TWAS hub - CSDC2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.200	0.0440	0.0e+00	0.305	0.321	0.315	0.315	0.324	1.3e-37	5.3e-40	4.6e-39	3.9e-39	2.1e-40
2	GTEx	Adipose Subcutaneous	0.224	0.1400	5.3e-03	0.001	NA	0.051	NA	0.010	2.6e-01	NA	4.9e-05	NA	4.9e-02
3	GTEx	Brain Caudate basal ganglia	0.128	0.0700	4.4e-03	0.028	NA	0.085	NA	0.081	5.4e-02	NA	2.0e-03	NA	2.5e-03
4	GTEx	Brain Cortex	0.309	0.0830	1.5e-08	0.322	NA	0.190	NA	0.283	1.2e-09	NA	6.0e-06	NA	1.7e-08
5	GTEx	Brain Frontal Cortex BA9	0.245	0.0811	5.7e-07	0.227	NA	0.226	NA	0.244	1.1e-06	NA	1.2e-06	NA	3.8e-07
6	GTEx	Brain Nucleus accumbens basal ganglia	0.254	0.0840	6.1e-07	0.281	NA	0.219	NA	0.291	3.4e-08	NA	1.5e-06	NA	1.8e-08
7	GTEx	Brain Putamen basal ganglia	0.191	0.0990	3.1e-03	0.060	NA	0.074	NA	0.131	1.5e-02	NA	8.2e-03	NA	5.3e-04
8	GTEx	Cells Transformed fibroblasts	0.095	0.0390	3.6e-05	0.024	NA	0.058	NA	0.055	5.8e-03	NA	3.6e-05	NA	5.5e-05
9	GTEx	Small Intestine Terminal Ileum	0.614	0.0920	6.5e-05	0.017	NA	0.045	NA	0.016	1.4e-01	NA	3.7e-02	NA	1.4e-01
10	TCGA	Breast Invasive Carcinoma	0.172	0.0858	1.7e-06	0.009	0.028	0.032	NA	0.030	4.7e-03	1.9e-06	2.9e-07	NA	6.9e-07
11	TCGA	Cervical Squamous Cell Carcinoma	0.163	0.0960	9.6e-03	0.005	0.023	0.013	NA	0.010	1.6e-01	2.6e-02	6.8e-02	NA	9.5e-02
12	TCGA	Pancreatic Adenocarcinoma	0.253	0.1100	2.4e-03	0.010	0.019	0.056	NA	0.042	1.2e-01	5.0e-02	2.3e-03	NA	7.3e-03
13	TCGA	Thyroid Carcinoma	0.233	0.0870	4.1e-05	0.058	0.026	0.061	NA	0.055	2.7e-06	1.3e-03	1.4e-06	NA	4.9e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	10	11	12	13
Basal cell carcinoma (self-reported)	8.7	10.4	18.9	3.8	0.7	2.4	3.8	4.3	3.8	3.4	4.3	3.7	3.6	2.6	1.5
Respiratory disease	7.8	17.4	35.0	5.7	2.4	5.7	5.8	5.9	5.9	5.3	4.2	1.1	1.6	1.3	-0.7
Medication: Ventolin 100micrograms inhaler	7.6	9.8	17.4	4.0	2.9	3.7	4.0	4.1	4.0	4.2	3.6	1.9	1.8	1.6	0.6
Asthma (self-reported)	7.4	14.8	27.2	5.2	3.2	4.7	5.2	5.2	5.2	4.8	4.4	1.9	2.1	1.5	0.1
Asthma	7.0	13.8	26.0	4.9	3.2	4.5	4.9	5.1	5.0	4.6	4.5	1.7	1.7	1.5	0.1
Allergy	6.9	15.8	32.3	-5.5	-1.5	-4.6	-5.6	-5.7	-5.5	-5.2	-4.2	-1.9	-2.9	0.0	1.4
Maternal smoking around birth	6.8	9.8	21.7	-4.7	-1.3	-2.6	-4.6	-4.4	-4.6	-3.6	-3.1	-1.5	-2.3	-2.0	-0.6
Impedance of arm (left)	6.6	30.5	56.8	7.5	2.4	6.3	7.5	6.9	7.4	7.1	6.4	3.0	2.7	4.9	2.3
Allergy or Eczema	6.0	15.7	33.6	5.4	1.7	4.6	5.6	5.8	5.5	5.2	4.0	2.1	2.7	0.9	-0.8
Current tobacco smoking	6.0	9.8	24.7	-4.4	2.0	-3.0	-4.8	-5.0	-4.9	-3.4	-1.0	0.1	-1.6	1.1	2.6
Impedance of arm (right)	6.0	27.9	50.1	7.0	2.2	5.9	7.1	6.5	7.0	6.5	6.3	3.2	2.7	5.0	2.6
Mood swings	6.0	10.9	24.7	4.1	0.2	4.3	4.3	4.7	4.2	5.0	3.4	2.1	2.5	0.9	-0.5
Blood Eosinophil Count	5.9	45.8	99.8	9.1	1.0	7.2	8.9	10.0	9.2	8.5	8.2	4.5	4.2	4.4	1.0
Neuroticism (Nagel 2018)	5.8	13.5	30.4	4.8	-0.7	4.1	5.2	5.5	5.1	5.3	3.0	2.3	2.9	1.2	-0.7
Hypothyroidism (self reported)	4.9	11.3	22.6	-4.6	-1.9	-2.6	-4.5	-4.8	-4.4	-3.6	-4.0	-2.8	-2.5	-2.7	-1.1
Hayfever, allergic rhinitis or eczema	4.9	10.7	21.7	4.4	1.1	3.7	4.6	4.7	4.4	4.2	3.5	2.1	2.7	0.3	-0.8
Impedance of whole body	4.9	24.8	44.8	6.7	1.8	5.7	6.7	6.1	6.6	6.1	5.9	2.8	2.4	4.7	2.6
Hypothyroidism/myxoedema (self-reported)	4.8	9.3	17.1	-4.0	-2.0	-2.2	-3.8	-4.1	-3.7	-2.9	-3.9	-2.9	-2.2	-3.2	-1.9
Smoking status: Current	4.8	7.6	17.4	-3.7	2.2	-2.5	-4.1	-4.2	-4.2	-2.9	-0.2	0.4	-1.6	1.7	2.9
Medication: Levothyroxine sodium	4.7	8.0	14.4	-3.7	-2.3	-2.3	-3.6	-3.8	-3.6	-2.9	-3.5	-2.7	-2.2	-2.5	-1.1
Serious illness, injury or assault of a close relative in last 2 years	4.5	5.1	11.1	-3.2	-1.0	-1.9	-3.3	-3.1	-3.3	-2.4	-2.9	-0.8	-1.5	-1.6	0.0
Irritability	4.5	7.6	16.1	3.7	0.2	2.6	3.8	4.0	3.7	3.9	2.3	2.4	2.7	1.0	-0.0
Depressed Affect (Nagel 2018)	4.2	8.8	18.3	4.0	0.0	3.5	4.2	4.3	4.1	4.1	2.8	1.4	2.1	0.1	-1.6
Trunk fat percentage	4.2	16.8	33.0	5.5	0.8	5.4	5.4	5.7	5.5	5.2	3.9	2.4	3.7	1.5	-0.7
Medication: Atenolol	4.2	5.3	9.5	-2.6	-2.3	-1.6	-2.4	-2.1	-2.4	-2.1	-3.1	-2.4	-3.0	-2.2	-2.1
Frequency of tiredness / lethargy in last 2 weeks	4.2	6.9	14.9	3.4	-1.4	3.4	3.3	3.5	3.3	3.9	1.5	0.9	2.7	-1.0	-2.0
Qualifications: NVQ or HND or HNC or equivalent	4.2	5.1	9.1	-2.5	-1.0	-2.6	-2.5	-2.4	-2.4	-2.3	-3.0	-2.6	-2.5	-1.9	-1.8
Tense / ‘highly strung’	4.1	6.7	15.9	3.6	-0.8	2.1	3.7	4.0	3.7	3.7	1.9	1.3	2.5	0.5	-0.7
Fed-up feelings	4.0	7.3	14.1	3.7	0.1	3.2	3.8	3.7	3.6	3.6	2.7	1.3	2.4	-0.4	-1.5
