[Hub]/) : Traits : Asthma (self-reported) : ← →

chr5:130,588,008-132,900,729

Best TWAS P=3.8e-23 · Best GWAS P=2.67e-25 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PDLIM4	0.11	0.18	lasso	5	0.18	8.0e-21	7.37	7.5	4.6e-14	0.33	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	KIF3A	0.08	0.07	lasso	3	0.07	1.2e-06	7.06	-7.3	2.3e-13	-0.16	0.95	0.00	FALSE
3	GTEx	Adipose Subcutaneous	SLC22A5	0.05	0.04	lasso	4	0.04	4.2e-04	-9.12	8.3	7.9e-17	0.47	0.58	0.10	FALSE
4	GTEx	Adipose Subcutaneous	AC034220.3	0.11	0.11	lasso	10	0.09	4.8e-08	5.74	-5.8	8.9e-09	-0.11	1.00	0.00	FALSE
5	GTEx	Adipose Visceral Omentum	AC034220.3	0.10	0.09	lasso	7	0.08	7.3e-05	5.70	-5.7	1.2e-08	-0.12	0.59	0.03	FALSE
6	GTEx	Adrenal Gland	AC034220.3	0.12	0.11	lasso	16	0.08	7.7e-04	5.73	-5.8	8.4e-09	-0.14	0.73	0.04	FALSE
7	GTEx	Artery Aorta	P4HA2	0.12	0.14	lasso	2	0.11	1.2e-06	-8.74	-8.7	2.4e-18	-0.46	0.96	0.00	FALSE
8	GTEx	Artery Aorta	KIF3A	0.13	0.07	enet	7	0.07	6.3e-05	6.61	-7.5	8.2e-14	-0.13	0.92	0.01	FALSE
9	GTEx	Artery Aorta	AC034220.3	0.08	0.06	lasso	3	0.05	1.1e-03	5.88	-6.1	8.4e-10	-0.17	0.61	0.07	FALSE
10	GTEx	Artery Aorta	P4HA2-AS1	0.08	0.03	lasso	3	0.01	6.6e-02	-8.68	-8.5	1.4e-17	-0.40	0.46	0.06	FALSE
11	GTEx	Artery Tibial	P4HA2	0.12	0.15	lasso	6	0.14	3.2e-11	-8.55	-8.4	4.9e-17	-0.39	1.00	0.00	FALSE
12	GTEx	Artery Tibial	KIF3A	0.11	0.08	lasso	5	0.09	3.2e-07	7.05	-7.5	5.4e-14	-0.12	0.98	0.00	FALSE
13	GTEx	Artery Tibial	SLC22A5	0.18	0.12	enet	8	0.12	2.5e-09	-9.12	9.9	3.8e-23	0.69	0.93	0.07	TRUE
14	GTEx	Artery Tibial	P4HA2-AS1	0.10	0.09	lasso	4	0.11	1.0e-08	-8.43	-8.8	1.2e-18	-0.41	1.00	0.00	TRUE
15	GTEx	Brain Caudate basal ganglia	AC034220.3	0.41	0.45	enet	19	0.46	8.8e-15	5.70	-6.0	1.6e-09	-0.12	1.00	0.00	FALSE
16	GTEx	Brain Cortex	AC034220.3	0.43	0.39	lasso	15	0.17	2.4e-05	5.70	-5.3	1.1e-07	-0.09	1.00	0.00	FALSE
17	GTEx	Brain Hippocampus	AC034220.3	0.21	0.15	lasso	14	0.18	5.8e-05	6.01	-7.2	6.9e-13	-0.24	0.52	0.04	FALSE
18	GTEx	Brain Nucleus accumbens basal ganglia	AC034220.3	0.24	0.24	enet	34	0.24	3.7e-07	5.65	-5.9	4.4e-09	-0.15	0.93	0.01	FALSE
19	GTEx	Breast Mammary Tissue	SLC22A5	0.10	0.02	enet	16	0.06	4.5e-04	-9.40	5.3	1.2e-07	0.05	0.69	0.02	FALSE
20	GTEx	Cells EBV-transformed lymphocytes	SLC22A5	0.37	0.05	lasso	13	0.10	2.8e-04	-9.40	8.6	5.9e-18	0.35	0.49	0.03	FALSE
21	GTEx	Cells Transformed fibroblasts	PDLIM4	0.08	0.09	lasso	1	0.07	6.4e-06	7.46	7.5	8.7e-14	0.32	0.85	0.01	FALSE
22	GTEx	Cells Transformed fibroblasts	KIF3A	0.15	0.16	enet	7	0.15	2.6e-11	6.66	-7.2	4.3e-13	-0.14	1.00	0.00	FALSE
