Hub : Genes

UBE2Z

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0510 0.0160 6.9e-06 0.081 0.041 0.073 0.050 0.078 4.8e-10 8.8e-06 3.3e-09 9.5e-07 9.8e-10
2 GTEx Cells EBV-transformed lymphocytes 0.1630 0.0750 8.4e-03 0.009 NA 0.101 NA 0.047 1.6e-01 NA 3.5e-04 NA 1.2e-02
3 GTEx Cells Transformed fibroblasts 0.1840 0.0550 3.1e-04 0.003 NA 0.001 NA 0.014 1.8e-01 NA 2.6e-01 NA 3.0e-02
4 GTEx Muscle Skeletal 0.0600 0.0205 8.8e-05 0.021 NA 0.025 NA 0.027 3.3e-03 NA 1.6e-03 NA 9.8e-04
5 GTEx Nerve Tibial 0.1192 0.0452 1.5e-03 0.041 NA 0.052 NA 0.047 6.8e-04 NA 1.5e-04 NA 2.9e-04
6 GTEx Skin Not Sun Exposed Suprapubic 0.1110 0.0500 7.1e-03 0.071 NA 0.032 NA 0.045 9.4e-05 NA 6.9e-03 NA 1.8e-03
7 GTEx Skin Sun Exposed Lower leg 0.1380 0.0360 1.2e-10 0.113 NA 0.131 NA 0.144 1.4e-09 NA 5.9e-11 NA 6.3e-12
8 GTEx Whole Blood 0.0820 0.0350 6.7e-04 0.011 NA 0.007 NA 0.020 2.8e-02 NA 6.8e-02 NA 4.9e-03
9 METSIM Adipose 0.0613 0.0199 9.0e-07 0.061 0.016 0.036 0.014 0.014 2.0e-09 1.5e-03 3.2e-06 3.2e-03 3.3e-03
10 YFS Blood 0.0621 0.0146 6.1e-15 0.031 0.055 0.059 0.058 0.057 2.0e-10 1.4e-17 1.5e-18 3.3e-18 3.8e-18
11 TCGA Thyroid Carcinoma 0.1280 0.0600 6.0e-10 0.091 0.098 0.105 NA 0.115 3.5e-09 8.9e-10 2.3e-10 NA 2.7e-11

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.4 0.6 3.4 0.9 -1.8 -1.0 0.4 0.1 0.3 0.3 -0.7 -0.8 -0.2 0.2
Bipolar Disorder or Schizophrenia 2.1 5.2 11.5 2.6 -3.4 -1.2 2.2 2.2 2.3 2.3 -2.3 -2.6 0.4 2.3
Depressed Affect (Nagel 2018) 1.4 3.0 5.5 1.5 -1.2 -0.2 2.0 2.3 2.3 2.2 -1.5 -1.6 0.6 2.0
Depression (Nagel 2018) 1.0 1.4 4.6 -0.0 -2.1 -0.6 0.8 1.5 1.7 1.3 0.1 -0.1 1.3 1.4
Intelligence (Savage-Jansen 2018) 2.8 8.8 11.3 -3.1 2.8 2.4 -3.3 -3.1 -3.2 -3.1 2.6 3.1 -2.2 -3.4
Neuroticism (Nagel 2018) 2.6 6.0 9.9 2.8 -1.7 -0.9 3.1 2.5 2.9 2.9 -2.7 -2.9 0.3 2.6
Schizophrenia (2018) 2.7 5.7 7.7 2.6 -2.3 -0.7 2.5 2.7 2.7 2.7 -2.4 -2.7 0.7 2.8
Schizophrenia vs Biploar Disorder 6.5 8.6 16.2 2.3 -0.9 -1.3 3.5 3.9 3.9 4.0 -1.6 -2.4 2.3 3.8
Worry (Nagel 2018) 1.3 2.8 5.7 2.4 -1.3 -1.9 1.9 0.6 1.2 1.4 -2.2 -2.4 -0.8 1.1
Alzheimer’s Disease (in mother) 0.6 0.7 4.7 -0.7 2.2 -0.1 -0.2 -0.5 -0.2 -0.9 0.3 0.7 0.6 -0.4
Alzheimer’s Disease (in father) 0.1 0.2 0.7 -0.5 -0.2 -0.2 -0.8 0.1 -0.4 -0.1 -0.3 0.5 0.3 0.2
Alzheimer’s Disease (including proxy) 0.4 0.6 2.5 -0.8 1.6 -0.6 -0.3 -0.1 -0.1 -0.3 -0.3 0.8 1.5 0.1
Crohns Disease (2017) 0.7 1.4 4.9 -1.6 1.8 0.5 -0.0 0.5 0.6 0.7 1.1 1.6 2.2 0.5
Irritable Bowel Disease (IBD) 0.4 1.0 3.7 -1.0 1.9 1.6 -0.4 0.4 0.5 0.1 1.0 0.9 1.2 0.0
Ulcerative Colitis (UC) 0.3 0.6 3.2 0.1 1.6 1.8 -0.3 0.3 0.2 -0.5 0.3 -0.2 0.1 -0.3
Major Depression (MDD) 0.9 1.1 2.7 0.7 -1.6 -0.3 0.7 1.6 1.1 1.2 -0.7 -0.8 0.3 1.1
Reaction Time 1.5 2.8 5.1 -1.8 2.1 -0.5 -2.1 -1.8 -2.3 -1.6 1.4 1.8 0.1 -1.6
Verbal and Numeric Reasoning (VNR) 2.7 6.5 8.9 -2.4 2.7 1.9 -2.7 -2.7 -3.0 -2.5 2.0 2.3 -2.9 -2.7
Breast Cancer 0.4 1.0 9.4 0.0 3.1 0.9 0.1 0.3 -0.1 0.3 -0.1 -0.0 -0.4 0.2
Ovarian Cancer 0.8 1.0 5.3 -0.8 2.3 0.7 -0.8 -0.8 -1.0 -0.7 0.7 0.7 0.6 -0.7
Prostate Cancer 1.4 2.0 6.4 -2.1 0.3 -0.6 -1.2 0.4 -0.5 -0.4 1.9 2.1 2.5 0.0
Age at First Birth 0.7 1.0 3.8 0.1 0.2 0.8 -0.9 -1.0 -1.1 -1.3 0.8 0.1 -2.0 -1.2
Bipolar Disorder (2011) 1.6 1.5 3.6 -0.9 -0.7 -0.5 -1.2 -1.9 -1.6 -1.6 1.1 0.9 -0.4 -1.8
Body Mass Index (BMI) (2010) 1.8 2.5 6.2 0.6 0.8 -0.7 2.0 1.7 2.1 2.1 -0.7 -0.5 2.5 1.8
Coronary Artery Disease (CAD) 10.3 12.3 21.2 4.6 -3.0 -3.8 4.1 2.4 3.3 3.2 -4.6 -4.1 -0.3 3.1
Crohns Disease (2012) 0.8 1.3 4.5 -0.9 0.4 -0.7 0.8 1.4 0.9 2.1 0.7 0.8 1.8 1.1
Mean Putamen Volume 1.6 1.8 7.0 -1.8 1.6 2.6 -1.0 0.1 -0.3 -0.1 1.8 1.7 0.5 -0.1
Fasting Glucose 0.8 1.0 2.4 0.6 0.8 1.0 1.1 1.6 1.1 0.8 -0.4 -0.4 1.0 1.2
HbA1C 3.9 4.4 8.8 1.6 -0.8 1.2 2.8 2.8 2.4 3.0 -1.6 -1.3 0.8 2.9
HDL Cholesterol 1.5 2.6 4.6 -1.6 2.1 1.0 -2.1 -1.3 -1.7 -1.5 1.8 1.6 -0.7 -1.5
LDL Cholesterol 0.5 0.8 4.2 1.0 -0.3 -2.0 0.8 -0.3 0.1 0.4 -1.1 -0.9 0.4 0.2
Lupus 1.7 2.6 9.1 -1.7 2.0 3.0 -1.9 -0.6 -1.4 -1.2 1.2 1.7 0.1 -1.2
Neuroticism (2016) 2.8 4.0 6.6 2.5 -0.7 -0.1 2.5 2.0 2.5 2.0 -2.2 -2.6 -0.5 2.1
