheeze or whistling in the chest in last year	0.6	1.1	2.1	0.2	0.4	1.2	1.3	0.8	1.1	1.2	1.1	0.5	1.3	1.4
Medication: Omeprazole	0.6	0.7	1.7	0.2	1.0	0.7	1.3	1.2	0.9	0.4	0.9	0.8	0.3	0.9
Family relationship satisfaction	0.6	0.7	1.5	1.2	0.5	1.2	0.6	0.3	-0.0	0.9	0.9	0.7	1.1	0.7
Loneliness, isolation	0.6	0.8	1.8	-0.2	-0.2	-1.2	-0.4	0.8	-0.9	-1.3	-1.1	-1.3	0.3	-0.9
Medication: Paracetamol	0.6	0.9	2.6	1.0	-1.6	-1.0	-1.2	0.7	-0.5	-0.9	-0.8	-1.0	0.6	-0.8
Ever smoked	0.6	1.1	2.2	-0.4	-1.0	-1.5	-1.2	-0.0	-0.8	-1.0	-1.3	-1.2	-1.0	-1.3
Pain experienced in last month	0.6	1.0	3.4	1.9	-1.3	-0.5	-1.2	1.3	-0.8	-0.0	-0.6	-0.5	0.2	-0.9
Schizophrenia vs Biploar Disorder	0.5	0.6	1.7	0.2	0.7	0.4	1.0	1.3	0.4	0.4	0.7	1.0	1.2	0.4
Heel T-Score	0.5	3.7	7.3	-0.1	-1.5	-2.5	-2.1	-1.0	-1.8	-2.0	-2.6	-2.7	-1.0	-2.1
Allergy or Eczema	0.5	1.2	11.1	-0.4	1.0	0.6	1.0	3.3	-0.1	0.2	0.1	0.1	0.2	0.1
Average weekly spirits intake	0.5	0.6	1.3	0.7	-0.9	-1.1	-1.0	-0.0	-0.0	-0.8	-1.0	-0.9	0.1	-1.0
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.1	0.4	0.7	0.7	0.6	0.1	0.9	1.1	0.7	0.5	1.0	0.6
Supplements: Glucosamine	0.5	0.6	2.1	1.2	-1.4	0.3	-0.4	0.8	0.5	0.3	0.5	0.1	1.4	0.5
Forced vital capacity (FVC)	0.5	1.8	3.2	-1.7	1.2	1.5	1.4	-0.8	0.3	1.6	1.5	1.5	0.0	1.8
Medication: Simvastatin	0.5	0.7	2.2	1.1	-0.6	0.6	0.1	0.4	1.0	0.5	0.8	0.6	1.5	0.8
Fluid intelligence score	0.5	1.1	4.3	2.1	-1.0	0.5	-0.8	0.7	-1.9	1.0	-0.1	-0.3	1.0	0.4
Birth weight	0.5	1.1	2.0	-0.4	-1.0	-0.8	-1.3	-1.0	-1.1	-0.7	-1.2	-1.4	-1.1	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	3.2	-1.8	1.5	-0.3	0.9	0.2	0.2	0.1	-0.1	-0.3	-0.6	0.3
Qualifications: College or University degree	0.5	1.4	4.7	-0.0	-0.4	-0.8	-1.3	-0.8	-2.2	-0.2	-1.4	-1.0	-1.8	-1.3
Medication: Allopurinol	0.5	0.6	1.2	0.4	-0.3	-0.8	-0.8	-0.2	-0.6	-1.1	-1.1	-1.1	-0.3	-1.1
Mean time to correctly identify matches	0.5	0.9	4.2	-0.5	-0.2	0.5	0.5	0.4	2.0	0.7	1.1	1.3	0.8	0.7
Alcohol intake frequency.	0.5	1.1	2.5	0.2	0.2	1.3	1.1	0.6	1.6	0.6	1.5	1.0	1.3	1.2
Had major operations	0.5	0.6	2.3	-1.5	-0.1	-0.7	-0.3	-0.3	0.3	-1.1	-0.6	-0.8	-0.8	-0.4
Age at last live birth	0.5	0.7	2.2	1.5	-1.1	0.4	-0.7	0.9	0.0	1.1	0.2	0.1	1.2	0.1
