[Hub]/) : Traits : Asthma (self-reported) :

chr5:130,588,008-132,900,729

Best TWAS P=3.8e-23 · Best GWAS P=2.67e-25 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PDLIM4 0.11 0.18 lasso 5 0.18 8.0e-21 7.37 7.5 4.6e-14 0.33 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous KIF3A 0.08 0.07 lasso 3 0.07 1.2e-06 7.06 -7.3 2.3e-13 -0.16 0.95 0.00 FALSE
3 GTEx Adipose Subcutaneous SLC22A5 0.05 0.04 lasso 4 0.04 4.2e-04 -9.12 8.3 7.9e-17 0.47 0.58 0.10 FALSE
4 GTEx Adipose Subcutaneous AC034220.3 0.11 0.11 lasso 10 0.09 4.8e-08 5.74 -5.8 8.9e-09 -0.11 1.00 0.00 FALSE
5 GTEx Adipose Visceral Omentum AC034220.3 0.10 0.09 lasso 7 0.08 7.3e-05 5.70 -5.7 1.2e-08 -0.12 0.59 0.03 FALSE
6 GTEx Adrenal Gland AC034220.3 0.12 0.11 lasso 16 0.08 7.7e-04 5.73 -5.8 8.4e-09 -0.14 0.73 0.04 FALSE
7 GTEx Artery Aorta P4HA2 0.12 0.14 lasso 2 0.11 1.2e-06 -8.74 -8.7 2.4e-18 -0.46 0.96 0.00 FALSE
8 GTEx Artery Aorta KIF3A 0.13 0.07 enet 7 0.07 6.3e-05 6.61 -7.5 8.2e-14 -0.13 0.92 0.01 FALSE
9 GTEx Artery Aorta AC034220.3 0.08 0.06 lasso 3 0.05 1.1e-03 5.88 -6.1 8.4e-10 -0.17 0.61 0.07 FALSE
10 GTEx Artery Aorta P4HA2-AS1 0.08 0.03 lasso 3 0.01 6.6e-02 -8.68 -8.5 1.4e-17 -0.40 0.46 0.06 FALSE
11 GTEx Artery Tibial P4HA2 0.12 0.15 lasso 6 0.14 3.2e-11 -8.55 -8.4 4.9e-17 -0.39 1.00 0.00 FALSE
12 GTEx Artery Tibial KIF3A 0.11 0.08 lasso 5 0.09 3.2e-07 7.05 -7.5 5.4e-14 -0.12 0.98 0.00 FALSE
13 GTEx Artery Tibial SLC22A5 0.18 0.12 enet 8 0.12 2.5e-09 -9.12 9.9 3.8e-23 0.69 0.93 0.07 TRUE
14 GTEx Artery Tibial P4HA2-AS1 0.10 0.09 lasso 4 0.11 1.0e-08 -8.43 -8.8 1.2e-18 -0.41 1.00 0.00 TRUE
15 GTEx Brain Caudate basal ganglia AC034220.3 0.41 0.45 enet 19 0.46 8.8e-15 5.70 -6.0 1.6e-09 -0.12 1.00 0.00 FALSE
16 GTEx Brain Cortex AC034220.3 0.43 0.39 lasso 15 0.17 2.4e-05 5.70 -5.3 1.1e-07 -0.09 1.00 0.00 FALSE
17 GTEx Brain Hippocampus AC034220.3 0.21 0.15 lasso 14 0.18 5.8e-05 6.01 -7.2 6.9e-13 -0.24 0.52 0.04 FALSE
18 GTEx Brain Nucleus accumbens basal ganglia AC034220.3 0.24 0.24 enet 34 0.24 3.7e-07 5.65 -5.9 4.4e-09 -0.15 0.93 0.01 FALSE
19 GTEx Breast Mammary Tissue SLC22A5 0.10 0.02 enet 16 0.06 4.5e-04 -9.40 5.3 1.2e-07 0.05 0.69 0.02 FALSE
20 GTEx Cells EBV-transformed lymphocytes SLC22A5 0.37 0.05 lasso 13 0.10 2.8e-04 -9.40 8.6 5.9e-18 0.35 0.49 0.03 FALSE
21 GTEx Cells Transformed fibroblasts PDLIM4 0.08 0.09 lasso 1 0.07 6.4e-06 7.46 7.5 8.7e-14 0.32 0.85 0.01 FALSE
22 GTEx Cells Transformed fibroblasts KIF3A 0.15 0.16 enet 7 0.15 2.6e-11 6.66 -7.2 4.3e-13 -0.14 1.00 0.00 FALSE