23	GTEx	Cells Transformed fibroblasts	SEPT8	0.15	0.12	lasso	4	0.11	6.9e-09	7.05	-7.4	1.0e-13	-0.14	1.00	0.00	FALSE
24	GTEx	Cells Transformed fibroblasts	SLC22A5	0.32	0.28	lasso	7	0.35	1.6e-27	7.96	9.4	3.9e-21	0.63	1.00	0.00	FALSE
25	GTEx	Colon Sigmoid	AC034220.3	0.18	0.11	lasso	12	0.06	3.7e-03	5.98	-6.1	8.9e-10	-0.08	0.26	0.10	FALSE
26	GTEx	Colon Transverse	SLC22A5	0.12	0.07	enet	8	0.07	2.5e-04	-9.40	8.1	6.4e-16	0.54	0.48	0.16	FALSE
27	GTEx	Colon Transverse	AC034220.3	0.30	0.15	lasso	3	0.11	8.4e-06	5.88	-6.4	2.0e-10	-0.15	0.96	0.00	FALSE
28	GTEx	Esophagus Gastroesophageal Junction	SEPT8	0.22	0.08	lasso	12	0.10	2.2e-04	4.69	-5.6	1.7e-08	-0.26	0.66	0.02	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	UQCRQ	0.21	0.01	enet	30	0.04	2.0e-02	7.50	9.2	5.0e-20	0.61	0.04	0.59	FALSE
30	GTEx	Esophagus Mucosa	P4HA2	0.23	0.10	lasso	6	0.14	6.1e-10	-8.74	-8.4	4.6e-17	-0.40	1.00	0.00	FALSE
31	GTEx	Esophagus Mucosa	SLC22A5	0.16	0.16	enet	8	0.16	6.3e-11	-9.40	8.8	1.7e-18	0.48	0.99	0.01	FALSE
32	GTEx	Esophagus Mucosa	AC034220.3	0.08	0.03	lasso	3	0.05	4.7e-04	6.01	-5.8	5.1e-09	-0.12	0.98	0.00	FALSE
33	GTEx	Esophagus Mucosa	P4HA2-AS1	0.09	0.06	lasso	6	0.08	5.4e-06	-8.74	-8.6	1.3e-17	-0.42	0.94	0.01	FALSE
34	GTEx	Esophagus Muscularis	KIF3A	0.31	0.17	lasso	5	0.20	2.2e-12	6.67	-7.2	7.5e-13	-0.13	1.00	0.00	FALSE
35	GTEx	Heart Atrial Appendage	KIF3A	0.11	0.00	enet	18	0.01	1.8e-01	5.66	-6.4	1.2e-10	-0.09	0.13	0.10	FALSE
36	GTEx	Heart Atrial Appendage	AC034220.3	0.16	0.09	enet	17	0.18	1.7e-08	5.76	-5.2	1.7e-07	-0.09	1.00	0.00	TRUE
37	GTEx	Heart Left Ventricle	AC034220.3	0.25	0.22	lasso	6	0.25	8.6e-14	5.88	-5.8	5.9e-09	-0.17	1.00	0.00	FALSE
38	GTEx	Lung	RAD50	0.12	0.09	lasso	11	0.08	1.3e-06	6.33	5.2	2.2e-07	0.21	0.93	0.01	FALSE
39	GTEx	Lung	SLC22A5	0.10	0.15	enet	11	0.13	3.4e-10	-9.40	9.3	2.1e-20	0.47	0.99	0.01	FALSE
40	GTEx	Lung	AC004041.2	0.13	0.08	lasso	9	0.08	8.8e-07	6.33	5.7	1.1e-08	0.20	0.97	0.00	FALSE
41	GTEx	Muscle Skeletal	SLC22A5	0.10	0.01	lasso	3	0.02	6.6e-03	4.86	9.6	9.5e-22	0.16	0.14	0.48	TRUE
42	GTEx	Muscle Skeletal	AC034220.3	0.27	0.23	lasso	9	0.24	9.1e-24	5.70	-6.8	1.0e-11	-0.19	1.00	0.00	FALSE
43	GTEx	Muscle Skeletal	MIR3936	0.04	0.01	lasso	4	0.00	9.9e-02	7.46	-8.8	2.1e-18	-0.41	0.24	0.04	FALSE
44	GTEx	Nerve Tibial	P4HA2	0.19	0.12	enet	26	0.14	6.2e-10	5.76	-6.7	1.9e-11	-0.15	1.00	0.00	FALSE
45	GTEx	Nerve Tibial	KIF3A	0.23	0.17	lasso	5	0.15	5.3e-11	6.67	-7.2	5.0e-13	-0.14	1.00	0.00	FALSE