Leg pain on walking	0.5	0.6	1.2	-0.9	0.9	0.5	0.9	-1.1	0.5	0.4	0.8	0.8	0.1	0.9
Mood swings	0.5	0.9	2.7	0.5	-0.4	-0.7	-0.8	-1.0	-1.6	-1.1	-1.0	-1.5	0.0	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	1.3	-0.0	-0.4	-0.7	-0.8	-1.1	-0.7	-0.5	-0.7	-0.4	-0.1	-1.1
Qualifications: nursing, teaching	0.5	0.7	2.2	0.8	0.3	1.1	0.2	0.6	0.2	1.5	1.0	0.9	1.0	0.8
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.1	-1.0	1.5	0.6	1.3	0.6	0.6	0.4	1.0	1.2	-0.3	0.7
Supplements: Fish oil (including cod liver oil)	0.5	0.6	2.1	0.5	-1.5	-0.9	-1.0	0.8	0.1	-0.8	-0.7	-0.5	0.1	-0.9
Fractured/broken bones in last 5 years	0.5	0.6	3.0	-1.1	0.5	-0.2	-0.1	-1.7	-0.6	0.2	-0.4	0.0	-1.3	-0.1
Myopia	0.5	0.7	1.5	-1.0	-0.3	-0.5	-0.5	-0.9	-1.0	-1.2	-0.5	-0.9	-1.2	-0.5
Ulcerative Colitis	0.4	0.5	2.2	-1.5	0.9	-0.4	0.5	-0.8	0.4	-0.5	-0.3	-0.4	-1.0	-0.1
Lung FVC	0.4	1.9	3.2	-0.6	-1.8	-1.7	-1.8	-0.6	-1.1	-1.4	-1.6	-1.6	-0.7	-1.6
Tanning	0.4	4.7	8.6	-0.7	-0.7	-2.9	-1.6	-2.2	-2.0	-2.6	-2.6	-2.8	-1.6	-2.6
Systolic blood pressure, automated reading	0.4	1.1	2.4	0.4	0.4	1.2	1.2	0.6	0.7	1.2	1.3	1.5	0.6	1.4
Relative age voice broke	0.4	0.6	2.8	1.4	-0.7	-0.2	-0.7	1.7	-0.1	-0.6	-0.2	-0.1	0.3	-0.6
Serious illness, injury or assault to yourself	0.4	0.4	2.5	0.4	0.3	-0.4	-0.1	-1.6	-1.2	0.3	-0.5	-0.5	-0.1	-0.3
Hayfever, allergic rhinitis or eczema	0.4	0.9	7.7	-0.3	0.8	0.7	0.9	2.8	-0.1	0.4	0.2	0.5	0.1	0.3
Nervous feelings	0.4	0.7	1.7	0.7	-1.0	-0.6	-0.9	1.3	-0.9	-0.5	-0.7	-0.7	-0.2	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.1	-0.1	0.9	1.0	1.1	0.8	0.4	1.0	0.8	0.8	0.6	0.9
Pain all over the body in last month	0.4	0.4	1.1	0.5	0.7	0.6	0.8	0.7	0.6	0.5	0.6	0.1	1.0	0.5
Illnesses of siblings	0.4	0.5	2.2	0.9	0.2	-0.2	-0.7	0.6	-1.5	0.0	-0.6	-0.5	-0.6	-0.8
Worrier / anxious feelings	0.4	0.8	3.3	0.5	-1.8	-0.5	-1.1	1.3	-0.2	-0.2	-0.9	-0.7	0.2	-0.9
Hair/balding pattern: Pattern 3	0.4	0.6	2.4	1.0	-1.5	0.2	-0.5	1.0	0.2	-0.0	0.4	0.1	1.3	0.3
Number of live births	0.4	0.5	1.0	0.7	-0.8	-0.7	-0.9	-0.9	-0.4	-0.7	-0.6	-0.6	0.2	-1.0
Hair/balding pattern: Pattern 4	0.4	0.9	1.6	0.5	-0.8	-1.1	-1.1	0.1	-1.2	-1.2	-1.1	-1.2	-0.4	-1.3
Pulse wave reflection index	0.4	0.5	1.2	-0.3	0.9	0.4	1.1	-0.5	0.8	0.7	0.3	-0.0	0.4	1.1