23 GTEx Cells Transformed fibroblasts SEPT8 0.15 0.12 lasso 4 0.11 6.9e-09 7.05 -7.4 1.0e-13 -0.14 1.00 0.00 FALSE
24 GTEx Cells Transformed fibroblasts SLC22A5 0.32 0.28 lasso 7 0.35 1.6e-27 7.96 9.4 3.9e-21 0.63 1.00 0.00 FALSE
25 GTEx Colon Sigmoid AC034220.3 0.18 0.11 lasso 12 0.06 3.7e-03 5.98 -6.1 8.9e-10 -0.08 0.26 0.10 FALSE
26 GTEx Colon Transverse SLC22A5 0.12 0.07 enet 8 0.07 2.5e-04 -9.40 8.1 6.4e-16 0.54 0.48 0.16 FALSE
27 GTEx Colon Transverse AC034220.3 0.30 0.15 lasso 3 0.11 8.4e-06 5.88 -6.4 2.0e-10 -0.15 0.96 0.00 FALSE
28 GTEx Esophagus Gastroesophageal Junction SEPT8 0.22 0.08 lasso 12 0.10 2.2e-04 4.69 -5.6 1.7e-08 -0.26 0.66 0.02 FALSE
29 GTEx Esophagus Gastroesophageal Junction UQCRQ 0.21 0.01 enet 30 0.04 2.0e-02 7.50 9.2 5.0e-20 0.61 0.04 0.59 FALSE
30 GTEx Esophagus Mucosa P4HA2 0.23 0.10 lasso 6 0.14 6.1e-10 -8.74 -8.4 4.6e-17 -0.40 1.00 0.00 FALSE
31 GTEx Esophagus Mucosa SLC22A5 0.16 0.16 enet 8 0.16 6.3e-11 -9.40 8.8 1.7e-18 0.48 0.99 0.01 FALSE
32 GTEx Esophagus Mucosa AC034220.3 0.08 0.03 lasso 3 0.05 4.7e-04 6.01 -5.8 5.1e-09 -0.12 0.98 0.00 FALSE
33 GTEx Esophagus Mucosa P4HA2-AS1 0.09 0.06 lasso 6 0.08 5.4e-06 -8.74 -8.6 1.3e-17 -0.42 0.94 0.01 FALSE
34 GTEx Esophagus Muscularis KIF3A 0.31 0.17 lasso 5 0.20 2.2e-12 6.67 -7.2 7.5e-13 -0.13 1.00 0.00 FALSE
35 GTEx Heart Atrial Appendage KIF3A 0.11 0.00 enet 18 0.01 1.8e-01 5.66 -6.4 1.2e-10 -0.09 0.13 0.10 FALSE
36 GTEx Heart Atrial Appendage AC034220.3 0.16 0.09 enet 17 0.18 1.7e-08 5.76 -5.2 1.7e-07 -0.09 1.00 0.00 TRUE
37 GTEx Heart Left Ventricle AC034220.3 0.25 0.22 lasso 6 0.25 8.6e-14 5.88 -5.8 5.9e-09 -0.17 1.00 0.00 FALSE
38 GTEx Lung RAD50 0.12 0.09 lasso 11 0.08 1.3e-06 6.33 5.2 2.2e-07 0.21 0.93 0.01 FALSE
39 GTEx Lung SLC22A5 0.10 0.15 enet 11 0.13 3.4e-10 -9.40 9.3 2.1e-20 0.47 0.99 0.01 FALSE
40 GTEx Lung AC004041.2 0.13 0.08 lasso 9 0.08 8.8e-07 6.33 5.7 1.1e-08 0.20 0.97 0.00 FALSE
41 GTEx Muscle Skeletal SLC22A5 0.10 0.01 lasso 3 0.02 6.6e-03 4.86 9.6 9.5e-22 0.16 0.14 0.48 TRUE
42 GTEx Muscle Skeletal AC034220.3 0.27 0.23 lasso 9 0.24 9.1e-24 5.70 -6.8 1.0e-11 -0.19 1.00 0.00 FALSE
43 GTEx Muscle Skeletal MIR3936 0.04 0.01 lasso 4 0.00 9.9e-02 7.46 -8.8 2.1e-18 -0.41 0.24 0.04 FALSE
44 GTEx Nerve Tibial P4HA2 0.19 0.12 enet 26 0.14 6.2e-10 5.76 -6.7 1.9e-11 -0.15 1.00 0.00 FALSE
45 GTEx Nerve Tibial KIF3A 0.23 0.17 lasso 5 0.15 5.3e-11 6.67 -7.2 5.0e-13 -0.14 1.00 0.00 FALSE
