Hub : Genes

IFT172

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0630	0.0240	1.1e-08	0.095	0.065	0.091	0.070	0.090	1.3e-11	2.1e-08	3.9e-11	7.3e-09	4.8e-11
2	GTEx	Cells Transformed fibroblasts	0.0390	0.0220	5.8e-03	0.040	NA	0.013	NA	0.022	5.2e-04	NA	3.6e-02	NA	8.1e-03
3	GTEx	Spleen	0.1670	0.0830	5.2e-03	0.132	NA	0.027	NA	0.069	2.9e-04	NA	6.8e-02	NA	7.8e-03
4	ROSMAP	Brain Pre-frontal Cortex	0.0665	0.0344	5.7e-05	0.018	0.031	0.027	0.031	0.023	1.9e-03	5.8e-05	2.0e-04	7.0e-05	5.0e-04
5	TCGA	Head and Neck Squamous Cell Carcinoma	0.0202	0.0157	4.4e-03	0.010	0.019	0.013	NA	0.016	2.6e-02	2.7e-03	1.2e-02	NA	5.5e-03
6	TCGA	Lung Squamous Cell Carcinoma	0.0206	0.0152	6.1e-03	0.010	0.012	0.006	NA	0.003	2.4e-02	1.4e-02	5.4e-02	NA	1.3e-01
7	TCGA	Thyroid Carcinoma	0.0790	0.0470	8.4e-03	0.012	0.018	0.000	NA	0.007	2.2e-02	6.1e-03	3.2e-01	NA	6.3e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	2.6	4.1	8.4	-2.6	-1.4	-0.5	-2.9	1.5	0.7	-2.9
Bipolar Disorder or Schizophrenia	1.5	3.8	14.4	-0.2	1.3	1.5	0.6	-1.4	-2.3	-3.8
Depressed Affect (Nagel 2018)	0.8	1.6	3.3	-1.8	-1.4	-1.1	-0.9	1.4	1.2	0.4
Depression (Nagel 2018)	0.9	1.4	2.8	-1.7	-1.2	-0.7	-1.0	1.2	0.8	-1.4
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.3	1.2	0.5	1.0	0.1	-0.4	-0.4	0.2
Neuroticism (Nagel 2018)	0.3	0.8	4.0	-0.3	-0.4	-0.9	0.3	0.4	0.6	2.0
Schizophrenia (2018)	3.8	7.8	12.2	1.9	2.8	2.3	3.1	-3.1	-3.5	-2.5
Schizophrenia vs Biploar Disorder	7.0	9.2	20.3	3.7	3.0	1.4	4.5	-3.3	-2.7	1.4
Worry (Nagel 2018)	0.3	0.7	2.6	-0.5	-0.5	-0.8	-0.3	0.6	0.7	1.6
Alzheimer’s Disease (in mother)	0.3	0.4	1.0	-0.7	-0.3	-0.7	-1.0	0.6	0.1	-0.5
Alzheimer’s Disease (in father)	0.1	0.1	0.5	-0.0	-0.2	-0.7	0.4	-0.2	0.1	0.1
Alzheimer’s Disease (including proxy)	0.1	0.2	0.6	-0.1	0.3	-0.7	-0.1	-0.2	-0.5	-0.8
Crohns Disease (2017)	6.4	14.0	24.5	-5.0	-4.4	-0.8	-3.2	4.1	2.9	-4.3
Irritable Bowel Disease (IBD)	5.6	13.2	22.9	-4.8	-4.5	-2.0	-3.2	4.1	3.4	-2.4
Ulcerative Colitis (UC)	2.7	5.2	8.1	-2.8	-2.9	-2.2	-2.1	2.5	2.3	-0.1
Major Depression (MDD)	3.2	3.9	7.4	1.7	2.3	1.2	1.6	-2.4	-2.7	-1.2
Reaction Time	0.7	1.4	2.8	-1.5	-1.6	-0.4	-0.3	1.7	1.3	-0.5
Verbal and Numeric Reasoning (VNR)	0.8	1.8	4.8	2.2	1.5	1.3	0.9	-1.3	-1.1	0.2
Breast Cancer	0.3	0.7	2.7	-0.7	0.2	1.0	-0.7	-0.1	-0.7	-1.6
Ovarian Cancer	2.5	3.3	4.8	-1.8	-2.1	-0.9	-1.4	2.2	2.2	1.8
Prostate Cancer	0.8	1.1	5.0	-0.3	0.6	0.2	-0.2	-0.7	-1.3	-2.2
Age at First Birth	0.8	1.2	3.6	-0.8	-0.4	0.5	-1.7	0.7	0.5	-1.9
Bipolar Disorder (2011)	3.1	3.0	7.0	-2.6	-1.8	-0.3	-1.8	1.8	1.2	-1.7
Body Mass Index (BMI) (2010)	1.5	2.0	5.9	1.5	1.2	1.3	2.4	-1.3	-1.0	0.2
Coronary Artery Disease (CAD)	0.7	0.8	3.6	-0.9	-0.9	0.2	0.2	0.7	0.4	-1.9
Crohns Disease (2012)	2.5	4.0	9.4	-2.6	-2.2	0.3	-1.2	2.0	1.3	-3.1
Mean Putamen Volume	0.6	0.6	2.5	-0.1	0.4	1.2	-0.3	-0.1	-0.5	-1.6
Fasting Glucose	21.8	26.1	74.5	8.6	5.5	0.2	4.3	-5.4	-3.3	4.5
HbA1C	0.3	0.4	0.9	0.9	0.3	0.5	0.7	-0.4	-0.3	0.8
HDL Cholesterol	1.6	2.7	7.8	1.5	1.5	1.9	2.8	-1.1	-0.6	1.3
LDL Cholesterol	2.0	3.1	14.7	-1.4	-0.6	0.3	-2.0	0.7	-0.6	-3.8
Lupus	4.3	6.5	9.3	-2.7	-2.7	-2.8	-3.0	2.6	2.6	0.0
Neuroticism (2016)	0.3	0.4	0.9	0.4	1.0	0.4	0.7	-0.6	-0.4	0.6
Primary Biliary Cirrhosis	3.7	5.3	10.5	-3.2	-2.2	-2.4	-2.4	2.5	1.7	-1.2
Rheumatoid Arthritis	0.3	0.4	1.2	0.8	0.3	0.7	1.1	-0.4	-0.4	-0.2