Loud music exposure frequency	0.4	0.4	1.8	-0.6	0.9	-0.3	0.6	-1.4	-0.4	-0.4	-0.3	-0.7	-0.1	-0.0
Headache pain in last month	0.4	0.7	1.9	-0.5	1.1	0.9	1.4	0.1	0.6	0.4	1.0	1.2	-0.1	0.8
Exposure to tobacco smoke outside home	0.4	0.5	1.6	-0.4	1.3	0.8	1.2	0.4	0.2	0.7	0.5	0.4	0.1	0.9
Pulse wave peak to peak time	0.4	0.5	1.1	-0.7	-0.4	-0.5	-0.8	0.6	-0.8	-0.6	-0.5	0.0	-1.1	-1.0
Medication for pain relief, constipation, heartburn	0.4	0.7	1.5	-0.0	1.2	0.9	0.9	-0.5	1.0	1.1	0.7	1.2	0.2	0.6
Medication: Blood pressure	0.4	0.6	2.2	-0.3	0.5	0.7	0.7	1.5	0.1	0.6	0.9	0.8	0.9	0.9
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.8	0.4	-0.5	-0.6	-0.7	0.6	-0.8	-0.7	-0.8	-1.3	-0.4	-0.6
Miserableness	0.4	0.7	2.2	0.5	-0.4	-0.7	-0.5	0.8	-1.5	-0.8	-0.9	-1.3	0.4	-0.7
Mother’s age at death	0.4	0.5	0.9	-0.2	-0.5	-0.5	-1.0	-0.8	-0.7	-0.5	-0.9	-0.6	-1.0	-0.9
Financial situation satisfaction	0.4	0.5	1.2	1.1	-0.6	0.7	-0.2	-0.1	1.0	1.0	0.5	0.6	0.9	0.1
Commuting to job workplace: Public transport	0.4	0.5	1.5	0.2	0.1	0.9	0.4	0.4	0.9	0.8	0.8	0.8	1.2	0.6
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.5	0.6	-0.2	0.6	0.1	-0.1	0.5	1.2	0.7	0.8	1.2	0.6
Medication: Atorvastatin	0.4	0.5	2.0	-1.4	-0.8	-0.4	-0.4	-0.8	-0.7	-0.7	-0.3	-0.7	-1.0	-0.1
Cholesterol lowering medication	0.4	0.6	2.0	-1.0	0.2	0.6	0.6	-0.9	1.4	0.4	0.7	0.5	-0.0	0.8
Heart disease (siblings)	0.4	0.5	2.5	-0.8	0.0	0.4	0.7	0.1	1.6	0.4	0.5	0.2	0.6	0.8
Intelligence (Savage-Jansen 2018)	0.3	1.0	3.6	1.6	-0.3	1.0	0.1	1.9	-0.5	0.8	0.6	0.2	1.2	0.9
Worry (Nagel 2018)	0.3	0.7	1.6	0.3	-0.6	-0.6	-0.9	1.3	-0.8	-0.5	-1.0	-1.1	-0.6	-1.1
Crohns Disease (2017)	0.3	0.7	1.1	0.9	-0.2	1.1	0.6	1.0	-0.4	0.7	1.0	0.6	1.1	1.0
Coronary Artery Disease (CAD)	0.3	0.4	1.6	0.5	-0.4	0.6	0.1	-0.6	-0.1	0.7	0.9	1.2	0.2	0.6
HbA1C	0.3	0.4	1.8	1.4	0.3	0.5	0.2	0.1	0.5	0.7	0.5	0.4	0.5	0.4
Lupus	0.3	0.5	1.8	-0.3	1.3	0.5	1.3	0.4	0.3	-0.1	0.4	0.6	-0.6	0.7
Blood Eosinophil Count	0.3	2.1	5.6	1.5	-1.5	-1.1	-1.4	2.4	-1.0	-0.8	-1.7	-1.7	0.3	-1.6
Cardiovascular Disease	0.3	1.0	1.8	-0.6	1.1	1.0	1.3	1.0	0.1	1.1	1.2	1.2	0.3	1.2