Primary Biliary Cirrhosis 0.6 0.9 2.2 -1.4 1.5 0.5 -0.9 -0.5 -0.3 -0.4 1.5 1.4 0.1 -0.5
Rheumatoid Arthritis 0.2 0.3 0.9 -1.0 -0.7 0.2 -0.2 0.5 0.4 0.5 0.4 0.9 0.3 0.5
Schizophrenia (2014) 2.8 6.2 10.0 2.4 -2.1 -0.7 2.7 3.2 3.1 3.1 -2.0 -2.4 1.4 3.0
Triglycerides 0.7 1.2 4.6 -0.4 -2.1 -1.6 -0.1 0.3 0.0 0.5 0.2 0.4 2.1 0.5
Type 2 Diabetes (T2D) (2012) 6.8 7.9 13.0 3.5 -2.7 -1.2 3.2 2.2 3.2 2.8 -3.3 -3.6 -1.0 2.7
Ulcerative Colitis 0.3 0.5 1.7 -0.3 1.3 1.1 -0.8 -0.3 -0.1 -0.7 0.5 0.2 0.1 -0.7
Blood Eosinophil Count 2.8 21.4 50.4 -6.6 2.0 -2.5 -5.1 -2.7 -4.2 -3.2 7.1 6.7 3.5 -3.7
Blood Platelet Count 1.5 17.3 34.8 -5.4 1.0 1.0 -5.6 -3.3 -4.1 -4.5 5.9 5.4 -0.1 -3.8
Blood Red Count 0.5 4.4 9.6 1.7 0.5 -0.8 2.6 2.1 2.3 2.5 -1.9 -1.7 3.1 2.3
Blood White Count 0.9 6.7 11.8 2.3 -3.2 -1.6 2.5 3.3 2.6 3.0 -1.6 -2.3 1.9 3.4
Heel T-Score 0.2 1.9 5.3 2.3 -1.5 -0.3 1.0 -0.0 0.5 -0.1 -2.0 -2.2 -1.8 0.3
BMI 6.6 38.2 65.3 5.0 -2.2 -2.6 8.0 7.1 8.0 8.1 -4.9 -5.0 5.4 7.8
Height 8.9 172.4 334.9 -18.3 9.8 13.9 -15.5 -6.0 -10.0 -10.5 17.6 18.3 7.3 -9.4
Waist Hip Ratio (WHR) 1.4 6.4 30.9 0.2 -3.8 -5.6 -1.5 -2.8 -1.9 -2.4 -0.1 -0.1 -0.5 -2.3
Systolic Blood Pressure 4.5 22.6 54.0 5.7 -7.3 -2.1 4.9 4.2 4.6 3.8 -5.5 -5.7 -0.1 4.1
Smoking Status 1.9 4.6 10.8 0.7 -1.1 -1.1 2.2 2.9 3.3 2.9 -1.2 -0.7 2.4 2.8
Allergy or Eczema 0.4 1.1 8.0 0.6 -1.2 -2.8 1.0 0.5 0.5 0.3 -0.8 -0.7 0.1 0.3
Cardiovascular Disease 9.4 31.1 43.4 6.0 -6.6 -3.2 6.5 5.4 6.5 5.8 -6.0 -5.9 1.6 5.7
Hypothyroidism (self reported) 2.0 4.7 10.2 2.1 -0.1 -1.0 3.2 2.3 2.7 2.8 -2.2 -2.1 -0.2 2.6
Respiratory disease 1.3 2.9 4.5 -2.0 0.2 -0.9 -2.1 -1.5 -1.8 -2.0 2.0 2.1 0.4 -2.1
Type 2 Diabetes (T2D) (2018) 7.3 13.6 23.3 3.9 -2.2 -1.3 4.8 4.2 4.3 4.5 -3.7 -4.0 -0.2 4.4
Lung FEV1/FVC ratio 0.8 3.9 9.3 2.3 -2.2 1.9 1.5 1.4 1.5 1.1 -2.4 -2.4 -3.0 1.1
Lung FVC 0.2 1.2 4.3 0.5 1.4 -2.1 -0.2 -1.6 -1.4 -0.7 -1.0 -0.6 -0.3 -1.0
Neuroticism 3.0 7.3 12.0 3.0 -2.3 -1.1 3.2 2.7 3.5 2.9 -3.0 -3.1 -0.1 2.8
Chronotype (morning person) 0.7 1.5 6.2 -0.2 0.9 -0.3 1.5 1.2 1.9 2.5 -0.3 0.2 0.7 1.4
Hair Pigment 0.1 3.3 6.3 -2.1 2.1 -0.8 -1.6 -2.5 -1.9 -1.5 1.9 1.9 -0.1 -2.1
Tanning 0.3 4.0 8.6 -2.3 2.2 0.9 -2.9 -0.9 -1.6 -2.0 2.4 2.4 1.9 -1.4
Hand grip strength (left) 1.3 3.3 11.5 -2.2 3.4 1.0 -1.4 -0.4 -0.4 -0.5 1.9 2.3 2.7 -0.3
Number of treatments/medications taken 4.1 7.3 15.4 2.3 -3.9 -1.8 2.8 2.8 3.2 3.3 -2.1 -2.3 1.4 2.8
Average weekly spirits intake 2.0 2.5 6.6 0.6 0.1 2.3 1.2 2.6 1.7 2.1 -0.1 -0.6 1.1 2.1
Sensitivity / hurt feelings 7.8 13.4 20.7 4.0 -3.3 -2.4 4.5 3.5 4.6 3.9 -3.8 -4.1 0.9 3.9
Frequency of depressed mood in last 2 weeks 1.3 1.8 5.5 0.6 -2.4 -1.7 1.1 0.9 1.9 1.4 -0.6 -0.7 0.6 1.2
Hearing difficulty/problems: Yes 0.1 0.2 0.4 -0.4 0.4 -0.5 -0.2 -0.1 -0.5 0.5 0.2 0.3 0.6 0.4
Relative age of first facial hair 0.7 1.4 2.9 -1.7 1.3 0.6 -1.3 -0.7 -1.1 -0.8 1.1 1.7 1.1 -0.8
Other serious medical condition/disability diagnosed by doctor 1.6 2.1 6.5 -1.4 0.7 2.5 -0.2 1.7 0.7 1.0 1.1 1.3 2.5 1.0
Ever used hormone-replacement therapy (HRT) 1.5 1.9 3.6 -1.2 1.3 1.1 -1.8 -1.3 -1.9 -1.4 0.9 1.2 -0.9 -1.6
Ever had hysterectomy (womb removed) 0.3 0.4 1.1 0.6 -0.8 -0.1 -0.5 -0.7 -0.3 -0.7 -0.2 -0.6 -1.1 -0.8
Systolic blood pressure, automated reading 3.6 10.3 28.2 4.1 -5.3 -1.4 3.2 2.5 2.8 2.4 -3.9 -4.0 0.1 2.3
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 1.2 0.6 -0.3 -0.9 1.1 0.9 1.1 1.1 -0.5 -0.7 0.3 1.1
Angina 1.1 1.5 2.9 0.5 -0.6 -1.1 1.7 1.4 1.6 1.7 -0.4 -0.5 1.3 1.3
Medication for hormone replacement therapy 0.4 0.4 2.4 -0.1 -0.2 0.3 -0.7 -0.3 -0.9 -0.7 0.3 0.0 -1.6 -0.6
Vitamin and mineral supplements 0.2 0.3 2.3 -0.1 -0.1 -0.6 0.1 0.4 0.3 0.4 0.1 0.1 1.5 0.4
Supplements: Zinc 0.2 0.2 0.9 -0.2 0.6 0.7 0.2 -0.5 0.1 -0.2 0.1 0.2 -0.9 -0.5
Medication: Co-codamol 1.5 1.7 4.5 1.4 -1.7 -1.1 1.4 0.1 0.7 0.7 -2.1 -1.5 -1.6 0.6
Medication: Metformin 4.1 5.7 8.9 2.5 -2.8 -0.2 3.0 2.6 2.8 2.8 -2.4 -2.6 -0.2 2.5
Diabetes (father) 10.3 12.7 20.4 3.5 -3.1 -1.1 4.4 3.8 4.5 4.4 -3.8 -3.5 0.8 4.0
Diabetes (mother) 2.9 3.7 6.0 2.1 -2.5 -2.0 1.7 1.7 2.1 1.6 -2.4 -2.1 0.6 1.8
