Best TWAS P=4.67e-08 · Best GWAS P=2.58e-07 conditioned to 0.75
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | GGNBP2 | 0.10 | 0.11 | enet | 9 | 0.11 | 3.5e-09 | 4.9 | -5.1 | 3.0e-07 | 0.93 | 0.02 | 0.97 | FALSE |
2 | GTEx | Artery Aorta | MYO19 | 0.20 | 0.16 | enet | 9 | 0.15 | 1.6e-08 | -5.0 | 5.2 | 2.2e-07 | -0.89 | 0.01 | 0.98 | FALSE |
3 | GTEx | Cells EBV-transformed lymphocytes | ZNHIT3 | 0.31 | 0.32 | enet | 9 | 0.22 | 1.1e-07 | 4.9 | 5.2 | 2.2e-07 | -0.86 | 0.02 | 0.98 | FALSE |
4 | GTEx | Lung | GGNBP2 | 0.08 | 0.01 | enet | 8 | 0.01 | 3.3e-02 | 4.5 | -5.2 | 1.9e-07 | 0.89 | 0.03 | 0.95 | FALSE |
5 | GTEx | Muscle Skeletal | GGNBP2 | 0.08 | 0.06 | enet | 14 | 0.05 | 2.5e-05 | -5.1 | -5.5 | 4.7e-08 | 0.92 | 0.01 | 0.99 | TRUE |
6 | GTEx | Skin Sun Exposed Lower leg | GGNBP2 | 0.11 | 0.06 | enet | 11 | 0.10 | 1.3e-08 | -5.1 | -5.1 | 3.0e-07 | 0.94 | 0.01 | 0.98 | FALSE |
7 | METSIM | Adipose | GGNBP2 | 0.16 | 0.14 | lasso | 5 | 0.14 | 6.2e-21 | 4.9 | -5.2 | 2.6e-07 | 0.91 | 0.02 | 0.98 | FALSE |
8 | The Cancer Genome Atlas | Colon Adenocarcinoma | GGNBP2 | 0.10 | 0.05 | lasso | 3 | 0.06 | 2.5e-04 | -5.1 | -5.1 | 2.9e-07 | 0.94 | 0.00 | 0.94 | FALSE |
9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GGNBP2 | 0.02 | 0.02 | enet | 4 | 0.02 | 6.0e-03 | -5.1 | -5.2 | 2.3e-07 | 0.95 | 0.00 | 0.83 | FALSE |