46	GTEx	Nerve Tibial	SLC22A5	0.17	0.11	lasso	9	0.09	5.5e-07	3.92	5.6	2.5e-08	0.55	0.81	0.14	FALSE
47	GTEx	Nerve Tibial	AC034220.3	0.15	0.11	lasso	5	0.10	1.9e-07	5.73	-5.9	2.9e-09	-0.11	1.00	0.00	FALSE
48	GTEx	Nerve Tibial	P4HA2-AS1	0.14	0.05	lasso	8	0.08	3.8e-06	-6.86	-7.2	4.5e-13	-0.28	0.98	0.00	FALSE
49	GTEx	Ovary	PDLIM4	0.25	0.22	enet	10	0.05	2.1e-02	4.47	-8.1	5.6e-16	-0.31	0.40	0.10	FALSE
50	GTEx	Ovary	AC004041.2	0.21	-0.01	lasso	2	-0.01	7.7e-01	6.82	-5.8	7.7e-09	-0.28	0.08	0.06	FALSE
51	GTEx	Pituitary	AC034220.3	0.25	0.22	lasso	12	0.18	3.1e-05	5.12	-5.6	1.8e-08	-0.20	0.72	0.02	FALSE
52	GTEx	Prostate	AC034220.3	0.38	0.37	lasso	5	0.37	3.0e-10	5.88	-5.8	6.3e-09	-0.10	0.97	0.02	FALSE
53	GTEx	Skin Not Sun Exposed Suprapubic	PDLIM4	0.13	0.08	lasso	2	0.06	2.6e-04	-9.40	8.5	1.8e-17	0.47	0.50	0.13	FALSE
54	GTEx	Skin Not Sun Exposed Suprapubic	SEPT8	0.15	0.17	lasso	2	0.17	1.4e-09	6.67	7.2	5.7e-13	0.14	0.99	0.00	FALSE
55	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A4	0.13	0.00	lasso	4	0.01	7.1e-02	8.41	8.3	1.5e-16	0.38	0.15	0.07	FALSE
56	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A5	0.13	0.05	lasso	8	0.05	8.3e-04	5.65	6.8	1.0e-11	0.24	0.98	0.01	FALSE
57	GTEx	Skin Sun Exposed Lower leg	PDLIM4	0.09	0.08	lasso	8	0.09	1.0e-07	-8.74	8.9	4.0e-19	0.52	1.00	0.00	FALSE
58	GTEx	Skin Sun Exposed Lower leg	KIF3A	0.11	0.04	lasso	4	0.04	6.2e-04	7.06	-7.5	6.4e-14	-0.15	0.63	0.03	FALSE
59	GTEx	Skin Sun Exposed Lower leg	SEPT8	0.46	0.35	lasso	6	0.33	3.2e-28	7.05	7.3	2.2e-13	0.13	1.00	0.00	FALSE
60	GTEx	Skin Sun Exposed Lower leg	SLC22A5	0.25	0.21	lasso	3	0.20	1.4e-16	-9.12	8.9	4.7e-19	0.45	1.00	0.00	FALSE
61	GTEx	Spleen	SLC22A5	0.26	0.28	lasso	4	0.28	6.6e-08	-9.40	-8.7	2.5e-18	-0.40	0.28	0.28	FALSE
62	GTEx	Stomach	SLC22A5	0.09	0.04	lasso	4	0.01	9.0e-02	8.68	7.8	5.3e-15	0.53	0.16	0.08	FALSE
63	GTEx	Stomach	AC034220.3	0.17	0.15	enet	21	0.16	4.2e-08	5.14	-6.1	8.1e-10	-0.23	1.00	0.00	FALSE
64	GTEx	Testis	P4HA2	0.14	0.13	lasso	5	0.11	1.4e-05	-8.74	-9.6	1.2e-21	-0.52	0.92	0.03	FALSE
65	GTEx	Testis	PDLIM4	0.15	0.07	enet	8	0.05	2.5e-03	6.01	-5.6	2.5e-08	-0.07	0.27	0.05	FALSE
66	GTEx	Testis	AC034220.3	0.15	0.12	lasso	9	0.12	4.4e-06	5.70	-5.7	1.3e-08	-0.11	0.90	0.01	FALSE
67	GTEx	Thyroid	P4HA2	0.08	0.07	enet	9	0.06	3.5e-05	-8.55	-8.3	1.3e-16	-0.41	0.80	0.01	FALSE
68	GTEx	Thyroid	PDLIM4	0.05	0.02	enet	5	0.01	3.1e-02	-6.86	9.2	2.7e-20	0.30	0.43	0.08	FALSE
69	GTEx	Thyroid	SLC22A5	0.17	0.07	lasso	5	0.13	4.8e-10	3.92	8.2	3.2e-16	0.61	0.94	0.02	FALSE
