TWAS hub - LRP1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.151	0.0632	0.0038	0.118	NA	0.064	NA	0.099	1.6e-09	NA	8.8e-06	NA	3.9e-08
2	GTEx	Esophagus Muscularis	0.072	0.0370	0.0099	0.001	NA	-0.001	NA	-0.003	2.6e-01	NA	3.6e-01	NA	5.6e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Headache pain in last month	51.5	88.5	176.9	13.3	0.4
Migraine (self-reported)	39.2	48.6	96.8	9.8	0.7
Medication: Paracetamol	23.8	39.4	77.7	8.8	-1.1
Medication: Ibuprofen (e.g. Nurofen)	22.9	29.1	56.1	7.5	1.5
Medication for pain relief, constipation, heartburn	22.4	38.3	76.6	-8.7	0.2
Medication: Paracetamol	19.6	30.3	60.1	7.8	-0.7
Medication: Ibuprofen	18.3	21.8	42.4	6.5	1.1
Lung FEV1/FVC ratio	13.0	66.0	130.0	-11.4	-1.4
Pain experienced in last month	12.6	21.1	39.2	-6.3	1.7
Allergy	11.0	25.3	29.8	4.5	5.5
Vitamin and mineral supplements	10.7	14.5	28.9	-5.4	-0.1
Respiratory disease	10.3	22.9	31.4	-5.6	-3.8
Allergy or Eczema	10.2	26.9	34.7	-4.4	-5.9
Asthma	9.4	18.6	21.9	-4.7	-3.9
Asthma (self-reported)	9.3	18.4	22.2	-4.7	-3.8
Hayfever/allergic rhinitis (self-reported)	8.9	11.7	18.4	-4.3	-2.2
Hayfever, allergic rhinitis or eczema	8.6	18.7	21.7	-4.0	-4.7
Myopia	8.5	12.4	20.4	4.5	2.1
Primary Biliary Cirrhosis	7.6	10.9	16.5	4.1	2.3
Wheeze or whistling in the chest in last year	7.6	13.6	23.1	-2.0	-4.8
Sitting height	6.4	45.4	45.7	6.7	6.8
Mineral and other dietary supplements	6.4	8.7	16.9	-4.1	-0.6
Number of treatments/medications taken	6.1	11.0	20.9	4.6	-1.1
Multivitamins +/- minerals	6.0	7.7	15.4	3.9	0.1
Supplements: Fish oil (including cod liver oil)	5.9	7.7	15.2	3.9	0.4
Schizophrenia vs Biploar Disorder	5.5	7.2	12.9	-1.2	3.6
Chest pain or discomfort	5.5	8.0	15.9	-0.2	-4.0
Knee pain experienced in last month	5.5	8.5	13.8	-1.8	-3.7
Average weekly beer plus cider intake	5.5	8.0	8.3	-2.8	-2.9
High blood pressure (siblings)	5.2	7.6	9.3	3.0	2.4
Gout (self-reported)	4.7	6.5	8.9	3.0	2.0
Neck or shoulder pain in last month	4.7	6.6	6.7	2.6	-2.6
Eye problems/disorders: Cataract	4.6	5.3	5.5	2.3	2.3
Number of operations (self-reported)	4.5	6.6	12.9	3.6	0.6
Sensitivity / hurt feelings	4.4	7.5	13.5	3.7	-1.3
Alcohol intake frequency.	4.4	10.2	20.2	4.5	-0.5
Blood Eosinophil Count	4.3	33.4	33.9	-5.8	-5.7
Mouth/teeth dental problems	4.3	6.6	12.5	0.8	3.5
Pulse wave reflection index	4.1	5.0	7.6	2.8	1.6
Depressed Affect (Nagel 2018)	3.8	8.1	12.5	3.5	-1.9
Medication: Ventolin 100micrograms inhaler	3.7	4.8	6.8	-2.6	-1.7
Medication: Gliclazide	3.7	4.2	8.3	0.3	-2.9
Miserableness	3.7	6.4	10.5	3.2	-1.5
Fluid intelligence score	3.6	7.6	8.0	2.8	2.7
Leg fat percentage (right)	3.6	13.2	23.3	-4.8	-1.8
Supplements: Calcium	3.6	4.0	8.0	2.8	0.1
Leg fat percentage (left)	3.4	12.4	22.0	-4.7	-1.7
Prospective memory result	3.3	4.1	7.9	-2.8	0.5
Supplements: Zinc	3.2	3.5	6.6	2.6	0.6
Medication: Seretide 50 evohaler	3.2	3.7	7.2	-2.7	-0.5
Hand grip strength (right)	3.1	8.5	14.8	3.9	1.5
Birth weight	3.1	6.8	11.3	3.4	1.5