Smoking Status	3.9	9.4	18.8	-4.0	1.5	-3.4	-4.3	-4.3	-4.3	-3.6	-0.4	1.6	-0.9	2.2	3.9
Neuroticism score	3.9	8.0	18.6	3.6	-0.7	3.1	3.9	4.3	3.8	4.1	2.0	1.8	2.7	0.6	-0.6
Mean time to correctly identify matches	3.9	7.5	13.3	-3.6	-1.3	-3.1	-3.5	-3.6	-3.6	-3.6	-2.6	-2.1	-2.4	-1.9	-1.1
Neuroticism	3.8	9.2	20.6	3.8	-0.5	3.6	4.1	4.5	4.0	4.5	2.3	1.9	2.5	1.4	-0.2
Average weekly spirits intake	3.8	4.7	10.5	-3.0	-0.2	-2.1	-3.2	-2.9	-3.1	-2.6	-1.3	-1.7	-2.2	-1.4	-0.6
Worrier / anxious feelings	3.8	7.1	15.8	3.2	-1.5	3.6	3.6	3.7	3.5	4.0	1.7	1.4	2.5	0.2	-0.8
Mouth/teeth dental problems: Loose teeth	3.8	4.6	10.1	-2.8	-0.8	-3.1	-2.9	-2.8	-2.9	-3.2	-1.9	-0.3	-1.4	-0.4	0.7
Worry (Nagel 2018)	3.7	7.8	18.1	3.2	-1.8	3.3	3.6	3.8	3.5	4.3	1.9	2.1	2.6	1.8	0.5
Neuroticism (2016)	3.6	5.2	11.4	2.8	-0.4	2.5	3.0	2.9	2.6	3.4	1.8	2.4	2.7	1.0	0.6
Number of children fathered	3.4	3.8	6.9	-2.4	-0.5	-1.8	-2.2	-2.0	-2.2	-2.6	-2.6	-2.4	-2.3	-1.2	-0.9
Body fat percentage	3.2	12.6	25.7	4.7	0.7	4.8	4.6	5.1	4.7	4.4	3.4	2.2	3.3	1.4	-0.7
Glaucoma (self-reported)	3.1	3.6	7.5	2.1	-0.5	1.4	2.1	2.6	2.2	1.5	2.7	2.5	1.8	1.9	1.2
Average weekly red wine intake	2.9	4.2	8.3	-2.5	-2.0	-2.7	-2.7	-2.5	-2.6	-2.9	-1.5	-1.7	-1.4	-1.3	-0.5
Age at First Birth	2.8	4.0	11.1	2.7	0.3	2.0	2.4	2.9	2.5	2.0	3.3	1.5	1.8	0.6	-0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	2.8	3.6	10.4	2.3	1.1	2.4	2.4	2.9	2.4	3.2	1.4	0.7	0.6	1.0	0.2
Number of self-reported non-cancer illnesses	2.8	4.8	9.7	2.5	-0.5	2.6	2.8	3.1	2.9	2.8	0.0	-1.8	-1.2	-1.5	-3.1
Age at last live birth	2.7	3.9	8.0	1.8	1.8	1.1	1.8	2.1	1.7	2.1	2.5	2.4	1.6	2.8	2.4
Arm fat percentage (left)	2.7	10.7	22.4	4.3	0.9	4.7	4.2	4.7	4.4	4.2	2.7	1.7	2.9	0.7	-1.3
Alzheimer’s Disease (in mother)	2.6	3.1	6.0	2.2	1.0	2.4	2.3	2.4	2.4	1.9	2.4	0.3	0.1	1.7	0.0
Diabetes (mother)	2.6	3.4	6.0	-2.3	-1.0	-1.2	-2.4	-2.4	-2.5	-2.1	-1.4	-2.2	-1.9	-1.4	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	2.6	5.9	10.5	2.2	1.0	2.6	2.4	2.9	2.3	2.9	3.2	3.0	1.9	2.8	2.1
Alcohol intake frequency.	2.6	5.9	12.9	3.1	-0.2	3.6	3.3	3.5	3.4	3.2	0.7	-1.1	-0.1	-0.4	-2.8
Arm fat percentage (right)	2.5	10.0	21.4	4.2	0.8	4.6	4.1	4.5	4.2	4.0	2.7	1.7	2.8	0.8	-1.1
Breastfed as a baby	2.5	3.1	7.2	2.4	-0.2	2.4	2.1	2.1	2.1	2.2	2.7	0.9	1.6	-0.0	-0.4
Eye problems/disorders: Glaucoma	2.5	2.9	5.5	1.9	-1.3	1.0	2.1	2.3	2.2	1.2	2.3	2.0	1.6	1.8	0.9
Pain experienced in last month	2.5	4.2	7.7	2.3	0.4	0.8	2.1	1.8	2.0	1.4	2.8	2.5	2.7	2.7	2.4
Primary Biliary Cirrhosis	2.4	3.5	8.2	2.5	0.4	2.9	2.5	2.6	2.6	2.6	1.8	0.5	0.5	0.7	0.1
Hayfever/allergic rhinitis (self-reported)	2.4	3.1	7.4	2.5	0.9	2.0	2.7	2.4	2.6	2.2	1.4	-0.2	1.0	-0.4	-1.3
Mouth/teeth dental problems: Dentures	2.4	4.1	6.7	-2.5	-0.7	-2.0	-2.6	-2.6	-2.5	-2.2	-1.4	-2.1	-1.9	-2.2	-1.6
Reaction Time	2.3	4.5	8.4	-2.7	-0.8	-2.6	-2.4	-2.6	-2.5	-2.9	-2.3	-1.8	-1.8	-1.9	-1.2
Prostate Cancer	2.3	3.2	9.9	2.2	0.8	2.0	2.0	2.3	2.0	2.1	3.1	1.1	1.8	0.3	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.3	3.1	9.5	1.9	0.4	3.1	2.0	2.2	2.0	2.7	1.2	1.7	1.4	0.4	0.1
Trunk fat mass	2.3	9.8	21.4	4.2	0.4	4.1	4.2	4.6	4.3	3.9	2.5	1.5	3.0	-0.1	-1.7
Friendships satisfaction	2.3	2.8	14.1	-0.6	-1.5	-0.5	-0.7	-0.5	-0.7	0.0	-1.9	-1.9	-0.6	-3.8	-3.2
Relative age of first facial hair	2.2	4.6	8.3	2.9	0.8	0.3	2.7	2.7	2.7	1.8	2.8	2.7	2.8	1.3	0.4
Taking other prescription medications	2.2	3.4	7.8	2.3	-0.7	2.8	2.4	2.6	2.5	2.5	1.6	0.2	0.8	0.2	-1.5
Wheeze or whistling in the chest in last year	2.2	3.9	9.2	2.5	0.4	3.0	2.4	2.3	2.4	2.9	2.0	1.4	2.1	0.1	-0.3
Myopia	2.2	3.2	11.6	-1.7	2.3	-0.7	-1.9	-1.5	-1.9	-1.5	0.4	1.4	-1.0	2.5	3.4
Pack years of smoking	2.2	3.2	6.6	-2.3	0.5	-0.9	-2.4	-2.6	-2.3	-1.5	-2.3	-1.7	-2.6	-0.4	0.1
Crohns Disease (2017)	2.1	4.6	11.8	3.0	0.3	2.6	3.0	3.4	3.2	2.9	1.4	1.1	0.8	0.2	-0.5
Heel T-Score	2.1	17.1	28.4	4.5	1.7	4.7	4.7	4.9	4.7	4.9	5.3	4.2	3.4	4.2	3.3
Happiness	2.1	2.5	12.7	0.4	-1.9	-0.1	0.5	0.7	0.5	0.7	-1.1	-1.3	-0.2	-3.4	-3.6
Miserableness	2.1	3.7	6.5	2.5	0.6	2.3	2.4	2.5	2.3	2.4	2.4	1.4	2.0	1.3	0.1
Illnesses of father: High blood pressure	2.1	2.6	5.5	2.0	2.3	1.6	2.0	2.3	2.0	2.1	1.4	1.2	1.0	0.3	0.0
Supplements: Calcium	2.1	2.3	6.2	2.1	0.1	1.5	2.2	2.5	2.2	1.6	1.7	-0.6	-0.6	0.3	-1.0
Alzheimer’s Disease (including proxy)	2.0	2.9	7.7	2.0	0.4	2.8	2.1	2.4	2.2	2.2	1.4	-1.0	-1.5	0.6	-0.9