Schizophrenia (2014)	3.3	7.2	11.1	1.6	2.7	2.5	2.7	-2.8	-3.3	-2.9
Triglycerides	101.1	165.5	302.8	-17.4	-12.5	-4.6	-14.6	12.3	7.4	-16.1
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.2	1.0	1.0	-0.3	0.8	-0.7	-0.3	1.1
Ulcerative Colitis	5.8	8.4	13.5	-3.7	-3.3	-3.3	-2.9	2.8	2.6	-0.6
Blood Eosinophil Count	1.1	8.7	28.0	-1.5	-2.5	-1.4	-1.0	2.9	3.7	5.3
Blood Platelet Count	13.2	153.5	272.2	-16.5	-12.5	-5.1	-13.8	12.9	9.4	-13.2
Blood Red Count	1.8	17.5	83.7	1.0	-0.6	-5.0	-1.4	1.1	3.0	9.1
Blood White Count	12.3	91.1	151.3	-12.3	-9.8	-4.8	-12.2	10.1	7.4	-7.8
Heel T-Score	0.4	2.8	4.4	1.8	1.9	1.1	2.1	-1.9	-1.6	0.9
BMI	1.0	5.8	24.3	1.8	0.6	-1.5	3.2	-0.8	0.4	4.9
Height	3.2	62.3	104.0	10.2	8.3	3.2	10.1	-8.5	-5.8	6.7
Waist Hip Ratio (WHR)	0.7	3.2	7.6	0.4	2.2	-0.5	0.8	-2.0	-2.8	-2.2
Systolic Blood Pressure	3.6	17.9	33.5	-4.6	-3.9	-5.8	-4.8	4.0	3.8	-1.3
Smoking Status	0.3	0.8	4.6	-0.8	-0.2	-0.1	-0.3	0.2	-0.2	-2.1
Allergy or Eczema	5.4	14.3	22.0	-4.7	-4.3	-2.4	-4.1	4.5	4.0	-0.9
Cardiovascular Disease	7.2	23.7	40.8	-6.4	-5.4	-4.9	-4.1	5.1	4.0	-3.7
Hypothyroidism (self reported)	0.5	1.1	2.8	-0.5	-0.5	-1.6	-1.7	0.8	0.9	0.1
Respiratory disease	0.1	0.2	0.5	-0.5	-0.1	-0.7	-0.2	0.2	-0.2	-0.6
Type 2 Diabetes (T2D) (2018)	10.9	20.3	36.7	6.1	4.7	1.0	5.5	-5.0	-3.4	4.1
Lung FEV1/FVC ratio	0.0	0.0	0.1	0.1	0.1	0.2	0.3	-0.2	-0.3	-0.2
Lung FVC	0.7	3.6	9.4	-2.1	-1.4	0.2	-2.7	1.4	0.7	-3.1
Neuroticism	1.8	4.3	5.8	-2.0	-2.2	-2.0	-1.6	2.4	2.4	1.9
Chronotype (morning person)	0.1	0.3	1.2	0.7	0.6	0.0	-0.0	-0.3	-0.4	1.1
Hair Pigment	1.8	50.2	73.6	-8.6	-8.0	-5.2	-7.7	8.0	7.6	2.3
Tanning	1.5	18.2	30.2	5.5	4.6	2.6	5.5	-4.4	-2.7	3.6
Hand grip strength (left)	1.8	4.8	8.5	2.9	2.3	1.5	2.4	-2.3	-1.9	1.6
Number of treatments/medications taken	6.7	12.1	17.9	-4.2	-3.6	-3.3	-3.8	3.8	3.6	-0.8
Average weekly spirits intake	0.3	0.4	1.9	-0.3	0.4	0.5	0.2	-0.1	-0.2	-1.4
Sensitivity / hurt feelings	0.4	0.7	2.0	-0.3	-0.3	-1.3	0.0	0.6	0.9	1.4
Frequency of depressed mood in last 2 weeks	1.2	1.7	3.5	-1.9	-1.4	-1.0	-1.3	1.5	1.1	-0.7
Hearing difficulty/problems: Yes	1.3	2.0	4.7	-1.8	-1.3	-2.2	-1.4	1.1	0.8	0.4
Relative age of first facial hair	2.6	5.3	15.8	-2.9	-1.8	1.8	-1.7	2.0	0.4	-4.0
Other serious medical condition/disability diagnosed by doctor	1.2	1.5	4.0	-1.7	-0.9	-1.0	-2.0	1.1	0.5	-0.9
Ever used hormone-replacement therapy (HRT)	8.1	10.3	15.8	3.3	4.0	1.8	3.4	-3.9	-3.9	-0.3
Ever had hysterectomy (womb removed)	1.3	1.4	4.8	-1.0	-0.3	-1.0	-1.7	0.1	-0.3	-2.2
Systolic blood pressure, automated reading	2.5	7.1	14.1	-2.7	-2.3	-3.8	-3.3	2.5	2.5	0.1
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	5.6	0.9	0.6	-0.9	0.6	-0.2	0.3	2.4
Angina	1.6	2.1	4.7	-1.9	-1.5	-2.2	-1.1	1.4	0.9	-0.4
Medication for hormone replacement therapy	0.5	0.6	2.0	-0.0	0.7	-0.4	0.4	-0.8	-0.7	-1.4
Vitamin and mineral supplements	3.9	5.2	9.1	3.0	2.3	2.0	2.0	-2.6	-2.7	0.4
Supplements: Zinc	0.1	0.2	0.6	0.4	0.3	-0.8	0.2	-0.2	0.1	-0.3
Medication: Co-codamol	0.6	0.6	2.9	-0.6	-0.0	1.7	-0.1	0.2	0.0	-1.1
Medication: Metformin	7.0	9.8	15.3	3.9	3.4	1.9	3.9	-3.3	-2.3	2.7
Diabetes (father)	4.4	5.4	9.6	3.1	2.2	1.8	2.8	-2.2	-1.5	2.3
Diabetes (mother)	3.5	4.5	14.1	2.2	1.5	0.8	2.9	-1.1	-0.3	3.8
Severe depression (siblings)	0.2	0.2	0.4	0.2	0.2	0.6	0.5	0.3	0.5	0.6