Severe depression (siblings) 0.3 0.3 1.4 0.2 -1.2 0.3 0.3 0.6 0.9 -0.1 -0.5 -0.2 -0.0 0.3
Pack years adult smoking proportion 5.2 7.9 12.9 3.6 -1.9 -1.8 3.0 2.8 3.0 3.1 -3.3 -3.6 0.6 2.9
Impedance of leg (right) 2.6 12.6 23.7 -2.6 0.4 3.8 -4.7 -3.3 -3.6 -4.9 3.0 2.5 -3.7 -4.2
Leg fat-free mass (left) 2.2 11.6 55.4 -3.7 2.8 1.6 0.3 2.9 2.1 2.3 3.2 3.7 7.4 2.3
Trunk fat percentage 3.0 11.9 26.4 1.3 -1.8 0.6 3.5 4.9 5.1 4.4 -0.9 -1.3 4.6 4.6
Hand grip strength (right) 1.5 4.1 8.8 -2.6 2.6 0.5 -2.2 -1.0 -1.0 -1.6 2.4 2.7 3.0 -0.7
Townsend deprivation index at recruitment 0.2 0.3 1.0 0.6 -0.1 -0.4 -0.3 -0.5 -0.4 -1.0 -0.5 -0.5 -0.3 -0.6
Current tobacco smoking 3.2 5.2 11.8 1.4 -0.1 -0.3 2.6 3.1 3.0 3.4 -1.3 -1.4 2.0 3.3
Average weekly fortified wine intake 0.1 0.1 0.9 -0.4 -0.2 0.3 -0.3 -0.1 -0.9 -0.0 0.2 0.4 -0.2 -0.2
Maternal smoking around birth 0.8 1.1 4.1 0.9 -2.0 -0.3 0.8 1.4 1.2 0.7 -0.8 -1.0 -0.1 1.1
Fed-up feelings 5.4 9.8 17.1 3.1 -2.9 0.0 3.8 3.7 4.1 3.6 -2.7 -3.3 0.8 3.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.5 2.0 4.5 0.5 -1.3 -0.5 1.2 1.9 2.1 1.8 -0.5 -0.6 1.7 1.9
Relative age voice broke 0.6 0.9 3.5 0.1 -1.9 -1.7 0.6 0.8 0.7 0.6 -0.6 -0.1 1.2 0.8
Taking other prescription medications 2.1 3.2 6.3 0.9 -2.2 -1.1 1.7 2.4 2.5 2.1 -0.7 -0.9 1.8 2.0
Age when periods started (menarche) 0.5 1.1 5.6 0.4 -1.0 2.4 0.1 -0.0 -0.0 -0.1 -1.2 -0.4 -2.0 -0.3
Bilateral oophorectomy (both ovaries removed) 1.6 1.8 4.2 1.4 -2.0 0.2 1.5 1.3 1.3 1.4 -1.4 -1.5 -0.8 1.2
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 1.2 -0.0 1.1 1.0 -0.4 -0.3 -0.8 -0.6 0.0 0.0 0.4 -0.3
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 2.4 -0.3 -0.8 1.2 -0.3 0.7 -0.2 -0.1 0.3 0.3 1.5 0.3
Qualifications: CSEs or equivalent 2.3 3.0 4.5 1.7 -2.1 -1.7 2.0 1.6 1.4 1.5 -1.8 -1.8 1.3 2.0
Serious illness, injury or assault to yourself 1.2 1.5 3.3 0.7 -1.7 -0.7 1.3 1.2 1.8 1.2 -0.7 -0.8 1.1 1.2
High blood pressure 8.5 23.8 35.4 4.4 -5.8 -2.5 5.7 5.3 6.0 5.5 -4.6 -4.4 2.3 5.4
Hayfever, allergic rhinitis or eczema 0.7 1.4 7.4 0.9 -1.6 -2.7 1.2 0.5 0.5 0.8 -1.0 -1.0 0.3 0.6
Multivitamins +/- minerals 0.2 0.3 1.8 -0.2 0.1 -0.5 -0.2 -0.6 -0.4 -0.3 0.2 0.2 -1.3 -0.5
Stomach or abdominal pain in last month 0.2 0.3 1.1 0.1 0.3 -1.1 0.5 0.4 0.5 0.8 -0.1 -0.1 0.7 0.5
Supplements: Glucosamine 3.7 4.9 9.5 -3.0 2.6 2.4 -2.1 -1.0 -1.7 -1.7 2.7 3.1 1.1 -1.7
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.9 -0.2 -0.4 0.9 0.3 0.6 0.6 0.0 0.1 0.1 0.7 0.2
Medication: Atenolol 1.5 1.9 3.7 1.5 -1.9 -1.5 1.8 0.7 0.9 1.5 -1.6 -1.4 -0.7 1.1
Medication: Levothyroxine sodium 2.4 4.0 7.7 2.0 -1.4 0.0 2.5 2.3 2.8 2.3 -1.9 -2.1 0.9 2.2
Sitting height 7.1 50.7 99.6 -10.0 5.5 8.7 -8.2 -2.0 -4.7 -5.0 9.5 9.9 5.3 -4.1
Chronic bronchitis/emphysema (father) 0.5 0.6 2.8 0.0 -1.3 -1.7 0.7 0.3 1.0 0.5 0.3 -0.0 0.0 0.8
High blood pressure (mother) 11.6 16.2 28.5 5.0 -4.5 -2.5 5.3 3.1 4.0 3.8 -4.5 -5.0 -0.4 3.5
Body mass index (BMI) 5.1 21.8 38.1 3.7 -2.1 -2.4 6.2 5.2 6.2 6.0 -3.5 -3.6 4.2 5.8
Impedance of leg (left) 2.4 11.8 23.7 -1.9 -0.2 2.7 -4.6 -3.6 -3.8 -4.9 2.6 1.9 -4.3 -4.3
Leg predicted mass (left) 2.2 11.6 54.9 -3.7 2.8 1.6 0.3 2.8 2.1 2.3 3.2 3.7 7.4 2.3
Trunk fat mass 2.3 10.1 33.9 -0.5 -0.4 1.4 2.4 4.4 4.4 3.8 0.7 0.5 5.8 3.9
Waist circumference 2.0 7.2 20.9 1.1 -1.6 -1.7 2.8 2.9 3.6 3.3 -0.9 -1.0 4.6 3.1
Number of incorrect matches in round 2.3 3.8 9.9 2.6 -2.5 -3.1 1.5 1.1 0.9 0.8 -2.4 -2.6 -0.1 1.2
Past tobacco smoking 1.3 2.3 5.8 0.3 2.4 -0.4 -1.2 -2.1 -2.3 -1.7 0.1 -0.3 -1.9 -1.3
Alcohol usually taken with meals 1.5 2.4 7.1 -2.0 1.8 1.7 -1.6 0.1 -0.9 -0.7 2.7 2.0 1.3 -0.1
Nervous feelings 1.8 3.4 6.8 2.6 -1.6 -1.4 2.0 1.1 1.8 1.7 -2.2 -2.6 -1.3 1.3
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 2.1 0.6 -1.1 -1.0 0.7 1.3 1.4 1.1 -1.0 -0.6 1.0 1.4
Hearing difficulty/problems with background noise 4.1 6.5 11.6 2.0 -1.5 -2.8 3.2 2.5 2.5 3.4 -2.5 -2.1 1.4 3.3
Hair/balding pattern: Pattern 2 0.1 0.2 1.2 -0.1 0.1 -1.1 -0.1 -0.4 -0.2 -0.4 0.4 0.1 -0.5 -0.0
