[Hub]/) : Traits : Worrier / anxious feelings : ← →

chr14:74,424,938-76,210,831

Best TWAS P=2.75e-11 · Best GWAS P=2.96e-10 conditioned to 0.999

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex DLST 0.09 0.11 lasso 2 0.11 4.0e-13 -5.8 6.2 7.3e-10 0.93 0.02 0.98 FALSE
2 CommonMind Brain Pre-frontal Cortex RPS6KL1 0.04 0.02 lasso 5 0.02 4.8e-04 5.1 -6.0 1.8e-09 -0.82 0.09 0.76 FALSE
3 GTEx Adipose Subcutaneous YLPM1 0.10 0.03 lasso 6 0.02 7.9e-03 -5.6 5.7 1.3e-08 0.77 0.06 0.63 FALSE
4 GTEx Adipose Subcutaneous RPS6KL1 0.09 0.12 lasso 3 0.10 2.5e-08 5.2 5.3 1.2e-07 0.78 0.74 0.26 FALSE
5 GTEx Adrenal Gland RPS6KL1 0.21 0.13 enet 25 0.15 4.4e-06 5.2 5.2 1.7e-07 0.73 0.19 0.76 FALSE
6 GTEx Colon Sigmoid MLH3 0.17 0.02 enet 9 0.00 2.4e-01 -2.2 -5.5 3.6e-08 -0.38 0.08 0.25 TRUE
7 GTEx Muscle Skeletal DLST 0.28 0.26 enet 23 0.26 2.1e-25 -5.1 -5.1 3.0e-07 -0.59 0.86 0.14 FALSE
8 GTEx Nerve Tibial YLPM1 0.08 0.06 lasso 1 0.04 5.1e-04 5.6 5.6 2.6e-08 0.86 0.05 0.84 FALSE
9 GTEx Nerve Tibial RPS6KL1 0.17 0.24 lasso 6 0.19 2.3e-13 5.2 5.3 1.4e-07 0.78 0.80 0.20 FALSE
10 GTEx Skin Not Sun Exposed Suprapubic RPS6KL1 0.08 0.08 enet 11 0.07 1.5e-04 6.0 6.4 1.7e-10 0.94 0.03 0.97 FALSE
11 GTEx Skin Sun Exposed Lower leg RPS6KL1 0.15 0.13 lasso 4 0.12 1.8e-10 4.7 5.2 2.5e-07 0.83 0.56 0.44 FALSE
12 GTEx Testis AREL1 0.20 0.14 enet 34 0.13 2.1e-06 6.2 6.7 2.7e-11 0.91 0.01 0.99 TRUE
13 The Cancer Genome Atlas Breast Invasive Carcinoma RPS6KL1 0.03 0.02 lasso 3 0.02 8.5e-06 6.2 6.2 4.8e-10 0.97 0.00 1.00 FALSE
14 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma RPS6KL1 0.04 0.04 lasso 3 0.03 1.8e-04 6.3 6.0 1.7e-09 0.96 0.00 0.99 FALSE
15 The Cancer Genome Atlas Lung Adenocarcinoma RPS6KL1 0.03 0.01 blup 49 0.02 2.3e-03 5.6 5.4 5.7e-08 0.77 0.02 0.60 FALSE