Best TWAS P=1.06e-11 · Best GWAS P=3.59e-10 conditioned to 0.0246
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cortex | NRBF2 | 0.30 | 0.26 | enet | 24 | 0.21 | 1.4e-06 | 5.1 | 5.1 | 2.8e-07 | -0.06 | 0.76 | 0.19 | FALSE |
| 2 | GTEx | Muscle Skeletal | ADO | 0.15 | 0.16 | lasso | 8 | 0.16 | 1.1e-15 | 4.9 | 5.3 | 1.4e-07 | -0.76 | 0.70 | 0.30 | FALSE |
| 3 | GTEx | Muscle Skeletal | RP11-436D10.3 | 0.08 | 0.04 | enet | 13 | 0.06 | 3.2e-06 | -6.2 | 6.3 | 3.1e-10 | -0.87 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | NRBF2 | 0.06 | 0.01 | lasso | 3 | 0.00 | 4.0e-01 | -5.4 | 6.8 | 1.1e-11 | -0.68 | 0.08 | 0.16 | TRUE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | ADO | 0.06 | 0.04 | lasso | 2 | 0.06 | 3.1e-08 | -6.2 | 5.2 | 2.1e-07 | -0.89 | 0.00 | 1.00 | FALSE |
| 6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NRBF2 | 0.04 | 0.04 | enet | 5 | 0.03 | 1.3e-04 | -4.8 | 5.1 | 2.9e-07 | -0.06 | 0.00 | 0.95 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | ADO | 0.14 | 0.05 | blup | 53 | 0.05 | 3.8e-06 | -5.4 | 6.3 | 2.3e-10 | -0.85 | 0.01 | 0.99 | FALSE |
| 8 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | NRBF2 | 0.09 | 0.02 | enet | 6 | 0.04 | 1.4e-05 | 3.9 | 5.4 | 7.1e-08 | -0.03 | 0.01 | 0.94 | FALSE |
| 9 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ADO | 0.06 | 0.04 | blup | 55 | 0.01 | 1.4e-01 | -6.2 | 5.6 | 1.9e-08 | -0.84 | 0.00 | 0.86 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | ADO | 0.12 | 0.10 | lasso | 5 | 0.09 | 5.2e-09 | -6.2 | 6.2 | 7.6e-10 | -0.97 | 0.00 | 1.00 | FALSE |