Best TWAS P=1.82e-10 · Best GWAS P=7.82e-11 conditioned to 0.0269
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue | MED19 | 0.11 | 0.04 | enet | 26 | 0.10 | 7.5e-06 | 6.0 | -5.1 | 2.7e-07 | -0.64 | 0.02 | 0.91 | FALSE |
| 2 | GTEx | Heart Atrial Appendage | MED19 | 0.11 | 0.14 | lasso | 1 | 0.14 | 6.0e-07 | 6.0 | -6.0 | 1.7e-09 | -0.84 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Pancreas | MED19 | 0.10 | 0.08 | lasso | 3 | 0.02 | 5.0e-02 | 6.3 | -6.3 | 2.5e-10 | -0.87 | 0.02 | 0.87 | FALSE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | MED19 | 0.12 | 0.05 | enet | 31 | 0.05 | 7.5e-04 | 6.3 | -5.6 | 2.8e-08 | -0.75 | 0.01 | 0.98 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | ZDHHC5 | 0.05 | 0.03 | lasso | 8 | 0.02 | 6.2e-03 | 6.2 | 6.1 | 1.3e-09 | 0.82 | 0.06 | 0.93 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | MED19 | 0.15 | 0.11 | lasso | 7 | 0.09 | 1.3e-07 | 6.3 | -6.3 | 3.2e-10 | -0.86 | 0.01 | 0.99 | FALSE |
| 7 | GTEx | Stomach | MED19 | 0.10 | 0.04 | lasso | 7 | 0.09 | 6.8e-05 | 6.2 | -5.7 | 1.5e-08 | -0.81 | 0.02 | 0.91 | FALSE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | ZDHHC5 | 0.05 | 0.02 | blup | 401 | 0.03 | 2.0e-04 | 5.9 | -5.6 | 2.6e-08 | -0.71 | 0.02 | 0.94 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | AP000662.4 | 0.05 | 0.01 | enet | 17 | 0.02 | 3.8e-04 | 2.7 | -5.2 | 2.0e-07 | -0.64 | 0.09 | 0.90 | FALSE |
| 10 | YFS | Blood | ZDHHC5 | 0.06 | 0.07 | enet | 20 | 0.07 | 1.2e-22 | 6.0 | 6.4 | 1.8e-10 | 0.82 | 0.02 | 0.98 | TRUE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MED19 | 0.05 | 0.03 | enet | 7 | 0.05 | 1.3e-10 | 6.2 | -5.2 | 2.2e-07 | -0.74 | 0.01 | 0.99 | FALSE |
| 12 | The Cancer Genome Atlas | Colon Adenocarcinoma | TMX2 | 0.07 | 0.06 | lasso | 1 | 0.05 | 5.0e-04 | 6.3 | 6.3 | 4.0e-10 | 0.87 | 0.00 | 0.91 | FALSE |
| 13 | The Cancer Genome Atlas | Esophageal Carcinoma | MED19 | 0.10 | 0.06 | lasso | 4 | 0.02 | 5.4e-02 | 6.3 | -6.3 | 3.5e-10 | -0.86 | 0.00 | 0.85 | FALSE |
| 14 | The Cancer Genome Atlas | Lung Adenocarcinoma | MED19 | 0.05 | 0.02 | blup | 26 | 0.03 | 6.0e-05 | 6.3 | -5.4 | 8.0e-08 | -0.74 | 0.01 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MED19 | 0.03 | 0.02 | lasso | 1 | 0.01 | 1.8e-02 | 6.0 | -6.0 | 1.7e-09 | -0.84 | 0.00 | 0.85 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TMX2 | 0.03 | 0.02 | blup | 29 | 0.02 | 3.7e-03 | -4.0 | 5.1 | 3.0e-07 | 0.65 | 0.06 | 0.58 | FALSE |