Medication: Simvastatin	2.0	3.0	5.2	-2.1	-2.0	-1.2	-2.0	-1.9	-2.0	-1.6	-2.3	-1.4	-1.1	-1.8	-1.8
Number of full sisters	2.0	2.4	6.4	-2.3	-1.2	-1.0	-2.5	-2.5	-2.5	-1.9	-0.7	-0.1	-0.2	-0.8	0.3
Commuting to job workplace: Car/motor vehicle	2.0	2.3	7.6	-1.1	-0.5	-1.2	-1.1	-1.4	-1.2	-0.9	-2.3	-2.0	-0.6	-2.8	-2.1
Illnesses of siblings: Diabetes	2.0	2.4	9.4	-0.9	-1.3	0.1	-0.9	-0.7	-0.8	-0.0	-1.7	-3.1	-2.3	-1.7	-2.6
Frequency of tenseness / restlessness in last 2 weeks	1.9	2.9	5.9	2.0	0.6	2.2	1.9	2.4	2.0	2.1	1.8	1.7	1.3	1.2	1.0
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.3	7.3	1.9	0.7	2.5	2.2	2.7	2.2	2.5	2.3	2.3	1.3	2.6	1.8
Headache pain in last month	1.9	3.2	16.4	0.1	-1.9	1.5	0.4	0.3	0.3	0.7	-1.3	-2.5	-1.0	-3.2	-4.0
Supplements: Zinc	1.8	2.0	4.4	1.7	2.1	1.6	1.5	1.2	1.5	1.9	1.3	0.8	1.1	1.3	1.0
Medication: Cholesterol lowering	1.8	2.7	6.0	-1.3	-2.4	-0.8	-1.3	-1.1	-1.2	-1.3	-2.0	-1.9	-1.6	-2.2	-2.5
Medication: Allopurinol	1.8	2.4	4.4	1.9	-0.9	1.8	2.1	1.8	2.0	2.1	1.3	0.8	1.8	-1.0	-1.3
Whole body fat mass	1.8	7.4	16.5	3.6	0.2	3.7	3.5	4.1	3.7	3.3	2.1	1.3	2.7	-0.3	-1.8
Had major operations	1.8	2.1	4.5	-1.4	-1.4	-1.1	-1.3	-1.2	-1.3	-1.0	-1.1	-2.1	-1.4	-2.0	-2.0
Intelligence (Savage-Jansen 2018)	1.7	5.3	14.4	-2.5	0.4	-3.8	-2.7	-2.6	-2.7	-3.1	0.7	2.2	0.9	1.3	3.1
Verbal and Numeric Reasoning (VNR)	1.7	4.0	11.7	-2.3	-0.7	-3.4	-2.5	-2.5	-2.4	-3.0	-0.0	1.4	0.6	0.3	2.1
Type 2 Diabetes (T2D) (2018)	1.7	3.2	14.1	1.9	-1.4	3.8	1.7	1.9	1.8	2.9	0.2	-0.6	0.1	-0.7	-1.6
Chronotype (morning person)	1.7	3.9	11.7	2.0	-0.6	2.2	2.2	2.2	2.2	1.9	-0.3	-1.2	1.0	-3.0	-3.4
Angina	1.7	2.2	7.9	0.4	-1.9	0.8	0.6	1.0	0.7	0.6	-0.4	-2.5	-2.5	-1.5	-2.8
Pack years adult smoking proportion	1.7	2.6	5.5	-2.2	0.6	-0.6	-2.2	-2.3	-2.2	-1.2	-2.1	-1.3	-2.3	-0.4	0.3
Schizophrenia (2018)	1.6	3.4	12.7	0.6	-2.2	3.6	1.0	1.7	1.0	2.6	-1.1	-2.0	-1.9	-0.8	-2.1
Impedance of leg (right)	1.6	7.6	13.8	3.7	1.0	2.9	3.7	3.3	3.6	3.0	3.4	1.0	0.2	3.3	2.2
Qualifications: CSEs or equivalent	1.6	2.1	5.6	2.0	0.6	1.9	1.9	1.4	1.8	1.4	1.1	1.1	2.4	0.1	-0.1
Impedance of leg (left)	1.6	7.7	13.5	3.7	0.8	3.2	3.7	3.3	3.6	3.3	3.4	1.3	0.6	3.1	2.2
Angina (self-reported)	1.6	2.2	7.5	0.2	-2.0	0.7	0.4	0.7	0.5	0.4	-0.5	-2.5	-2.5	-1.5	-2.7
Pain type(s) experienced in last month: Hip pain	1.6	2.0	4.6	-1.7	-0.4	-1.6	-1.7	-1.3	-1.5	-2.0	-1.6	-1.5	-2.1	-0.7	-0.7
Alcohol drinker status: Never	1.6	1.9	5.6	1.7	0.5	2.4	1.7	1.6	1.6	2.1	1.4	-0.0	1.1	0.1	-0.9
Schizophrenia (2014)	1.5	3.4	10.6	0.1	-2.0	3.3	0.8	1.1	0.7	2.3	-1.9	-2.6	-2.2	-1.2	-2.2
Health satisfaction	1.5	2.0	8.7	-0.4	-0.5	-0.1	-0.5	-0.2	-0.4	0.3	-1.9	-1.9	-1.4	-3.0	-2.7
Arm fat mass (left)	1.5	6.0	12.9	3.1	0.2	3.6	3.1	3.6	3.2	3.1	1.2	0.5	2.1	-1.1	-2.5
Guilty feelings	1.5	2.3	7.3	1.7	-1.1	0.3	1.9	2.1	1.8	1.5	0.7	1.3	2.7	-1.0	-1.4
Irritable Bowel Disease (IBD)	1.4	3.2	8.8	2.4	0.5	2.3	2.3	3.0	2.5	2.4	1.9	0.1	-0.1	0.7	-0.2
Crohns Disease (2012)	1.4	2.2	6.7	1.8	-0.2	2.6	1.8	2.2	2.0	2.3	0.6	-0.3	-0.6	-0.3	-0.7
Diverticular disease/diverticulitis (self-reported)	1.4	1.6	3.6	-1.5	-0.4	-1.8	-1.6	-1.9	-1.6	-1.6	-1.8	-0.4	-0.5	-0.4	0.5
Fluid intelligence score	1.4	2.8	7.7	-2.2	-1.2	-2.8	-2.2	-1.9	-2.1	-2.8	-0.6	1.1	0.1	-0.2	1.1
Trunk fat-free mass	1.4	8.1	33.6	-2.2	-1.8	-1.9	-1.8	-1.6	-1.8	-1.9	-3.9	-2.9	-1.1	-5.8	-4.7
Prospective memory result	1.4	1.7	3.9	2.0	0.5	0.9	1.7	1.5	1.7	1.4	2.0	0.2	1.7	-0.1	-0.7
Arm fat mass (right)	1.4	5.9	13.1	3.1	0.1	3.5	3.1	3.6	3.3	3.0	1.3	0.7	2.2	-0.8	-2.2
Trunk predicted mass	1.4	8.1	34.0	-2.2	-1.9	-1.9	-1.8	-1.5	-1.8	-1.8	-3.9	-2.8	-1.0	-5.8	-4.8
Length of working week for main job	1.4	1.5	7.2	-0.6	0.1	-0.8	-1.0	-0.4	-1.0	-0.9	-0.7	-1.3	-0.7	-2.7	-2.5
Medication: Seretide 50 evohaler	1.4	1.7	3.7	1.8	1.4	1.9	1.6	1.7	1.7	1.7	1.1	0.5	0.4	0.2	-0.1
Arm predicted mass (right)	1.4	7.1	30.3	-2.2	-2.0	-1.6	-1.9	-1.6	-1.8	-1.8	-3.7	-2.3	-0.4	-5.5	-4.5
Illness, injury, bereavement, stress in last 2 years	1.4	1.7	7.7	0.9	0.8	0.2	0.9	1.0	0.9	0.2	1.8	1.7	0.7	2.8	1.9
Medication: Co-codamol	1.3	1.5	3.7	-1.9	-1.1	-1.2	-1.9	-1.5	-1.9	-1.3	-0.9	-0.1	0.1	-1.1	-0.5
Nervous feelings	1.3	2.5	5.0	1.6	-1.3	1.1	1.9	2.2	1.9	2.2	1.4	1.5	1.9	1.1	0.6
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	7.9	0.5	-0.9	0.0	0.6	1.0	0.6	0.4	-0.5	-2.2	-1.3	-1.8	-2.8
Illnesses of siblings	1.3	1.8	7.2	0.5	0.6	-0.9	0.2	-0.2	0.1	-0.2	0.7	2.4	2.7	1.1	2.6