Hypothyroidism (self reported)	0.3	0.8	2.8	1.7	-0.9	-0.2	-0.4	1.5	0.2	-0.8	-0.1	-0.3	1.4	-0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.3	0.8	-0.0	-0.2	-0.3	-0.4	0.8	-0.9	-0.6	-0.7	-0.9	-0.5	-0.4
Diabetes (mother)	0.3	0.4	1.0	-0.7	0.7	0.5	0.9	-1.0	0.5	0.2	0.8	0.4	0.1	0.8
Average weekly fortified wine intake	0.3	0.4	1.3	0.5	-0.4	-0.7	-0.3	-0.4	-0.4	-0.7	-0.8	-1.1	0.4	-0.3
Lung cancer (father)	0.3	0.3	0.8	0.1	0.2	-0.7	-0.3	0.6	-0.8	-0.6	-0.6	-0.9	-0.4	-0.5
Exposure to tobacco smoke at home	0.3	0.4	1.0	0.3	-0.5	-0.7	-0.5	-0.4	1.0	-0.1	-0.8	-0.5	0.7	-0.9
Medication: Amlodipine	0.3	0.4	1.6	-1.3	0.3	-0.6	-0.1	-0.1	-1.1	-0.8	-0.3	-0.3	-0.5	-0.4
Chronic bronchitis/emphysema (mother)	0.3	0.4	3.3	0.4	0.3	0.3	0.3	1.8	-0.1	0.2	0.1	-0.3	0.5	0.2
Comparative body size at age 10	0.3	0.9	3.6	-1.1	0.0	-1.0	-0.6	-1.9	-0.2	-0.6	-0.9	-1.1	-0.8	-0.9
Age at first live birth	0.3	0.5	1.9	1.4	-0.9	0.4	-0.6	0.9	0.2	0.9	0.0	-0.3	0.8	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.3	0.8	0.9	-0.3	0.6	0.1	0.5	-0.3	0.8	0.5	0.4	0.7	0.8
Knee pain experienced in last month	0.3	0.4	1.7	0.7	-1.3	-0.4	-0.8	-0.6	-0.2	-0.7	-0.3	0.0	0.4	-0.5
Osteoporosis (self-reported)	0.3	0.4	2.9	-0.5	0.5	-0.4	0.1	1.7	-0.2	-0.2	-0.6	-0.2	-0.6	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.5	2.9	-1.1	-0.2	-0.5	-0.3	-1.7	-0.4	-0.5	-0.4	-0.1	-0.7	-0.6
Number of operations (self-reported)	0.3	0.4	0.8	-0.7	0.9	0.6	0.8	0.2	0.6	0.3	0.6	0.3	-0.4	0.8
Unable to work because of sickness or disability	0.3	0.4	1.4	1.2	-1.0	0.0	-0.6	0.7	0.8	0.1	0.1	0.0	0.7	-0.1
Bipolar Disorder (2018)	0.2	0.3	1.9	0.8	0.0	0.2	-0.0	1.4	-0.1	0.2	-0.3	-0.5	0.3	-0.1
Depression (Nagel 2018)	0.2	0.3	1.7	0.9	-0.4	0.1	0.1	0.8	-0.3	0.1	0.2	-0.5	1.3	0.4
Neuroticism (Nagel 2018)	0.2	0.5	2.1	0.8	-0.1	-0.4	-0.4	0.7	-1.5	-0.2	-0.5	-0.7	0.6	-0.4
Irritable Bowel Disease (IBD)	0.2	0.5	1.3	-0.2	0.8	0.9	1.1	0.4	0.1	0.6	0.8	0.5	0.7	1.1
Ulcerative Colitis (UC)	0.2	0.4	1.0	-1.0	0.9	0.4	0.9	-0.1	0.4	0.3	0.4	0.2	0.1	0.7
Ovarian Cancer	0.2	0.3	1.3	0.0	-0.5	-0.5	-0.5	-0.4	0.1	-0.7	-0.6	-1.1	0.3	-0.3
Crohns Disease (2012)	0.2	0.3	1.4	-1.0	0.1	0.1	0.3	-1.2	-0.3	-0.3	0.0	0.2	-1.0	0.1
HDL Cholesterol	0.2	0.3	1.0	1.0	0.2	0.5	-0.1	0.9	0.3	0.6	0.4	0.1	0.4	0.4