46 GTEx Nerve Tibial SLC22A5 0.17 0.11 lasso 9 0.09 5.5e-07 3.92 5.6 2.5e-08 0.55 0.81 0.14 FALSE
47 GTEx Nerve Tibial AC034220.3 0.15 0.11 lasso 5 0.10 1.9e-07 5.73 -5.9 2.9e-09 -0.11 1.00 0.00 FALSE
48 GTEx Nerve Tibial P4HA2-AS1 0.14 0.05 lasso 8 0.08 3.8e-06 -6.86 -7.2 4.5e-13 -0.28 0.98 0.00 FALSE
49 GTEx Ovary PDLIM4 0.25 0.22 enet 10 0.05 2.1e-02 4.47 -8.1 5.6e-16 -0.31 0.40 0.10 FALSE
50 GTEx Ovary AC004041.2 0.21 -0.01 lasso 2 -0.01 7.7e-01 6.82 -5.8 7.7e-09 -0.28 0.08 0.06 FALSE
51 GTEx Pituitary AC034220.3 0.25 0.22 lasso 12 0.18 3.1e-05 5.12 -5.6 1.8e-08 -0.20 0.72 0.02 FALSE
52 GTEx Prostate AC034220.3 0.38 0.37 lasso 5 0.37 3.0e-10 5.88 -5.8 6.3e-09 -0.10 0.97 0.02 FALSE
53 GTEx Skin Not Sun Exposed Suprapubic PDLIM4 0.13 0.08 lasso 2 0.06 2.6e-04 -9.40 8.5 1.8e-17 0.47 0.50 0.13 FALSE
54 GTEx Skin Not Sun Exposed Suprapubic SEPT8 0.15 0.17 lasso 2 0.17 1.4e-09 6.67 7.2 5.7e-13 0.14 0.99 0.00 FALSE
55 GTEx Skin Not Sun Exposed Suprapubic SLC22A4 0.13 0.00 lasso 4 0.01 7.1e-02 8.41 8.3 1.5e-16 0.38 0.15 0.07 FALSE
56 GTEx Skin Not Sun Exposed Suprapubic SLC22A5 0.13 0.05 lasso 8 0.05 8.3e-04 5.65 6.8 1.0e-11 0.24 0.98 0.01 FALSE
57 GTEx Skin Sun Exposed Lower leg PDLIM4 0.09 0.08 lasso 8 0.09 1.0e-07 -8.74 8.9 4.0e-19 0.52 1.00 0.00 FALSE
58 GTEx Skin Sun Exposed Lower leg KIF3A 0.11 0.04 lasso 4 0.04 6.2e-04 7.06 -7.5 6.4e-14 -0.15 0.63 0.03 FALSE
59 GTEx Skin Sun Exposed Lower leg SEPT8 0.46 0.35 lasso 6 0.33 3.2e-28 7.05 7.3 2.2e-13 0.13 1.00 0.00 FALSE
60 GTEx Skin Sun Exposed Lower leg SLC22A5 0.25 0.21 lasso 3 0.20 1.4e-16 -9.12 8.9 4.7e-19 0.45 1.00 0.00 FALSE
61 GTEx Spleen SLC22A5 0.26 0.28 lasso 4 0.28 6.6e-08 -9.40 -8.7 2.5e-18 -0.40 0.28 0.28 FALSE
62 GTEx Stomach SLC22A5 0.09 0.04 lasso 4 0.01 9.0e-02 8.68 7.8 5.3e-15 0.53 0.16 0.08 FALSE
63 GTEx Stomach AC034220.3 0.17 0.15 enet 21 0.16 4.2e-08 5.14 -6.1 8.1e-10 -0.23 1.00 0.00 FALSE
64 GTEx Testis P4HA2 0.14 0.13 lasso 5 0.11 1.4e-05 -8.74 -9.6 1.2e-21 -0.52 0.92 0.03 FALSE
65 GTEx Testis PDLIM4 0.15 0.07 enet 8 0.05 2.5e-03 6.01 -5.6 2.5e-08 -0.07 0.27 0.05 FALSE
66 GTEx Testis AC034220.3 0.15 0.12 lasso 9 0.12 4.4e-06 5.70 -5.7 1.3e-08 -0.11 0.90 0.01 FALSE
67 GTEx Thyroid P4HA2 0.08 0.07 enet 9 0.06 3.5e-05 -8.55 -8.3 1.3e-16 -0.41 0.80 0.01 FALSE
68 GTEx Thyroid PDLIM4 0.05 0.02 enet 5 0.01 3.1e-02 -6.86 9.2 2.7e-20 0.30 0.43 0.08 FALSE
69 GTEx Thyroid SLC22A5 0.17 0.07 lasso 5 0.13 4.8e-10 3.92 8.2 3.2e-16 0.61 0.94 0.02 FALSE
