Hub : Traits :

Glaucoma (self-reported)

26 significantly associated models · 8 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 164933115 166462417 3 1 2.1e-27 2.2e-29 1.0e+00 100 TMCO1
2 4 7060959 8640389 2 1 2.0e-09 4.1e-13 5.7e-07 52 AFAP1
3 9 21303958 22705094 1 1 5.7e-12 1.3e-14 4.2e-04 79 CDKN2B
4 14 60168943 61664530 1 1 2.4e-07 1.0e-10 5.3e-05 61 C14orf39
5 17 9114358 10799013 1 1 1.3e-09 1.2e-12 1.5e-04 71 GAS7

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depressed Affect (Nagel 2018) 1.68 1 0 0.0 0 1.00000 AFAP1
Breast Cancer 2.22 1 0 0.0 0 1.00000 CDKN2B
Coronary Artery Disease (CAD) 15.74 1 1 2.2 0 1.00000 CDKN2B
Type 2 Diabetes (T2D) (2012) 2.82 1 0 0.0 0 1.00000 CDKN2B
Blood Platelet Count 0.46 1 0 0.0 0 1.00000 CDKN2B
Blood Red Count 0.53 2 0 0.0 0 1.00000 C14orf39 CDKN2B
Blood White Count 0.52 1 0 0.0 0 1.00000 CDKN2B
Heel T-Score 3.03 2 2 4.4 0 1.00000 C14orf39 GAS7
Height 5.22 3 3 6.7 0 1.00000 AFAP1 C14orf39 GAS7
Waist Hip Ratio (WHR) 1.98 2 0 0.0 0 1.00000 C14orf39 TMCO1
Systolic Blood Pressure 1.57 1 1 2.2 0 1.00000 AFAP1
Smoking Status 2.48 1 0 0.0 0 1.00000 C14orf39
Cardiovascular Disease 1.29 1 0 0.0 0 1.00000 TMCO1
Lung FEV1/FVC ratio 2.12 1 1 2.2 0 1.00000 AFAP1
Neuroticism 1.55 1 0 0.0 0 1.00000 AFAP1
Chronotype (morning person) 1.77 1 0 0.0 0 1.00000 C14orf39
Hair Pigment 0.62 1 1 2.2 0 1.00000 CDKN2B
Tanning 0.19 1 0 0.0 0 1.00000 GAS7
Hand grip strength (left) 2.87 2 0 0.0 0 1.00000 AFAP1 C14orf39
Average weekly spirits intake 2.48 1 0 0.0 0 1.00000 AFAP1
Hearing difficulty/problems: Yes 2.32 1 0 0.0 0 1.00000 AFAP1
Angina 15.17 1 1 2.2 0 1.00000 CDKN2B
Medication: Metformin 2.45 1 0 0.0 0 1.00000 CDKN2B
Impedance of leg (right) 1.23 1 0 0.0 0 1.00000 C14orf39
Leg fat-free mass (left) 2.93 1 1 2.2 0 1.00000 C14orf39
Trunk fat percentage 1.00 1 0 0.0 0 1.00000 AFAP1
Hand grip strength (right) 3.10 2 0 0.0 0 1.00000 AFAP1 C14orf39
Fed-up feelings 1.93 1 0 0.0 0 1.00000 AFAP1
Age when periods started (menarche) 3.16 1 1 2.2 0 1.00000 C14orf39
Heel bone mineral density (BMD) T-score, automated (left) 3.92 2 0 0.0 0 1.00000 C14orf39 GAS7
Medication: Atenolol 2.72 1 0 0.0 0 1.00000 CDKN2B
Sitting height 4.31 3 3 6.7 0 1.00000 AFAP1 C14orf39 GAS7
Body mass index (BMI) 0.90 1 0 0.0 0 1.00000 AFAP1
Impedance of leg (left) 1.07 1 0 0.0 0 1.00000 C14orf39
Leg predicted mass (left) 2.89 1 1 2.2 0 1.00000 C14orf39
Trunk fat mass 1.02 1 0 0.0 0 1.00000 C14orf39
Nervous feelings 1.56 1 0 0.0 0 1.00000 C14orf39
Forced vital capacity (FVC) 2.43 2 0 0.0 0 1.00000 AFAP1 GAS7
Heel bone mineral density (BMD) T-score, automated (right) 3.58 1 0 0.0 0 1.00000 C14orf39
Mouth/teeth dental problems 2.46 1 0 0.0 0 1.00000 CDKN2B
Heart attack 11.89 1 1 2.2 0 1.00000 CDKN2B
Medication: Simvastatin 2.52 1 0 0.0 0 1.00000 CDKN2B
Neuroticism score 1.88 1 0 0.0 0 1.00000 AFAP1
Weight 2.05 1 1 2.2 0 1.00000 C14orf39
Impedance of arm (right) 0.80 1 0 0.0 0 1.00000 CDKN2B
Arm fat percentage (right) 1.41 1 0 0.0 0 1.00000 AFAP1
Trunk fat-free mass 5.08 3 1 2.2 0 1.00000 AFAP1 C14orf39 GAS7