Neuroticism	0.2	0.6	2.2	1.2	-0.0	0.7	0.2	1.5	0.0	0.5	0.5	0.1	1.4	0.1
Sensitivity / hurt feelings	0.2	0.3	2.1	0.2	0.2	0.2	0.2	1.4	-0.9	0.5	0.0	-0.2	0.2	0.2
Relative age of first facial hair	0.2	0.3	2.4	0.1	0.4	0.3	0.2	1.6	-0.4	0.3	0.2	0.4	-0.5	0.3
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	1.6	0.6	0.3	-0.3	0.2	-1.3	-0.8	0.0	-0.1	0.3	0.1	-0.1
Vitamin and mineral supplements	0.2	0.2	1.2	-0.1	-0.1	-0.1	-0.5	-0.7	-1.1	0.0	-0.4	-0.1	-0.6	-0.3
Medication: Metformin	0.2	0.3	1.1	1.1	-0.6	0.5	-0.2	-0.2	0.2	0.2	0.6	0.1	0.8	0.5
Townsend deprivation index at recruitment	0.2	0.3	0.7	-0.2	0.5	0.5	0.7	0.8	0.2	0.4	0.7	0.9	0.5	0.5
Age when periods started (menarche)	0.2	0.6	1.3	-0.3	-0.1	-0.7	-0.8	-0.4	-0.9	-0.6	-0.9	-0.7	-1.1	-1.0
Medication: Atenolol	0.2	0.3	1.1	-0.2	-0.0	0.7	0.2	0.4	0.5	1.0	0.6	0.6	-0.2	0.7
Had menopause	0.2	0.2	1.0	0.2	0.2	-0.1	-0.2	1.0	-0.2	-0.4	-0.4	-0.7	-0.5	-0.1
Financial difficulties in last 2 years	0.2	0.2	0.9	0.3	-0.6	0.1	0.0	-1.0	0.0	0.3	0.5	0.6	0.7	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.1	-0.7	0.8	-0.5	0.4	-0.1	0.3	-0.5	-0.6	-1.0	-0.1	-0.4
Gout (self-reported)	0.2	0.3	1.1	1.0	-0.8	-0.3	-0.7	-0.0	0.1	-0.4	-0.4	-0.5	0.6	-0.5
Neck or shoulder pain in last month	0.2	0.3	2.1	-0.2	0.4	-0.2	0.0	-1.4	-0.0	-0.4	-0.2	-0.1	-0.3	-0.4
Angina (self-reported)	0.2	0.2	0.8	0.5	-0.8	-0.2	-0.5	0.2	0.3	-0.2	-0.1	-0.1	0.9	-0.4
Medication: Ibuprofen	0.2	0.3	1.2	0.1	-0.3	-0.5	-0.4	-0.2	-0.7	-0.8	-0.4	-1.1	-0.5	-0.2
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	1.3	-0.2	-0.3	0.3	-0.2	1.1	0.9	0.2	0.4	0.6	-0.0	-0.0
Medication: Aspirin	0.2	0.2	1.0	-1.0	0.6	0.2	0.6	0.2	-0.3	0.0	0.4	-0.1	0.1	0.6
Average weekly red wine intake	0.2	0.3	1.1	-0.4	-0.1	-0.4	-0.5	0.2	-0.8	-0.2	-0.5	-0.2	-1.0	-0.5
Diabetes diagnosed by doctor	0.2	0.3	0.6	-0.6	-0.0	-0.4	-0.4	-0.7	-0.6	-0.5	-0.4	-0.7	-0.8	-0.2
Medication: Aspirin	0.2	0.2	0.9	-0.9	0.5	0.3	0.5	0.3	-0.3	0.0	0.4	-0.1	0.0	0.6
Smoking status: Current	0.2	0.3	0.8	-0.0	-0.9	-0.9	-0.6	-0.2	-0.1	-0.7	-0.5	-0.9	0.3	-0.4
High cholesterol (Self-reported)	0.2	0.3	1.7	-1.3	-0.6	-0.4	-0.3	-0.2	-0.2	-0.5	-0.2	-0.4	-0.8	-0.1
Irritability	0.2	0.4	1.1	0.6	0.4	-0.3	-0.0	0.8	-1.1	-0.1	-0.6	-1.0	0.7	-0.4
