TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Breast cancer (self-reported)
:
→
chr3:26,720,690-28,211,713
Best TWAS P=7.52e-12 · Best GWAS P=1.24e-13 conditioned to 0.00462
26.8M
27M
27.2M
27.4M
27.6M
27.8M
28M
28.2M
0
5
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
The Cancer Genome Atlas
Breast Invasive Carcinoma
NEK10
0.02
0.02
lasso
4
0.02
1.3e-05
-6.5
6.8
7.5e-12
-0.93
0.03
0.96
TRUE
4
The Cancer Genome Atlas
Prostate Adenocarcinoma
NEK10
0.04
0.04
lasso
2
0.03
3.0e-04
-5.8
5.9
4.6e-09
-0.75
0.54
0.27
FALSE
1
GTEx
Cells Transformed fibroblasts
SLC4A7
0.15
0.02
enet
21
0.04
4.0e-04
-5.9
-5.6
1.7e-08
0.63
0.48
0.18
FALSE
3
The Cancer Genome Atlas
Breast Invasive Carcinoma
SLC4A7
0.02
0.02
blup
69
0.01
3.7e-04
-7.4
5.5
4.4e-08
-0.76
0.00
0.99
FALSE