Pack years adult smoking proportion	0.0	0.1	0.4	-0.1	0.0	-0.6	0.2	-0.2	-0.1	0.0
Impedance of leg (right)	2.9	14.3	76.9	-2.2	0.1	2.0	-3.2	0.1	-2.0	-8.8
Leg fat-free mass (left)	4.8	25.6	69.9	5.7	3.6	-0.1	6.9	-3.8	-1.4	8.4
Trunk fat percentage	0.3	1.2	4.4	-0.3	0.5	0.0	2.1	-0.6	-0.9	-1.6
Hand grip strength (right)	1.7	4.6	8.1	2.8	2.2	1.0	2.4	-2.4	-1.8	1.9
Townsend deprivation index at recruitment	1.5	2.1	4.0	1.5	1.3	1.3	2.0	-1.5	-1.7	0.1
Current tobacco smoking	0.3	0.5	1.7	-1.3	-0.7	0.3	-0.2	0.8	0.4	-0.6
Average weekly fortified wine intake	0.3	0.3	0.9	1.0	0.5	0.0	0.4	-0.6	-0.4	0.4
Maternal smoking around birth	0.2	0.3	0.9	0.0	0.3	-0.3	-0.2	-0.6	-0.9	-0.9
Fed-up feelings	1.0	1.9	2.6	-1.6	-1.5	-1.0	-0.4	1.6	1.5	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.5	0.9	-1.0	-0.8	-0.3	-0.6	0.8	0.7	-0.2
Relative age voice broke	2.5	3.7	7.2	-2.7	-2.3	0.8	-2.0	2.2	1.5	-1.5
Taking other prescription medications	2.5	3.8	6.2	-2.1	-1.7	-2.1	-2.5	2.1	2.0	0.5
Age when periods started (menarche)	3.3	8.0	14.1	2.0	3.1	3.2	2.1	-2.9	-3.8	-2.2
Bilateral oophorectomy (both ovaries removed)	4.1	4.8	8.4	-2.2	-2.0	-2.9	-2.7	2.0	2.1	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	2.8	1.7	1.6	1.6	1.4	-1.6	-1.4	0.2
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.4	0.5	0.9	0.2	1.2	-0.8	-0.8	0.5
Qualifications: CSEs or equivalent	0.1	0.2	0.6	0.0	-0.1	-0.0	0.7	-0.0	0.1	-0.8
Serious illness, injury or assault to yourself	1.6	2.0	3.3	-1.8	-1.4	-1.2	-1.7	1.4	1.5	0.4
High blood pressure	2.6	7.3	15.8	-3.2	-2.8	-4.0	-2.0	2.6	2.4	-0.4
Hayfever, allergic rhinitis or eczema	6.5	14.1	21.1	-4.5	-4.4	-2.4	-4.0	4.6	4.1	-0.7
Multivitamins +/- minerals	2.1	2.7	4.6	-2.2	-1.8	-1.0	-1.2	2.0	2.1	0.0
Stomach or abdominal pain in last month	4.2	5.2	9.9	-3.1	-2.4	-1.0	-1.6	3.0	2.7	1.0
Supplements: Glucosamine	0.5	0.7	2.1	0.5	0.7	1.4	0.6	-0.9	-0.8	-0.1
Diverticular disease/diverticulitis (self-reported)	5.0	5.9	8.9	-2.5	-2.7	-1.5	-2.9	2.8	3.0	0.6
Medication: Atenolol	0.3	0.3	0.8	-0.5	-0.7	-0.3	-0.1	0.6	0.5	0.9
Medication: Levothyroxine sodium	0.7	1.1	3.1	-0.7	-0.7	-1.6	-1.8	0.8	0.9	-0.2
Sitting height	3.8	26.9	47.1	6.9	5.0	1.3	6.3	-5.2	-3.3	6.1
Chronic bronchitis/emphysema (father)	0.3	0.3	1.3	-0.8	-0.3	-0.5	-0.1	0.2	-0.2	-1.1
High blood pressure (mother)	3.1	4.4	6.8	-2.4	-2.6	-1.5	-2.1	2.3	2.4	0.5
Body mass index (BMI)	0.8	3.6	16.2	1.0	0.4	-0.9	2.6	-0.3	0.6	4.0
Impedance of leg (left)	2.8	13.5	71.6	-2.6	-0.4	1.7	-3.3	0.5	-1.5	-8.5
Leg predicted mass (left)	4.8	25.3	69.7	5.6	3.5	-0.1	6.9	-3.8	-1.4	8.3
Trunk fat mass	1.2	5.3	18.0	2.1	2.0	0.0	4.2	-2.1	-1.5	1.9
Waist circumference	1.7	6.4	16.2	2.4	2.3	-0.1	4.0	-2.1	-1.2	3.4
Number of incorrect matches in round	1.0	1.7	6.9	0.5	0.6	1.4	1.1	-0.6	-0.7	-2.6
Past tobacco smoking	0.1	0.2	1.1	0.3	-0.3	0.2	0.3	0.2	0.2	1.1
Alcohol usually taken with meals	2.4	3.9	6.0	-2.4	-2.0	-1.4	-2.1	2.0	1.7	-1.9
Nervous feelings	0.2	0.3	1.8	-0.1	-0.4	-0.3	-0.2	0.2	0.2	1.4
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	2.8	-1.6	-1.3	-1.7	-1.4	1.2	1.0	-0.7
Hearing difficulty/problems with background noise	0.7	1.1	3.6	-1.4	-0.8	-1.9	-0.9	0.7	0.7	-0.3
Hair/balding pattern: Pattern 2	0.4	0.5	1.0	-0.5	-0.0	0.7	-0.3	0.9	0.8	1.0
Had menopause	24.5	30.6	45.0	6.1	6.7	3.6	5.3	-6.7	-6.7	-1.2
Had other major operations	0.4	0.5	2.6	-0.6	-0.6	-1.6	-0.5	-0.1	0.4	-0.0
