TWAS hub - TTLL6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2290	0.0460	2.3e-11	0.125	0.121	0.141	0.147	0.134	5.4e-15	1.7e-14	8.1e-17	1.6e-17	4.9e-16
2	TCGA	Brain Lower Grade Glioma	0.0334	0.0182	2.4e-03	0.003	0.019	0.008	NA	0.004	1.4e-01	2.7e-03	3.8e-02	NA	9.8e-02
3	TCGA	Pancreatic Adenocarcinoma	0.1350	0.0620	8.9e-04	0.042	0.048	0.062	NA	0.039	7.0e-03	4.6e-03	1.4e-03	NA	9.3e-03
4	TCGA	Prostate Adenocarcinoma	0.0314	0.0170	3.4e-03	0.039	0.027	0.022	NA	0.030	5.3e-05	7.0e-04	1.9e-03	NA	3.4e-04
5	TCGA	Rectum Adenocarcinoma	0.2330	0.0990	5.3e-03	-0.013	0.002	-0.013	NA	-0.004	9.2e-01	2.9e-01	8.8e-01	NA	4.0e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Impedance of leg (left)	5.5	26.6	48.6	3.0	3.9	7.0	4.6	6.3
High blood pressure (mother)	5.4	7.6	19.1	1.0	-4.4	-1.2	-4.0	-0.4
Prostate Cancer	5.1	7.2	17.0	-4.1	1.6	1.7	3.2	1.8
Height	4.8	93.3	222.0	-10.2	11.3	3.5	14.9	0.8
Impedance of leg (right)	4.8	23.3	42.8	2.5	3.8	6.5	4.5	5.7
Standing height	4.8	47.2	104.0	-8.6	7.3	2.0	10.2	0.1
Crohns Disease (2012)	4.6	7.4	17.6	-1.6	-1.7	-3.5	-1.1	-4.2
Impedance of whole body	4.6	23.4	45.3	1.8	3.4	6.7	4.6	5.9
BMI	4.4	25.6	45.0	-3.2	-6.7	-5.8	-4.8	-4.0
Medication: Amlodipine	4.2	5.9	12.3	2.7	-2.8	-0.7	-3.5	-1.3
Diabetes (father)	4.1	5.1	15.9	-0.7	-4.0	-1.1	-2.6	-1.1
Illnesses of mother	4.1	5.0	14.1	-0.5	3.8	-0.1	3.3	0.3
Hypothyroidism/myxoedema (self-reported)	4.1	8.0	14.0	0.0	-3.7	-3.0	-2.8	-3.0
Average weekly champagne plus white wine intake	4.1	5.6	16.2	-1.2	4.0	-0.3	3.0	-1.1
Hypothyroidism (self reported)	4.0	9.2	12.2	0.2	-3.5	-3.4	-3.4	-3.3
Chronotype (morning person)	3.8	8.7	15.5	-1.4	-3.5	-3.9	-2.3	-2.9
Sitting height	3.7	26.2	65.3	-5.5	5.6	2.0	8.1	-0.1
Medication: Blood pressure	3.6	6.4	21.3	-1.8	-4.6	0.1	-2.8	0.2
Impedance of arm (left)	3.5	16.1	29.7	0.6	3.1	5.4	4.3	4.7
Comparative height size at age 10	3.5	19.5	58.1	-7.6	2.7	-1.6	5.0	-2.0
Medication: Co-codamol	3.4	3.9	7.2	1.2	-1.4	-1.7	-2.5	-2.7
Body mass index (BMI)	3.4	14.6	30.5	-2.6	-5.5	-4.0	-3.9	-2.2
Leg predicted mass (left)	3.4	18.0	47.3	-6.9	-1.1	-4.7	0.6	-4.3
Leg fat-free mass (left)	3.3	17.7	47.2	-6.9	-1.1	-4.6	0.6	-4.3
Breastfed as a baby	3.3	4.0	8.6	-0.3	2.9	1.5	2.7	1.4
High blood pressure	3.2	8.9	29.9	-1.6	-5.5	-0.6	-3.4	-0.3
Cardiovascular Disease	3.1	10.2	32.4	-0.1	-5.7	-1.1	-4.1	-0.3
Sensitivity / hurt feelings	3.1	5.3	13.3	-0.5	-3.6	-0.8	-3.4	-0.9
Hypertension (Self-reported)	3.1	8.5	28.2	-1.6	-5.3	-0.8	-3.3	-0.5
Leg fat-free mass (right)	3.1	16.7	41.3	-6.4	-0.9	-4.7	0.6	-4.3
Leg predicted mass (right)	3.1	16.5	40.7	-6.4	-0.8	-4.7	0.6	-4.3
Whole body water mass	3.0	17.0	45.0	-6.7	0.2	-4.5	1.6	-4.2
Type 2 Diabetes (T2D) (2018)	2.9	5.4	17.1	-0.2	-4.1	0.2	-3.1	-0.1
Hand grip strength (left)	2.9	7.7	19.7	-0.9	2.0	-4.4	0.4	-3.7
Impedance of arm (right)	2.9	13.4	27.1	0.4	2.3	5.2	3.8	4.5
