[Hub]/) : Traits : Hypertension (Self-reported) :

chr12:49,780,778-51,256,065

Best TWAS P=4.5e-11 · Best GWAS P=3.68e-12 conditioned to 1.18e-09

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Artery Tibial RP4-605O3.4 0.04 0.01 lasso 4 0.00 3.2e-01 6.6 5.2 2.2e-07 0.03 0.04 0.85 FALSE
2 GTEx Brain Cerebellar Hemisphere RP4-605O3.4 0.18 0.12 enet 14 0.10 1.5e-03 6.6 5.4 5.7e-08 0.02 0.03 0.78 FALSE
3 GTEx Nerve Tibial RP4-605O3.4 0.11 0.00 lasso 3 0.00 1.7e-01 6.6 6.6 5.2e-11 -0.15 0.03 0.83 FALSE
4 GTEx Prostate CERS5 0.19 0.08 lasso 4 0.02 1.2e-01 6.6 6.2 4.4e-10 -0.11 0.04 0.59 FALSE
5 GTEx Skin Sun Exposed Lower leg SMARCD1 0.07 0.02 lasso 2 0.03 1.4e-03 -5.1 -5.3 1.0e-07 0.19 0.06 0.80 FALSE
6 GTEx Testis CERS5 0.12 0.06 lasso 6 0.07 4.0e-04 6.6 6.6 4.5e-11 -0.14 0.03 0.86 TRUE
7 GTEx Whole Blood RP4-605O3.4 0.04 0.04 lasso 4 0.01 1.5e-02 6.6 6.3 2.6e-10 -0.09 0.02 0.92 FALSE
8 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma LIMA1 0.08 0.10 blup 59 0.10 1.8e-11 5.9 -5.6 2.6e-08 0.09 0.22 0.78 FALSE