Hub : Traits :

Breast cancer (self-reported)

12 significantly associated models · 8 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 26720690 28211713 2 1 7.5e-12 1.2e-13 4.6e-03 85 NEK10
2 5 44129083 45516364 1 1 1.5e-09 3.5e-08 3.3e-01 97 RP11-53O19.3
3 5 55524108 56923759 1 1 3.3e-08 3.6e-16 1.5e-09 45 CTD-2310F14.1
4 8 128107136 129812343 1 1 8.1e-09 1.7e-12 6.2e-06 59 PVT1
5 16 52222053 52828325 1 1 1.9e-26 1.3e-35 5.3e-11 72 TOX3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 2.12 1 0 0.0 0.00 1.0000 RP11-53O19.3
Neuroticism (Nagel 2018) 1.77 1 0 0.0 0.00 1.0000 TOX3
Schizophrenia (2018) 2.51 1 0 0.0 0.00 1.0000 RP11-53O19.3
Worry (Nagel 2018) 1.32 1 0 0.0 0.00 1.0000 TOX3
Breast Cancer 139.22 5 5 11.1 -0.99 0.0014 CTD-2310F14.1 NEK10 PVT1 RP11-53O19.3 TOX3
Prostate Cancer 2.56 1 0 0.0 0.00 1.0000 PVT1
Neuroticism (2016) 2.20 1 0 0.0 0.00 1.0000 TOX3
Schizophrenia (2014) 2.22 1 0 0.0 0.00 1.0000 RP11-53O19.3
Blood Platelet Count 0.52 2 0 0.0 0.00 1.0000 NEK10 PVT1
Blood Red Count 0.49 1 0 0.0 0.00 1.0000 PVT1
Blood White Count 0.32 1 0 0.0 0.00 1.0000 NEK10
Heel T-Score 0.66 1 0 0.0 0.00 1.0000 NEK10
BMI 1.04 2 0 0.0 0.00 1.0000 CTD-2310F14.1 NEK10
Height 1.41 4 2 4.4 0.12 0.8825 CTD-2310F14.1 NEK10 PVT1 RP11-53O19.3
Waist Hip Ratio (WHR) 1.61 2 0 0.0 0.00 1.0000 PVT1 RP11-53O19.3
Systolic Blood Pressure 4.79 2 2 4.4 0.00 1.0000 NEK10 TOX3
Smoking Status 1.09 1 0 0.0 0.00 1.0000 RP11-53O19.3
Cardiovascular Disease 2.71 2 1 2.2 0.00 1.0000 CTD-2310F14.1 NEK10
Type 2 Diabetes (T2D) (2018) 1.47 1 0 0.0 0.00 1.0000 RP11-53O19.3
Lung FEV1/FVC ratio 0.49 1 0 0.0 0.00 1.0000 RP11-53O19.3
Lung FVC 0.78 1 0 0.0 0.00 1.0000 TOX3
Neuroticism 1.31 1 0 0.0 0.00 1.0000 TOX3
Hair Pigment 0.77 2 2 4.4 0.00 1.0000 CTD-2310F14.1 TOX3
Systolic blood pressure, automated reading 2.42 2 0 0.0 0.00 1.0000 NEK10 TOX3
Supplements: Zinc 3.63 1 0 0.0 0.00 1.0000 CTD-2310F14.1
Medication: Metformin 3.50 1 0 0.0 0.00 1.0000 RP11-53O19.3
Impedance of leg (right) 0.96 1 0 0.0 0.00 1.0000 CTD-2310F14.1
Trunk fat percentage 1.42 2 0 0.0 0.00 1.0000 NEK10 TOX3
Fed-up feelings 1.93 1 0 0.0 0.00 1.0000 RP11-53O19.3
Heel bone mineral density (BMD) T-score, automated (left) 1.35 1 0 0.0 0.00 1.0000 NEK10
High blood pressure 3.11 1 1 2.2 0.00 1.0000 NEK10
Sitting height 1.24 3 0 0.0 0.00 1.0000 CTD-2310F14.1 NEK10 PVT1
High blood pressure (mother) 2.24 1 0 0.0 0.00 1.0000 NEK10
Impedance of leg (left) 1.11 1 0 0.0 0.00 1.0000 CTD-2310F14.1
Trunk fat mass 0.90 1 0 0.0 0.00 1.0000 TOX3
Forced vital capacity (FVC) 2.02 2 0 0.0 0.00 1.0000 NEK10 TOX3
Heel bone mineral density (BMD) T-score, automated (right) 1.49 1 0 0.0 0.00 1.0000 PVT1
Ever unenthusiastic/disinterested for a whole week 2.20 1 0 0.0 0.00 1.0000 RP11-53O19.3
Neuroticism score 2.16 1 0 0.0 0.00 1.0000 TOX3
Arm fat percentage (right) 1.51 1 0 0.0 0.00 1.0000 NEK10
Impedance of arm (left) 0.73 1 0 0.0 0.00 1.0000 CTD-2310F14.1
Standing height 1.36 3 1 2.2 0.00 1.0000 CTD-2310F14.1 NEK10 PVT1
Tense / 'highly strung' 2.22 1 0 0.0 0.00 1.0000 TOX3
Medication for cholesterol, blood pressure or diabetes 2.57 1 0 0.0 0.00 1.0000 NEK10
High blood pressure (siblings) 1.71 1 0 0.0 0.00 1.0000 NEK10
Forced vital capacity (FVC), Best measure 1.67 1 0 0.0 0.00 1.0000 PVT1
Body fat percentage 1.62 2 0 0.0 0.00 1.0000 NEK10 TOX3
Leg fat percentage (right) 1.69 2 0 0.0 0.00 1.0000 NEK10 TOX3
Comparative body size at age 10 1.09 1 0 0.0 0.00 1.0000 NEK10
Worry too long after embarrassment 1.92 1 0 0.0 0.00 1.0000 TOX3
Medication: Blood pressure 5.45 2 1 2.2 0.00 1.0000 NEK10 TOX3