Comparative body size at age 10	2.9	7.9	20.8	-0.2	-1.5	-4.6	-2.5	-3.2
Forced expiratory volume in 1-second (FEV1), predicted	2.9	6.0	14.0	-3.7	2.3	-0.9	2.7	-1.6
Whole body fat-free mass	2.9	16.6	44.6	-6.7	0.2	-4.3	1.6	-4.1
Vascular/heart problems diagnosed by doctor	2.9	8.0	26.0	1.2	5.1	0.5	3.5	0.4
Hearing difficulty/problems with background noise	2.8	4.5	7.7	-0.3	-2.8	-2.1	-2.4	-2.0
Basal metabolic rate	2.8	15.6	44.0	-6.6	-0.4	-4.2	1.4	-3.8
Arm fat-free mass (right)	2.7	13.8	37.2	-6.1	0.0	-4.0	1.5	-3.7
Medication: Atenolol	2.6	3.3	6.3	1.5	-2.0	-1.4	-2.5	-1.4
Time employed in main current job	2.6	3.0	5.1	-2.3	-1.5	-1.8	-0.2	-2.0
Arm predicted mass (right)	2.6	13.2	35.6	-6.0	0.4	-3.8	1.8	-3.5
Tinnitus: Yes, now most or all of the time	2.6	3.0	5.0	-0.8	-1.3	-2.1	-2.2	-1.8
Arm fat-free mass (left)	2.6	13.0	33.6	-5.8	-0.6	-4.2	1.1	-3.5
Type 2 Diabetes (T2D) (2012)	2.5	2.9	5.7	1.5	-2.4	-0.5	-2.4	-0.8
Trunk fat-free mass	2.5	14.5	38.3	-6.2	1.2	-3.6	2.2	-3.9
Arm fat mass (right)	2.5	10.4	19.0	-4.3	-4.4	-3.1	-1.7	-1.6
Trunk predicted mass	2.5	14.2	37.2	-6.1	1.1	-3.7	2.1	-3.8
Arm predicted mass (left)	2.5	12.6	33.2	-5.8	-0.6	-4.0	1.1	-3.5
Weight	2.4	11.6	38.4	-6.2	-2.1	-3.1	0.8	-2.2
Arm fat percentage (right)	2.4	9.6	28.2	-2.7	-5.3	-2.0	-2.8	-0.4
Worry too long after embarrassment	2.4	4.1	9.6	0.3	-2.7	-1.1	-3.1	-1.5
Alcohol intake frequency.	2.4	5.7	17.3	-0.6	-4.2	-1.8	-2.4	-1.3
Lupus	2.3	3.5	6.0	-0.4	1.3	2.1	2.4	2.4
Forced vital capacity (FVC)	2.3	8.7	17.0	-4.1	2.9	-1.1	3.8	-1.6
Qualifications: None of the above	2.3	5.0	13.2	1.2	-3.6	1.1	-2.5	1.7
Medication: Aspirin	2.3	3.0	8.8	-1.2	-3.0	1.6	-0.9	1.3
Diabetes diagnosed by doctor	2.3	3.8	12.5	0.2	-3.5	0.5	-2.5	-0.3
Schizophrenia vs Biploar Disorder	2.2	2.9	8.7	-1.3	-3.0	-0.7	-1.8	0.6
Crohns Disease (2017)	2.2	4.8	11.3	-1.9	-1.2	-2.8	-0.1	-3.4
Coronary Artery Disease (CAD)	2.2	2.6	8.2	1.1	-2.9	-0.4	-1.6	-1.0
Hearing difficulty/problems: Yes	2.2	3.4	9.4	-0.2	0.3	-2.5	-0.9	-3.1
Hand grip strength (right)	2.2	5.9	10.5	-1.1	3.2	-2.8	1.7	-2.7
Hair/balding pattern: Pattern 4	2.2	5.4	17.3	-0.3	-0.5	2.8	1.1	4.2
Arm fat percentage (left)	2.2	8.8	24.8	-2.9	-5.0	-2.0	-2.5	-0.4
Arm fat mass (left)	2.2	9.2	19.5	-4.4	-3.9	-2.8	-1.3	-1.3
Medication: Levothyroxine sodium	2.1	3.5	8.0	-1.0	-2.8	-1.3	-1.7	-2.0
High blood pressure (siblings)	2.1	3.0	11.1	-1.1	-3.3	1.2	-1.2	0.1
Medication: Aspirin	2.1	2.8	8.3	-1.2	-2.9	1.4	-1.0	1.1
Smoking status: Current	2.1	3.4	7.2	-1.0	-2.7	-2.3	-1.9	0.0
Heart attack/myocardial infarction (self-reported)	2.1	2.6	6.6	-0.3	-2.6	-0.3	-2.2	-1.3
Systolic blood pressure, automated reading	2.0	5.9	12.2	0.7	-2.9	3.5	-0.1	2.9
Current tobacco smoking	2.0	3.2	6.9	-1.1	-2.6	-2.2	-1.8	0.1
Medication: Cholesterol lowering	2.0	3.0	8.3	-0.2	-2.6	-0.0	-2.9	0.2
Medication for cholesterol, blood pressure or diabetes	2.0	3.2	8.9	1.3	3.0	-0.6	2.2	-0.5
Medication: Gliclazide	2.0	2.2	7.0	-1.0	-2.6	0.6	-0.9	1.4