Lung cancer (father)	1.3	1.5	3.1	-1.3	-0.9	-1.3	-1.3	-1.5	-1.4	-1.5	-0.9	-1.8	-1.0	-1.2	-1.1
Comparative body size at age 10	1.3	3.7	8.1	-2.8	-0.1	-1.8	-2.8	-2.6	-2.7	-2.8	-2.4	-0.1	-0.6	0.0	0.5
Chest pain or discomfort	1.3	1.9	8.6	0.7	-1.7	0.8	0.8	1.0	0.7	1.0	-1.2	-1.2	-0.8	-2.2	-2.9
Family relationship satisfaction	1.3	1.6	9.3	0.4	-0.9	0.1	0.3	0.8	0.4	0.4	-0.9	-0.9	-0.3	-2.8	-3.1
High cholesterol (Self-reported)	1.3	2.2	4.8	-1.7	-2.2	-1.1	-1.7	-1.7	-1.8	-1.4	-1.8	-0.7	-0.9	-1.7	-1.3
Mean Putamen Volume	1.2	1.3	3.1	1.5	1.8	1.2	1.4	0.8	1.4	1.1	0.7	1.0	1.0	1.1	1.2
Fasting Glucose	1.2	1.4	3.5	1.6	0.0	1.0	1.9	1.6	1.9	1.1	0.7	-1.2	-0.6	-0.2	-1.1
Hand grip strength (left)	1.2	3.3	6.0	-2.2	-0.3	-2.4	-2.4	-1.8	-2.4	-2.4	-1.9	-0.5	-0.5	-2.4	-1.1
Hip circumference	1.2	5.0	9.9	2.6	-0.2	3.1	2.8	3.1	2.9	2.7	1.0	1.6	3.1	-0.4	-1.3
Arm fat-free mass (right)	1.2	6.3	29.0	-1.8	-1.9	-1.4	-1.5	-1.2	-1.5	-1.6	-3.4	-2.1	-0.2	-5.4	-4.4
Diabetes diagnosed by doctor	1.2	1.9	8.7	1.0	-1.4	2.9	0.8	1.0	0.9	2.2	-0.3	-0.7	0.2	-1.3	-1.9
Illnesses of father: None of the above (group 1)	1.2	1.5	3.9	-1.3	-1.1	-2.0	-1.3	-1.6	-1.4	-1.9	0.1	0.2	-0.0	1.0	1.3
Commuting to job workplace: Public transport	1.2	1.5	4.4	-1.0	0.6	-1.5	-0.8	-1.1	-1.0	-1.4	1.1	0.8	-0.4	2.1	2.1
Arm fat-free mass (left)	1.2	5.9	25.6	-1.9	-2.0	-1.2	-1.5	-1.1	-1.5	-1.4	-3.4	-2.1	-0.5	-5.1	-4.3
Rheumatoid Arthritis	1.1	1.5	4.8	-1.6	-0.9	-1.4	-1.7	-1.4	-1.6	-2.2	-1.0	-0.1	-0.5	-0.8	-0.3
Blood Platelet Count	1.1	12.9	32.5	-4.8	1.2	-5.7	-4.6	-4.8	-4.8	-4.5	-3.6	-1.6	-2.2	-0.2	1.5
Qualifications: A levels/AS levels or equivalent	1.1	2.4	10.3	-0.3	2.3	-0.8	-0.4	0.0	-0.4	-0.7	1.5	2.1	0.4	2.6	3.2
Depression (self-reported)	1.1	1.3	3.2	1.3	-1.1	1.8	1.3	1.7	1.4	1.6	0.9	0.8	0.8	0.2	-0.2
Gout (self-reported)	1.1	1.5	2.9	1.4	-1.3	1.1	1.7	1.3	1.6	1.6	1.4	0.8	1.4	0.1	-0.3
Leg fat percentage (right)	1.1	3.9	9.3	2.6	0.2	2.8	2.4	3.0	2.6	2.1	1.9	1.3	1.9	0.9	-0.6
Loneliness, isolation	1.1	1.5	3.9	1.6	-0.3	0.4	1.6	1.6	1.6	1.1	1.2	0.8	2.0	-0.8	-1.3
Leg fat percentage (left)	1.1	4.0	9.0	2.5	0.1	2.9	2.3	3.0	2.5	2.2	1.9	1.5	2.2	0.7	-0.6
Commuting to job workplace: Cycle	1.1	1.4	6.0	0.8	2.4	1.2	0.6	0.8	0.7	1.0	0.9	1.4	1.3	1.2	1.2
Arm predicted mass (left)	1.1	5.7	25.0	-1.8	-1.9	-1.1	-1.4	-1.1	-1.4	-1.4	-3.2	-2.2	-0.5	-5.0	-4.3
Bipolar Disorder or Schizophrenia	1.0	2.6	10.9	0.3	-1.7	3.3	0.9	1.5	1.0	2.5	-1.5	-1.4	-1.9	-0.1	-1.2
Serious illness, injury or assault to yourself	1.0	1.3	2.4	1.2	-0.6	1.5	1.2	1.5	1.3	1.5	0.3	0.3	0.3	-1.4	-1.6
Ever highly irritable/argumentative for 2 days	1.0	1.2	4.1	0.1	-2.0	0.9	0.4	0.4	0.3	0.8	-0.6	-1.4	-0.7	-1.6	-2.0
Migraine (self-reported)	1.0	1.2	4.2	1.0	1.1	2.0	0.9	1.0	0.8	1.7	0.5	-0.4	0.8	-0.8	-1.4
Suffer from ‘nerves’	1.0	1.5	3.6	1.1	-1.2	1.8	1.5	1.5	1.2	1.9	0.4	0.9	1.8	0.6	0.1
Mineral and other dietary supplements	1.0	1.3	7.7	0.7	0.3	-0.4	0.5	0.5	0.5	0.1	1.1	2.4	2.8	0.4	0.7
Ever taken oral contraceptive pill	1.0	1.1	3.5	-0.9	1.1	-1.9	-1.2	-1.4	-1.2	-1.4	-0.0	0.5	0.3	0.2	1.3
Cholesterol lowering medication	1.0	1.5	4.0	-1.1	-2.0	-0.1	-0.9	-0.8	-1.0	-0.0	-1.7	-1.4	-1.2	-1.6	-1.6
Body Mass Index (BMI) (2010)	0.9	1.3	3.0	1.6	0.1	1.1	1.7	1.5	1.7	1.5	-0.0	-0.0	1.0	-0.6	-1.0
Lung FVC	0.9	4.5	10.9	-2.7	-0.7	-3.3	-2.6	-2.6	-2.5	-3.1	-1.2	-1.5	-2.3	0.8	0.9
Number of treatments/medications taken	0.9	1.6	4.7	1.2	-0.7	1.2	1.3	1.9	1.4	1.5	0.4	-1.0	-1.2	-0.7	-2.2
Sensitivity / hurt feelings	0.9	1.6	4.8	1.8	0.1	1.0	1.9	2.2	1.9	1.6	0.2	0.9	0.5	0.8	0.3
Frequency of depressed mood in last 2 weeks	0.9	1.2	2.7	1.4	0.0	1.4	1.4	1.5	1.4	1.6	0.7	1.0	1.1	-0.3	-0.4
Ever had hysterectomy (womb removed)	0.9	1.0	3.7	1.0	0.4	1.4	1.0	0.6	0.9	1.5	0.8	1.0	1.9	-0.1	-0.0
Hand grip strength (right)	0.9	2.4	6.0	-1.8	0.2	-1.4	-2.0	-1.5	-2.0	-1.8	-1.6	-1.1	-0.9	-2.5	-1.4
Diabetes (self-reported)	0.9	1.3	4.7	0.7	-1.5	2.2	0.5	0.8	0.6	1.4	-0.3	-0.7	-0.1	-1.5	-2.0
Illnesses of mother	0.9	1.1	3.7	-1.0	0.7	-1.3	-1.1	-1.5	-1.2	-1.1	-0.6	0.5	-0.1	0.8	1.9
Pulse wave Arterial Stiffness index	0.9	1.1	5.4	0.2	-1.3	-0.1	0.2	-0.1	0.1	-0.3	-0.8	-1.4	-0.1	-2.1	-2.3
Birth weight	0.9	2.0	3.5	-1.9	-1.2	-1.2	-1.6	-1.3	-1.5	-1.1	-1.4	-1.7	-1.2	-1.6	-1.8
Age at first live birth	0.9	1.6	3.8	1.1	1.0	0.0	0.9	1.4	1.0	1.0	1.9	1.6	1.3	1.8	1.5
Pulse wave peak to peak time	0.9	1.0	4.9	0.0	1.0	0.3	0.1	0.3	0.1	0.6	0.8	1.5	0.3	2.0	2.2
