Best TWAS P=8.9e-09 · Best GWAS P=1.14e-08 conditioned to 0.16
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SENP1 | 0.05 | 0.02 | blup | 555 | 0.04 | 1.7e-05 | 5.7 | -5.4 | 6.3e-08 | 0.12 | 0.03 | 0.97 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | ZNF641 | 0.10 | 0.10 | lasso | 4 | 0.10 | 2.8e-08 | 5.3 | 5.4 | 8.0e-08 | -0.07 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Artery Tibial | ZNF641 | 0.19 | 0.16 | lasso | 5 | 0.16 | 1.6e-12 | 5.3 | 5.4 | 8.1e-08 | -0.07 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Lung | ZNF641 | 0.08 | 0.10 | lasso | 2 | 0.08 | 8.0e-07 | 5.6 | 5.5 | 3.7e-08 | -0.07 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Nerve Tibial | ZNF641 | 0.14 | 0.11 | lasso | 4 | 0.08 | 2.3e-06 | 5.3 | 5.5 | 2.9e-08 | -0.07 | 0.02 | 0.98 | FALSE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | ZNF641 | 0.15 | 0.11 | enet | 30 | 0.10 | 3.1e-06 | 5.3 | 5.4 | 6.8e-08 | -0.09 | 0.02 | 0.98 | FALSE |
| 7 | GTEx | Spleen | ZNF641 | 0.42 | 0.21 | lasso | 11 | 0.28 | 5.4e-08 | -3.1 | 5.4 | 5.7e-08 | -0.08 | 0.05 | 0.92 | FALSE |
| 8 | GTEx | Thyroid | ZNF641 | 0.16 | 0.06 | enet | 26 | 0.13 | 2.0e-10 | -2.9 | 5.1 | 2.8e-07 | -0.09 | 0.04 | 0.96 | FALSE |
| 9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | HDAC7 | 0.05 | 0.02 | blup | 85 | 0.01 | 7.5e-03 | -5.4 | -5.4 | 5.2e-08 | 0.82 | 0.00 | 0.97 | TRUE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | ZNF641 | 0.11 | 0.12 | enet | 10 | 0.12 | 5.2e-12 | 5.5 | 5.8 | 8.9e-09 | -0.08 | 0.00 | 1.00 | TRUE |