Illnesses of father: None of the above (group 1)	2.0	2.5	6.9	0.5	2.6	0.6	1.7	1.4
Body Mass Index (BMI) (2010)	1.9	2.7	3.7	-1.9	-1.3	-1.9	-1.2	-1.8
Number of treatments/medications taken	1.9	3.5	11.5	-1.1	-3.4	-0.6	-2.0	-0.7
Medication: Metformin	1.9	2.7	8.1	-0.6	-2.8	1.4	-1.1	1.3
Heart attack	1.9	2.4	5.9	-0.3	-2.4	-0.3	-2.1	-1.3
Diabetes (self-reported)	1.9	2.9	10.0	0.1	-3.2	0.4	-2.1	-0.1
Medication: Simvastatin	1.9	2.8	7.2	-0.3	-2.5	-0.3	-2.7	0.3
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.0	8.5	0.3	-2.9	0.2	-2.4	0.8
Noisy workplace	1.9	2.3	3.4	0.4	-1.8	-1.8	-1.8	-1.3
Forced vital capacity (FVC), Best measure	1.9	7.0	11.8	-3.4	2.4	-1.9	3.1	-2.1
Whole body fat mass	1.9	7.8	22.5	-4.7	-3.6	-1.9	-0.3	-0.6
Illnesses of father: Heart disease	1.9	2.7	8.2	0.9	-2.9	-0.3	-2.0	-0.4
Alcohol drinker status: Never	1.9	2.2	4.9	0.7	-2.2	-1.4	-1.9	-0.3
Systolic Blood Pressure	1.8	8.8	16.3	1.0	-4.0	3.8	-1.1	3.3
Frequency of depressed mood in last 2 weeks	1.8	2.5	4.6	-0.6	-0.8	-2.1	-1.8	-1.9
Ever used hormone-replacement therapy (HRT)	1.8	2.3	4.6	0.4	1.0	2.1	1.2	2.1
Trunk fat mass	1.8	7.7	27.2	-5.2	-3.0	-1.3	0.7	-0.1
Alcohol usually taken with meals	1.8	2.8	6.9	-0.7	2.2	1.3	2.6	0.4
Bilateral oophorectomy (both ovaries removed)	1.7	2.0	3.5	1.7	-1.9	0.3	-1.6	0.7
Past tobacco smoking	1.7	3.2	11.9	3.4	2.0	0.2	0.2	0.1
Pain all over the body in last month	1.7	1.8	4.5	-0.2	0.7	1.7	1.1	2.1
Hip circumference	1.7	7.3	20.1	-4.5	-2.7	-2.7	0.0	-1.2
Father’s age at death	1.7	2.2	5.3	-1.1	2.2	-0.1	2.3	0.1
Peak expiratory flow (PEF)	1.7	4.0	9.9	-0.6	2.8	1.4	3.1	-0.0
Chronic bronchitis/emphysema (mother)	1.7	2.0	6.9	-0.9	-2.6	-0.1	-1.5	0.0
Angina (self-reported)	1.7	2.2	7.1	-1.7	-2.7	0.5	-1.0	0.4
Leg fat mass (right)	1.7	6.7	14.1	-3.7	-3.8	-2.0	-0.9	-0.6
Mother’s age at death	1.7	2.1	5.8	1.3	2.4	1.1	0.8	1.2
Leg fat mass (left)	1.7	6.8	14.7	-3.7	-3.8	-2.0	-1.0	-0.6
HbA1C	1.6	1.8	6.9	-1.2	-2.6	-0.0	-0.8	-0.1
Blood Platelet Count	1.6	18.2	30.1	-0.8	5.4	3.9	5.5	3.9
Ever had hysterectomy (womb removed)	1.6	1.8	6.2	0.6	0.4	1.4	0.7	2.5
Angina	1.6	2.2	6.8	-1.6	-2.6	0.5	-1.0	0.5
Illnesses of siblings	1.6	2.2	8.9	1.0	3.0	-0.5	1.0	-0.1
Qualifications: O levels/GCSEs or equivalent	1.6	2.6	9.1	0.4	3.0	0.7	1.6	-0.7
Overall health rating	1.6	3.4	8.2	-0.8	-2.9	-0.8	-2.7	-0.6
Smoking status: Previous	1.6	2.4	9.9	-3.2	-0.1	1.0	1.0	0.5
Ever taken oral contraceptive pill	1.6	1.8	3.0	-1.1	1.7	-1.2	0.8	-1.6
Myopia	1.6	2.3	5.5	2.1	0.7	2.4	-0.3	1.0
Pain experienced in last month	1.6	2.7	4.9	0.4	2.2	1.2	2.0	1.8
Smoking Status	1.5	3.5	9.8	-3.1	-2.4	-1.1	-0.9	-0.2
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	7.0	-2.7	-1.1	0.2	1.2	-0.3
Trunk fat percentage	1.5	6.0	15.9	-4.0	-3.6	-0.3	0.2	1.1
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	4.5	-0.5	0.8	0.8	1.4	2.1
Body fat percentage	1.5	5.9	17.8	-3.1	-4.2	-0.8	-0.8	0.7