Back pain experienced in last month	3.1	4.5	8.5	2.9	-0.7
Schizophrenia (2018)	3.0	6.3	9.5	-3.1	1.8
Mouth/teeth dental problems: Bleeding gums	3.0	3.8	7.4	0.5	-2.7
Supplements: Glucosamine	2.9	3.8	6.6	2.6	-1.0
Hair/balding pattern: Pattern 2	2.9	3.6	7.3	2.7	-0.1
Standing height	2.9	29.1	34.6	5.9	4.9
Mood swings	2.9	5.2	9.4	3.1	-1.0
Alcohol drinker status: Previous	2.9	3.4	6.6	2.6	0.4
Chronic bronchitis/emphysema (father)	2.8	3.3	4.0	2.0	-1.6
BMI	2.7	15.9	21.6	-4.7	-3.2
Arm fat percentage (left)	2.6	10.4	13.3	-3.6	-2.7
Depression (self-reported)	2.5	2.9	5.9	2.4	-0.2
Body fat percentage	2.5	9.8	16.0	-4.0	-1.9
Intelligence (Savage-Jansen 2018)	2.4	7.4	10.2	2.1	3.2
Arm fat percentage (right)	2.4	9.5	13.3	-3.6	-2.4
Medication: Allopurinol	2.4	3.2	4.6	2.2	1.3
Heart disease (siblings)	2.4	2.9	5.6	0.4	-2.4
Ever unenthusiastic/disinterested for a whole week	2.3	2.8	5.5	2.3	-0.4
Pulse wave Arterial Stiffness index	2.3	2.7	5.2	2.3	0.4
Neuroticism	2.2	5.4	10.1	3.2	-0.8
Chronotype (morning person)	2.2	5.0	9.9	0.3	-3.1
Pack years adult smoking proportion	2.2	3.4	6.8	-2.6	-0.2
Forced vital capacity (FVC), Best measure	2.2	8.2	11.8	2.2	3.4
Qualifications: College or University degree	2.2	7.0	12.3	1.3	3.5
Bipolar Disorder (2011)	2.1	2.0	3.4	-0.8	-1.8
Qualifications: None of the above	2.1	4.5	8.2	-2.9	-0.9
Had major operations	2.1	2.4	3.1	1.8	1.3
Bipolar Disorder or Schizophrenia	2.0	4.9	9.7	-3.1	0.2
Schizophrenia (2014)	2.0	4.3	5.8	-2.4	1.7
Height	2.0	38.7	45.7	6.8	5.6
Bilateral oophorectomy (both ovaries removed)	2.0	2.3	3.1	1.2	-1.8
Alcohol usually taken with meals	2.0	3.3	6.6	2.6	-0.1
Forced vital capacity (FVC)	2.0	7.7	8.1	2.7	2.8
Health satisfaction	2.0	2.6	3.3	1.8	-1.4
Angina (self-reported)	2.0	2.6	4.0	-1.1	-2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.3	2.5	1.5	-1.6
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.1	4.1	2.0	2.0
Angina	1.9	2.5	3.8	-1.1	-1.9
Body mass index (BMI)	1.9	7.9	9.8	-3.1	-2.5
Verbal and Numeric Reasoning (VNR)	1.8	4.3	5.3	1.8	2.3
Crohns Disease (2012)	1.8	2.8	4.1	1.2	2.0
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	4.0	2.0	-0.8
Tinnitus: Yes, but not now, but have in the past	1.8	2.0	3.9	2.0	0.0
Trunk predicted mass	1.8	10.3	14.9	3.9	2.4
Age at first live birth	1.8	3.2	5.4	-1.0	2.3
Supplements: Vitamin C	1.8	2.2	3.8	2.0	0.7
Illnesses of father: Heart disease	1.8	2.6	3.5	-1.9	-1.3
Medication: Lisinopril	1.8	2.3	2.5	-1.5	-1.6
Illnesses of father: High blood pressure	1.8	2.2	3.2	1.8	1.1
Neuroticism (Nagel 2018)	1.7	3.9	5.5	2.3	-1.6
Frequency of depressed mood in last 2 weeks	1.7	2.4	4.7	2.2	-0.2
Diabetes (mother)	1.7	2.2	4.4	0.1	2.1
Trunk fat percentage	1.7	6.7	11.4	-3.4	-1.5
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	3.9	1.1	-2.0
Trunk fat-free mass	1.7	10.0	14.7	3.8	2.3
Worrier / anxious feelings	1.7	3.3	5.9	2.4	-0.9
Mouth/teeth dental problems: Dentures	1.7	2.8	2.8	-1.7	-1.7
Qualifications: O levels/GCSEs or equivalent	1.7	2.7	4.4	2.1	0.9
