Best TWAS P=2.95e-09 · Best GWAS P=7.49e-08 conditioned to 0.31
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | RP11-538P18.2 | 0.11 | 0.09 | lasso | 3 | 0.08 | 2.9e-05 | 4.6 | -5.2 | 2.1e-07 | -0.74 | 0.04 | 0.96 | FALSE |
2 | GTEx | Artery Tibial | RP11-538P18.2 | 0.17 | 0.14 | enet | 24 | 0.21 | 3.7e-16 | 4.4 | -5.9 | 2.9e-09 | -0.80 | 0.14 | 0.85 | TRUE |
3 | GTEx | Brain Cerebellar Hemisphere | RP11-538P18.2 | 0.17 | 0.11 | lasso | 4 | 0.04 | 4.1e-02 | 5.4 | -5.6 | 2.7e-08 | -0.95 | 0.02 | 0.78 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | RP11-538P18.2 | 0.10 | 0.08 | enet | 10 | 0.13 | 5.1e-10 | 4.4 | -5.4 | 7.1e-08 | -0.82 | 0.04 | 0.96 | FALSE |
5 | GTEx | Esophagus Muscularis | RP11-538P18.2 | 0.11 | 0.16 | lasso | 5 | 0.15 | 1.2e-09 | 5.0 | 5.2 | 1.7e-07 | 0.83 | 0.04 | 0.96 | FALSE |
6 | GTEx | Lung | RP11-379F4.7 | 0.05 | 0.01 | lasso | 3 | 0.01 | 1.2e-01 | 4.3 | 5.5 | 4.6e-08 | 0.76 | 0.07 | 0.55 | FALSE |
7 | GTEx | Ovary | RP11-538P18.2 | 0.23 | 0.08 | lasso | 6 | 0.13 | 4.5e-04 | 4.4 | -5.4 | 5.8e-08 | -0.87 | 0.03 | 0.60 | FALSE |
8 | GTEx | Pancreas | RP11-538P18.2 | 0.14 | 0.02 | lasso | 11 | 0.02 | 5.3e-02 | 4.9 | -5.2 | 1.8e-07 | -0.90 | 0.03 | 0.84 | FALSE |
9 | GTEx | Stomach | RSRC1 | 0.08 | 0.06 | lasso | 3 | 0.07 | 2.9e-04 | 4.6 | -5.1 | 2.9e-07 | -0.89 | 0.02 | 0.96 | FALSE |
10 | GTEx | Vagina | RP11-538P18.2 | 0.25 | 0.19 | lasso | 3 | 0.18 | 6.7e-05 | 5.4 | -5.5 | 3.1e-08 | -0.99 | 0.01 | 0.92 | FALSE |
11 | METSIM | Adipose | RSRC1 | 0.14 | 0.19 | blup | 532 | 0.21 | 6.0e-31 | 4.4 | -5.8 | 6.6e-09 | -0.59 | 0.28 | 0.68 | FALSE |