Neck or shoulder pain in last month	1.5	2.2	6.0	1.4	-1.7	-0.0	-2.4	-0.2
Heart disease (mother)	1.5	1.8	3.6	1.5	-1.6	0.3	-1.9	0.6
Medication for hormone replacement therapy	1.4	1.6	4.0	0.2	0.4	2.0	0.2	1.9
Fed-up feelings	1.4	2.5	7.9	-1.5	-2.8	0.2	-1.4	0.4
Taking other prescription medications	1.4	2.2	5.0	-2.2	-2.1	0.8	-0.8	0.6
Waist circumference	1.4	5.1	7.4	-2.7	-2.7	-2.7	-1.4	-1.3
Nervous feelings	1.4	2.6	6.2	1.5	-1.7	-1.2	-2.5	-0.5
Mouth/teeth dental problems	1.4	2.2	4.5	1.3	2.1	-0.7	1.1	-1.8
Forced expiratory volume in 1-second (FEV1)	1.4	4.6	8.9	-2.3	2.7	-0.6	3.0	-1.0
Mouth/teeth dental problems: Dentures	1.4	2.3	6.4	-1.5	-2.5	-0.4	-1.4	0.9
Birth weight of first child	1.4	2.5	4.2	-1.4	1.4	-1.5	1.5	-2.0
Leg fat percentage (right)	1.4	5.0	18.7	-1.5	-4.3	-0.5	-1.7	0.9
Medication: Allopurinol	1.4	1.9	8.4	2.9	0.1	-0.6	-0.7	0.4
Qualifications: NVQ or HND or HNC or equivalent	1.4	1.7	5.1	-0.6	-0.7	-2.3	-0.5	-1.5
Leg fat percentage (left)	1.4	4.9	18.6	-1.3	-4.3	-0.3	-1.7	1.1
Ovarian Cancer	1.3	1.7	4.6	-0.3	0.8	-2.1	-0.5	-1.6
Number of incorrect matches in round	1.3	2.1	5.7	0.7	0.2	2.4	0.5	2.0
Financial difficulties in last 2 years	1.3	1.8	4.3	-2.1	0.6	0.7	1.2	1.5
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	3.2	1.4	0.7	-1.8	0.0	-1.7
Medication: Paracetamol	1.3	2.1	4.1	0.5	-1.5	-1.6	-1.1	-2.0
Health satisfaction	1.3	1.7	4.2	-2.0	-1.5	-0.8	-1.2	-0.4
Average weekly red wine intake	1.3	2.0	4.0	1.9	2.0	1.2	0.9	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	4.4	-0.9	-0.3	-1.4	-0.1	-2.1
Commuting to job workplace: Public transport	1.3	1.5	4.0	0.4	-0.9	-2.0	-1.0	-1.3
High cholesterol (Self-reported)	1.3	2.3	5.9	1.5	-1.8	-0.0	-2.4	-0.0
Medication: Bendroflumethiazide	1.3	2.0	4.5	-2.1	-2.1	0.7	-0.5	0.5
Ever smoked	1.3	2.4	5.0	-1.5	-2.2	-1.4	-1.4	-0.9
Age started oral contraceptive pill	1.3	1.7	3.6	1.9	1.4	1.2	1.2	0.2
Neuroticism (Nagel 2018)	1.2	2.8	5.8	-0.0	-2.4	-0.6	-2.4	-1.5
Average weekly spirits intake	1.2	1.4	3.5	-1.0	-1.0	-1.9	-1.1	-0.7
Severe depression (siblings)	1.2	1.3	3.6	-0.3	-0.1	1.9	0.6	1.6
Loud music exposure frequency	1.2	1.4	4.1	-0.0	0.6	-2.0	-0.0	-1.5
Gout (self-reported)	1.2	1.7	8.1	2.8	0.3	-0.5	-0.2	0.2
Qualifications: College or University degree	1.2	3.8	11.0	0.5	3.3	0.8	2.7	-0.2
Leg pain on walking	1.2	1.5	3.7	-0.3	-1.9	-1.5	-1.0	-0.4
Knee pain experienced in last month	1.2	1.9	6.2	-0.4	-2.5	-0.3	-1.3	-1.1
Number of self-reported non-cancer illnesses	1.2	2.1	6.6	-0.3	-2.6	0.0	-1.9	-0.3
Alzheimer’s Disease (in mother)	1.1	1.3	2.7	-1.6	1.0	1.3	0.8	-0.7
Townsend deprivation index at recruitment	1.1	1.5	5.1	0.1	0.8	1.3	0.6	2.3
Had menopause	1.1	1.4	2.5	-0.6	0.4	1.6	1.4	1.4
Neuroticism score	1.1	2.2	5.4	-0.2	-2.3	-0.6	-2.3	-0.4
Ever highly irritable/argumentative for 2 days	1.1	1.3	4.0	-0.8	0.0	-1.4	0.0	-2.0
Birth weight	1.1	2.4	4.5	-2.1	1.5	-0.9	1.3	-1.6