70 GTEx Thyroid P4HA2-AS1 0.08 0.06 enet 14 0.05 1.6e-04 -8.55 -8.6 6.1e-18 -0.46 0.73 0.02 FALSE
71 GTEx Whole Blood SLC22A4 0.07 0.05 enet 16 0.05 4.6e-05 7.96 9.3 1.0e-20 0.64 0.57 0.07 FALSE
72 GTEx Whole Blood SLC22A5 0.09 0.12 lasso 2 0.10 1.7e-09 -9.40 9.4 5.3e-21 0.51 0.98 0.02 FALSE
73 GTEx Whole Blood AC034220.3 0.08 0.05 enet 31 0.06 4.0e-06 -9.10 9.3 2.1e-20 0.59 0.95 0.01 FALSE
74 GTEx Whole Blood AC116366.6 0.05 0.04 lasso 17 0.03 5.7e-04 6.33 -6.9 6.3e-12 -0.33 0.55 0.04 FALSE
75 METSIM Adipose KIF3A 0.08 0.08 lasso 15 0.07 4.0e-11 6.91 -7.4 1.7e-13 -0.14 1.00 0.00 TRUE
76 METSIM Adipose P4HA2 0.09 0.08 lasso 12 0.09 2.4e-13 -8.43 -6.9 7.1e-12 -0.27 1.00 0.00 FALSE
77 METSIM Adipose PDLIM4 0.05 0.04 lasso 4 0.02 2.8e-04 -6.89 6.9 4.4e-12 0.21 0.92 0.02 FALSE
78 METSIM Adipose SLC22A4 0.05 0.02 lasso 3 0.03 8.4e-06 -4.45 6.3 3.4e-10 0.19 0.95 0.00 FALSE
79 METSIM Adipose SLC22A5 0.05 0.08 lasso 1 0.08 1.0e-11 -9.40 9.4 5.5e-21 0.50 0.99 0.01 FALSE
80 NTR Blood ACSL6 0.01 0.00 bslmm 399 0.00 2.8e-02 1.82 5.4 8.2e-08 0.28 0.19 0.24 FALSE
81 NTR Blood C5orf56 0.01 0.01 blup 439 0.01 1.7e-03 9.82 5.9 4.7e-09 0.81 0.06 0.78 FALSE
82 NTR Blood IRF1 0.03 0.02 blup 424 0.01 5.7e-05 6.33 -7.4 1.3e-13 -0.47 1.00 0.00 FALSE
83 NTR Blood SLC22A5 0.02 0.01 lasso 5 0.02 2.3e-06 -9.74 7.2 8.4e-13 0.45 0.60 0.18 FALSE
84 ROSMAP Brain Pre-frontal Cortex PDLIM4 0.25 0.27 lasso 4 0.26 2.7e-33 7.43 7.6 2.5e-14 0.31 1.00 0.00 FALSE
85 ROSMAP Brain Pre-frontal Cortex SLC22A4 0.03 0.05 lasso 2 0.04 1.2e-05 6.82 6.6 4.1e-11 0.22 0.83 0.03 FALSE
86 ROSMAP Brain Pre-frontal Cortex AC034220.3 0.04 0.02 blup 415 0.04 1.3e-05 0.36 -5.4 5.8e-08 0.09 0.72 0.27 FALSE
87 YFS Blood SLC22A4 0.10 0.12 enet 47 0.14 5.1e-42 5.77 7.1 1.4e-12 0.26 1.00 0.00 FALSE
88 YFS Blood SLC22A5 0.38 0.36 bslmm 430 0.37 3.0e-128 -9.40 8.6 9.5e-18 0.52 0.98 0.02 TRUE
89 The Cancer Genome Atlas Breast Invasive Carcinoma P4HA2 0.03 0.02 blup 47 0.03 3.1e-06 -8.43 -7.2 5.1e-13 -0.34 0.06 0.92 FALSE
90 The Cancer Genome Atlas Breast Invasive Carcinoma PDLIM4 0.05 0.05 lasso 4 0.05 9.0e-11 7.43 7.6 3.5e-14 0.35 0.73 0.27 FALSE
91 The Cancer Genome Atlas Breast Invasive Carcinoma SLC22A4 0.05 0.01 enet 7 0.02 1.6e-05 -9.40 7.5 6.2e-14 0.32 0.01 0.99 FALSE
92 The Cancer Genome Atlas Breast Invasive Carcinoma SLC22A5 0.05 0.07 enet 11 0.09 5.3e-17 5.14 6.6 4.7e-11 0.32 1.00 0.00 TRUE
93 The Cancer Genome Atlas Colon Adenocarcinoma PDLIM4 0.14 0.04 enet 9 0.09 6.8e-06 5.51 6.5 7.8e-11 0.39 0.24 0.59 FALSE