Had menopause 1.0 1.3 3.5 -0.8 1.1 1.9 -1.5 -1.0 -1.3 -1.0 0.4 0.8 -0.9 -1.2
Had other major operations 0.1 0.1 1.2 -0.0 -0.1 1.1 -0.1 0.3 0.0 0.3 -0.2 0.0 0.2 0.1
Forced vital capacity (FVC) 3.5 13.7 27.5 -5.2 3.9 2.2 -4.2 -2.1 -3.3 -2.9 4.7 5.2 2.4 -2.8
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 1.0 -0.2 0.6 0.1 -0.7 -0.5 -1.0 -0.8 0.5 0.3 0.5 -0.5
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 2.4 -1.5 0.5 -0.1 -1.5 -0.7 -0.8 -0.8 1.3 1.5 0.6 -0.8
Qualifications: None of the above 5.3 11.3 22.4 4.0 -4.7 -1.9 3.5 2.8 3.1 3.4 -3.9 -4.0 -0.3 3.1
Financial difficulties in last 2 years 0.8 1.0 4.3 0.2 -2.1 -1.0 0.3 1.1 1.2 0.6 -0.1 -0.2 1.7 0.7
Mouth/teeth dental problems 3.9 5.9 9.7 -2.6 1.3 -1.3 -2.8 -3.1 -3.0 -2.8 2.4 2.7 0.5 -2.8
Heart attack 2.2 2.8 5.4 1.3 -1.2 -2.3 2.2 1.4 1.7 2.1 -1.7 -1.4 0.8 1.8
Allergy 0.3 0.7 5.2 -0.2 1.4 2.3 -0.5 -0.1 0.0 -0.2 0.2 0.2 -0.6 0.0
Pain all over the body in last month 0.3 0.3 1.1 0.4 -1.1 0.7 0.2 0.5 0.6 -0.1 -0.1 -0.5 0.9 0.5
Diabetes (self-reported) 3.9 6.0 10.9 2.5 -1.9 -1.8 3.3 2.4 2.8 3.0 -2.4 -2.6 -0.3 2.6
Hayfever/allergic rhinitis (self-reported) 1.2 1.5 3.0 -0.9 -0.7 -1.6 -1.3 -1.5 -1.7 -1.2 1.1 0.9 0.7 -1.3
Medication: Ramipril 2.8 3.6 7.2 1.5 -1.9 -1.0 1.8 2.0 2.7 1.9 -2.1 -1.6 1.3 2.2
Medication: Simvastatin 6.4 9.4 14.0 3.6 -3.3 -1.6 3.7 2.8 3.3 3.3 -3.5 -3.6 0.2 2.9
Fluid intelligence score 2.5 5.1 12.9 -2.6 3.6 2.0 -2.3 -1.7 -2.4 -1.6 1.9 2.5 -2.0 -1.8
Illnesses of siblings 5.4 7.6 11.7 -3.1 3.2 1.4 -3.3 -2.5 -2.9 -2.8 3.4 3.1 -0.4 -2.7
Neuroticism score 4.0 8.3 14.3 3.1 -2.7 -1.3 3.3 3.0 3.8 3.2 -2.9 -3.1 0.7 3.0
Weight 2.1 10.3 48.0 -2.4 1.4 2.0 1.2 3.6 3.3 2.9 2.3 2.4 6.9 3.0
Impedance of arm (right) 0.5 2.3 7.2 -1.0 -0.7 2.7 -2.1 -0.6 -1.3 -2.0 1.3 0.9 -1.5 -1.2
Arm fat percentage (right) 5.8 22.7 43.4 3.8 -2.7 -1.8 6.1 5.6 6.6 6.0 -3.4 -3.8 4.0 6.0
Trunk fat-free mass 3.2 18.6 42.2 -6.4 4.8 3.6 -3.1 0.1 -0.9 -0.8 5.8 6.5 6.2 -0.9
Hip circumference 1.8 7.7 31.0 -1.1 1.2 2.1 1.9 3.5 3.2 3.0 1.3 1.1 5.6 2.9
Time employed in main current job 2.4 2.8 14.1 -1.7 3.8 1.7 0.1 0.5 0.8 0.7 1.1 1.7 2.3 0.2
Alcohol intake versus 10 years previously 1.1 1.7 6.1 1.4 -2.5 -1.9 1.3 0.3 0.1 0.8 -1.4 -1.3 -0.5 0.8
Father’s age at death 2.9 3.9 6.7 -2.5 0.7 1.7 -2.5 -1.6 -1.9 -2.0 2.6 2.5 0.2 -1.9
Worrier / anxious feelings 2.9 5.6 13.2 3.6 -2.1 -2.2 2.4 1.2 1.7 1.4 -3.3 -3.6 -0.4 1.6
Frequency of tiredness / lethargy in last 2 weeks 8.9 14.5 22.3 4.5 -3.0 -1.3 4.3 3.7 4.7 4.0 -4.6 -4.6 0.4 4.0
Falls in the last year 1.6 2.1 5.0 1.1 -0.6 0.0 1.7 2.1 1.6 2.2 -1.0 -1.1 0.7 1.9
Hair/balding pattern: Pattern 3 0.3 0.4 1.4 0.4 -1.2 0.1 0.8 0.5 0.9 0.2 -0.4 -0.3 0.9 0.5
Number of live births 1.8 2.6 4.0 1.7 -1.9 -1.0 1.7 1.7 2.0 1.5 -1.9 -1.7 -0.3 1.5
Forced expiratory volume in 1-second (FEV1) 2.5 8.4 14.5 -3.8 2.9 1.7 -3.5 -2.3 -2.9 -2.8 3.3 3.7 1.0 -2.7
Pulse rate 0.7 1.1 2.0 1.4 -0.2 -0.2 1.2 1.1 1.3 1.2 -1.3 -1.4 0.0 1.0
Happiness 1.1 1.3 6.0 1.1 -1.2 -2.5 1.2 0.4 0.4 1.2 -0.9 -1.1 -0.3 0.7
Noisy workplace 1.3 1.6 2.6 1.5 -1.3 -1.5 1.6 0.6 1.5 1.2 -1.3 -1.4 0.5 1.0
Qualifications: A levels/AS levels or equivalent 1.6 3.5 5.4 -1.5 0.3 1.5 -2.2 -2.2 -2.2 -2.3 1.7 1.5 -2.0 -2.3
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.2 0.4 -0.7 -0.5 0.1 -0.3 -0.1 -0.3 0.1 0.6 0.7 -0.3 -0.1
Mouth/teeth dental problems: Dentures 1.7 2.9 6.9 0.5 0.3 0.2 2.1 2.6 2.3 2.6 -0.9 -0.6 1.0 2.4
Asthma 2.1 4.2 7.0 -2.5 0.0 -0.9 -2.4 -1.8 -2.0 -2.4 2.6 2.6 1.2 -2.3
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.4 0.8 -0.6 0.2 -0.7 -0.8 -0.9 -0.7 -0.6 0.2 0.5 -0.2 -0.7
Medication: Cholesterol lowering 3.7 5.7 9.9 2.8 -2.0 -0.7 3.1 2.3 2.8 2.9 -2.5 -2.8 -0.1 2.4
Depression (self-reported) 0.7 0.9 3.3 1.0 -1.8 0.7 0.9 1.0 0.5 0.9 -0.6 -1.0 0.2 0.6
Medication: Lansoprazole 0.3 0.3 0.9 -0.9 0.0 -0.4 -0.1 0.0 0.2 -0.1 0.8 0.9 0.8 -0.1
Prospective memory result 1.1 1.3 2.1 1.4 -1.2 -1.4 1.2 0.9 1.1 1.0 -1.1 -1.4 0.7 0.8
Lung cancer (father) 0.3 0.3 1.0 -0.8 0.8 0.0 -0.1 -0.2 -0.4 -0.2 1.0 0.8 0.0 -0.6