Age at first live birth	1.1	2.0	5.6	1.6	2.4	0.2	1.4	-0.2
Medication for pain relief, constipation, heartburn	1.1	1.9	3.5	0.4	1.9	1.2	1.4	1.5
Qualifications: nursing, teaching	1.1	1.7	5.5	0.3	2.3	0.8	1.2	1.0
Commuting to job workplace: Walk	1.1	1.2	3.6	0.8	1.9	-0.7	1.1	0.3
Osteoporosis (self-reported)	1.1	1.3	3.4	-0.2	-1.8	0.2	-0.3	1.7
Irritability	1.1	1.8	5.1	0.9	-1.7	-0.5	-2.3	-0.5
Fractured/broken bones in last 5 years	1.1	1.4	2.8	-1.6	-1.7	-0.2	0.3	1.2
Worry (Nagel 2018)	1.0	2.2	5.4	1.5	-1.0	-0.9	-2.3	-1.2
Fasting Glucose	1.0	1.2	2.6	-0.9	-0.7	1.3	0.5	1.6
Supplements: Zinc	1.0	1.1	3.2	-0.6	-0.5	-1.2	-0.3	-1.8
Supplements: Glucosamine	1.0	1.3	2.0	-1.0	1.4	1.0	1.2	0.9
Happiness	1.0	1.2	2.4	0.4	-0.8	-0.9	-1.3	-1.6
Depression (self-reported)	1.0	1.2	3.0	-0.5	-1.2	1.7	-0.6	0.8
Glaucoma (self-reported)	1.0	1.2	3.3	-0.9	-0.7	1.8	0.5	1.0
Number of full sisters	1.0	1.2	2.3	1.1	-1.4	-0.3	-1.5	0.1
Long-standing illness, disability or infirmity	1.0	1.5	3.1	-1.8	-0.8	1.5	0.6	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	2.5	-0.6	-1.2	1.0	-0.7	1.6
Hearing aid user	1.0	1.1	2.0	0.3	0.9	1.0	1.3	1.4
Number of operations (self-reported)	1.0	1.4	3.2	-0.2	-1.6	0.9	-0.7	1.8
Deep venous thrombosis (DVT) (self-reported)	1.0	1.2	2.7	-0.1	-1.6	0.1	-1.6	0.9
Alzheimer’s Disease (including proxy)	0.9	1.3	4.6	-2.2	0.3	1.0	0.7	-0.6
HDL Cholesterol	0.9	1.6	3.0	0.7	1.7	1.2	1.3	1.2
Neuroticism (2016)	0.9	1.3	3.0	0.7	-1.6	0.5	-1.7	0.4
Rheumatoid Arthritis	0.9	1.2	3.3	-1.8	-0.5	-0.2	1.4	-0.7
Blood Eosinophil Count	0.9	6.6	13.0	-3.4	2.8	0.1	3.6	0.9
Alcohol intake versus 10 years previously	0.9	1.4	2.7	0.7	-1.6	1.1	-1.5	0.2
Headache pain in last month	0.9	1.5	2.5	-0.7	-1.3	-0.8	-1.6	-1.5
Migraine (self-reported)	0.9	1.1	3.3	-0.3	0.6	-1.2	-0.0	-1.8
Medication: Ibuprofen	0.9	1.1	2.2	1.5	0.6	-1.4	-0.1	-1.0
Medication: Seretide 50 evohaler	0.9	1.1	2.0	-0.9	0.5	-0.7	1.3	-1.4
Chest pain or discomfort	0.9	1.2	3.4	-0.6	-0.5	1.4	-0.4	1.9
Illnesses of siblings: Diabetes	0.9	1.1	3.8	-0.2	-1.9	0.5	-1.0	0.6
Wears glasses or contact lenses	0.9	1.0	3.0	-1.7	1.0	0.1	1.0	0.2
Financial situation satisfaction	0.9	1.1	4.2	0.3	-0.6	-0.5	-2.0	-0.5
Pack years of smoking	0.9	1.3	4.1	-1.0	-2.0	0.1	-0.7	1.0
Primary Biliary Cirrhosis	0.8	1.1	2.6	-0.7	0.5	-1.6	0.5	-1.4
Lung FEV1/FVC ratio	0.8	4.0	7.2	2.3	-1.3	2.4	-0.3	2.7
Neuroticism	0.8	2.0	4.8	-0.5	-2.2	-0.2	-2.1	-0.2
Pack years adult smoking proportion	0.8	1.3	4.5	-0.7	-2.1	-0.1	-1.0	0.7
Maternal smoking around birth	0.8	1.2	2.6	-1.0	-0.4	1.6	0.1	1.4
Medication: Ramipril	0.8	1.0	3.1	-1.7	-1.2	0.3	-0.7	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	4.5	-1.6	1.9	-1.3	2.1	-1.0
Blood clot in the leg (DVT)	0.8	1.1	2.6	-0.1	-1.4	0.2	-1.6	0.9
Number of children fathered	0.8	0.9	3.6	0.2	1.9	0.4	0.8	-0.1
Mouth/teeth dental problems: Loose teeth	0.8	0.9	3.6	-0.2	-1.9	0.3	-0.9	0.2
