Best TWAS P=2.28e-11 · Best GWAS P=2.7e-14 conditioned to 0.000258
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ATP5G1 | 0.07 | 0.05 | lasso | 3 | 0.06 | 4.7e-08 | -5.8 | 5.8 | 5.5e-09 | -0.01 | 0.99 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | SNF8 | 0.08 | 0.07 | lasso | 5 | 0.08 | 9.3e-10 | -4.9 | 5.8 | 7.8e-09 | -0.09 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Artery Aorta | SNF8 | 0.12 | 0.12 | lasso | 6 | 0.10 | 2.3e-06 | -4.8 | 5.3 | 1.5e-07 | -0.01 | 0.86 | 0.02 | FALSE |
| 4 | GTEx | Artery Aorta | AC091133.1 | 0.10 | 0.07 | lasso | 5 | 0.07 | 1.2e-04 | -4.8 | 6.1 | 9.6e-10 | 0.02 | 0.53 | 0.06 | TRUE |
| 5 | GTEx | Cells EBV-transformed lymphocytes | UBE2Z | 0.16 | 0.01 | enet | 25 | 0.10 | 3.5e-04 | -4.2 | -5.6 | 2.8e-08 | -0.09 | 0.28 | 0.04 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | SNF8 | 0.12 | 0.10 | lasso | 3 | 0.12 | 5.1e-09 | -4.9 | 5.4 | 6.4e-08 | -0.05 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | RP11-463M16.4 | 0.10 | 0.00 | enet | 21 | 0.01 | 2.8e-02 | -5.6 | 6.5 | 1.1e-10 | 0.22 | 0.27 | 0.07 | FALSE |
| 8 | GTEx | Esophagus Muscularis | SNF8 | 0.08 | 0.03 | lasso | 3 | 0.01 | 5.7e-02 | -5.7 | 5.9 | 3.7e-09 | -0.06 | 0.12 | 0.04 | FALSE |
| 9 | GTEx | Heart Left Ventricle | ATP5G1 | 0.24 | 0.22 | lasso | 4 | 0.22 | 9.3e-12 | -5.6 | 5.7 | 1.3e-08 | -0.03 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Muscle Skeletal | UBE2Z | 0.06 | 0.02 | lasso | 8 | 0.03 | 9.8e-04 | -5.6 | 5.5 | 2.9e-08 | -0.08 | 0.78 | 0.01 | FALSE |
| 11 | GTEx | Nerve Tibial | UBE2Z | 0.12 | 0.04 | enet | 16 | 0.05 | 1.5e-04 | -4.8 | 5.1 | 2.7e-07 | -0.02 | 0.90 | 0.00 | FALSE |
| 12 | GTEx | Ovary | ATP5G1 | 0.15 | 0.08 | enet | 13 | 0.09 | 2.8e-03 | -4.1 | 5.4 | 7.6e-08 | -0.06 | 0.22 | 0.04 | FALSE |
| 13 | GTEx | Skin Not Sun Exposed Suprapubic | UBE2Z | 0.11 | 0.07 | lasso | 6 | 0.04 | 1.8e-03 | -5.7 | 5.8 | 8.9e-09 | -0.06 | 0.11 | 0.04 | FALSE |
| 14 | GTEx | Skin Sun Exposed Lower leg | UBE2Z | 0.14 | 0.11 | lasso | 9 | 0.14 | 6.3e-12 | -4.5 | 5.3 | 9.9e-08 | -0.04 | 1.00 | 0.00 | FALSE |
| 15 | GTEx | Thyroid | SNF8 | 0.11 | 0.08 | lasso | 3 | 0.07 | 2.5e-06 | -4.9 | 5.3 | 1.5e-07 | -0.03 | 0.97 | 0.00 | FALSE |
| 16 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SNF8 | 0.01 | 0.01 | blup | 47 | 0.01 | 9.1e-03 | -4.2 | 5.2 | 2.5e-07 | -0.10 | 0.06 | 0.24 | FALSE |
| 17 | The Cancer Genome Atlas | Colon Adenocarcinoma | ZNF652 | 0.09 | 0.01 | enet | 12 | 0.05 | 5.5e-04 | 5.8 | -5.3 | 1.1e-07 | -0.60 | 0.01 | 0.58 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ZNF652 | 0.03 | 0.03 | enet | 5 | 0.03 | 2.6e-04 | 5.3 | -6.0 | 2.0e-09 | -0.80 | 0.13 | 0.68 | FALSE |
| 19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SNF8 | 0.11 | 0.12 | lasso | 4 | 0.12 | 1.4e-13 | -4.8 | 5.1 | 2.8e-07 | -0.06 | 0.29 | 0.71 | FALSE |
| 20 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TTLL6 | 0.03 | 0.00 | blup | 59 | 0.02 | 2.7e-03 | -3.6 | -5.3 | 1.1e-07 | -0.01 | 0.02 | 0.82 | FALSE |
| 21 | The Cancer Genome Atlas | Lung Adenocarcinoma | ZNF652 | 0.05 | 0.02 | blup | 55 | 0.02 | 2.5e-03 | 6.9 | -6.7 | 2.3e-11 | -0.79 | 0.04 | 0.86 | TRUE |
| 22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SNF8 | 0.05 | 0.06 | blup | 47 | 0.06 | 1.0e-06 | -5.7 | 5.3 | 1.2e-07 | -0.09 | 0.05 | 0.95 | FALSE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | UBE2Z | 0.13 | 0.09 | lasso | 4 | 0.12 | 2.7e-11 | -4.9 | 5.2 | 1.6e-07 | -0.05 | 0.05 | 0.95 | FALSE |