Best TWAS P=7.52e-12 · Best GWAS P=1.24e-13 conditioned to 0.00462
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | SLC4A7 | 0.15 | 0.02 | enet | 21 | 0.04 | 4.0e-04 | -5.9 | -5.6 | 1.7e-08 | 0.63 | 0.48 | 0.18 | FALSE |
| 2 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NEK10 | 0.02 | 0.02 | lasso | 4 | 0.02 | 1.3e-05 | -6.5 | 6.8 | 7.5e-12 | -0.93 | 0.03 | 0.96 | TRUE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SLC4A7 | 0.02 | 0.02 | blup | 69 | 0.01 | 3.7e-04 | -7.4 | 5.5 | 4.4e-08 | -0.76 | 0.00 | 0.99 | FALSE |
| 4 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NEK10 | 0.04 | 0.04 | lasso | 2 | 0.03 | 3.0e-04 | -5.8 | 5.9 | 4.6e-09 | -0.75 | 0.54 | 0.27 | FALSE |