Handedness (chirality/laterality): Left-handed	0.8	0.9	2.5	1.6	0.1	-1.1	-0.9	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.5	-0.6	-0.9	1.4	0.1	1.9
Medication for cholesterol	0.8	1.2	3.2	-0.4	1.8	-0.4	1.4	-0.6
Ever had prostate specific antigen (PSA) test	0.8	0.9	3.4	-1.9	-0.1	-0.2	0.1	-1.0
Depression (Nagel 2018)	0.7	1.0	2.5	-1.2	-0.4	-1.0	-0.2	-1.6
Irritable Bowel Disease (IBD)	0.7	1.6	3.5	-1.9	-0.2	-0.7	1.1	-1.6
Schizophrenia (2014)	0.7	1.6	5.2	-0.2	-2.3	-0.4	-1.3	0.9
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.5	-0.9	0.9	0.0	1.6	0.1
Number of live births	0.7	1.0	2.2	-0.6	-1.5	1.0	-1.0	0.7
Qualifications: A levels/AS levels or equivalent	0.7	1.6	4.0	1.6	2.0	-0.8	0.9	-0.3
Pulse wave reflection index	0.7	0.9	2.0	0.1	-1.0	-0.9	-0.8	-1.4
Eye problems/disorders: Glaucoma	0.7	0.8	1.3	-1.2	-0.5	0.8	0.7	1.1
Risk taking	0.7	1.0	3.6	-1.9	-0.9	-0.1	0.4	-0.5
Diastolic blood pressure, automated reading	0.7	2.3	8.3	-0.6	-2.9	-0.6	-1.5	-0.6
Commuting to job workplace: Cycle	0.7	0.9	1.8	-1.2	0.2	0.8	1.3	0.7
Cholesterol lowering medication	0.7	1.0	2.8	0.4	-1.7	-0.1	-1.2	-0.5
Bipolar Disorder (2018)	0.6	0.9	1.6	1.3	-0.4	-0.9	-1.0	-0.8
Ulcerative Colitis (UC)	0.6	1.1	2.6	-1.1	0.6	1.2	1.6	0.2
Reaction Time	0.6	1.1	2.2	0.9	1.5	-1.4	-0.2	-0.8
Age at First Birth	0.6	0.9	1.6	1.2	0.7	1.0	-0.1	1.3
Blood Red Count	0.6	6.2	10.8	-1.3	-1.9	-3.3	-2.7	-2.7
Waist Hip Ratio (WHR)	0.6	2.5	6.7	1.9	2.6	1.0	0.7	0.8
Diabetes (mother)	0.6	0.8	2.5	-0.3	-0.9	1.6	0.7	-0.2
Relative age voice broke	0.6	0.9	2.4	-1.5	-0.5	0.6	1.1	0.5
Hayfever, allergic rhinitis or eczema	0.6	1.4	4.3	0.7	-0.9	-0.8	-2.1	-0.7
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.7	0.2	1.6	-0.6	0.8	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.4	-0.5	0.2	-1.6	0.2	-0.7
Exposure to tobacco smoke at home	0.6	0.7	1.9	-0.6	-0.3	1.4	-0.1	1.1
Exposure to tobacco smoke outside home	0.6	0.9	2.8	0.9	-0.5	0.6	-1.7	0.3
Medication: Omeprazole	0.6	0.7	1.9	0.5	-0.9	-0.4	-1.4	-0.5
Loneliness, isolation	0.6	0.8	1.5	-1.2	-1.2	-0.4	-0.9	0.2
Medication: Blood pressure	0.6	1.1	4.3	-0.6	-2.1	-0.0	-1.0	-0.2
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.3	-1.0	-1.5	0.9	0.1	0.2
Medication: Paracetamol	0.6	1.0	1.7	0.5	-1.0	-0.9	-1.1	-1.3
Ever depressed for a whole week	0.6	0.8	2.1	-0.1	-0.1	-1.2	-0.5	-1.5
Bipolar Disorder or Schizophrenia	0.5	1.1	2.6	1.2	-1.6	-0.6	-1.2	0.3
Depressed Affect (Nagel 2018)	0.5	1.1	2.6	-1.4	-1.6	-0.0	-0.7	-0.8
Bipolar Disorder (2011)	0.5	0.5	1.5	0.5	1.2	-0.7	0.3	-0.4
Ulcerative Colitis	0.5	0.8	2.2	-0.7	0.8	0.6	1.5	-0.2
Tanning	0.5	6.7	16.5	-0.1	4.1	1.7	3.5	1.5
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.3	-0.4	-1.1	1.0	0.3	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	1.9	0.4	1.3	1.4	1.4	0.3
Allergy	0.5	1.0	3.5	-0.4	0.9	0.6	1.9	0.6
Falls in the last year	0.5	0.7	2.5	-0.6	-1.6	0.0	-0.8	0.1