Medication: Aspirin	0.9	1.2	6.5	-1.3	-0.5	-0.9	-1.2	-0.8	-1.1	-1.2	-0.6	-1.1	-2.6	0.0	-0.4
Whole body fat-free mass	0.9	4.9	26.1	-1.2	-1.4	-1.0	-0.8	-0.5	-0.8	-0.9	-2.9	-1.9	0.0	-5.1	-4.4
Medication: Aspirin	0.9	1.2	5.4	-1.2	-0.8	-0.9	-1.2	-0.9	-1.2	-1.2	-0.4	-1.2	-2.3	-0.2	-0.7
Whole body water mass	0.9	5.1	25.9	-1.4	-1.5	-1.1	-1.0	-0.7	-1.0	-1.0	-2.9	-2.0	-0.1	-5.1	-4.4
Ever had prostate specific antigen (PSA) test	0.9	1.0	2.2	-1.2	0.6	-1.1	-1.1	-0.9	-1.1	-1.2	-1.1	-0.8	-1.5	-1.0	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.8	1.3	-0.3	1.2	1.4	1.4	1.5	1.7	0.7	0.7	0.9	0.1	-0.4
Breast Cancer	0.8	2.0	9.9	0.7	-0.8	1.9	0.6	0.6	0.6	1.4	0.3	-1.8	-0.1	-2.2	-3.1
Vitamin and mineral supplements	0.8	1.1	3.0	-1.3	-0.6	-0.9	-1.5	-1.7	-1.6	-1.0	-0.3	0.9	0.8	0.6	0.9
Relative age voice broke	0.8	1.3	2.8	1.7	1.2	0.5	1.5	1.5	1.6	0.8	1.6	1.0	0.4	0.7	0.3
Supplements: Glucosamine	0.8	1.0	2.5	-1.0	-0.4	-1.5	-1.3	-1.0	-1.2	-1.6	-0.2	-0.8	-1.4	0.4	0.6
Waist circumference	0.8	2.9	6.3	1.8	-0.5	2.5	1.7	2.3	1.9	1.9	0.9	0.6	1.8	-1.5	-2.4
Number of incorrect matches in round	0.8	1.4	2.7	1.3	-1.6	1.6	1.5	1.6	1.6	1.5	-0.2	-0.5	0.3	0.0	-1.1
Medication: Amlodipine	0.8	1.1	2.6	-1.4	0.4	-1.2	-1.6	-1.5	-1.6	-1.1	-1.1	-0.7	-0.1	-0.6	-0.2
Qualifications: College or University degree	0.8	2.4	7.8	-0.0	2.1	-1.3	-0.1	0.2	-0.1	-0.3	1.8	2.8	1.6	1.9	2.8
Leg fat mass (right)	0.8	3.0	7.3	2.2	0.2	2.3	2.2	2.7	2.3	1.8	1.1	0.8	1.9	-0.5	-1.6
Illnesses of father: Heart disease	0.8	1.2	2.9	-0.4	-1.0	-0.8	-0.2	-0.1	-0.2	-0.9	-1.5	-1.6	-1.7	-1.4	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	3.4	1.8	1.2	1.2	1.8	1.7	1.8	1.8	-0.1	0.6	1.0	-1.0	-0.6
Long-standing illness, disability or infirmity	0.8	1.2	3.9	0.2	-1.7	1.0	0.2	0.5	0.3	1.0	-1.6	-1.0	-0.3	-1.7	-2.0
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	3.1	0.4	0.6	0.1	0.3	0.7	0.3	0.1	1.2	1.7	1.1	1.4	1.6
Qualifications: nursing, teaching	0.8	1.2	3.1	1.3	0.8	-0.1	1.3	1.5	1.3	0.7	1.4	1.8	1.0	0.8	0.6
Supplements: Fish oil (including cod liver oil)	0.8	1.0	4.9	0.4	-0.3	0.7	0.6	0.3	0.6	0.8	-0.4	-2.2	-1.8	-0.8	-1.6
Average weekly beer plus cider intake	0.8	1.1	4.1	-1.4	1.0	-1.0	-1.6	-2.0	-1.7	-1.0	-0.2	-0.0	0.1	-0.1	0.7
Risk taking	0.8	1.1	5.3	0.4	2.3	-0.2	-0.1	0.1	-0.1	-0.0	1.8	1.2	-0.1	1.5	1.6
Ever depressed for a whole week	0.8	0.9	3.8	-0.0	-0.8	-1.3	-0.0	0.2	0.0	-0.2	-0.7	-1.7	-1.1	-1.1	-1.9
Unable to work because of sickness or disability	0.8	1.1	1.9	-1.3	0.8	-1.1	-1.2	-1.3	-1.3	-0.5	-1.3	-1.4	-0.9	-0.9	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.2	-0.9	-1.5	-1.3	-0.9	-0.8	-0.9	-0.9	-1.5	-1.0	-0.2	-1.2	-1.0
Multivitamins +/- minerals	0.7	0.8	2.6	1.1	0.2	1.0	1.3	1.6	1.3	1.0	0.4	-0.5	-0.5	-0.6	-0.8
Weight	0.7	3.6	8.4	2.1	-0.2	2.1	2.2	2.7	2.2	1.9	0.4	0.3	2.0	-2.2	-2.9
Pulse wave reflection index	0.7	0.9	2.9	-0.2	-1.3	-0.6	0.0	-0.4	-0.1	-0.5	-1.7	-1.4	-0.6	-1.5	-1.3
Chronic bronchitis/emphysema (mother)	0.7	0.9	4.4	0.1	0.3	2.1	-0.0	0.0	0.1	1.6	-0.6	-0.2	0.5	-1.3	-1.3
Exposure to tobacco smoke outside home	0.7	1.0	2.7	-1.0	-0.2	-1.6	-1.4	-1.4	-1.4	-1.4	-0.0	0.4	0.6	-0.6	0.4
Shortness of breath walking on level ground	0.7	0.8	4.7	0.9	-0.3	0.1	0.8	0.9	0.8	0.1	0.5	-1.0	-0.5	-1.2	-2.2
Average weekly champagne plus white wine intake	0.7	1.0	2.6	-0.2	-0.9	-0.8	0.1	-0.1	0.2	-0.6	-1.4	-1.4	-1.2	-1.6	-1.6
Medication: Bendroflumethiazide	0.7	1.1	5.6	1.0	0.6	-0.7	0.8	1.2	0.9	-0.2	2.4	0.5	-0.2	1.9	0.5
Ever smoked	0.7	1.3	5.7	0.1	0.1	-0.9	-0.1	0.1	-0.1	-0.1	1.0	2.4	1.8	1.5	1.8
Leg fat mass (left)	0.7	2.9	7.0	2.1	0.2	2.3	2.1	2.6	2.1	1.8	1.0	0.9	1.9	-0.6	-1.5
Alzheimer’s Disease (in father)	0.6	0.6	4.8	-0.0	0.0	1.1	0.1	0.3	0.1	0.5	-0.4	-1.3	-2.2	0.1	-0.4
Ulcerative Colitis (UC)	0.6	1.2	3.0	1.1	0.9	1.3	1.0	1.7	1.1	1.3	1.7	-0.8	-0.9	0.7	-0.2
HbA1C	0.6	0.7	2.6	0.2	-1.6	-0.4	0.1	0.1	0.4	-0.4	-0.6	-1.1	0.3	-1.3	-1.6
Cardiovascular Disease	0.6	1.9	5.3	1.8	0.3	1.9	1.8	1.7	1.8	2.3	0.9	0.8	0.9	0.7	-0.0
Hearing difficulty/problems: Yes	0.6	0.9	1.9	-1.1	0.2	-0.9	-1.3	-1.4	-1.4	-1.0	-0.1	-0.5	-0.3	-1.2	-0.6
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	2.2	1.0	-0.7	1.5	1.0	0.7	1.0	1.4	-0.2	-0.3	0.7	-0.3	-0.7
Average weekly fortified wine intake	0.6	0.7	2.6	0.8	1.6	-0.2	0.7	0.8	0.7	0.1	1.4	1.0	0.4	0.9	0.8
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.2	-0.7	0.9	-0.4	-0.7	-0.7	-0.7	-0.7	-1.1	-1.5	-1.0	-0.3	-0.7