Alzheimer’s Disease (in mother)	1.6	1.8	3.5	0.4	1.9
Crohns Disease (2017)	1.6	3.4	4.2	1.6	2.0
Systolic blood pressure, automated reading	1.6	4.8	7.3	-2.7	1.5
Illnesses of siblings	1.6	2.3	3.6	-1.9	-1.0
Father’s age at death	1.6	2.2	2.7	1.6	1.3
Serious illness, injury or assault of a close relative in last 2 years	1.6	1.9	3.0	1.7	0.9
Birth weight of first child	1.6	2.9	5.7	2.4	0.3
Medication: Amlodipine	1.6	2.2	2.4	-1.4	-1.6
Overall health rating	1.6	3.5	3.8	-1.9	-1.8
Age at last live birth	1.6	2.3	3.7	-1.0	1.9
Loneliness, isolation	1.6	2.2	4.2	0.3	-2.0
Ever had prostate specific antigen (PSA) test	1.6	1.9	2.4	1.5	1.2
Pack years of smoking	1.6	2.3	4.6	-2.1	-0.2
Bipolar Disorder (2018)	1.5	2.4	3.5	-1.1	-1.9
Major Depression (MDD)	1.5	1.9	2.1	1.3	1.4
Mean Putamen Volume	1.5	1.7	1.8	1.3	1.3
Relative age of first facial hair	1.5	3.0	5.0	-1.0	-2.2
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	2.7	-1.6	-0.8
Fed-up feelings	1.5	2.8	3.4	1.5	-1.8
Taking other prescription medications	1.5	2.3	4.4	0.4	-2.1
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	3.6	1.9	-0.3
Neuroticism score	1.5	3.1	4.6	2.1	-1.3
Length of working week for main job	1.5	1.6	1.7	-1.3	-1.3
Leg fat mass (right)	1.5	6.0	10.0	-3.2	-1.4
Suffer from ‘nerves’	1.5	2.4	4.2	0.8	-2.0
Irritable Bowel Disease (IBD)	1.4	3.4	5.2	1.3	2.3
Neuroticism (2016)	1.4	2.0	3.4	1.8	-0.8
Hypothyroidism (self reported)	1.4	3.1	5.3	-0.9	2.3
Medication for hormone replacement therapy	1.4	1.6	3.0	1.7	0.4
Qualifications: A levels/AS levels or equivalent	1.4	3.1	5.6	0.8	2.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	4.2	2.0	0.1
Glaucoma (self-reported)	1.4	1.7	3.2	1.8	0.4
Pulse wave peak to peak time	1.4	1.7	3.4	-1.8	-0.1
Number of self-reported non-cancer illnesses	1.4	2.4	4.6	0.3	-2.1
Medication: Blood pressure	1.4	2.7	5.3	-0.2	-2.3
Ever depressed for a whole week	1.4	1.8	2.9	0.8	-1.7
Leg fat mass (left)	1.4	5.4	9.5	-3.1	-1.2
Current tobacco smoking	1.3	2.1	4.0	0.5	-2.0
Waist circumference	1.3	4.8	5.8	-2.0	-2.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.1	6.5	-1.3	2.6
Peak expiratory flow (PEF)	1.3	3.1	5.5	-2.3	0.8
Guilty feelings	1.3	2.0	4.0	-0.0	-2.0
Ever highly irritable/argumentative for 2 days	1.2	1.4	1.9	-0.9	-1.4
Comparative body size at age 10	1.2	3.3	6.5	0.0	-2.5
Pain type(s) experienced in last month: Hip pain	1.2	1.5	2.4	-0.8	-1.6
Medication: Bendroflumethiazide	1.2	1.7	3.3	-0.4	-1.8
Alzheimer’s Disease (in father)	1.1	1.2	2.4	-0.2	-1.6
Heel T-Score	1.1	8.5	10.9	2.5	-3.3
High blood pressure (mother)	1.1	1.6	3.2	-0.0	1.8
Medication: Simvastatin	1.1	1.6	2.9	-1.7	0.5
Exposure to tobacco smoke at home	1.1	1.3	2.4	-1.6	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.7	1.6	0.4
Comparative height size at age 10	1.1	5.8	9.2	1.5	3.0
Whole body fat-free mass	1.1	6.3	9.9	3.1	1.7
Whole body water mass	1.1	6.2	10.0	3.2	1.5
Hearing aid user	1.1	1.2	1.7	1.3	0.9
Commuting to job workplace: Cycle	1.1	1.4	2.7	-1.6	0.3