Hair/balding pattern: Pattern 3	0.5	0.7	1.4	0.8	-0.2	-1.2	-0.5	-1.0
Pulse rate	0.5	0.8	3.0	-0.6	0.1	0.9	-0.0	1.7
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.4	-0.7	0.6	0.9	0.6	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	2.2	-1.5	0.1	0.7	0.8	0.0
Emphysema/chronic bronchitis	0.5	0.5	1.7	-0.6	-0.4	1.3	0.4	0.6
Had major operations	0.5	0.5	1.8	-0.7	-1.4	-0.4	-0.4	0.2
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	0.9	0.8	0.7	1.0	0.7	0.6
Back pain experienced in last month	0.5	0.7	2.3	0.5	-0.1	1.5	-0.4	1.0
Asthma (self-reported)	0.5	1.0	3.2	-0.5	1.8	0.4	1.2	0.0
Illnesses of father: High blood pressure	0.5	0.7	1.6	0.4	-0.8	1.2	-0.9	-0.3
Schizophrenia (2018)	0.4	0.8	2.8	0.5	-1.7	-0.0	-0.7	0.9
Mean Putamen Volume	0.4	0.5	1.9	-1.4	0.1	0.4	0.6	0.3
LDL Cholesterol	0.4	0.6	1.3	0.7	-0.5	-1.1	-0.9	-0.5
Triglycerides	0.4	0.7	1.4	-1.1	0.3	-0.4	0.9	-1.2
Blood White Count	0.4	3.3	8.4	-0.6	-1.1	2.6	-0.1	2.9
Respiratory disease	0.4	1.0	2.0	-1.1	1.4	0.3	1.1	-0.4
Relative age of first facial hair	0.4	0.9	2.8	-1.1	0.3	-0.2	1.7	-0.3
Stomach or abdominal pain in last month	0.4	0.5	1.6	-1.3	-0.1	0.1	0.6	-0.7
Chronic bronchitis/emphysema (father)	0.4	0.5	0.9	-0.2	-1.0	0.6	-0.9	-0.6
Worrier / anxious feelings	0.4	0.7	1.7	1.3	0.1	0.1	-1.2	-0.6
Asthma	0.4	0.8	1.7	-1.0	1.3	0.4	1.2	0.0
Prospective memory result	0.4	0.4	1.1	0.3	-1.0	0.5	-0.3	0.8
Pulse wave Arterial Stiffness index	0.4	0.5	1.1	-0.8	-0.4	1.1	0.4	0.3
Length of working week for main job	0.4	0.5	1.5	0.2	0.7	-1.2	0.4	-0.0
Tense / ‘highly strung’	0.4	0.7	1.3	0.7	0.3	-0.6	-1.1	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.5	1.2	0.4	0.8	-0.4	0.1
Pulse rate, automated reading	0.4	1.2	4.8	0.7	-0.3	0.8	0.2	2.2
Age at last live birth	0.4	0.5	1.9	1.4	0.3	-0.3	-0.3	-0.6
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.2	-1.1	-0.1	0.2	-0.3	-1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.4	1.2	0.5	-0.8	0.1	-1.1	-0.1
Eye problems/disorders: Cataract	0.4	0.5	0.8	0.9	0.8	-0.9	0.3	-0.2
Miserableness	0.4	0.6	1.6	-1.2	-0.0	1.3	0.4	0.3
Medication: Atorvastatin	0.4	0.5	0.9	-0.8	-1.0	0.1	0.3	-0.7
Basal cell carcinoma (self-reported)	0.4	0.4	0.9	-0.7	0.5	-1.0	-0.2	-0.6
Heart disease (siblings)	0.4	0.5	1.3	-0.4	-1.1	0.9	-0.1	0.7
Alcohol drinker status: Previous	0.4	0.5	0.9	0.4	-0.8	0.7	-0.9	0.6
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.1	0.3	1.5	0.3	1.1	-1.1
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.5	0.9	1.2	0.5	0.7	-0.8
Heel T-Score	0.3	2.1	8.1	2.9	0.1	0.9	-0.4	1.2
Average weekly fortified wine intake	0.3	0.3	0.9	0.6	0.2	-0.9	-0.3	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.6	-0.8	-0.5	-0.7	-0.4	-0.5
Serious illness, injury or assault to yourself	0.3	0.4	1.2	-0.7	-1.1	0.3	-0.4	-0.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.1	-0.9	-1.1	0.1	0.5	0.1
Fluid intelligence score	0.3	0.7	1.5	-0.4	1.2	0.4	0.8	-1.0