Illnesses of mother 13.8 17.0 25.8 -4.8 4.5 2.0 -5.1 -3.9 -4.3 -4.0 4.9 4.9 0.1 -4.1
Forced expiratory volume in 1-second (FEV1), Best measure 1.6 5.0 9.5 -3.1 2.4 1.4 -2.7 -1.3 -2.2 -1.7 2.8 3.0 1.3 -1.7
Pulse wave Arterial Stiffness index 0.7 0.9 4.8 -0.5 -0.1 2.2 0.1 1.4 0.0 1.1 0.4 0.4 0.0 1.0
Impedance of arm (left) 0.7 3.1 7.3 -1.4 -0.2 2.4 -2.7 -1.0 -1.7 -2.6 1.8 1.3 -1.4 -1.5
Arm fat mass (right) 3.7 15.2 31.8 1.4 -0.9 -0.4 4.5 5.1 5.5 5.1 -1.2 -1.3 5.6 5.1
Trunk predicted mass 3.2 18.3 41.6 -6.4 4.8 3.7 -3.0 0.1 -0.9 -0.8 5.8 6.5 6.1 -0.9
Standing height 8.9 87.8 185.0 -13.6 7.5 9.5 -10.7 -3.4 -6.1 -6.8 12.9 13.5 6.6 -5.9
Length of working week for main job 0.7 0.8 1.7 -1.0 0.4 0.6 -0.9 -1.1 -0.5 -1.2 1.3 1.0 0.1 -0.8
Exposure to tobacco smoke at home 0.2 0.3 1.6 -0.0 -1.3 -0.8 0.2 0.6 0.5 0.2 0.1 -0.0 0.0 0.3
Breastfed as a baby 4.2 5.2 10.3 -2.5 0.8 1.5 -3.2 -2.2 -2.6 -2.8 2.2 2.6 -0.6 -2.5
Tense / ‘highly strung’ 0.1 0.1 0.4 -0.3 0.5 -0.6 -0.1 -0.4 0.1 -0.1 0.2 0.2 0.1 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 3.2 1.5 -1.4 -0.5 0.7 0.2 0.2 0.4 -1.8 -1.6 -1.1 0.3
Hair/balding pattern: Pattern 4 0.2 0.6 2.1 1.0 -1.4 0.6 0.0 0.3 0.4 -0.2 -0.9 -1.1 -0.7 -0.5
Birth weight of first child 2.0 3.7 14.9 -2.4 3.9 0.8 -1.6 -0.8 -1.4 -0.8 2.4 2.5 0.9 -0.8
Peak expiratory flow (PEF) 2.5 5.8 10.9 -2.3 1.3 0.2 -3.3 -2.9 -3.1 -2.7 1.9 2.3 -2.1 -2.8
Pulse wave reflection index 0.4 0.5 1.0 -0.8 0.4 0.9 0.3 1.0 -0.1 0.9 0.6 0.7 0.3 0.9
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.1 -1.0 0.5 -1.1 -0.3 -0.8 -0.3 -0.6 0.9 1.0 0.1 -0.6
Loud music exposure frequency 2.2 2.4 5.6 -2.3 2.3 0.2 -1.4 -0.9 -1.2 -0.7 2.0 2.4 1.0 -0.9
Qualifications: O levels/GCSEs or equivalent 2.7 4.3 9.2 -1.5 1.6 -0.1 -2.2 -2.9 -2.5 -3.0 1.4 1.5 -1.2 -2.8
Mouth/teeth dental problems: Bleeding gums 0.9 1.1 3.5 1.8 -1.1 -0.5 0.6 -0.0 0.6 0.3 -1.2 -1.9 -1.5 0.2
Blood clot in the leg (DVT) 0.9 1.2 2.0 1.0 -0.6 0.9 1.4 1.2 1.4 1.2 -1.2 -1.1 0.5 1.1
Medication: Paracetamol 0.3 0.5 2.7 -0.0 -1.6 -1.4 0.5 0.3 0.2 0.6 -0.6 -0.1 -0.5 0.3
Headache pain in last month 0.8 1.4 3.6 -0.5 -0.5 -1.9 0.9 1.3 1.1 1.5 -0.1 0.4 1.7 1.3
Medication for cholesterol, blood pressure or diabetes 4.5 7.5 14.1 -2.6 2.9 1.2 -3.4 -2.8 -3.8 -3.1 2.8 2.6 -0.9 -2.7
Glaucoma (self-reported) 2.0 2.3 5.2 0.7 -0.3 0.8 1.4 2.3 2.2 1.4 -1.1 -0.8 2.3 1.9
Gout (self-reported) 0.7 0.9 2.0 0.0 -1.4 0.0 -1.2 -1.4 -1.1 -1.0 -0.3 -0.0 -0.8 -1.4
Hypothyroidism/myxoedema (self-reported) 2.6 5.2 9.9 2.2 -1.0 -0.9 3.1 2.5 2.7 3.0 -2.3 -2.2 0.6 2.6
Medication: Amlodipine 5.2 7.3 16.6 3.9 -2.0 -1.6 3.3 1.3 1.8 1.9 -4.1 -3.9 -1.7 1.7
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.6 0.5 -0.4 -1.0 0.1 1.0 0.5 0.1 -0.2 -0.4 1.3 0.6
Birth weight 0.7 1.5 3.2 -1.5 0.5 -1.1 -1.3 -1.4 -0.2 -1.8 1.1 1.6 0.5 -1.3
Chronic bronchitis/emphysema (mother) 4.2 4.9 10.6 1.8 -2.2 0.6 2.8 3.3 2.5 2.6 -1.5 -1.8 0.8 2.8
High blood pressure (siblings) 6.3 9.1 15.8 3.6 -3.3 -1.2 3.6 2.8 2.8 3.0 -4.0 -3.7 -0.3 2.8
Forced vital capacity (FVC), Best measure 2.8 10.3 21.8 -4.7 3.6 1.7 -3.6 -1.4 -2.9 -1.9 4.2 4.6 2.6 -1.9
Body fat percentage 3.5 13.7 30.1 2.1 -2.1 -0.2 4.3 4.9 5.5 4.7 -1.6 -2.1 4.1 4.8
Leg fat percentage (right) 3.1 11.4 25.0 2.6 -2.2 -0.8 4.2 4.1 5.0 4.1 -2.2 -2.6 2.9 4.1
Arm fat-free mass (right) 2.4 12.3 39.4 -4.9 3.9 2.6 -1.6 1.2 0.4 0.7 4.5 5.0 6.3 0.5
Exposure to tobacco smoke outside home 1.2 1.6 6.5 1.3 -1.7 -2.5 1.2 0.1 0.7 0.9 -1.5 -1.3 0.2 0.5
Comparative body size at age 10 0.6 1.5 8.4 1.1 -0.1 -2.9 1.6 0.2 0.9 1.2 -1.0 -0.9 0.1 0.8
Number of full brothers 0.8 1.0 1.8 1.1 0.0 -0.2 1.2 1.2 0.8 1.2 -1.3 -1.1 -0.2 1.3
Worry too long after embarrassment 3.9 6.6 12.5 2.8 -1.7 -2.3 3.5 2.1 2.9 2.7 -3.1 -2.9 -0.2 2.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.7 -0.4 0.5 0.0 -0.3 0.9 -0.2 0.7 0.5 0.4 0.8 0.8
Wheeze or whistling in the chest in last year 0.5 0.8 6.5 -0.4 0.1 -0.4 -0.0 0.7 0.8 -0.1 1.0 0.6 2.5 0.0
Number of children fathered 2.5 2.8 6.2 -1.4 0.3 0.4 -2.2 -2.2 -2.0 -2.4 1.0 1.4 0.1 -2.5
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 1.7 0.1 0.8 -1.3 0.2 -0.8 -0.6 0.1 -0.6 -0.2 -0.5 -0.4