Basal cell carcinoma (self-reported)	1.1	1.3	1.9	1.4	-0.9
Fasting Glucose	1.0	1.2	1.6	1.3	0.9
Ulcerative Colitis	1.0	1.5	2.9	0.2	1.7
Blood Platelet Count	1.0	12.0	14.8	3.0	-3.9
Smoking Status	1.0	2.4	4.1	0.8	-2.0
Impedance of leg (right)	1.0	4.7	5.8	-1.9	2.4
Time employed in main current job	1.0	1.2	1.6	-1.3	0.9
Blood clot in the leg (DVT)	1.0	1.3	2.5	-0.3	-1.6
Mother’s age at death	1.0	1.3	1.9	1.4	-0.8
Commuting to job workplace: Public transport	1.0	1.2	2.5	-0.1	1.6
Age started oral contraceptive pill	1.0	1.2	1.9	0.7	-1.4
Coronary Artery Disease (CAD)	0.9	1.1	1.8	-1.3	-0.6
Waist Hip Ratio (WHR)	0.9	3.9	7.2	-0.8	-2.7
Hand grip strength (left)	0.9	2.4	3.8	1.9	1.0
Average weekly fortified wine intake	0.9	1.1	2.0	-0.4	-1.4
Impedance of leg (left)	0.9	4.3	6.2	-1.6	2.5
Hearing difficulty/problems with background noise	0.9	1.5	3.0	1.7	0.1
Alcohol intake versus 10 years previously	0.9	1.4	2.8	1.7	-0.2
Arm fat mass (right)	0.9	3.7	5.0	-2.2	-1.5
Whole body fat mass	0.9	3.6	6.1	-2.5	-1.1
Ever had bowel cancer screening	0.9	1.0	1.6	0.6	-1.3
Breast cancer (self-reported)	0.9	1.0	1.2	-1.1	-0.9
Smoking status: Current	0.9	1.4	2.3	0.7	-1.5
Arm fat mass (left)	0.9	3.8	4.3	-2.1	-1.8
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.3	-0.3	-1.5
Blood White Count	0.8	5.9	9.2	-1.6	-3.0
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	5.0	-0.7	2.2
Medication: Lansoprazole	0.8	0.9	1.3	1.1	0.7
Illnesses of mother	0.8	1.0	1.6	0.6	-1.3
Arm fat-free mass (right)	0.8	3.9	6.9	2.6	1.0
Number of full brothers	0.8	1.0	1.6	-1.3	0.6
Eye problems/disorders: None of the above	0.8	0.9	1.4	-0.6	-1.2
Average weekly champagne plus white wine intake	0.8	1.0	1.4	0.8	1.2
Ever taken oral contraceptive pill	0.8	0.9	1.6	0.4	1.3
Eye problems/disorders: Glaucoma	0.8	0.9	1.0	1.0	1.0
Ulcerative Colitis (UC)	0.7	1.3	2.5	0.4	1.6
Cardiovascular Disease	0.7	2.2	3.9	0.7	-2.0
Trunk fat mass	0.7	2.9	5.1	-2.3	-0.8
Pain all over the body in last month	0.7	0.7	1.3	-0.3	-1.1
Noisy workplace	0.7	0.9	1.7	0.3	-1.3
Medication: Cholesterol lowering	0.7	1.1	1.7	-1.3	0.6
Arm predicted mass (right)	0.7	3.8	6.5	2.6	1.0
Leg pain on walking	0.7	0.9	1.3	-0.7	-1.1
Commuting to job workplace: Car/motor vehicle	0.7	0.9	1.4	-0.5	-1.2
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.5	-0.4	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.2	1.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.5	3.0	-1.7	0.2
Arm fat-free mass (left)	0.7	3.5	5.2	2.3	1.4
Fractured/broken bones in last 5 years	0.7	1.0	1.8	-1.3	0.4
Arm predicted mass (left)	0.7	3.6	5.3	2.3	1.4
Alzheimer’s Disease (including proxy)	0.6	0.9	1.9	0.0	1.4
Body Mass Index (BMI) (2010)	0.6	0.9	1.7	-0.3	-1.3
Medication: Metformin	0.6	0.8	1.4	-0.4	-1.2
Maternal smoking around birth	0.6	0.9	1.8	-1.3	-0.3
Medication: Atenolol	0.6	0.8	1.6	0.1	-1.3
Impedance of arm (right)	0.6	2.9	4.4	-1.1	2.1
Loud music exposure frequency	0.6	0.7	1.3	0.3	-1.2
Medication: Omeprazole	0.6	0.7	0.8	0.8	0.9