Whole body fat mass 0.88 1 0 0.0 0.00 1.0000 TOX3
Leg fat mass (right) 0.96 1 0 0.0 0.00 1.0000 TOX3
Pulse rate, automated reading 2.58 2 0 0.0 0.00 1.0000 NEK10 RP11-53O19.3
Alcohol intake frequency. 1.00 1 0 0.0 0.00 1.0000 CTD-2310F14.1
Comparative height size at age 10 0.89 1 0 0.0 0.00 1.0000 CTD-2310F14.1
Hypertension (Self-reported) 3.33 1 1 2.2 0.00 1.0000 NEK10
Forced expiratory volume in 1-second (FEV1), predicted 1.43 1 0 0.0 0.00 1.0000 PVT1
Arm fat percentage (left) 1.55 2 0 0.0 0.00 1.0000 NEK10 TOX3
Mood swings 1.06 1 0 0.0 0.00 1.0000 TOX3
Mouth/teeth dental problems: Mouth ulcers 3.45 1 0 0.0 0.00 1.0000 RP11-53O19.3
Mother's age at death 3.04 1 0 0.0 0.00 1.0000 NEK10
Medication: Blood pressure 1.55 1 0 0.0 0.00 1.0000 NEK10
Medication: Bendroflumethiazide 1.69 1 0 0.0 0.00 1.0000 NEK10
Medication: Lisinopril 2.12 1 0 0.0 0.00 1.0000 NEK10
Illnesses of father: High blood pressure 2.99 1 0 0.0 0.00 1.0000 NEK10
Leg fat percentage (left) 1.72 2 0 0.0 0.00 1.0000 NEK10 TOX3
Average weekly beer plus cider intake 1.98 1 0 0.0 0.00 1.0000 TOX3
Irritability 2.74 1 0 0.0 0.00 1.0000 TOX3
Diastolic blood pressure, automated reading 1.27 1 0 0.0 0.00 1.0000 TOX3
Ever depressed for a whole week 2.49 1 0 0.0 0.00 1.0000 RP11-53O19.3
Vascular/heart problems diagnosed by doctor 3.30 2 1 2.2 0.00 1.0000 CTD-2310F14.1 NEK10
Impedance of whole body 1.02 1 0 0.0 0.00 1.0000 CTD-2310F14.1
Leg fat mass (left) 0.99 1 0 0.0 0.00 1.0000 TOX3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.2
GTEx Adipose Visceral Omentum 1 0.049 1.2
GTEx Adrenal Gland 0 0.000 1.2
GTEx Artery Aorta 0 0.000 1.2
GTEx Artery Coronary 0 0.000 1.3
GTEx Artery Tibial 1 0.027 1.2
GTEx Brain Caudate basal ganglia 0 0.000 1.3
GTEx Brain Cerebellar Hemisphere 0 0.000 1.2
GTEx Brain Cerebellum 0 0.000 1.2
GTEx Brain Cortex 0 0.000 1.3
GTEx Brain Frontal Cortex BA9 0 0.000 1.2
GTEx Brain Hippocampus 0 0.000 1.3
GTEx Brain Hypothalamus 0 0.000 1.4
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.3
GTEx Breast Mammary Tissue 0 0.000 1.3
GTEx Breast Mammary Tissue (Male) 0 0.000 1.3
GTEx Breast Mammary Tissue (Female) 0 0.000 1.3
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.3
GTEx Cells Transformed fibroblasts 1 0.024 1.2
GTEx Colon Sigmoid 0 0.000 1.3
GTEx Colon Transverse 0 0.000 1.2
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.2
GTEx Esophagus Mucosa 0 0.000 1.2
GTEx Esophagus Muscularis 0 0.000 1.2
GTEx Heart Atrial Appendage 0 0.000 1.3
GTEx Heart Left Ventricle 0 0.000 1.3
GTEx Liver 0 0.000 1.3
GTEx Lung 1 0.035 1.3
GTEx Muscle Skeletal 0 0.000 1.2
GTEx Nerve Tibial 0 0.000 1.2
GTEx Ovary 0 0.000 1.3
GTEx Pancreas 0 0.000 1.3
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.3
GTEx Skin Not Sun Exposed Suprapubic 1 0.041 1.2
GTEx Skin Sun Exposed Lower leg 0 0.000 1.2
GTEx Small Intestine Terminal Ileum 0 0.000 1.3
GTEx Spleen 2 0.142 1.3
GTEx Stomach 0 0.000 1.2
GTEx Testis 0 0.000 1.2
GTEx Thyroid 0 0.000 1.2
GTEx Uterus 0 0.000 1.4
GTEx Vagina 0 0.000 1.3
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.1
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.1
YFS Blood 0 0.000 1.1
CommonMind Brain Pre-frontal Cortex 0 0.000 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Breast Invasive Carcinoma 3 0.068 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 1 0.037 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 1 0.022 1.1
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.1
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.1
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2