Chronic bronchitis/emphysema (father)	0.6	0.7	2.4	-0.8	-0.2	0.4	-0.9	-1.0	-0.8	0.2	-1.1	-0.9	-0.1	-1.6	-0.9
Mouth/teeth dental problems	0.6	1.0	2.3	1.3	0.4	1.5	1.3	1.0	1.3	0.9	-0.0	0.1	-0.6	1.3	1.1
Father’s age at death	0.6	0.8	3.5	-0.6	-0.4	0.8	-0.6	-0.4	-0.6	0.4	0.6	1.9	1.4	0.7	1.5
Number of live births	0.6	0.8	2.4	0.7	-1.5	0.7	0.7	0.5	0.6	1.0	1.1	1.1	1.6	0.6	0.4
Noisy workplace	0.6	0.8	3.7	0.1	-0.0	1.0	-0.1	-0.3	-0.0	0.4	-0.3	-1.7	-0.9	-1.1	-1.9
Medication: Lansoprazole	0.6	0.7	1.9	0.1	-1.2	1.4	0.3	0.7	0.5	0.8	-0.5	-0.7	-1.1	-0.6	-1.2
Loud music exposure frequency	0.6	0.7	3.2	0.4	1.8	0.7	0.3	0.2	0.4	0.6	0.5	1.2	0.5	1.0	1.3
Blood clot in the leg (DVT)	0.6	0.8	2.3	-0.6	-1.5	-1.2	-0.5	-0.4	-0.6	-0.8	-1.3	-0.9	-0.1	-1.1	-1.0
High blood pressure (siblings)	0.6	0.8	3.5	-0.8	-0.9	0.6	-0.4	-0.1	-0.3	0.4	-0.9	-1.3	-1.9	-0.5	-1.4
Worry too long after embarrassment	0.6	0.9	3.4	1.1	-0.5	1.0	1.4	1.5	1.3	1.9	0.1	0.3	0.4	0.2	-0.2
Medication for pain relief, constipation, heartburn	0.6	1.1	3.1	-0.9	-0.5	-1.4	-1.2	-1.3	-1.2	-1.6	0.3	0.8	1.8	-0.2	0.6
Heart disease (mother)	0.6	0.7	3.6	0.5	-1.9	-0.1	0.6	0.9	0.6	-0.2	0.4	-0.7	-0.5	-0.7	-1.6
Overall health rating	0.6	1.4	5.4	1.2	-0.7	0.8	1.1	1.3	1.2	1.3	-1.0	-0.7	0.3	-1.6	-2.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	4.3	1.2	0.5	0.6	1.2	1.1	1.3	1.0	1.4	0.5	0.4	2.1	1.4
Basal metabolic rate	0.6	3.3	19.5	-0.3	-1.1	0.0	0.1	0.4	0.1	-0.0	-2.0	-1.3	0.5	-4.4	-4.1
Age started oral contraceptive pill	0.6	0.7	1.4	1.2	-1.1	0.7	1.0	1.1	1.0	0.5	1.1	0.3	0.3	1.1	0.4
Heart attack/myocardial infarction (self-reported)	0.6	0.7	2.6	-0.3	-1.4	1.0	0.1	0.4	0.2	0.2	-0.3	-1.2	-1.6	-0.7	-1.3
Alcohol drinker status: Previous	0.6	0.7	1.9	-1.0	-1.1	-0.4	-1.0	-0.6	-0.9	-0.3	-1.1	-0.6	-0.6	-0.8	-1.4
Type 2 Diabetes (T2D) (2012)	0.5	0.5	1.7	-0.8	1.3	-1.0	-0.8	-1.0	-0.9	-0.6	-0.8	-0.3	0.2	-0.4	-0.1
Systolic blood pressure, automated reading	0.5	1.5	5.2	-0.4	-2.3	0.2	-0.3	-0.5	-0.3	-0.0	-1.2	-2.0	-1.1	-1.5	-2.1
Townsend deprivation index at recruitment	0.5	0.7	2.5	-0.1	1.6	1.2	-0.3	0.1	-0.3	0.7	0.9	1.1	0.3	0.8	1.2
Age when periods started (menarche)	0.5	1.1	3.3	-1.0	1.4	-1.3	-1.1	-1.0	-1.1	-0.4	0.5	1.1	0.4	1.1	1.8
Stomach or abdominal pain in last month	0.5	0.6	3.5	-1.3	-0.1	0.0	-0.6	-0.6	-0.7	-0.7	-1.9	0.5	-0.5	0.0	0.4
Hair/balding pattern: Pattern 2	0.5	0.6	2.4	-0.6	-0.5	-0.8	-0.8	-0.4	-0.8	-0.9	-0.9	0.0	0.1	-1.5	-0.9
Heart attack	0.5	0.6	2.3	-0.3	-1.4	1.1	0.1	0.4	0.3	0.2	-0.4	-1.0	-1.5	-0.4	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	4.5	1.7	1.2	0.5	2.1	2.0	2.1	1.2	0.6	-0.8	-0.6	0.5	-0.2
Exposure to tobacco smoke at home	0.5	0.6	3.3	-0.3	0.6	-1.2	-0.1	-0.4	-0.3	-0.6	-0.1	0.8	-0.1	1.3	1.8
Hair/balding pattern: Pattern 4	0.5	1.1	2.2	-1.0	-1.2	-0.9	-1.3	-1.2	-1.3	-1.4	0.6	0.9	0.8	0.8	1.5
Birth weight of first child	0.5	0.8	2.4	-0.1	-1.2	1.4	0.3	0.1	0.3	1.1	-1.1	-1.3	-0.0	-1.0	-1.6
Smoking status: Previous	0.5	0.8	2.3	0.9	-0.8	0.4	1.1	1.3	1.1	0.8	0.2	1.2	1.5	0.3	0.0
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.5	0.7	0.7	-0.2	0.8	0.9	0.7	0.7	1.2	1.2	0.9	1.2	1.1
Financial situation satisfaction	0.5	0.6	2.3	0.8	0.2	0.1	0.7	0.5	0.6	0.9	-0.3	-0.6	0.3	-1.5	-1.4
Tinnitus: Yes, now most or all of the time	0.5	0.6	2.3	-0.3	1.4	-0.1	-0.0	-0.2	-0.2	0.4	0.2	0.1	-1.2	1.3	1.5
Fractured/broken bones in last 5 years	0.5	0.7	1.4	1.2	1.1	0.4	1.1	0.8	1.1	0.5	1.0	0.8	1.1	-0.2	0.0
Depression (Nagel 2018)	0.4	0.6	1.9	0.8	-0.7	1.4	1.0	1.1	0.9	1.4	0.1	0.6	0.1	-0.1	-0.2
Coronary Artery Disease (CAD)	0.4	0.5	2.1	-0.2	1.4	-0.4	-0.5	-0.2	-0.5	-0.4	1.0	-0.5	-1.2	0.7	0.5
BMI	0.4	2.3	5.2	1.6	0.6	2.2	1.4	2.1	1.6	1.3	-0.2	0.3	1.8	-1.8	-2.3
Height	0.4	7.9	36.2	1.4	-1.3	-0.0	2.1	1.7	1.9	1.2	-1.2	-3.4	-1.5	-6.0	-5.8
Lung FEV1/FVC ratio	0.4	2.3	9.9	2.0	0.6	1.6	1.9	3.1	2.1	1.7	0.7	0.4	0.1	0.8	-1.0
Ever used hormone-replacement therapy (HRT)	0.4	0.4	1.8	0.0	-1.3	0.6	0.1	-0.1	0.0	0.3	0.5	-0.9	-0.6	-0.9	-1.2
Medication: Metformin	0.4	0.5	1.7	-0.3	-1.3	1.1	-0.5	-0.3	-0.4	0.5	-0.9	-0.6	-0.5	-0.9	-0.9
Diabetes (father)	0.4	0.5	1.2	0.6	0.9	1.1	0.4	0.7	0.4	0.7	-0.5	-0.4	-0.6	-0.8	-1.0
Leg fat-free mass (left)	0.4	2.3	10.8	0.7	-0.4	0.8	1.0	1.3	1.0	0.9	-0.8	-0.3	1.3	-3.2	-3.3
Leg predicted mass (left)	0.4	2.3	10.5	0.8	-0.3	0.8	1.1	1.4	1.1	1.0	-0.7	-0.2	1.4	-3.2	-3.2