Medication: Aspirin	0.6	0.8	1.7	1.3	-0.1
Illnesses of siblings: Diabetes	0.6	0.7	1.2	1.1	0.5
Leg fat-free mass (right)	0.6	3.0	5.4	2.3	0.7
Friendships satisfaction	0.6	0.7	1.3	0.4	-1.1
Leg predicted mass (right)	0.6	3.0	5.4	2.3	0.7
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.5	-0.0	1.2
Alcohol drinker status: Never	0.6	0.7	1.4	1.2	-0.1
Basal metabolic rate	0.6	3.3	5.0	2.2	1.3
Risk taking	0.6	0.8	1.1	-0.7	-1.1
Reaction Time	0.5	0.9	1.5	-0.4	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.3	1.5	-0.1
Stomach or abdominal pain in last month	0.5	0.6	1.2	0.2	-1.1
Happiness	0.5	0.6	1.2	1.1	0.2
Lung cancer (father)	0.5	0.6	1.1	-1.1	0.3
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.1	0.1	-1.1
Worry too long after embarrassment	0.5	0.8	1.6	1.3	0.0
Heart disease (mother)	0.5	0.7	1.0	-0.6	1.0
Average weekly red wine intake	0.5	0.7	0.9	-0.9	0.7
Qualifications: nursing, teaching	0.5	0.7	1.3	1.1	0.4
Medication: Aspirin	0.5	0.7	1.2	1.1	0.3
Wears glasses or contact lenses	0.5	0.6	1.0	-1.0	-0.3
Ever smoked	0.5	0.9	1.8	0.3	-1.3
Irritability	0.5	0.9	1.3	0.7	-1.1
Impedance of whole body	0.5	2.8	3.9	-1.3	2.0
Depression (Nagel 2018)	0.4	0.6	1.2	1.1	-0.0
Age at First Birth	0.4	0.6	1.0	-1.0	-0.4
Lupus	0.4	0.6	1.0	-0.4	1.0
Rheumatoid Arthritis	0.4	0.5	0.9	-0.9	0.3
Systolic Blood Pressure	0.4	1.8	3.3	-1.8	0.5
Hearing difficulty/problems: Yes	0.4	0.6	1.1	-0.2	1.1
Leg fat-free mass (left)	0.4	2.1	3.8	1.9	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.1	1.0	-0.1
High blood pressure	0.4	1.1	2.1	0.2	-1.4
Medication: Levothyroxine sodium	0.4	0.7	1.3	-0.1	1.2
Leg predicted mass (left)	0.4	2.0	3.7	1.9	0.6
Past tobacco smoking	0.4	0.8	1.4	-0.4	1.2
Had other major operations	0.4	0.5	1.0	-0.2	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	1.4	-0.4	-1.2
Diabetes (self-reported)	0.4	0.7	0.7	-0.8	-0.8
Tense / ‘highly strung’	0.4	0.7	1.3	-1.1	-0.2
Shortness of breath walking on level ground	0.4	0.5	1.0	-0.3	-1.0
Mean time to correctly identify matches	0.4	0.9	1.7	0.2	1.3
Hypertension (Self-reported)	0.4	1.2	1.7	0.8	-1.3
Long-standing illness, disability or infirmity	0.4	0.6	0.9	-0.9	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.0	-0.4	-1.0
Medication for cholesterol	0.4	0.7	0.7	-0.8	0.8
Financial situation satisfaction	0.4	0.5	0.7	0.8	-0.5
Medication: Atorvastatin	0.4	0.5	0.7	-0.6	-0.8
LDL Cholesterol	0.3	0.5	0.9	-0.3	0.9
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.2	-1.1	-0.3
Lung FVC	0.3	1.7	2.1	1.1	1.4
Hair Pigment	0.3	9.2	17.7	-4.2	0.8
Townsend deprivation index at recruitment	0.3	0.4	0.6	-0.8	-0.5
Age when periods started (menarche)	0.3	0.7	1.3	1.1	0.2
Qualifications: CSEs or equivalent	0.3	0.5	0.5	0.7	-0.7
Number of incorrect matches in round	0.3	0.5	0.6	-0.8	0.6
Pulse rate	0.3	0.5	1.0	-0.1	-1.0
Impedance of arm (left)	0.3	1.2	1.3	-1.0	1.1
Number of children fathered	0.3	0.3	0.7	0.8	-0.2
Diabetes diagnosed by doctor	0.3	0.5	0.7	-0.9	-0.4