Forced vital capacity (FVC)	0.4	1.7	2.8	1.4	1.5	1.0	1.7	-1.4	-1.1	1.1
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.1	1.4	1.5	0.5	0.7	-1.4	-1.2	-0.2
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.7	-0.2	0.3	0.5	0.4	-0.2	-0.7	-0.8
Qualifications: None of the above	0.4	0.9	1.4	0.3	1.0	1.1	1.0	-1.0	-1.2	-0.6
Financial difficulties in last 2 years	0.2	0.2	0.4	-0.2	0.6	0.5	0.4	-0.3	-0.5	-0.6
Mouth/teeth dental problems	0.3	0.5	1.8	-0.3	-0.4	1.0	0.8	0.4	0.0	-1.3
Heart attack	1.1	1.4	2.2	-1.3	-1.4	-1.5	-0.5	1.2	1.4	0.4
Allergy	3.0	6.8	9.5	2.9	2.8	2.5	3.1	-2.9	-2.7	-0.0
Pain all over the body in last month	2.6	2.8	10.3	-1.6	-1.3	-3.2	-1.4	1.2	1.3	0.4
Diabetes (self-reported)	9.9	15.3	28.0	5.3	4.4	1.9	4.7	-4.4	-3.1	2.2
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.0	-0.7	-0.9	0.2	-0.6	1.0	0.9	-0.2
Medication: Ramipril	0.3	0.3	1.1	-0.6	-0.3	-1.0	-0.0	0.5	0.7	-0.3
Medication: Simvastatin	4.8	7.0	12.0	-3.5	-2.2	-2.3	-3.1	2.3	1.3	-3.2
Fluid intelligence score	0.9	1.9	4.5	2.1	1.3	1.5	1.1	-1.1	-0.8	1.1
Illnesses of siblings	3.4	4.8	6.6	2.6	2.5	2.1	2.1	-2.4	-2.4	0.4
Neuroticism score	1.4	2.9	4.7	-1.4	-1.6	-1.5	-1.4	1.8	1.9	2.2
Weight	3.3	16.2	36.8	4.3	3.1	-0.1	6.0	-3.2	-1.5	6.1
Impedance of arm (right)	4.8	22.6	110.2	-4.7	-2.4	1.2	-3.7	2.1	-0.5	-10.5
Arm fat percentage (right)	0.1	0.4	1.7	-0.6	-0.4	-0.7	1.3	0.4	0.3	0.3
Trunk fat-free mass	7.2	41.5	118.8	7.6	5.0	0.3	7.7	-5.0	-2.0	10.9
Hip circumference	1.4	5.9	17.3	2.2	1.4	-0.2	4.0	-1.3	-0.0	4.2
Time employed in main current job	0.2	0.3	0.5	-0.5	-0.7	-0.3	-0.4	0.5	0.5	-0.7
Alcohol intake versus 10 years previously	8.4	12.6	25.5	-5.0	-3.5	-0.4	-3.4	3.5	2.4	-4.4
Father’s age at death	0.3	0.4	1.6	-0.5	-0.3	-1.3	-0.6	0.5	0.5	0.2
Worrier / anxious feelings	2.3	4.4	5.6	-1.9	-2.0	-2.3	-2.0	2.2	2.4	1.9
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	3.1	-1.8	-1.3	-1.7	-0.7	1.4	1.2	0.6
Falls in the last year	0.7	0.9	1.6	-1.2	-0.8	-0.7	-1.0	0.9	1.0	-0.9
Hair/balding pattern: Pattern 3	1.9	2.8	4.2	1.9	1.8	1.3	2.1	-1.9	-1.7	-0.3
Number of live births	1.2	1.7	3.1	-1.5	-1.2	-1.4	-1.8	1.1	0.9	-0.7
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	2.9	0.7	0.7	0.3	1.0	-0.7	-0.5	1.7
Pulse rate	6.1	10.2	17.8	-4.1	-3.0	-1.6	-3.8	3.0	1.6	-4.2
Happiness	0.6	0.8	1.7	-1.1	-0.6	-0.1	-1.3	0.9	0.8	-0.9
Noisy workplace	0.4	0.5	0.9	0.4	0.8	1.0	0.4	-0.6	-0.7	-0.6
Qualifications: A levels/AS levels or equivalent	0.6	1.2	3.0	-0.5	-1.0	-1.0	-1.7	1.2	1.2	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	4.7	0.2	0.5	-0.6	0.1	-0.5	-0.5	-2.2
Mouth/teeth dental problems: Dentures	1.8	3.1	12.5	1.9	1.5	0.5	1.1	-1.3	-0.5	3.5
Asthma	0.1	0.2	0.6	-0.1	0.1	-0.7	-0.4	-0.0	-0.3	-0.8
Medication: Ibuprofen (e.g. Nurofen)	3.3	4.1	5.9	-2.1	-2.3	-2.2	-2.0	2.0	2.4	0.3
Medication: Cholesterol lowering	9.7	15.1	25.3	-5.0	-3.9	-3.1	-4.4	3.7	2.4	-4.1
Depression (self-reported)	0.2	0.3	1.2	0.1	0.3	0.5	-0.0	-0.3	-0.4	-1.1
Medication: Lansoprazole	0.1	0.2	0.4	-0.6	-0.4	-0.6	0.1	0.2	0.3	0.4
Prospective memory result	0.2	0.3	0.6	0.3	0.5	0.6	0.8	-0.5	-0.4	-0.5
Lung cancer (father)	0.3	0.3	0.7	-0.7	-0.8	-0.3	0.0	0.8	0.4	0.1
Illnesses of mother	2.1	2.5	3.4	1.4	1.5	1.9	1.1	-1.7	-1.8	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	1.7	1.1	0.9	0.7	1.1	-0.9	-0.7	1.3