Medication: Lansoprazole	0.3	0.3	0.6	-0.7	-0.5	0.8	0.4	-0.3
Lung cancer (father)	0.3	0.4	0.5	-0.5	-0.7	-0.7	-0.7	0.1
Mouth/teeth dental problems: Bleeding gums	0.3	0.3	0.8	0.9	0.6	-0.4	-0.2	-0.6
Wheeze or whistling in the chest in last year	0.3	0.6	2.1	-1.5	0.2	0.3	0.3	0.6
Pulse wave peak to peak time	0.3	0.4	0.9	0.3	0.8	-0.9	0.1	-0.4
Mean time to correctly identify matches	0.3	0.7	2.4	0.7	1.5	0.2	0.5	0.4
Family relationship satisfaction	0.3	0.4	0.7	0.2	-0.4	-0.5	-0.8	-0.9
Mood swings	0.3	0.5	1.6	0.6	0.0	-0.5	-0.4	-1.3
Osteoarthritis (self-reported)	0.3	0.3	0.9	-0.3	0.3	-0.7	0.1	-1.0
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.9	0.6	0.2	0.7	-0.6	0.9
Medication: Lisinopril	0.3	0.4	0.8	-0.9	-0.9	0.5	0.1	-0.1
Major Depression (MDD)	0.2	0.3	0.5	-0.6	-0.5	0.7	-0.4	0.3
Allergy or Eczema	0.2	0.6	1.9	0.2	-1.0	0.4	-1.4	0.2
Age when periods started (menarche)	0.2	0.5	1.4	1.2	-0.6	0.2	-0.8	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	1.1	0.6	0.6	1.1	0.9	0.0
Multivitamins +/- minerals	0.2	0.3	0.7	0.1	-0.4	-0.7	-0.5	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.3	0.1	0.2	1.1	0.0	0.7
Number of full brothers	0.2	0.2	0.7	-0.6	-0.8	0.2	0.0	0.2
Supplements: Vitamin C	0.2	0.3	0.6	0.3	-0.8	0.2	-0.8	-0.2
Ever had bowel cancer screening	0.2	0.2	0.8	0.5	0.1	0.9	0.2	-0.3
Breast cancer (self-reported)	0.2	0.2	0.6	-0.7	-0.8	0.1	-0.2	-0.1
Unable to work because of sickness or disability	0.2	0.3	1.0	0.2	-1.0	0.3	-0.4	0.6
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.8	-0.4	-0.5	0.0	-0.2	-0.9
Supplements: Calcium	0.2	0.2	0.9	0.9	-0.0	0.4	-0.3	0.1
Lung FVC	0.1	0.7	2.0	0.2	-0.1	-1.4	-0.1	-1.3
Vitamin and mineral supplements	0.1	0.1	0.2	-0.1	0.1	0.2	0.5	0.4
Qualifications: CSEs or equivalent	0.1	0.2	0.4	-0.3	-0.6	0.5	-0.5	0.0
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.2	-0.4	0.3	0.1	0.3	-0.4
Hair/balding pattern: Pattern 2	0.1	0.1	0.3	-0.1	0.5	-0.4	0.0	-0.1
Had other major operations	0.1	0.2	0.5	-0.3	-0.3	0.2	0.4	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.5	-0.1	0.2	-0.1	-0.7	-0.2
Shortness of breath walking on level ground	0.1	0.1	0.3	0.0	-0.6	-0.1	-0.3	-0.2
Eye problems/disorders: None of the above	0.1	0.1	0.2	0.1	0.1	0.4	-0.4	-0.0
Friendships satisfaction	0.1	0.2	0.5	0.7	0.5	0.2	-0.3	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.6	0.1	0.8	0.1	0.7	0.4
Guilty feelings	0.1	0.1	0.3	0.3	-0.6	-0.4	-0.4	-0.0
Average weekly beer plus cider intake	0.1	0.1	0.4	0.6	0.1	0.4	-0.1	-0.3
Alzheimer’s Disease (in father)	0.0	0.0	0.1	-0.0	0.1	0.1	0.4	0.1
Breast Cancer	0.0	0.1	0.2	0.1	0.3	-0.3	-0.4	-0.2
Hair Pigment	0.0	0.6	1.9	-0.1	-1.0	0.1	0.1	1.4
Suffer from ‘nerves’	0.0	0.0	0.2	0.4	0.1	0.1	-0.1	0.1
Mineral and other dietary supplements	0.0	0.1	0.1	-0.0	0.3	-0.3	0.3	-0.3

Hub : Genes

TTLL6

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Trait associations