94 The Cancer Genome Atlas Colon Adenocarcinoma SLC22A5 0.08 0.04 blup 92 0.07 1.2e-04 7.96 8.3 7.4e-17 0.51 0.03 0.91 FALSE
95 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SLC22A5 0.06 0.05 blup 93 0.08 1.2e-09 5.74 7.0 3.2e-12 0.32 0.06 0.94 FALSE
96 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PDLIM4 0.09 0.02 lasso 6 0.05 4.5e-06 6.82 8.2 2.5e-16 0.40 0.13 0.76 FALSE
97 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SLC22A4 0.03 0.03 lasso 1 0.02 3.5e-03 5.65 5.7 1.6e-08 0.11 0.31 0.36 FALSE
98 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma SLC22A4 0.04 0.03 blup 108 0.01 7.1e-02 5.13 5.8 6.8e-09 0.29 0.11 0.24 FALSE
99 The Cancer Genome Atlas Brain Lower Grade Glioma C5orf56 0.03 0.01 blup 98 0.02 4.2e-03 6.26 -5.8 7.0e-09 -0.12 0.15 0.02 FALSE
100 The Cancer Genome Atlas Liver Hepatocellular Carcinoma PDLIM4 0.08 0.03 blup 67 0.05 2.4e-03 5.16 5.9 4.3e-09 0.31 0.04 0.45 FALSE
101 The Cancer Genome Atlas Lung Adenocarcinoma SLC22A5 0.06 0.03 lasso 4 0.02 9.3e-04 7.96 8.6 1.1e-17 0.66 0.08 0.64 FALSE
102 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SLC22A4 0.04 0.01 blup 111 0.03 3.0e-04 4.33 6.6 5.4e-11 0.47 0.03 0.85 FALSE
103 The Cancer Genome Atlas Lung Squamous Cell Carcinoma SLC22A5 0.05 0.03 blup 93 0.05 1.9e-06 5.13 6.6 3.9e-11 0.34 0.05 0.95 FALSE
104 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma SLC22A5 0.12 0.04 blup 92 0.07 2.2e-05 7.96 6.4 1.5e-10 0.63 0.11 0.60 FALSE
105 The Cancer Genome Atlas Prostate Adenocarcinoma PDLIM4 0.32 0.36 enet 13 0.37 3.8e-40 6.82 7.7 2.0e-14 0.33 1.00 0.00 FALSE
106 The Cancer Genome Atlas Prostate Adenocarcinoma SLC22A4 0.09 0.07 blup 108 0.09 3.0e-09 5.76 7.4 1.7e-13 0.36 0.08 0.92 FALSE
107 The Cancer Genome Atlas Prostate Adenocarcinoma SLC22A5 0.12 0.05 lasso 4 0.08 1.8e-08 5.45 6.0 1.4e-09 0.45 0.96 0.00 FALSE
108 The Cancer Genome Atlas Stomach Adenocarcinoma SLC22A5 0.05 0.01 blup 92 0.02 1.1e-02 6.52 6.6 5.5e-11 0.57 0.09 0.13 FALSE
109 The Cancer Genome Atlas Thyroid Carcinoma C5orf56 0.06 0.04 blup 98 0.03 1.3e-03 6.18 -8.1 5.6e-16 -0.37 0.88 0.02 FALSE
110 The Cancer Genome Atlas Thyroid Carcinoma IRF1 0.05 0.02 blup 83 0.03 1.5e-03 -9.23 -8.9 5.6e-19 -0.51 0.05 0.10 FALSE
111 The Cancer Genome Atlas Thyroid Carcinoma P4HA2 0.21 0.35 enet 10 0.35 4.7e-35 -8.43 -8.3 1.3e-16 -0.43 0.04 0.96 FALSE
112 The Cancer Genome Atlas Thyroid Carcinoma SLC22A5 0.03 0.02 lasso 1 0.01 2.6e-02 7.96 8.0 1.7e-15 0.61 0.02 0.72 FALSE