Pulse wave Arterial Stiffness index	0.3	0.3	0.9	-0.5	-0.2	-0.9	-0.4	0.1	0.2	0.9
Impedance of arm (left)	4.8	22.4	116.6	-4.4	-2.0	1.0	-3.4	1.7	-1.0	-10.8
Arm fat mass (right)	1.1	4.4	12.7	1.8	1.3	-0.6	3.6	-1.3	-0.5	3.3
Trunk predicted mass	7.3	41.9	116.6	7.7	5.1	0.4	7.8	-5.1	-2.1	10.8
Standing height	3.4	33.9	61.2	7.2	6.0	1.8	7.8	-6.3	-4.5	5.0
Length of working week for main job	1.2	1.3	2.5	1.4	1.1	1.6	1.2	-1.0	-0.5	0.9
Exposure to tobacco smoke at home	0.2	0.3	1.4	-0.1	-0.4	-0.6	0.2	0.1	0.2	-1.2
Breastfed as a baby	1.8	2.3	3.5	1.5	1.9	1.3	1.1	-1.5	-1.4	-1.7
Tense / ‘highly strung’	0.2	0.3	0.9	-0.9	-0.6	-0.4	-0.4	0.7	0.4	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.1	0.1	0.6	0.2	0.4	-0.6	-0.6	-1.0
Hair/balding pattern: Pattern 4	1.0	2.4	4.3	2.0	1.7	-0.5	1.5	-2.1	-1.8	-0.1
Birth weight of first child	2.5	4.6	11.1	2.3	1.6	3.3	2.7	-1.8	-1.6	-0.3
Peak expiratory flow (PEF)	0.8	1.8	8.3	-0.7	-0.6	-1.5	-0.2	0.6	0.9	2.9
Pulse wave reflection index	2.0	2.5	4.7	1.7	1.4	0.6	2.0	-1.5	-1.0	2.2
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.4	-0.6	-0.4	-1.1	-0.6	0.4	0.6	1.5
Loud music exposure frequency	0.3	0.3	1.1	0.3	0.0	-0.7	1.0	-0.3	-0.2	0.6
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	4.3	-0.8	-1.5	-1.3	-1.6	1.8	2.1	0.7
Mouth/teeth dental problems: Bleeding gums	4.5	5.8	9.5	-3.1	-2.5	-2.9	-2.8	2.1	1.7	-1.1
Blood clot in the leg (DVT)	0.5	0.7	2.2	0.2	-0.1	-1.5	-0.7	-0.1	0.3	1.4
Medication: Paracetamol	5.6	9.3	17.7	-3.5	-3.1	-4.2	-3.1	2.7	2.8	-0.1
Headache pain in last month	3.7	6.4	10.3	-3.2	-3.0	-1.4	-2.8	2.9	2.5	-1.1
Medication for cholesterol, blood pressure or diabetes	4.4	7.3	11.3	3.4	2.8	3.1	2.9	-2.6	-2.1	1.7
Glaucoma (self-reported)	0.4	0.5	1.2	0.5	0.4	1.1	0.6	-0.5	-0.7	0.7
Gout (self-reported)	30.5	41.8	74.5	-8.6	-7.1	-2.7	-6.6	7.0	5.0	-6.7
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.8	0.1	0.6	-0.2	-0.7	-0.1	-0.2	-0.9
Medication: Amlodipine	0.4	0.5	1.1	-0.9	-0.9	-0.8	-0.2	0.5	1.0	0.4
Medication: Ventolin 100micrograms inhaler	2.1	2.7	5.1	-1.6	-1.6	-2.2	-2.1	1.6	1.2	-0.6
Birth weight	0.3	0.6	2.2	-0.4	-0.6	-1.5	0.1	0.5	0.8	0.5
Chronic bronchitis/emphysema (mother)	1.3	1.5	3.5	-0.9	-0.9	-1.2	-0.8	1.1	1.5	1.9
High blood pressure (siblings)	4.5	6.6	10.9	-3.3	-2.9	-2.7	-2.0	2.6	2.3	-1.8
Forced vital capacity (FVC), Best measure	0.6	2.1	3.2	1.8	1.6	0.9	1.7	-1.6	-1.2	1.2
Body fat percentage	0.2	0.6	2.3	-0.5	0.2	-0.4	1.5	-0.2	-0.5	-1.0
Leg fat percentage (right)	0.1	0.2	0.9	-0.2	0.4	-0.3	0.9	-0.2	-0.4	-0.2
Arm fat-free mass (right)	7.6	38.9	102.0	7.3	5.3	0.1	7.5	-5.2	-2.3	10.1
Exposure to tobacco smoke outside home	0.4	0.5	2.2	-0.2	-0.4	-0.6	0.1	0.4	0.6	1.5
Comparative body size at age 10	2.6	7.2	13.1	-3.6	-3.0	-0.5	-2.1	3.4	2.9	-1.8
Number of full brothers	1.5	1.9	2.5	1.2	1.2	1.6	1.2	-1.5	-1.5	-1.4
Worry too long after embarrassment	1.6	2.6	9.7	-0.3	-1.1	-0.8	-0.8	1.7	1.8	3.1
Seen a psychiatrist for nerves, anxiety, tension or depression	2.6	3.3	7.2	1.4	2.1	0.8	1.6	-2.3	-2.7	-1.2
Wheeze or whistling in the chest in last year	0.9	1.6	2.0	-1.4	-1.3	-1.3	-0.6	1.4	1.3	1.2
Number of children fathered	1.7	2.0	8.0	0.9	1.1	0.1	1.3	-1.2	-0.9	2.8
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.0	1.7	1.1	0.6	0.5	-1.4	-0.8	1.2
Age at first live birth	0.5	0.9	2.0	-0.7	-1.0	-0.1	-1.4	1.1	1.3	0.1
