Best TWAS P=1.96e-09 · Best GWAS P=4.14e-13 conditioned to 5.72e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | AFAP1 | 0.60 | 0.28 | lasso | 11 | 0.34 | 1.1e-09 | -5.5 | -5.2 | 1.6e-07 | -0.38 | 0.70 | 0.19 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | AFAP1-AS1 | 0.33 | 0.16 | lasso | 7 | 0.16 | 5.9e-05 | -5.5 | -5.8 | 8.8e-09 | -0.37 | 0.29 | 0.13 | FALSE |
| 3 | GTEx | Brain Cerebellum | AFAP1 | 0.47 | 0.19 | lasso | 4 | 0.19 | 2.8e-06 | 5.7 | -6.0 | 2.0e-09 | -0.48 | 0.20 | 0.63 | TRUE |
| 4 | GTEx | Skin Not Sun Exposed Suprapubic | AFAP1 | 0.47 | 0.46 | lasso | 4 | 0.45 | 2.8e-27 | -5.1 | -5.2 | 1.6e-07 | -0.31 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | AFAP1-AS1 | 0.33 | 0.30 | lasso | 6 | 0.29 | 4.0e-16 | -5.1 | -5.2 | 1.6e-07 | -0.32 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Skin Sun Exposed Lower leg | AFAP1 | 0.50 | 0.45 | lasso | 8 | 0.46 | 4.2e-42 | -5.1 | -5.2 | 2.0e-07 | -0.32 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | AFAP1-AS1 | 0.34 | 0.26 | lasso | 5 | 0.24 | 8.3e-20 | -5.1 | -5.3 | 1.1e-07 | -0.33 | 1.00 | 0.00 | FALSE |
| 8 | METSIM | Adipose | AFAP1 | 0.05 | 0.03 | enet | 13 | 0.03 | 1.3e-05 | -5.1 | -5.7 | 1.6e-08 | -0.31 | 0.87 | 0.04 | FALSE |
| 9 | NTR | Blood | AFAP1 | 0.13 | 0.12 | lasso | 6 | 0.13 | 3.1e-39 | -5.1 | -5.2 | 2.4e-07 | -0.32 | 1.00 | 0.00 | FALSE |