Age at first live birth 3.6 6.3 9.7 -2.1 2.9 2.5 -3.0 -2.4 -3.1 -2.7 2.4 2.1 -1.2 -2.8
Pulse wave peak to peak time 0.9 1.1 2.6 -0.6 0.7 -1.4 -0.8 -1.6 -0.6 -1.5 0.6 0.6 0.5 -1.4
Health satisfaction 3.4 4.4 8.6 1.8 -1.7 -0.1 2.6 2.6 2.5 2.9 -1.5 -1.9 1.5 2.6
Shortness of breath walking on level ground 0.9 1.1 3.1 1.1 -1.8 -1.0 0.9 1.0 1.0 0.8 -0.7 -1.1 0.7 1.0
Qualifications: College or University degree 3.6 11.4 16.5 -3.5 3.2 2.6 -4.1 -3.2 -3.6 -3.7 3.8 3.5 -2.0 -3.5
Eye problems/disorders: None of the above 0.7 0.8 2.1 -0.7 0.6 -0.7 -0.6 -0.9 -1.4 -1.1 0.8 0.7 -1.0 -1.0
Mouth/teeth dental problems: Loose teeth 2.9 3.5 5.3 2.2 -1.6 0.3 2.2 2.0 2.1 2.1 -2.0 -2.3 -1.0 1.8
Emphysema/chronic bronchitis 0.8 0.9 2.6 0.1 0.4 0.6 0.6 1.6 1.4 0.9 -0.3 -0.2 1.4 1.2
Medication for pain relief, constipation, heartburn 3.4 5.8 8.2 -1.8 2.8 2.6 -2.5 -2.5 -2.8 -2.9 2.2 1.9 -1.2 -2.7
Neck or shoulder pain in last month 1.6 2.3 4.8 1.8 -2.0 -1.9 1.6 0.6 0.8 1.4 -2.2 -1.8 -0.7 0.8
Medication: Blood pressure 7.7 13.6 26.2 3.1 -3.7 -1.3 4.6 4.2 5.1 4.2 -3.4 -3.1 1.8 4.1
Angina (self-reported) 1.4 1.8 3.8 0.5 -0.6 -0.9 1.8 1.8 1.7 1.9 -0.4 -0.6 1.4 1.7
Migraine (self-reported) 0.7 0.9 2.6 -1.4 0.9 -0.1 -0.7 0.2 -0.4 0.3 1.2 1.3 1.6 0.4
Medication: Ibuprofen 0.1 0.2 0.4 -0.3 -0.3 -0.5 -0.6 -0.5 -0.7 -0.4 0.1 0.3 -0.0 -0.3
Medication: Allopurinol 0.6 0.8 1.9 0.1 -1.4 -0.5 -0.9 -1.3 -0.7 -1.0 -0.2 -0.1 -1.4 -1.0
Medication: Omeprazole 3.7 4.4 9.4 2.3 -3.1 -1.8 1.9 1.8 2.5 2.1 -1.5 -2.3 -0.3 2.3
Medication: Seretide 50 evohaler 0.6 0.7 2.0 -1.4 -0.2 0.1 -1.2 0.1 -0.5 -0.3 1.0 1.3 1.2 -0.3
Mean time to correctly identify matches 1.7 3.2 6.7 -1.6 1.8 -0.6 -2.2 -2.0 -2.6 -1.9 1.2 1.6 -0.2 -2.2
Heart disease (mother) 5.6 6.9 11.9 3.2 -2.5 -2.3 3.0 1.9 2.6 2.3 -3.5 -3.2 0.3 2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.3 1.0 0.6 -0.0 -0.6 0.2 -0.5 0.1 -0.4 -1.0 -0.6 -0.0 -0.6
Whole body fat mass 2.8 11.5 32.4 0.3 -0.6 0.6 3.2 4.7 4.8 4.3 -0.1 -0.3 5.7 4.4
Leg fat mass (right) 2.8 10.8 24.8 0.9 -0.8 0.2 3.5 4.4 4.8 4.3 -0.6 -0.9 5.0 4.2
Arm predicted mass (right) 2.5 12.9 41.3 -5.1 3.7 2.7 -1.9 1.1 0.2 0.5 4.7 5.1 6.4 0.4
Pulse rate, automated reading 0.7 2.2 4.3 2.1 -0.8 -0.3 1.5 1.5 1.7 1.5 -1.7 -2.0 0.3 1.5
Alcohol intake frequency. 4.7 10.9 18.5 3.1 -2.1 -1.9 4.3 3.4 3.9 4.2 -3.1 -3.1 1.0 4.2
Comparative height size at age 10 5.6 30.8 70.7 -8.4 5.8 5.2 -5.0 -0.2 -1.9 -1.8 8.3 8.4 5.8 -1.7
Number of full sisters 2.1 2.6 6.0 2.0 -2.4 -2.1 1.3 0.0 1.0 0.5 -2.4 -2.0 -1.0 0.4
Suffer from ‘nerves’ 0.1 0.2 0.6 -0.1 -0.7 -0.1 -0.5 -0.6 -0.3 -0.2 0.3 0.1 -0.3 -0.5
Overall health rating 5.8 12.5 16.3 3.8 -3.7 -2.2 4.0 3.5 4.0 3.8 -3.9 -3.9 1.6 3.6
Chest pain or discomfort 0.7 1.0 3.0 1.7 -0.5 -0.9 0.9 0.3 0.5 0.4 -1.7 -1.7 -0.3 0.2
Had major operations 1.9 2.2 5.0 1.2 -1.8 -2.2 1.5 1.2 1.3 1.8 -1.2 -1.3 1.2 1.4
Age at last live birth 0.3 0.4 1.3 -0.0 -0.2 -0.2 -0.6 -0.8 -0.5 -0.8 0.3 0.0 -1.1 -1.0
Family relationship satisfaction 0.5 0.6 1.6 0.8 -1.1 -1.3 0.7 0.6 0.3 0.7 -0.7 -0.9 -0.1 0.5
Leg pain on walking 2.0 2.5 8.0 1.6 -2.8 -0.1 1.6 1.5 1.5 1.7 -1.5 -1.6 0.0 1.4
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.5 2.9 -0.5 -1.4 -1.7 0.2 -0.4 0.6 0.1 -0.0 0.5 0.4 -0.1
Commuting to job workplace: Car/motor vehicle 0.2 0.2 1.4 -0.2 -1.2 -0.2 0.1 -0.2 -0.0 0.1 0.1 0.1 0.9 -0.2
Illness, injury, bereavement, stress in last 2 years 1.8 2.2 6.8 -0.6 2.6 0.9 -1.4 -1.5 -2.0 -1.4 0.8 0.7 -1.6 -1.7
Medication: Aspirin 8.4 11.1 18.1 3.3 -3.4 -1.3 3.9 3.8 4.3 3.5 -3.6 -3.3 1.3 3.6
Supplements: Vitamin C 0.9 1.1 2.3 1.3 -0.7 -0.1 1.4 0.8 1.5 0.9 -1.3 -1.3 -0.3 0.8
Knee pain experienced in last month 3.2 5.0 10.0 1.9 -1.9 -1.1 2.5 2.5 2.4 3.2 -2.4 -2.0 0.7 2.8
Hypertension (Self-reported) 7.9 22.0 33.1 4.2 -5.6 -2.2 5.5 5.1 5.8 5.3 -4.5 -4.2 2.2 5.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.3 2.6 4.6 1.9 -2.1 -1.4 1.6 1.5 1.7 1.6 -1.4 -1.9 -0.1 1.7
Illnesses of father: Heart disease 4.7 6.5 10.4 2.9 -2.5 0.3 3.0 2.6 2.2 3.1 -3.2 -2.9 0.6 2.8