Pulse wave peak to peak time	0.5	0.6	1.2	1.1	0.7	0.9	1.0	-0.6	-0.5	-0.4
Health satisfaction	3.6	4.7	9.0	-3.0	-2.4	-1.4	-1.8	2.6	2.4	-0.3
Shortness of breath walking on level ground	0.3	0.4	0.7	0.4	0.8	0.8	0.7	-0.4	-0.4	0.4
Qualifications: College or University degree	0.3	1.0	2.4	-0.8	-0.9	0.0	-1.5	1.1	1.2	-0.4
Eye problems/disorders: None of the above	3.2	3.7	5.2	1.8	1.8	1.0	2.1	-2.1	-2.2	-2.3
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.6	-0.6	-0.3	-0.5	-0.2	0.1	-0.2	-1.3
Emphysema/chronic bronchitis	0.4	0.5	1.1	1.1	0.9	-0.2	0.3	-0.8	-0.6	0.7
Medication for pain relief, constipation, heartburn	5.8	9.9	13.4	3.6	3.2	3.7	3.1	-3.3	-3.5	-0.8
Neck or shoulder pain in last month	0.9	1.3	6.1	-0.9	-0.6	-2.5	-0.4	0.3	0.7	1.2
Medication: Blood pressure	1.5	2.6	6.6	-1.4	-1.5	-2.6	-1.1	1.4	1.7	1.3
Angina (self-reported)	1.2	1.6	3.6	-1.7	-1.4	-1.9	-0.9	1.2	0.7	-0.4
Migraine (self-reported)	0.3	0.4	1.5	-0.5	-0.4	-0.9	-1.2	0.2	0.1	0.2
Medication: Ibuprofen	2.0	2.4	3.5	-1.9	-1.8	-1.0	-1.6	1.6	1.8	-0.3
Medication: Allopurinol	24.1	32.1	54.3	-7.3	-5.8	-2.3	-6.0	5.4	3.5	-7.4
Medication: Omeprazole	0.6	0.7	2.2	-0.4	-0.4	-1.4	-0.5	0.4	0.5	1.5
Medication: Seretide 50 evohaler	0.1	0.1	0.4	0.6	0.3	0.2	0.4	-0.4	-0.3	-0.4
Mean time to correctly identify matches	0.3	0.5	0.8	-0.8	-0.8	-0.7	-0.5	0.9	0.7	-0.5
Heart disease (mother)	1.9	2.3	4.3	-1.6	-1.4	-2.1	-1.7	1.6	1.4	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	2.6	-1.3	-1.3	-0.6	-1.6	1.4	1.3	0.8
Whole body fat mass	1.0	4.2	13.9	1.9	1.6	-0.3	3.7	-1.7	-1.1	2.3
Leg fat mass (right)	1.3	5.0	11.8	2.3	2.0	-0.5	3.4	-1.9	-1.1	3.1
Arm predicted mass (right)	7.3	37.5	106.1	7.1	4.9	-0.1	7.4	-4.9	-2.0	10.3
Pulse rate, automated reading	9.6	31.0	56.0	-7.5	-5.4	-2.1	-6.2	5.2	2.8	-7.4
Alcohol intake frequency.	17.6	41.0	90.4	-8.6	-5.9	-0.6	-6.4	6.0	3.3	-9.5
Comparative height size at age 10	3.7	20.6	45.8	5.3	3.8	1.7	6.8	-3.8	-2.1	5.8
Number of full sisters	0.1	0.1	0.5	-0.3	-0.2	-0.4	-0.7	0.1	-0.1	-0.1
Suffer from ‘nerves’	0.3	0.5	3.2	0.1	0.2	-0.0	0.0	0.2	0.1	1.8
Overall health rating	3.5	7.6	13.3	-3.6	-3.0	-3.2	-2.2	2.9	2.7	0.5
Chest pain or discomfort	1.2	1.8	3.2	-1.8	-1.8	-0.4	-1.1	1.7	1.3	-0.3
Had major operations	0.6	0.7	2.0	-0.7	-0.2	-1.4	-1.4	0.3	0.3	0.3
Age at last live birth	0.2	0.3	0.7	0.0	0.3	0.8	-0.8	-0.2	-0.1	-0.8
Family relationship satisfaction	2.4	2.9	5.0	2.0	2.2	1.1	1.7	-2.0	-1.5	1.0
Leg pain on walking	0.8	1.0	4.4	0.5	0.8	-1.1	0.0	-0.6	-0.3	2.1
Qualifications: NVQ or HND or HNC or equivalent	2.4	2.9	7.1	-1.7	-1.6	-2.7	-1.5	1.6	1.7	0.3
Commuting to job workplace: Car/motor vehicle	0.5	0.5	1.8	-0.9	-0.3	-0.8	-1.3	0.3	0.5	0.2
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	0.6	-0.2	-0.0	-0.3	-0.2	-0.2	-0.4
Medication: Aspirin	0.7	0.9	2.0	-1.4	-0.9	0.5	-0.5	1.3	1.2	-0.1
Supplements: Vitamin C	0.7	0.8	3.2	-0.7	-0.6	-1.8	-0.4	0.5	1.0	0.3
Knee pain experienced in last month	0.2	0.3	0.8	0.2	0.4	-0.2	0.5	-0.9	-0.7	-0.8
Hypertension (Self-reported)	2.6	7.2	16.0	-3.1	-2.8	-4.0	-1.9	2.6	2.5	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.9	-0.7	-0.7	-0.7	-1.0	0.7	0.8	0.3
Illnesses of father: Heart disease	2.2	3.0	5.0	-2.1	-1.4	-1.7	-2.2	1.5	0.8	-1.9
Illnesses of siblings: Diabetes	1.5	1.8	8.9	1.0	0.0	-1.1	0.9	-0.1	0.7	3.0