Past tobacco smoking	0.4	0.7	3.2	-0.3	0.6	0.1	-0.3	-0.6	-0.4	-0.2	-0.7	-1.8	-1.3	-1.0	-1.1
Financial difficulties in last 2 years	0.4	0.5	1.8	0.5	0.9	-0.4	0.1	0.1	0.1	0.1	1.1	1.1	1.4	0.2	0.9
Alcohol intake versus 10 years previously	0.4	0.7	2.8	0.6	0.9	0.2	0.9	0.6	0.8	0.5	-0.3	-0.8	0.2	-1.3	-1.7
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	4.5	1.7	0.3	-0.1	2.1	2.1	2.1	0.9	0.8	-0.7	-0.5	0.3	-0.5
Standing height	0.4	4.0	8.8	2.4	-0.5	1.2	3.0	2.7	2.8	2.3	0.7	-0.8	0.5	-2.6	-2.7
Peak expiratory flow (PEF)	0.4	1.0	3.4	1.4	1.1	0.1	1.5	1.8	1.5	0.9	0.8	-0.2	-0.3	0.1	-0.6
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.2	0.5	1.5	0.9	0.5	0.2	0.4	0.7	1.1	0.7	0.6	1.0	1.5
Eye problems/disorders: None of the above	0.4	0.5	3.0	-0.5	1.7	0.7	-0.4	-1.0	-0.6	0.1	-0.2	-0.3	-0.4	-0.0	0.7
Neck or shoulder pain in last month	0.4	0.6	1.5	-0.3	-0.6	0.9	-0.1	0.0	-0.1	0.6	-1.2	-0.9	-1.0	-1.1	-1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.2	0.5	-1.0	0.5	0.4	0.6	0.3	0.9	1.1	1.1	0.7	0.5	0.3
Leg fat-free mass (right)	0.4	2.3	12.4	0.5	-0.5	0.6	0.7	1.0	0.7	0.8	-1.0	-0.2	1.5	-3.5	-3.4
Eye problems/disorders: Cataract	0.4	0.5	1.6	0.8	-0.4	-0.1	0.6	1.2	0.8	0.2	0.5	1.0	0.3	1.3	0.3
Medication for cholesterol	0.4	0.6	1.6	1.1	0.5	-0.1	1.1	0.7	1.1	-0.1	0.5	0.8	1.3	0.7	0.8
Medication: Gliclazide	0.4	0.4	1.2	-0.8	-0.7	1.1	-1.1	-0.8	-1.0	-0.0	-0.5	0.2	0.1	-0.5	-0.2
Leg predicted mass (right)	0.4	2.3	12.2	0.5	-0.5	0.6	0.7	1.0	0.7	0.8	-1.0	-0.2	1.6	-3.5	-3.3
Hearing aid user	0.4	0.5	2.1	-0.4	-0.2	-1.5	-0.4	-0.8	-0.6	-1.1	-0.1	0.1	0.9	-0.7	-0.4
Number of operations (self-reported)	0.4	0.6	3.5	-0.7	-1.9	-0.5	-0.9	-0.8	-0.8	-0.0	-0.1	-0.8	-0.6	-0.3	-0.5
Diastolic blood pressure, automated reading	0.4	1.2	4.8	0.9	-0.6	1.3	0.8	1.1	0.9	1.2	-0.5	-0.5	1.0	-1.4	-2.2
Schizophrenia vs Biploar Disorder	0.3	0.3	1.0	0.4	-1.0	0.9	0.6	0.6	0.6	0.7	0.1	-0.5	-0.7	0.2	-0.2
Ovarian Cancer	0.3	0.4	2.3	-0.2	-0.0	-0.8	-0.4	-0.7	-0.5	-0.0	0.5	0.8	1.5	-0.5	-0.1
Triglycerides	0.3	0.5	1.8	0.3	1.1	-0.3	0.3	0.3	0.5	0.5	-0.5	1.3	0.5	0.6	1.3
Ulcerative Colitis	0.3	0.5	2.1	0.2	0.4	0.8	-0.0	0.8	0.2	0.7	0.3	-1.3	-1.5	0.1	-0.6
Hair Pigment	0.3	7.5	16.9	-3.6	-0.1	-3.0	-3.7	-4.1	-3.7	-3.7	-2.0	-2.3	-2.9	-0.6	0.4
Severe depression (siblings)	0.3	0.3	1.8	0.6	0.4	0.4	0.7	0.4	0.7	0.7	-0.2	0.4	1.4	0.0	0.3
Sitting height	0.3	2.4	11.5	-0.3	0.1	-2.6	0.3	-0.1	0.1	-1.3	-1.4	-1.7	-0.4	-3.4	-2.4
Body mass index (BMI)	0.3	1.3	3.5	1.0	-0.1	1.7	0.9	1.5	1.1	1.0	-0.1	0.5	1.7	-1.2	-1.9
Hearing difficulty/problems with background noise	0.3	0.5	1.4	-0.9	0.1	-0.5	-1.2	-0.9	-1.2	-0.5	-0.5	-0.1	-0.5	-0.7	-0.2
Had menopause	0.3	0.4	3.4	-0.6	-1.8	-0.4	-0.6	-0.5	-0.6	-0.3	0.8	0.2	0.1	-0.1	-0.3
Had other major operations	0.3	0.4	1.4	0.2	0.1	-0.5	-0.1	0.2	-0.1	0.5	0.6	1.2	0.5	0.9	1.1
Medication: Ramipril	0.3	0.4	1.6	0.1	-1.3	1.2	0.1	0.3	0.1	1.2	0.0	-0.3	-0.5	-0.2	-0.3
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	2.5	-0.0	1.5	-0.3	0.2	0.1	0.1	-0.2	-0.1	0.5	-0.6	1.2	1.6
Medication: Paracetamol	0.3	0.5	1.5	0.5	-0.7	0.6	0.6	0.7	0.6	0.5	-0.3	-0.8	-1.0	-0.8	-1.2
Number of full brothers	0.3	0.4	2.1	0.1	-0.0	-0.7	-0.0	-0.3	-0.1	-0.2	0.7	1.1	1.4	0.4	0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	3.3	-0.3	-1.8	0.5	-0.0	-0.3	-0.0	0.1	-0.5	-0.5	-0.2	-0.1	-0.2
Emphysema/chronic bronchitis	0.3	0.3	0.8	-0.6	0.6	-0.6	-0.7	-0.6	-0.7	-0.5	-0.9	0.3	-0.2	-0.4	-0.1
Medication: Ibuprofen	0.3	0.4	1.6	0.5	1.3	-0.5	0.6	0.6	0.6	0.2	0.6	-0.2	-0.9	0.7	0.5
Comparative height size at age 10	0.3	1.9	7.1	-0.6	-0.4	-0.9	-0.2	-0.4	-0.4	-0.2	-1.8	-2.4	-1.5	-2.7	-2.2
Leg pain on walking	0.3	0.4	3.1	-0.5	0.5	-0.5	-0.4	-0.3	-0.4	-0.2	0.1	-0.5	-1.8	0.6	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.9	-0.4	0.2	-0.9	-0.4	-0.4	-0.3	-0.7	-0.7	-0.9	-0.7	-0.6	-0.7
Commuting to job workplace: Walk	0.3	0.3	0.9	-0.4	-0.0	0.9	0.0	0.1	-0.0	0.4	0.5	0.7	-0.1	0.9	0.9
Breast cancer (self-reported)	0.3	0.4	2.0	0.0	-0.4	-0.4	-0.1	0.1	-0.2	0.1	0.7	1.4	1.3	0.4	0.6
Osteoporosis (self-reported)	0.3	0.4	3.0	0.3	-1.7	-0.2	0.4	0.7	0.3	0.0	-0.1	-0.6	-0.3	-0.3	-0.8
Osteoarthritis (self-reported)	0.3	0.4	2.0	0.0	-0.4	0.2	-0.0	0.2	0.2	0.3	-0.4	-1.3	-0.4	-0.9	-1.4
Medication: Lisinopril	0.3	0.3	1.7	0.4	-0.4	-0.5	0.4	0.5	0.4	0.2	0.5	-0.1	0.7	-0.8	-1.3
Medication: Atorvastatin	0.3	0.4	3.6	0.1	-1.9	0.4	-0.0	0.4	0.1	0.3	0.1	-0.4	-0.1	-0.6	-0.9