70	GTEx	Thyroid	P4HA2-AS1	0.08	0.06	enet	14	0.05	1.6e-04	-8.55	-8.6	6.1e-18	-0.46	0.73	0.02	FALSE
71	GTEx	Whole Blood	SLC22A4	0.07	0.05	enet	16	0.05	4.6e-05	7.96	9.3	1.0e-20	0.64	0.57	0.07	FALSE
72	GTEx	Whole Blood	SLC22A5	0.09	0.12	lasso	2	0.10	1.7e-09	-9.40	9.4	5.3e-21	0.51	0.98	0.02	FALSE
73	GTEx	Whole Blood	AC034220.3	0.08	0.05	enet	31	0.06	4.0e-06	-9.10	9.3	2.1e-20	0.59	0.95	0.01	FALSE
74	GTEx	Whole Blood	AC116366.6	0.05	0.04	lasso	17	0.03	5.7e-04	6.33	-6.9	6.3e-12	-0.33	0.55	0.04	FALSE
75	METSIM	Adipose	KIF3A	0.08	0.08	lasso	15	0.07	4.0e-11	6.91	-7.4	1.7e-13	-0.14	1.00	0.00	TRUE
76	METSIM	Adipose	P4HA2	0.09	0.08	lasso	12	0.09	2.4e-13	-8.43	-6.9	7.1e-12	-0.27	1.00	0.00	FALSE
77	METSIM	Adipose	PDLIM4	0.05	0.04	lasso	4	0.02	2.8e-04	-6.89	6.9	4.4e-12	0.21	0.92	0.02	FALSE
78	METSIM	Adipose	SLC22A4	0.05	0.02	lasso	3	0.03	8.4e-06	-4.45	6.3	3.4e-10	0.19	0.95	0.00	FALSE
79	METSIM	Adipose	SLC22A5	0.05	0.08	lasso	1	0.08	1.0e-11	-9.40	9.4	5.5e-21	0.50	0.99	0.01	FALSE
80	NTR	Blood	ACSL6	0.01	0.00	bslmm	399	0.00	2.8e-02	1.82	5.4	8.2e-08	0.28	0.19	0.24	FALSE
81	NTR	Blood	C5orf56	0.01	0.01	blup	439	0.01	1.7e-03	9.82	5.9	4.7e-09	0.81	0.06	0.78	FALSE
82	NTR	Blood	IRF1	0.03	0.02	blup	424	0.01	5.7e-05	6.33	-7.4	1.3e-13	-0.47	1.00	0.00	FALSE
83	NTR	Blood	SLC22A5	0.02	0.01	lasso	5	0.02	2.3e-06	-9.74	7.2	8.4e-13	0.45	0.60	0.18	FALSE
84	ROSMAP	Brain Pre-frontal Cortex	PDLIM4	0.25	0.27	lasso	4	0.26	2.7e-33	7.43	7.6	2.5e-14	0.31	1.00	0.00	FALSE
85	ROSMAP	Brain Pre-frontal Cortex	SLC22A4	0.03	0.05	lasso	2	0.04	1.2e-05	6.82	6.6	4.1e-11	0.22	0.83	0.03	FALSE
86	ROSMAP	Brain Pre-frontal Cortex	AC034220.3	0.04	0.02	blup	415	0.04	1.3e-05	0.36	-5.4	5.8e-08	0.09	0.72	0.27	FALSE
87	YFS	Blood	SLC22A4	0.10	0.12	enet	47	0.14	5.1e-42	5.77	7.1	1.4e-12	0.26	1.00	0.00	FALSE
88	YFS	Blood	SLC22A5	0.38	0.36	bslmm	430	0.37	3.0e-128	-9.40	8.6	9.5e-18	0.52	0.98	0.02	TRUE
89	The Cancer Genome Atlas	Breast Invasive Carcinoma	P4HA2	0.03	0.02	blup	47	0.03	3.1e-06	-8.43	-7.2	5.1e-13	-0.34	0.06	0.92	FALSE
90	The Cancer Genome Atlas	Breast Invasive Carcinoma	PDLIM4	0.05	0.05	lasso	4	0.05	9.0e-11	7.43	7.6	3.5e-14	0.35	0.73	0.27	FALSE
91	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A4	0.05	0.01	enet	7	0.02	1.6e-05	-9.40	7.5	6.2e-14	0.32	0.01	0.99	FALSE
92	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A5	0.05	0.07	enet	11	0.09	5.3e-17	5.14	6.6	4.7e-11	0.32	1.00	0.00	TRUE
93	The Cancer Genome Atlas	Colon Adenocarcinoma	PDLIM4	0.14	0.04	enet	9	0.09	6.8e-06	5.51	6.5	7.8e-11	0.39	0.24	0.59	FALSE
