Best TWAS P=7.35e-23 · Best GWAS P=7.88e-23 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | STAT6 | 0.11 | 0.08 | lasso | 3 | 0.11 | 9.1e-14 | -3.6 | -6.3 | 3.1e-10 | 0.52 | 0.95 | 0.05 | FALSE |
| 2 | GTEx | Artery Aorta | STAT6 | 0.12 | 0.07 | enet | 22 | 0.05 | 1.1e-03 | -5.4 | -5.3 | 9.2e-08 | 0.32 | 0.49 | 0.08 | FALSE |
| 3 | GTEx | Artery Tibial | LRP1 | 0.15 | 0.12 | lasso | 2 | 0.10 | 3.9e-08 | -9.8 | 9.8 | 7.3e-23 | -1.00 | 0.00 | 1.00 | TRUE |
| 4 | GTEx | Artery Tibial | STAT6 | 0.08 | 0.03 | enet | 4 | 0.02 | 1.3e-02 | -7.6 | -7.7 | 1.7e-14 | 0.61 | 0.22 | 0.27 | FALSE |
| 5 | METSIM | Adipose | NXPH4 | 0.04 | 0.01 | bslmm | 354 | 0.02 | 1.7e-04 | -9.3 | 6.2 | 7.4e-10 | -0.47 | 0.03 | 0.71 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | STAT6 | 0.04 | 0.01 | blup | 47 | 0.01 | 2.3e-02 | -9.3 | -9.4 | 7.5e-21 | 0.79 | 0.01 | 0.87 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | TMEM194A | 0.15 | 0.07 | blup | 43 | 0.09 | 1.9e-09 | -6.8 | -5.6 | 1.9e-08 | 0.42 | 0.26 | 0.67 | FALSE |