Bipolar Disorder (2018)	0.2	0.3	1.0	-0.3	-0.2	0.9	0.2	0.2	0.2	0.6	-1.0	0.1	-0.5	0.9	0.8
LDL Cholesterol	0.2	0.3	1.4	-0.2	-0.9	-1.2	-0.4	-0.2	-0.3	-0.7	-0.4	0.3	0.1	-0.4	-0.3
Lupus	0.2	0.4	1.3	0.6	-0.7	0.1	0.4	1.1	0.6	-0.1	0.7	-0.1	-0.8	0.4	-1.0
Blood Red Count	0.2	2.3	3.7	-1.8	-1.0	-1.8	-1.9	-1.6	-1.9	-1.7	-1.4	-1.5	-1.2	-1.4	-1.4
Systolic Blood Pressure	0.2	0.9	5.2	-0.1	-2.3	-1.1	0.1	-0.4	-0.1	-0.0	-1.5	-1.1	-0.3	-0.9	-0.8
Tanning	0.2	3.0	6.0	-2.4	1.1	-1.9	-2.3	-2.3	-2.4	-2.4	-1.5	-0.6	-1.7	-0.6	0.3
Medication for hormone replacement therapy	0.2	0.2	0.6	-0.8	-0.4	0.5	-0.8	-0.6	-0.8	0.0	-0.3	-0.1	-0.6	-0.1	0.1
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.7	-0.1	0.3	0.4	0.1	-0.1	-0.0	0.2	-0.6	-0.8	-0.5	-0.6	-0.8
High blood pressure (mother)	0.2	0.3	1.1	-0.4	0.7	-0.7	-0.3	-0.3	-0.3	-0.6	-0.7	-0.6	-1.0	-0.4	-0.5
Forced vital capacity (FVC)	0.2	0.6	1.8	1.0	0.1	-0.9	1.3	1.1	1.3	0.2	0.6	-1.0	-0.7	0.3	-0.0
Qualifications: None of the above	0.2	0.4	1.3	-0.7	-0.7	1.1	-0.8	-1.0	-0.7	-0.2	-0.6	-0.8	-0.3	-0.2	-0.1
Pain all over the body in last month	0.2	0.3	0.9	-0.2	-0.1	0.6	-0.1	-0.5	-0.1	1.0	-0.3	-0.9	-0.8	0.2	0.4
Pulse rate	0.2	0.3	1.5	0.3	1.2	-0.5	-0.0	0.3	0.1	0.2	0.7	0.5	1.0	0.7	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.3	0.3	1.1	-0.4	0.3	0.3	0.3	0.3	0.0	-0.3	-0.9	0.6	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.0	0.2	-0.3	0.3	0.4	1.0	0.4	0.8	-0.6	-0.2	-0.2	-0.7	-1.0
Medication: Omeprazole	0.2	0.3	0.9	0.4	-0.5	0.9	0.6	0.7	0.6	1.0	0.1	-0.1	-0.2	0.0	-0.5
Pulse rate, automated reading	0.2	0.5	3.1	-0.0	0.9	0.2	-0.5	0.1	-0.4	0.5	0.8	0.3	1.8	-0.4	-0.9
Supplements: Vitamin C	0.2	0.2	1.1	0.2	1.0	-0.2	0.1	-0.2	0.2	0.1	-0.4	-0.9	-0.2	-0.7	-0.5
Knee pain experienced in last month	0.2	0.2	1.2	-0.4	0.0	-0.6	-0.4	-0.5	-0.4	-0.3	-1.1	-0.1	0.0	-0.7	-0.6
Hypertension (Self-reported)	0.2	0.5	1.7	0.8	0.1	0.5	0.6	0.8	0.7	1.3	0.9	0.1	0.4	-0.2	-1.0
Handedness (chirality/laterality): Left-handed	0.2	0.3	1.6	-0.4	1.3	0.0	-0.4	-0.4	-0.4	0.1	0.3	0.3	0.1	0.6	0.9
Back pain experienced in last month	0.2	0.2	0.8	-0.3	-0.1	-0.0	-0.1	-0.0	-0.1	-0.0	-0.8	-0.5	-0.7	-0.8	-0.9
Medication: Paracetamol	0.2	0.3	0.9	0.3	0.1	0.6	0.4	0.5	0.5	0.6	-0.2	-0.6	-0.9	-0.4	-0.7
Vascular/heart problems diagnosed by doctor	0.2	0.6	3.6	0.1	0.6	0.3	0.2	-0.0	0.1	-0.6	-0.0	1.3	0.8	1.1	1.9
Heart disease (siblings)	0.2	0.2	1.3	-0.2	-1.1	0.6	0.0	-0.0	-0.0	-0.3	-0.1	-0.6	-0.4	-0.4	-0.8
Major Depression (MDD)	0.1	0.1	0.6	-0.3	-0.2	-0.4	-0.2	0.1	-0.2	-0.5	0.4	0.8	0.2	0.6	0.4
Bipolar Disorder (2011)	0.1	0.1	1.0	-0.5	0.2	0.1	-0.3	-0.3	-0.3	0.0	-1.0	0.1	0.0	-0.4	0.3
HDL Cholesterol	0.1	0.1	0.7	0.0	-0.8	-0.3	-0.0	-0.1	-0.1	-0.3	0.8	0.1	0.5	0.2	-0.3
Blood White Count	0.1	0.4	1.6	-0.1	0.3	-1.3	-0.7	-0.3	-0.7	-0.4	0.8	0.5	1.1	0.0	-0.3
Waist Hip Ratio (WHR)	0.1	0.4	1.2	0.2	1.1	0.4	-0.3	-0.0	-0.3	0.6	0.8	-0.1	-0.5	-1.0	-0.8
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.6	0.2	-0.7	0.2	0.1	0.3	0.1	0.5	-0.5	-0.5	-0.4	-0.2	-0.4
High blood pressure	0.1	0.3	1.1	0.5	0.4	0.1	0.3	0.4	0.3	1.1	0.6	-0.2	0.2	-0.3	-1.0
Alcohol usually taken with meals	0.1	0.2	0.5	0.4	0.1	0.1	0.7	0.7	0.7	0.2	-0.1	-0.2	-0.7	-0.1	-0.3
Time employed in main current job	0.1	0.2	0.7	0.1	-0.9	0.1	0.3	0.4	0.4	-0.3	-0.5	-0.0	0.5	-0.1	-0.5
Falls in the last year	0.1	0.1	0.4	0.3	-0.2	0.5	0.1	0.1	0.1	0.6	-0.1	0.1	-0.0	-0.2	0.0
Hair/balding pattern: Pattern 3	0.1	0.2	0.6	-0.2	-0.1	0.8	-0.2	-0.1	-0.2	0.6	-0.3	-0.4	-0.5	-0.1	-0.6
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.4	-0.0	-0.4	0.1	0.1	0.3	0.1	0.4	-0.4	0.3	0.6	-0.2	-0.6
Forced vital capacity (FVC), Best measure	0.1	0.5	1.4	0.6	1.2	-0.8	1.1	0.6	1.0	0.1	0.2	-1.0	-0.9	0.4	0.4
Medication: Blood pressure	0.1	0.1	0.4	-0.0	-0.6	-0.2	0.1	0.4	0.2	-0.0	-0.4	-0.4	-0.6	0.1	-0.7
Ever had bowel cancer screening	0.1	0.1	0.4	-0.3	0.1	-0.6	0.0	0.2	0.0	-0.3	0.3	-0.3	-0.6	0.5	-0.2
Wears glasses or contact lenses	0.1	0.1	0.7	0.2	0.9	0.0	0.3	0.4	0.2	0.5	-0.3	0.1	0.6	0.1	-0.1
Mother’s age at death	0.1	0.2	0.7	-0.3	0.5	-0.1	-0.3	-0.6	-0.4	-0.2	0.5	0.2	0.3	0.6	0.8
Medication: Blood pressure	0.1	0.2	1.1	-0.2	-0.7	0.1	-0.3	0.1	-0.2	0.3	0.4	-0.6	-0.8	-0.5	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.1	0.3	0.0	-0.4	0.0	-0.1	0.2	-0.1	0.1	0.1	0.6	0.1	0.3	0.2

Hub : Genes

CSDC2

Models

Trait associations