94	The Cancer Genome Atlas	Colon Adenocarcinoma	SLC22A5	0.08	0.04	blup	92	0.07	1.2e-04	7.96	8.3	7.4e-17	0.51	0.03	0.91	FALSE
95	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC22A5	0.06	0.05	blup	93	0.08	1.2e-09	5.74	7.0	3.2e-12	0.32	0.06	0.94	FALSE
96	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PDLIM4	0.09	0.02	lasso	6	0.05	4.5e-06	6.82	8.2	2.5e-16	0.40	0.13	0.76	FALSE
97	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC22A4	0.03	0.03	lasso	1	0.02	3.5e-03	5.65	5.7	1.6e-08	0.11	0.31	0.36	FALSE
98	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SLC22A4	0.04	0.03	blup	108	0.01	7.1e-02	5.13	5.8	6.8e-09	0.29	0.11	0.24	FALSE
99	The Cancer Genome Atlas	Brain Lower Grade Glioma	C5orf56	0.03	0.01	blup	98	0.02	4.2e-03	6.26	-5.8	7.0e-09	-0.12	0.15	0.02	FALSE
100	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PDLIM4	0.08	0.03	blup	67	0.05	2.4e-03	5.16	5.9	4.3e-09	0.31	0.04	0.45	FALSE
101	The Cancer Genome Atlas	Lung Adenocarcinoma	SLC22A5	0.06	0.03	lasso	4	0.02	9.3e-04	7.96	8.6	1.1e-17	0.66	0.08	0.64	FALSE
102	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A4	0.04	0.01	blup	111	0.03	3.0e-04	4.33	6.6	5.4e-11	0.47	0.03	0.85	FALSE
103	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A5	0.05	0.03	blup	93	0.05	1.9e-06	5.13	6.6	3.9e-11	0.34	0.05	0.95	FALSE
104	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SLC22A5	0.12	0.04	blup	92	0.07	2.2e-05	7.96	6.4	1.5e-10	0.63	0.11	0.60	FALSE
105	The Cancer Genome Atlas	Prostate Adenocarcinoma	PDLIM4	0.32	0.36	enet	13	0.37	3.8e-40	6.82	7.7	2.0e-14	0.33	1.00	0.00	FALSE
106	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC22A4	0.09	0.07	blup	108	0.09	3.0e-09	5.76	7.4	1.7e-13	0.36	0.08	0.92	FALSE
107	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC22A5	0.12	0.05	lasso	4	0.08	1.8e-08	5.45	6.0	1.4e-09	0.45	0.96	0.00	FALSE
108	The Cancer Genome Atlas	Stomach Adenocarcinoma	SLC22A5	0.05	0.01	blup	92	0.02	1.1e-02	6.52	6.6	5.5e-11	0.57	0.09	0.13	FALSE
109	The Cancer Genome Atlas	Thyroid Carcinoma	C5orf56	0.06	0.04	blup	98	0.03	1.3e-03	6.18	-8.1	5.6e-16	-0.37	0.88	0.02	FALSE
110	The Cancer Genome Atlas	Thyroid Carcinoma	IRF1	0.05	0.02	blup	83	0.03	1.5e-03	-9.23	-8.9	5.6e-19	-0.51	0.05	0.10	FALSE
111	The Cancer Genome Atlas	Thyroid Carcinoma	P4HA2	0.21	0.35	enet	10	0.35	4.7e-35	-8.43	-8.3	1.3e-16	-0.43	0.04	0.96	FALSE
112	The Cancer Genome Atlas	Thyroid Carcinoma	SLC22A5	0.03	0.02	lasso	1	0.01	2.6e-02	7.96	8.0	1.7e-15	0.61	0.02	0.72	FALSE