Illnesses of siblings: Diabetes 1.7 2.1 6.9 1.5 -2.6 -0.8 1.5 1.0 1.5 1.4 -1.3 -1.5 -0.8 1.0
Smoking status: Previous 0.5 0.8 2.6 -1.0 -1.6 0.4 -0.1 0.6 1.0 0.1 0.5 1.0 1.6 0.1
Forced expiratory volume in 1-second (FEV1), predicted 4.2 8.6 19.5 -4.4 3.1 2.8 -2.6 -0.1 -1.1 -0.9 4.4 4.3 3.3 -0.5
Whole body fat-free mass 2.6 14.8 48.4 -5.4 4.1 2.9 -1.7 1.3 0.4 0.6 4.9 5.5 7.0 0.5
Leg fat-free mass (right) 1.8 9.7 46.9 -3.4 2.7 1.1 0.2 2.6 1.8 2.1 3.0 3.4 6.8 2.2
Arm fat percentage (left) 5.2 20.9 39.8 3.4 -2.3 -1.9 5.8 5.4 6.3 5.8 -3.0 -3.4 4.3 5.9
Average weekly red wine intake 0.6 0.9 2.8 0.1 0.1 -0.3 -1.0 -1.5 -0.9 -1.7 0.1 -0.1 -1.4 -1.1
Handedness (chirality/laterality): Left-handed 0.5 0.6 1.4 -0.7 -0.6 0.3 -0.5 -1.1 -1.0 -0.3 0.8 0.6 -1.2 -0.7
Mood swings 0.1 0.1 0.3 0.3 0.1 0.3 -0.4 0.0 -0.5 0.3 -0.4 -0.3 -0.3 -0.3
Loneliness, isolation 1.6 2.3 5.3 1.1 -1.1 -0.5 1.4 2.0 2.3 1.8 -1.4 -1.2 0.7 1.9
Long-standing illness, disability or infirmity 0.6 0.9 2.2 0.6 -1.3 -0.2 0.5 1.3 1.5 0.6 -0.3 -0.7 1.4 0.9
Ever had bowel cancer screening 0.6 0.7 4.2 0.6 0.6 0.0 -0.2 -0.5 -0.6 -0.1 -1.2 -0.6 -2.0 -0.6
Diabetes diagnosed by doctor 5.2 8.6 14.5 3.1 -2.6 -1.7 3.8 3.0 3.3 3.4 -3.0 -3.2 -0.8 3.1
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 4.4 -0.9 0.0 -0.2 -0.1 1.0 0.9 0.7 1.1 0.9 2.1 1.0
Friendships satisfaction 0.5 0.7 3.5 0.3 0.5 -0.3 -0.4 -1.1 -1.0 -0.6 0.0 -0.3 -1.9 -0.8
Qualifications: nursing, teaching 2.3 3.6 5.7 -2.1 0.2 1.6 -2.3 -1.8 -2.2 -2.4 2.1 2.1 -0.2 -2.2
Commuting to job workplace: Walk 1.6 1.8 2.9 -1.1 0.7 -1.2 -1.7 -1.5 -1.7 -1.7 1.4 1.2 -0.4 -1.4
Eye problems/disorders: Cataract 0.5 0.6 2.1 -0.6 -0.0 -0.4 -0.9 -1.4 -0.7 -0.6 0.5 0.7 -0.8 -1.0
Mouth/teeth dental problems: Mouth ulcers 1.1 1.7 5.0 1.3 -1.5 2.2 1.1 1.5 1.0 1.0 -1.3 -1.3 -0.0 1.3
Medication for cholesterol 2.1 3.2 6.2 -2.0 2.5 1.6 -1.9 -1.7 -0.9 -1.7 2.0 2.1 0.3 -1.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.4 2.8 5.1 2.2 -0.7 0.0 2.2 1.8 1.6 1.6 -2.2 -2.3 0.3 1.5
Back pain experienced in last month 0.7 1.1 7.1 0.6 -1.5 -2.7 0.5 0.1 0.9 0.2 -0.7 -0.7 0.1 0.3
Mineral and other dietary supplements 1.1 1.5 4.5 1.2 -2.0 -2.1 0.6 0.5 1.0 0.6 -1.1 -1.3 0.8 0.9
Breast cancer (self-reported) 0.5 0.6 1.3 1.0 0.0 -0.6 1.0 0.3 1.1 0.5 -1.1 -1.0 -0.1 0.6
Asthma (self-reported) 2.6 5.2 7.9 -2.6 0.1 -0.9 -2.7 -2.2 -2.5 -2.8 2.8 2.7 0.9 -2.7
Osteoporosis (self-reported) 1.6 2.0 9.5 0.4 0.1 3.1 1.1 1.8 1.2 1.8 -0.5 -0.5 -0.4 1.5
Osteoarthritis (self-reported) 0.6 0.8 1.4 -1.1 0.6 0.1 -0.9 -0.8 -1.2 -0.8 0.9 1.2 0.3 -0.9
Medication: Aspirin 7.5 9.8 15.9 3.1 -3.1 -1.5 3.8 3.4 4.0 3.3 -3.5 -3.1 1.4 3.3
Medication: Gliclazide 4.2 4.7 13.5 1.7 -3.7 0.1 2.3 2.4 2.4 2.7 -1.8 -1.7 0.8 2.2
Illnesses of father: None of the above (group 1) 5.1 6.3 10.0 -2.3 2.5 1.1 -3.1 -2.6 -3.0 -3.2 2.5 2.4 -0.8 -3.0
Smoking status: Current 2.8 4.4 10.1 1.4 -0.2 -0.3 2.5 2.8 2.8 3.2 -1.3 -1.4 1.4 3.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.3 -0.2 1.1 -1.1 -0.7 -0.7 -0.9 -0.6 -0.2 0.1 0.7 -0.4
Whole body water mass 2.7 15.3 49.7 -5.5 4.2 3.1 -1.7 1.4 0.4 0.6 4.9 5.5 7.0 0.6
Leg predicted mass (right) 1.8 9.6 46.6 -3.3 2.6 1.1 0.2 2.5 1.8 2.1 3.0 3.4 6.8 2.2
Arm fat mass (left) 3.4 13.9 34.0 1.0 -0.5 -0.4 4.1 4.9 5.3 4.8 -0.8 -1.0 5.8 4.9
Number of self-reported non-cancer illnesses 3.5 6.1 13.0 2.2 -3.6 -1.3 2.6 2.6 3.0 2.7 -2.0 -2.2 1.9 2.3
Average weekly champagne plus white wine intake 7.3 10.0 16.4 -3.9 3.4 2.3 -4.0 -2.3 -3.5 -2.9 3.7 3.9 0.5 -2.6
Miserableness 0.3 0.5 1.5 0.6 -0.4 -0.7 0.7 0.6 1.2 0.6 -0.7 -0.6 0.7 0.6
Guilty feelings 0.6 0.9 3.2 0.7 -0.6 -0.1 1.0 1.0 0.9 1.1 -0.5 -0.7 1.8 1.1
Wears glasses or contact lenses 2.6 3.0 5.9 -2.2 1.2 1.1 -2.0 -1.4 -1.6 -1.4 2.4 2.3 0.8 -1.8
Ever taken oral contraceptive pill 3.0 3.3 8.1 -2.5 0.5 0.7 -2.2 -1.4 -1.3 -1.9 2.9 2.5 0.9 -1.5
Hearing aid user 0.3 0.4 1.4 -0.6 0.0 0.5 -1.2 -0.3 -0.9 -0.6 0.5 0.7 0.3 -0.4
Mother’s age at death 5.8 7.3 11.4 -2.1 3.1 1.9 -2.7 -3.1 -3.2 -3.3 2.5 2.1 -1.7 -3.4
Financial situation satisfaction 1.6 2.0 3.5 1.8 -1.5 -1.5 1.6 0.7 1.1 1.2 -1.9 -1.9 -0.5 1.3