Illnesses of father: None of the above (group 1)	0.3	0.3	0.6	0.1	0.8
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.6	-0.0	1.3
Average weekly spirits intake	0.2	0.2	0.3	0.3	-0.5
Diabetes (father)	0.2	0.2	0.2	-0.5	-0.4
Financial difficulties in last 2 years	0.2	0.3	0.5	-0.7	-0.2
Hip circumference	0.2	0.7	1.1	-1.1	-0.5
Hair/balding pattern: Pattern 3	0.2	0.4	0.6	0.8	0.3
Number of live births	0.2	0.3	0.5	0.4	-0.7
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.4	-0.6	0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.3	0.3	0.5
Emphysema/chronic bronchitis	0.2	0.3	0.5	-0.0	-0.7
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.4	-0.6	-0.4
Commuting to job workplace: Walk	0.2	0.3	0.4	0.3	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.6	0.1	0.7
Diastolic blood pressure, automated reading	0.2	0.7	1.5	-0.0	1.2
Cholesterol lowering medication	0.2	0.3	0.6	-0.8	-0.2
Worry (Nagel 2018)	0.1	0.2	0.4	0.2	-0.7
Ovarian Cancer	0.1	0.1	0.2	0.5	0.1
HDL Cholesterol	0.1	0.2	0.3	-0.3	0.5
Triglycerides	0.1	0.2	0.3	0.4	0.6
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.1	0.4	-0.2
Blood Red Count	0.1	1.3	1.7	1.3	-1.0
Tanning	0.1	1.7	3.2	1.8	-0.5
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	0.5	-0.2
Medication: Co-codamol	0.1	0.1	0.1	0.3	0.1
Severe depression (siblings)	0.1	0.1	0.1	-0.3	-0.3
Relative age voice broke	0.1	0.1	0.1	0.2	0.4
Serious illness, injury or assault to yourself	0.1	0.1	0.2	0.0	0.4
Nervous feelings	0.1	0.2	0.4	0.1	0.6
Heart attack	0.1	0.2	0.2	-0.4	-0.5
Medication: Ramipril	0.1	0.1	0.2	0.5	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.5	-0.0	-0.7
Falls in the last year	0.1	0.2	0.3	0.2	-0.6
Breastfed as a baby	0.1	0.2	0.3	0.6	0.0
Hair/balding pattern: Pattern 4	0.1	0.2	0.3	0.3	-0.5
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	0.2	-0.5
Pulse rate, automated reading	0.1	0.2	0.3	-0.5	-0.3
Number of full sisters	0.1	0.1	0.2	-0.4	0.0
Family relationship satisfaction	0.1	0.2	0.2	0.4	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.5	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.1	0.1	0.4
Smoking status: Previous	0.1	0.1	0.1	0.4	-0.3
Osteoarthritis (self-reported)	0.1	0.1	0.1	-0.4	-0.1
High cholesterol (Self-reported)	0.1	0.2	0.3	-0.2	-0.6
Unable to work because of sickness or disability	0.1	0.1	0.1	-0.3	0.3
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.4	-0.2
Breast Cancer	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
HbA1C	0.0	0.0	0.1	-0.0	-0.2
Ever had hysterectomy (womb removed)	0.0	0.0	0.0	0.2	-0.1
Had menopause	0.0	0.0	0.1	-0.2	-0.2
Weight	0.0	0.1	0.1	-0.3	-0.3
Medication for cholesterol, blood pressure or diabetes	0.0	0.1	0.1	0.3	-0.1
Exposure to tobacco smoke outside home	0.0	0.0	0.1	0.0	-0.2
Medication: Blood pressure	0.0	0.0	0.1	0.3	-0.1
Osteoporosis (self-reported)	0.0	0.1	0.1	0.3	0.1
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.0	0.2	-0.2

Hub : Genes

LRP1

Models

Trait associations