Smoking status: Previous	0.2	0.2	1.3	-0.1	0.3	-0.4	-0.2	-0.2	-0.2	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	3.8	1.6	1.1	0.4	1.9	-1.5	-0.9	0.4
Whole body fat-free mass	6.5	37.4	106.1	7.0	4.6	0.1	7.7	-4.7	-1.8	10.3
Leg fat-free mass (right)	4.7	25.0	74.8	5.4	3.3	-0.2	6.8	-3.6	-1.1	8.7
Arm fat percentage (left)	0.1	0.5	2.1	-0.5	-0.3	-0.9	1.5	0.2	0.1	0.2
Average weekly red wine intake	0.3	0.4	1.5	0.9	0.5	-0.4	0.2	-0.6	-0.1	1.2
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.2	0.9	1.1	0.3	0.6	-1.1	-1.0	-0.4
Mood swings	2.0	3.7	4.8	-2.2	-1.9	-2.2	-2.0	1.9	1.9	1.2
Loneliness, isolation	0.9	1.2	2.0	-1.4	-0.9	-0.5	-1.4	1.2	1.0	1.1
Long-standing illness, disability or infirmity	0.3	0.5	1.4	-0.8	-0.4	0.1	-0.5	0.7	0.9	1.2
Ever had bowel cancer screening	1.6	1.9	3.2	-1.7	-1.5	-0.8	-1.6	1.1	0.8	-1.8
Diabetes diagnosed by doctor	10.5	17.2	30.2	5.5	4.5	1.9	5.0	-4.5	-3.0	3.5
Ever had stillbirth, spontaneous miscarriage or termination	3.2	3.4	5.0	-2.2	-1.8	-2.0	-2.1	1.9	1.9	0.3
Friendships satisfaction	0.1	0.2	0.9	-0.1	0.2	0.1	-1.0	0.0	0.1	-0.3
Qualifications: nursing, teaching	0.9	1.4	2.9	-0.7	-1.1	-1.7	-1.1	1.1	1.6	-0.2
Commuting to job workplace: Walk	0.3	0.3	1.3	0.3	-0.1	0.5	0.5	-0.0	-0.1	-1.2
Eye problems/disorders: Cataract	6.0	6.9	9.4	-3.0	-3.1	-1.7	-2.9	3.0	3.0	1.1
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.5	-1.0	-0.7	-1.3	-1.9	1.0	1.0	-0.4
Medication for cholesterol	4.5	6.8	13.6	3.3	2.3	1.8	2.7	-2.1	-1.6	3.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.8	-1.7	-0.4	0.5	-0.4	1.0	0.6	-1.5
Back pain experienced in last month	1.6	2.4	4.2	-1.2	-1.4	-2.0	-1.6	1.0	1.2	2.0
Mineral and other dietary supplements	0.0	0.0	0.1	0.2	-0.1	-0.3	-0.0	-0.1	-0.1	0.1
Breast cancer (self-reported)	0.2	0.2	1.1	-0.2	-0.2	0.1	-0.5	0.1	0.2	1.0
Asthma (self-reported)	0.2	0.3	1.1	-0.5	-0.2	-0.5	-0.7	0.3	0.0	-1.1
Osteoporosis (self-reported)	3.6	4.4	9.2	-3.0	-2.1	-0.9	-2.3	2.3	1.8	-1.6
Osteoarthritis (self-reported)	0.3	0.4	1.8	0.1	0.4	-0.6	-0.1	-0.6	-0.4	-1.4
Medication: Aspirin	0.8	1.0	2.0	-1.4	-1.0	0.4	-0.6	1.3	1.3	0.3
Medication: Gliclazide	3.9	4.4	7.7	2.8	2.3	1.3	2.8	-2.1	-1.5	1.5
Illnesses of father: None of the above (group 1)	0.3	0.4	1.6	0.3	-0.4	0.1	0.4	0.5	0.7	1.3
Smoking status: Current	0.2	0.3	1.1	-1.0	-0.3	0.5	-0.1	0.5	0.0	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	2.3	-0.7	-0.6	-0.6	-1.5	0.4	0.3	-0.8
Whole body water mass	6.7	38.2	110.2	7.1	4.6	0.0	7.7	-4.7	-1.8	10.5
Leg predicted mass (right)	4.7	25.2	75.3	5.4	3.3	-0.3	6.8	-3.6	-1.1	8.7
Arm fat mass (left)	1.1	4.4	12.3	1.8	1.3	-0.7	3.5	-1.3	-0.5	3.3
Number of self-reported non-cancer illnesses	6.4	11.0	18.5	-4.3	-3.3	-3.1	-3.9	3.3	2.4	-2.7
Average weekly champagne plus white wine intake	0.5	0.7	3.2	0.9	0.0	-0.7	0.3	-0.2	0.2	1.8
Miserableness	1.8	3.1	5.2	-2.2	-2.0	-1.3	-2.3	1.9	1.4	-0.6
Guilty feelings	0.4	0.6	3.8	0.0	-0.1	-0.3	0.4	0.2	0.4	1.9
Wears glasses or contact lenses	0.1	0.1	0.3	-0.2	-0.0	-0.5	-0.2	0.1	0.4	0.1
Ever taken oral contraceptive pill	0.6	0.6	1.8	0.0	-0.5	-1.4	-0.4	0.5	1.0	0.9
Hearing aid user	1.4	1.6	2.6	-1.6	-1.4	-1.0	-1.6	1.4	0.9	-0.6
Mother’s age at death	1.6	2.0	2.8	1.5	1.5	0.6	1.3	-1.5	-1.6	-1.7
Financial situation satisfaction	0.2	0.3	0.6	-0.7	-0.4	-0.2	-0.2	0.5	0.8	0.6