Depressed Affect (Nagel 2018)	0.1	0.3	1.0	0.2	0.4	-0.3	0.2	-0.3	-0.9	-0.4	-0.5	-1.0	0.7	-0.2
Primary Biliary Cirrhosis	0.1	0.2	0.3	-0.2	0.2	0.4	0.5	-0.5	0.1	0.0	0.5	0.5	0.3	0.5
Smoking Status	0.1	0.3	0.8	0.6	-0.9	-0.3	-0.4	0.6	0.5	-0.3	-0.1	-0.5	0.7	-0.1
Hand grip strength (left)	0.1	0.3	0.9	-0.8	-1.0	-0.4	-0.8	-0.6	0.0	-0.1	-0.4	-0.4	-0.3	-0.3
Angina	0.1	0.2	1.1	0.5	-0.6	0.0	-0.3	0.0	0.3	0.1	0.1	0.1	1.0	-0.2
Hand grip strength (right)	0.1	0.3	0.8	-0.6	-0.3	0.5	0.1	-0.1	0.6	0.9	0.6	0.7	0.2	0.5
Current tobacco smoking	0.1	0.2	0.5	-0.1	-0.7	-0.7	-0.4	-0.4	-0.1	-0.6	-0.3	-0.6	0.2	-0.3
Alcohol usually taken with meals	0.1	0.2	1.3	-0.1	0.2	0.1	-0.1	1.1	-0.0	-0.5	-0.2	-0.1	-0.6	-0.4
Diabetes (self-reported)	0.1	0.1	0.5	-0.7	0.2	-0.2	-0.0	-0.2	-0.2	-0.3	-0.1	-0.3	-0.6	-0.0
Neuroticism score	0.1	0.3	1.1	0.8	-0.4	0.3	0.0	1.0	-0.4	0.2	0.1	-0.2	1.0	0.1
Father’s age at death	0.1	0.2	0.8	0.1	-0.9	-0.1	-0.8	0.1	-0.2	0.3	-0.2	-0.2	-0.4	-0.0
Falls in the last year	0.1	0.2	0.5	0.7	0.1	0.5	0.1	-0.1	-0.0	0.7	0.3	0.3	0.3	0.3
Pulse rate	0.1	0.2	1.5	0.4	-0.0	-0.3	0.2	-0.1	0.1	-0.2	-0.0	-0.4	1.2	-0.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.6	-0.3	0.5	-0.3	-0.0	-0.8	0.6	-0.2	-0.5	-0.2	-0.8	-0.5
Number of full brothers	0.1	0.1	0.5	-0.5	0.2	0.1	0.1	0.2	0.7	0.2	0.1	0.3	0.1	-0.4
Migraine (self-reported)	0.1	0.1	0.4	-0.6	-0.6	-0.0	-0.3	0.2	-0.5	-0.1	0.2	0.4	-0.4	-0.0
Suffer from ‘nerves’	0.1	0.2	0.6	-0.8	0.4	-0.2	0.3	0.6	-0.3	-0.1	-0.4	-0.6	-0.5	-0.2
Chest pain or discomfort	0.1	0.1	0.4	-0.1	-0.5	-0.1	-0.1	0.6	-0.1	-0.0	-0.0	0.4	0.4	-0.3
Hearing aid user	0.1	0.1	0.3	-0.2	-0.3	-0.4	-0.5	-0.0	-0.3	0.5	-0.5	-0.0	-0.2	-0.6
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.4	-0.4	0.1	-0.6	-0.3	-0.2	0.1	-0.0	-0.5	-0.6	-0.1	-0.4
Medication: Lisinopril	0.1	0.1	0.8	-0.7	-0.0	0.1	0.0	-0.3	-0.1	-0.4	0.0	-0.1	-0.9	0.0
Commuting to job workplace: Cycle	0.1	0.1	0.6	0.1	0.6	0.1	0.0	0.7	0.5	-0.1	-0.1	-0.0	0.0	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.6	-0.5	0.7	0.2	0.7	0.3	0.1	-0.1	0.1	0.3	-0.6	0.2
Hair Pigment	0.0	0.6	1.2	0.8	0.7	0.8	0.7	0.6	0.5	0.8	0.9	0.6	1.1	0.7

Hub : Genes

EXOSC9

Models

Trait associations