Best TWAS P=4.02e-21 · Best GWAS P=8.1e-40 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | WDR36 | 0.05 | 0.03 | enet | 13 | 0.01 | 1.0e-02 | -2.0 | -5.7 | 1.3e-08 | 0.38 | 0.16 | 0.37 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | WDR36 | 0.32 | 0.12 | lasso | 7 | 0.17 | 4.8e-05 | -4.7 | -7.5 | 9.0e-14 | 0.54 | 0.01 | 0.89 | FALSE |
| 3 | GTEx | Spleen | SLC25A46 | 0.25 | 0.00 | enet | 6 | 0.02 | 1.3e-01 | 6.2 | -5.8 | 7.7e-09 | 0.03 | 0.07 | 0.06 | TRUE |
| 4 | GTEx | Testis | WDR36 | 0.61 | 0.37 | lasso | 10 | 0.34 | 5.7e-16 | -4.6 | -5.4 | 8.2e-08 | 0.20 | 1.00 | 0.00 | FALSE |
| 5 | METSIM | Adipose | CAMK4 | 0.05 | 0.01 | bslmm | 518 | 0.03 | 8.3e-05 | 6.1 | 7.1 | 1.1e-12 | -0.05 | 0.32 | 0.02 | FALSE |
| 6 | METSIM | Adipose | TSLP | 0.16 | 0.18 | lasso | 7 | 0.18 | 8.5e-26 | -9.1 | 8.9 | 4.2e-19 | -0.09 | 1.00 | 0.00 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | TSLP | 0.13 | 0.08 | enet | 14 | 0.09 | 4.1e-11 | -8.6 | 6.8 | 9.4e-12 | 0.05 | 1.00 | 0.00 | TRUE |
| 8 | ROSMAP | Brain Pre-frontal Cortex | CAMK4 | 0.10 | 0.03 | lasso | 4 | 0.04 | 7.8e-06 | 6.0 | -6.1 | 1.3e-09 | 0.13 | 0.98 | 0.00 | FALSE |
| 9 | YFS | Blood | SLC25A46 | 0.03 | 0.02 | enet | 12 | 0.02 | 9.5e-07 | 6.2 | -9.4 | 4.0e-21 | 0.16 | 0.93 | 0.02 | TRUE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TSLP | 0.03 | 0.03 | lasso | 2 | 0.03 | 5.5e-07 | -9.1 | 7.5 | 5.0e-14 | -0.02 | 1.00 | 0.00 | FALSE |
| 11 | The Cancer Genome Atlas | Colon Adenocarcinoma | TSLP | 0.08 | 0.01 | blup | 39 | 0.03 | 5.4e-03 | -8.4 | 7.2 | 5.0e-13 | 0.02 | 0.04 | 0.04 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TSLP | 0.05 | 0.02 | blup | 39 | 0.02 | 7.9e-04 | -8.4 | 8.7 | 2.5e-18 | -0.10 | 0.24 | 0.02 | FALSE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TMEM232 | 0.09 | 0.03 | blup | 160 | 0.04 | 3.3e-05 | 6.2 | 6.0 | 1.4e-09 | -0.06 | 0.66 | 0.33 | FALSE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TSLP | 0.06 | 0.07 | blup | 39 | 0.06 | 6.4e-07 | -8.4 | 7.6 | 3.6e-14 | -0.08 | 1.00 | 0.00 | FALSE |
| 15 | The Cancer Genome Atlas | Lung Adenocarcinoma | TSLP | 0.02 | 0.02 | blup | 39 | 0.02 | 1.9e-03 | -9.1 | 7.1 | 1.5e-12 | -0.03 | 0.05 | 0.03 | FALSE |
| 16 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TSLP | 0.04 | 0.03 | enet | 6 | 0.02 | 1.6e-03 | -8.7 | 8.2 | 2.1e-16 | -0.06 | 0.14 | 0.03 | TRUE |
| 17 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | TMEM232 | 0.17 | 0.03 | blup | 162 | 0.06 | 1.9e-03 | 5.7 | 5.4 | 5.3e-08 | -0.02 | 0.12 | 0.20 | TRUE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TSLP | 0.03 | 0.01 | blup | 39 | 0.02 | 2.7e-03 | -5.9 | 6.1 | 8.8e-10 | 0.06 | 0.08 | 0.03 | FALSE |
| 19 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | TSLP | 0.12 | 0.11 | lasso | 3 | 0.08 | 6.9e-04 | -9.1 | 8.8 | 1.2e-18 | -0.09 | 0.11 | 0.05 | TRUE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | TSLP | 0.13 | 0.14 | blup | 39 | 0.15 | 1.4e-14 | -8.4 | 6.2 | 6.5e-10 | -0.08 | 1.00 | 0.00 | TRUE |