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.3	-0.8	-1.2	-1.5	-1.5	1.0	1.0	-0.2
Commuting to job workplace: Public transport	0.9	1.0	1.7	1.3	0.9	1.1	0.9	-1.0	-1.2	-0.5
Eye problems/disorders: Glaucoma	0.6	0.7	1.7	0.8	0.6	1.2	0.4	-0.5	-0.5	1.3
Medication: Blood pressure	1.2	2.3	4.3	-2.1	-1.6	-1.5	-1.2	1.4	1.2	-1.6
Pain type(s) experienced in last month: Hip pain	0.4	0.6	1.3	0.9	0.9	-0.1	0.4	-1.1	-0.8	0.5
Supplements: Fish oil (including cod liver oil)	0.4	0.6	0.9	-1.0	-0.8	-0.3	-0.6	0.9	1.0	0.4
High cholesterol (Self-reported)	20.9	37.0	67.1	-8.2	-6.0	-3.2	-6.8	6.0	3.8	-7.0
Medication: Bendroflumethiazide	0.1	0.2	0.6	-0.8	-0.3	-0.6	-0.2	0.4	0.3	-0.4
Medication: Paracetamol	3.9	6.0	10.8	-3.1	-2.4	-3.3	-2.7	2.0	2.0	-0.5
Medication: Lisinopril	0.6	0.8	2.8	-0.1	-0.4	-1.4	0.2	0.4	0.6	1.7
Medication: Atorvastatin	12.1	15.0	28.7	-5.4	-4.2	-1.6	-4.1	4.1	2.8	-3.9
Illnesses of father: High blood pressure	1.8	2.2	4.0	-1.7	-1.4	-2.0	-1.3	1.4	1.6	-0.2
Alcohol drinker status: Never	0.3	0.3	1.2	-0.4	0.2	0.4	-0.7	-0.0	-0.4	-1.1
Ever smoked	0.1	0.2	0.8	-0.4	0.3	0.5	-0.1	-0.1	0.0	-0.9
Basal metabolic rate	5.7	31.3	88.5	6.3	4.2	-0.1	7.2	-4.3	-1.6	9.4
Leg fat percentage (left)	0.1	0.2	1.0	-0.3	0.1	-0.6	1.0	0.0	0.0	0.3
Arm fat-free mass (left)	6.8	34.6	99.0	6.8	4.7	0.1	7.0	-4.6	-1.9	10.0
Number of operations (self-reported)	3.1	4.7	12.4	-2.1	-1.7	-3.5	-3.2	1.0	1.1	-0.5
Average weekly beer plus cider intake	1.3	1.9	3.9	1.2	1.3	1.0	2.0	-1.5	-1.7	0.5
Irritability	1.5	2.6	4.6	-1.2	-1.6	-2.1	-0.6	1.6	1.6	1.9
Risk taking	0.5	0.7	2.2	0.1	0.5	1.2	1.5	-0.6	-0.5	-0.4
Ever had prostate specific antigen (PSA) test	0.8	0.9	5.0	-0.1	-0.3	-2.2	-0.4	0.1	0.4	1.1
Fractured/broken bones in last 5 years	2.3	2.9	5.9	-2.0	-1.9	-0.6	-0.7	2.1	2.4	1.4
Age started oral contraceptive pill	0.3	0.4	1.8	0.5	0.1	1.4	0.0	-0.1	-0.5	-0.8
Diastolic blood pressure, automated reading	0.6	2.0	7.1	-1.0	-0.9	-2.7	-1.4	0.8	1.3	0.8
Ever depressed for a whole week	0.2	0.3	0.7	0.3	0.9	0.0	-0.2	-0.5	-0.7	-0.3
Unable to work because of sickness or disability	3.0	3.9	6.0	1.6	2.4	2.0	2.1	-2.2	-2.3	-0.4
Commuting to job workplace: Cycle	0.3	0.4	0.9	0.5	0.4	1.0	0.6	-0.3	-0.2	0.9
Myopia	0.6	0.9	3.3	0.3	0.3	0.8	1.0	-0.6	-0.6	-1.8
Vascular/heart problems diagnosed by doctor	2.6	7.0	15.8	3.2	2.7	4.0	1.8	-2.5	-2.3	0.5
Cholesterol lowering medication	8.9	13.0	22.2	-4.7	-3.2	-1.9	-4.3	3.4	2.0	-4.6
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.2	-1.0	-1.0	-1.8	-1.3	1.0	0.8	0.8
Pain experienced in last month	2.5	4.2	6.7	2.5	2.2	2.6	1.6	-1.9	-2.2	-0.9
Supplements: Calcium	0.5	0.6	2.0	-0.6	-0.3	-0.5	-1.1	0.2	0.2	-1.4
Basal cell carcinoma (self-reported)	0.7	0.9	2.1	-0.6	-0.8	-1.0	-0.8	0.6	1.0	1.4
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.1	-1.4	-1.5	-1.4	-0.4	1.2	1.3	0.2
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.1	0.3	0.0	-1.3	-0.4	-0.2	0.1	1.4
Heart disease (siblings)	0.8	0.9	2.0	-1.3	-0.9	-0.0	-1.4	1.0	0.5	-0.9
Alcohol drinker status: Previous	0.5	0.6	2.8	-0.5	-0.5	0.8	-0.2	0.3	0.0	-1.7
Pack years of smoking	0.2	0.3	0.6	0.5	0.7	-0.3	0.5	-0.8	-0.7	0.0
Impedance of whole body	4.4	22.4	118.8	-4.0	-1.5	1.4	-3.8	1.3	-1.3	-10.9
Leg fat mass (left)	1.3	5.2	12.2	2.2	1.8	-0.6	3.5	-1.7	-0.9	3.5
Arm predicted mass (left)	6.8	34.4	95.3	6.8	4.7	0.3	7.1	-4.7	-1.9	9.8