Best TWAS P=1.36e-09 · Best GWAS P=2.17e-10 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | IFT172 | 0.06 | 0.09 | enet | 16 | 0.09 | 3.9e-11 | 4.2 | 5.3 | 1.2e-07 | -0.75 | 0.43 | 0.57 | FALSE |
2 | GTEx | Adipose Subcutaneous | AC074117.10 | 0.06 | 0.04 | lasso | 5 | 0.02 | 4.8e-03 | 5.3 | -5.7 | 1.2e-08 | 0.65 | 0.46 | 0.25 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | AC074117.10 | 0.21 | 0.19 | enet | 23 | 0.18 | 1.6e-13 | 5.3 | -5.7 | 1.1e-08 | 0.66 | 0.47 | 0.53 | FALSE |
4 | GTEx | Esophagus Mucosa | AC074117.10 | 0.12 | 0.14 | lasso | 8 | 0.14 | 2.1e-09 | 5.3 | -5.4 | 6.1e-08 | 0.74 | 0.84 | 0.16 | FALSE |
5 | GTEx | Esophagus Muscularis | NRBP1 | 0.07 | 0.04 | lasso | 6 | 0.04 | 1.3e-03 | 5.3 | -5.4 | 5.7e-08 | 0.82 | 0.02 | 0.96 | FALSE |
6 | GTEx | Esophagus Muscularis | AC074117.10 | 0.17 | 0.14 | enet | 5 | 0.09 | 6.6e-06 | 5.3 | -5.4 | 6.1e-08 | 0.65 | 0.54 | 0.45 | FALSE |
7 | GTEx | Nerve Tibial | NRBP1 | 0.06 | 0.00 | enet | 9 | 0.02 | 2.0e-02 | 5.3 | -5.3 | 1.5e-07 | 0.61 | 0.34 | 0.53 | FALSE |
8 | GTEx | Ovary | AC074117.10 | 0.16 | 0.04 | enet | 9 | 0.05 | 2.0e-02 | 4.4 | -5.2 | 2.2e-07 | 0.77 | 0.05 | 0.76 | FALSE |
9 | GTEx | Testis | NRBP1 | 0.16 | 0.09 | lasso | 3 | 0.06 | 1.8e-03 | 5.3 | -5.9 | 4.2e-09 | 0.80 | 0.03 | 0.96 | FALSE |
10 | GTEx | Testis | AC074117.10 | 0.14 | 0.08 | lasso | 6 | 0.12 | 4.5e-06 | 4.5 | -5.8 | 7.7e-09 | 0.85 | 0.04 | 0.96 | FALSE |
11 | METSIM | Adipose | NRBP1 | 0.06 | 0.09 | lasso | 3 | 0.08 | 1.6e-12 | 5.3 | -5.5 | 4.4e-08 | 0.67 | 0.78 | 0.22 | FALSE |
12 | ROSMAP | Brain Pre-frontal Cortex | FTH1P3 | 0.04 | 0.01 | bslmm | 280 | 0.02 | 2.8e-03 | 5.3 | -5.4 | 7.9e-08 | 0.65 | 0.04 | 0.71 | FALSE |
13 | YFS | Blood | NRBP1 | 0.01 | 0.01 | lasso | 6 | 0.01 | 9.1e-06 | 4.5 | -5.1 | 3.0e-07 | 0.61 | 0.93 | 0.06 | FALSE |
14 | The Cancer Genome Atlas | Glioblastoma Multiforme | NRBP1 | 0.15 | 0.10 | lasso | 2 | 0.10 | 5.8e-04 | 5.3 | -5.3 | 1.1e-07 | 0.67 | 0.00 | 0.68 | FALSE |
15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FNDC4 | 0.13 | 0.06 | lasso | 2 | 0.05 | 1.1e-03 | -6.3 | 6.1 | 1.4e-09 | -0.99 | 0.00 | 0.94 | TRUE |