Tinnitus: Yes, now most or all of the time 1.0 1.2 3.1 1.4 -0.5 -0.9 1.8 0.6 0.9 1.0 -1.3 -1.5 -0.4 0.7
Commuting to job workplace: Public transport 0.5 0.5 1.5 0.8 -0.5 -1.2 0.6 0.1 0.6 0.5 -0.8 -0.8 -1.0 0.5
Eye problems/disorders: Glaucoma 1.8 2.1 5.0 0.1 0.1 2.0 0.8 2.2 1.7 1.5 -0.1 -0.2 2.1 1.8
Medication: Blood pressure 2.0 3.8 7.7 1.7 -2.8 -1.3 2.1 2.1 1.6 2.1 -1.8 -1.7 1.1 2.3
Pain type(s) experienced in last month: Hip pain 2.5 3.1 7.2 1.5 -0.3 0.9 1.6 2.7 2.0 2.3 -1.4 -1.6 1.5 2.2
Supplements: Fish oil (including cod liver oil) 1.1 1.4 2.4 -1.1 1.3 1.0 -1.0 -1.4 -1.1 -1.3 1.1 1.2 -0.8 -1.6
High cholesterol (Self-reported) 3.6 6.3 10.9 3.2 -3.3 -2.1 2.8 1.8 2.2 2.4 -3.0 -3.1 -0.0 2.1
Medication: Bendroflumethiazide 2.8 4.2 7.3 1.9 -2.7 -1.0 2.0 2.1 2.3 2.3 -2.4 -2.0 0.7 2.2
Medication: Paracetamol 0.6 0.9 4.9 0.5 -2.2 -1.3 0.7 0.5 0.2 0.6 -1.0 -0.6 -0.2 0.5
Medication: Lisinopril 0.8 1.0 6.2 0.0 -2.5 -1.8 0.4 0.0 0.9 0.3 -0.0 0.0 0.7 0.1
Medication: Atorvastatin 0.4 0.6 1.8 -0.2 -0.9 -1.4 0.6 0.5 0.5 0.6 0.5 0.2 1.3 0.6
Illnesses of father: High blood pressure 4.2 5.2 10.0 2.9 -2.1 -2.1 2.4 1.7 2.2 1.9 -3.2 -2.9 -0.1 1.9
Alcohol drinker status: Never 2.8 3.4 5.5 1.9 -1.2 -0.6 2.2 1.8 2.3 2.3 -2.1 -1.9 -0.1 2.2
Ever smoked 0.8 1.4 4.2 0.4 -2.0 -0.2 1.3 1.4 1.8 1.5 -0.6 -0.4 0.4 0.9
Basal metabolic rate 2.4 13.2 51.3 -4.8 3.6 2.6 -1.0 1.9 1.2 1.2 4.4 4.8 7.2 1.2
Leg fat percentage (left) 3.4 12.3 24.7 3.1 -2.7 -1.6 4.4 4.0 5.0 4.1 -2.5 -3.1 2.5 4.1
Arm fat-free mass (left) 2.3 11.9 37.7 -4.7 3.8 3.2 -1.2 1.4 0.7 0.9 4.3 4.7 6.1 0.6
Number of operations (self-reported) 1.8 2.6 7.2 1.8 -2.7 -0.9 1.5 1.3 1.2 1.6 -2.1 -1.9 -0.1 1.1
Average weekly beer plus cider intake 1.1 1.5 6.1 -0.4 -0.6 0.9 -1.0 -1.6 -1.1 -1.1 0.5 0.4 -2.5 -1.8
Irritability 3.7 6.2 9.9 2.8 -1.9 -0.4 3.0 2.8 3.1 2.6 -2.7 -2.9 1.0 2.7
Risk taking 1.3 1.8 5.1 -1.7 1.3 2.2 -0.5 0.7 0.1 0.3 1.5 1.7 2.1 0.0
Ever had prostate specific antigen (PSA) test 0.1 0.2 0.7 -0.5 0.0 0.2 0.2 0.1 0.7 -0.1 0.2 0.5 0.9 -0.1
Fractured/broken bones in last 5 years 2.3 2.9 6.8 -0.7 0.1 2.1 0.8 2.6 1.8 2.2 1.0 0.7 2.2 2.4
Age started oral contraceptive pill 1.4 1.8 4.1 -0.9 0.5 -0.0 -1.8 -2.0 -1.9 -1.7 0.2 0.9 -1.1 -1.7
Diastolic blood pressure, automated reading 4.7 14.6 23.4 3.9 -4.8 -3.1 4.1 3.5 4.1 3.8 -4.2 -3.9 2.4 3.9
Ever depressed for a whole week 0.2 0.3 1.2 -0.5 0.2 -1.1 -0.4 -0.7 -0.4 -0.2 0.5 0.5 -0.5 -0.6
Unable to work because of sickness or disability 1.8 2.3 3.7 1.7 -1.8 -0.6 1.2 1.7 1.6 1.6 -1.9 -1.7 -0.6 1.8
Commuting to job workplace: Cycle 0.5 0.6 4.4 -0.4 0.5 0.6 0.0 0.6 0.7 0.1 -0.2 0.4 2.1 0.6
Myopia 1.0 1.4 4.0 2.0 -0.4 -1.1 0.4 -0.4 0.1 -0.4 -1.6 -2.0 -1.8 -0.4
Vascular/heart problems diagnosed by doctor 7.9 21.4 32.3 -4.4 5.7 3.2 -5.4 -4.7 -5.5 -5.0 4.6 4.3 -2.1 -4.9
Cholesterol lowering medication 2.6 3.8 7.3 1.9 -2.7 -2.7 2.2 1.3 1.4 1.7 -2.2 -1.9 1.0 1.7
Medication: Omeprazole (e.g. Zanprol) 2.4 2.9 5.4 1.5 -2.2 -1.8 1.4 1.7 2.3 1.7 -0.9 -1.5 1.0 2.1
Pain experienced in last month 1.4 2.4 6.5 -0.3 1.0 1.8 -1.8 -1.6 -1.3 -2.5 1.0 0.4 -1.7 -2.0
Supplements: Calcium 0.7 0.7 2.8 0.1 -0.8 -0.8 -0.4 -1.2 -0.8 -0.8 0.1 -0.1 -1.7 -1.2
Basal cell carcinoma (self-reported) 0.4 0.5 2.7 -0.7 1.1 0.5 -0.2 0.2 0.5 0.2 0.2 0.7 1.6 0.4
Heart attack/myocardial infarction (self-reported) 2.6 3.3 6.9 1.4 -1.3 -2.6 2.4 1.4 1.9 2.2 -1.8 -1.4 1.0 1.9
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 2.7 0.8 -0.7 1.0 1.4 1.4 1.6 1.4 -1.0 -0.9 0.7 1.3
Heart disease (siblings) 0.8 1.0 4.8 0.8 -0.9 -2.2 1.1 0.1 0.6 0.4 -0.9 -0.8 -0.9 0.5
Alcohol drinker status: Previous 1.2 1.4 2.9 1.6 -0.1 -1.3 1.4 0.6 0.6 0.7 -1.4 -1.7 -1.4 0.9
Pack years of smoking 4.2 6.2 10.0 3.2 -1.6 -1.5 2.6 2.6 2.6 2.7 -3.0 -3.2 0.6 2.5
Impedance of whole body 1.3 6.7 13.4 -1.6 -0.6 3.0 -3.7 -2.0 -2.8 -3.6 2.1 1.5 -2.9 -2.8
Leg fat mass (left) 2.8 10.8 23.4 1.1 -0.9 -0.4 3.6 4.4 4.8 4.3 -0.8 -1.1 4.8 4.2
Arm predicted mass (left) 2.3 11.5 37.0 -4.6 3.7 3.1 -1.2 1.5 0.7 1.0 4.2 4.7 6.1 0.7