Best TWAS P=4.5e-11 · Best GWAS P=3.68e-12 conditioned to 1.18e-09
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | RP4-605O3.4 | 0.04 | 0.01 | lasso | 4 | 0.00 | 3.2e-01 | 6.6 | 5.2 | 2.2e-07 | 0.03 | 0.04 | 0.85 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | RP4-605O3.4 | 0.18 | 0.12 | enet | 14 | 0.10 | 1.5e-03 | 6.6 | 5.4 | 5.7e-08 | 0.02 | 0.03 | 0.78 | FALSE |
| 3 | GTEx | Nerve Tibial | RP4-605O3.4 | 0.11 | 0.00 | lasso | 3 | 0.00 | 1.7e-01 | 6.6 | 6.6 | 5.2e-11 | -0.15 | 0.03 | 0.83 | FALSE |
| 4 | GTEx | Prostate | CERS5 | 0.19 | 0.08 | lasso | 4 | 0.02 | 1.2e-01 | 6.6 | 6.2 | 4.4e-10 | -0.11 | 0.04 | 0.59 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | SMARCD1 | 0.07 | 0.02 | lasso | 2 | 0.03 | 1.4e-03 | -5.1 | -5.3 | 1.0e-07 | 0.19 | 0.06 | 0.80 | FALSE |
| 6 | GTEx | Testis | CERS5 | 0.12 | 0.06 | lasso | 6 | 0.07 | 4.0e-04 | 6.6 | 6.6 | 4.5e-11 | -0.14 | 0.03 | 0.86 | TRUE |
| 7 | GTEx | Whole Blood | RP4-605O3.4 | 0.04 | 0.04 | lasso | 4 | 0.01 | 1.5e-02 | 6.6 | 6.3 | 2.6e-10 | -0.09 | 0.02 | 0.92 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LIMA1 | 0.08 | 0.10 | blup | 59 | 0.10 | 1.8e-11 | 5.9 | -5.6 | 2.6e-08 | 0.09 | 0.22 | 0.78 | FALSE |