Best TWAS P=3.14e-08 · Best GWAS P=7.96e-08 conditioned to 0.487
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CSDC2 | 0.20 | 0.30 | lasso | 5 | 0.32 | 2.1e-40 | 4.8 | 5.2 | 2.1e-07 | 0.95 | 0.07 | 0.93 | FALSE |
2 | GTEx | Artery Aorta | ACO2 | 0.08 | 0.08 | lasso | 5 | 0.06 | 2.8e-04 | 5.4 | 5.4 | 8.1e-08 | 0.98 | 0.04 | 0.92 | FALSE |
3 | GTEx | Brain Cerebellar Hemisphere | POLR3H | 0.10 | 0.08 | lasso | 7 | 0.08 | 4.9e-03 | 5.2 | 5.2 | 2.1e-07 | 0.96 | 0.05 | 0.76 | FALSE |
4 | GTEx | Brain Cortex | POLR3H | 0.27 | 0.21 | lasso | 8 | 0.18 | 8.5e-06 | 5.2 | 5.2 | 2.6e-07 | 0.97 | 0.05 | 0.94 | FALSE |
5 | GTEx | Brain Cortex | CSDC2 | 0.31 | 0.32 | lasso | 5 | 0.28 | 1.8e-08 | 4.7 | 5.2 | 2.5e-07 | 0.95 | 0.13 | 0.87 | FALSE |
6 | GTEx | Brain Frontal Cortex BA9 | POLR3H | 0.13 | 0.09 | lasso | 7 | 0.04 | 3.4e-02 | 5.3 | 5.2 | 1.9e-07 | 0.97 | 0.05 | 0.78 | FALSE |
7 | GTEx | Brain Frontal Cortex BA9 | CSDC2 | 0.25 | 0.23 | lasso | 8 | 0.24 | 3.8e-07 | 5.3 | 5.2 | 1.8e-07 | 0.99 | 0.05 | 0.94 | FALSE |
8 | GTEx | Brain Hippocampus | POLR3H | 0.16 | 0.11 | lasso | 14 | 0.05 | 2.4e-02 | 5.3 | 5.2 | 1.7e-07 | 0.98 | 0.06 | 0.72 | FALSE |
9 | GTEx | Brain Nucleus accumbens basal ganglia | CSDC2 | 0.25 | 0.28 | lasso | 2 | 0.29 | 1.8e-08 | 5.2 | 5.2 | 2.2e-07 | 0.96 | 0.08 | 0.91 | FALSE |
10 | GTEx | Cells EBV-transformed lymphocytes | PMM1 | 0.20 | 0.16 | lasso | 7 | 0.14 | 1.9e-05 | 5.4 | -5.4 | 5.7e-08 | -0.98 | 0.05 | 0.94 | FALSE |
11 | GTEx | Cells EBV-transformed lymphocytes | TEF | 0.23 | 0.13 | lasso | 7 | 0.16 | 6.9e-06 | 5.4 | 5.3 | 1.0e-07 | 0.99 | 0.04 | 0.96 | FALSE |
12 | GTEx | Esophagus Muscularis | PMM1 | 0.07 | 0.05 | lasso | 5 | 0.05 | 6.8e-04 | 4.8 | -5.1 | 3.1e-07 | -0.96 | 0.14 | 0.83 | FALSE |
13 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | PMM1 | 0.04 | 0.03 | lasso | 6 | 0.02 | 6.1e-03 | 5.2 | -5.2 | 2.1e-07 | -0.96 | 0.01 | 0.75 | FALSE |
14 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ACO2 | 0.03 | 0.01 | blup | 41 | 0.04 | 3.9e-03 | -3.8 | 5.5 | 4.6e-08 | 0.95 | 0.02 | 0.56 | FALSE |
15 | The Cancer Genome Atlas | Lung Adenocarcinoma | PMM1 | 0.02 | 0.03 | lasso | 5 | 0.02 | 1.1e-03 | 5.1 | -5.1 | 2.9e-07 | -0.96 | 0.01 | 0.89 | FALSE |
16 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PHF5A | 0.03 | 0.00 | blup | 30 | 0.01 | 2.9e-02 | 5.3 | 5.5 | 3.1e-08 | 0.92 | 0.01 | 0.56 | TRUE |
17 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | TOB2 | 0.03 | 0.00 | blup | 28 | 0.02 | 3.4e-03 | 5.1 | 5.3 | 1.2e-07 | 0.96 | 0.01 | 0.60 | FALSE |
18 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | PMM1 | 0.05 | 0.06 | blup | 18 | 0.06 | 4.1e-05 | 4.8 | -5.1 | 3.0e-07 | -0.95 | 0.02 | 0.97 | FALSE |
19 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | POLR3H | 0.10 | 0.02 | blup | 23 | 0.06 | 3.4e-03 | 5.2 | -5.2 | 2.1e-07 | -0.92 | 0.01 | 0.78 | FALSE |