Hip circumference 1.41 1 1 2.2 0 1.00000 C14orf39
Father's age at death 4.31 1 0 0.0 0 1.00000 CDKN2B
Forced expiratory volume in 1-second (FEV1) 2.52 1 0 0.0 0 1.00000 AFAP1
Medication: Cholesterol lowering 3.17 1 0 0.0 0 1.00000 CDKN2B
Illnesses of mother 2.33 1 0 0.0 0 1.00000 CDKN2B
Forced expiratory volume in 1-second (FEV1), Best measure 2.39 1 0 0.0 0 1.00000 AFAP1
Arm fat mass (right) 1.00 1 0 0.0 0 1.00000 C14orf39
Trunk predicted mass 5.22 3 1 2.2 0 1.00000 AFAP1 C14orf39 GAS7
Standing height 5.56 3 3 6.7 0 1.00000 AFAP1 C14orf39 GAS7
Forced vital capacity (FVC), Best measure 2.01 1 0 0.0 0 1.00000 AFAP1
Body fat percentage 1.08 1 0 0.0 0 1.00000 AFAP1
Leg fat percentage (right) 1.11 1 0 0.0 0 1.00000 AFAP1
Arm fat-free mass (right) 3.80 1 1 2.2 0 1.00000 C14orf39
Age at first live birth 2.73 1 0 0.0 0 1.00000 GAS7
Shortness of breath walking on level ground 2.73 1 0 0.0 0 1.00000 AFAP1
Eye problems/disorders: None of the above 7.30 2 0 0.0 0 1.00000 AFAP1 TMCO1
Angina (self-reported) 15.03 1 1 2.2 0 1.00000 CDKN2B
Heart disease (mother) 7.06 1 1 2.2 0 1.00000 CDKN2B
Arm predicted mass (right) 3.97 1 1 2.2 0 1.00000 C14orf39
Comparative height size at age 10 3.03 2 1 2.2 0 1.00000 C14orf39 GAS7
Chest pain or discomfort 1.70 1 0 0.0 0 1.00000 CDKN2B
Age at last live birth 2.70 1 0 0.0 0 1.00000 AFAP1
Medication: Aspirin 6.57 1 1 2.2 0 1.00000 CDKN2B
Illnesses of father: Heart disease 14.01 1 1 2.2 0 1.00000 CDKN2B
Forced expiratory volume in 1-second (FEV1), predicted 4.65 3 0 0.0 0 1.00000 AFAP1 C14orf39 GAS7
Whole body fat-free mass 4.34 1 1 2.2 0 1.00000 C14orf39
Leg fat-free mass (right) 3.09 1 1 2.2 0 1.00000 C14orf39
Arm fat percentage (left) 1.39 1 0 0.0 0 1.00000 AFAP1
Long-standing illness, disability or infirmity 2.81 1 0 0.0 0 1.00000 CDKN2B
Breast cancer (self-reported) 3.04 1 0 0.0 0 1.00000 CDKN2B
Osteoarthritis (self-reported) 1.80 1 0 0.0 0 1.00000 GAS7
Medication: Aspirin 6.35 1 1 2.2 0 1.00000 CDKN2B
Illnesses of father: None of the above (group 1) 5.23 1 1 2.2 0 1.00000 CDKN2B
Whole body water mass 4.23 1 1 2.2 0 1.00000 C14orf39
Leg predicted mass (right) 3.10 1 1 2.2 0 1.00000 C14orf39
Miserableness 2.51 1 0 0.0 0 1.00000 AFAP1
Eye problems/disorders: Glaucoma 51.71 5 5 11.1 1 0.00015 AFAP1 C14orf39 CDKN2B GAS7 TMCO1
Medication: Atorvastatin 4.75 1 1 2.2 0 1.00000 CDKN2B
Basal metabolic rate 3.75 1 1 2.2 0 1.00000 C14orf39
Leg fat percentage (left) 1.01 1 0 0.0 0 1.00000 AFAP1
Arm fat-free mass (left) 4.28 1 1 2.2 0 1.00000 C14orf39
Number of operations (self-reported) 2.77 1 0 0.0 0 1.00000 C14orf39
Diastolic blood pressure, automated reading 1.26 1 0 0.0 0 1.00000 CDKN2B
Myopia 4.93 2 0 0.0 0 1.00000 C14orf39 TMCO1
Vascular/heart problems diagnosed by doctor 1.33 1 0 0.0 0 1.00000 CDKN2B
Cholesterol lowering medication 1.81 1 0 0.0 0 1.00000 CDKN2B
Basal cell carcinoma (self-reported) 4.16 1 0 0.0 0 1.00000 CDKN2B
Heart attack/myocardial infarction (self-reported) 12.26 1 1 2.2 0 1.00000 CDKN2B
Heart disease (siblings) 2.01 1 0 0.0 0 1.00000 CDKN2B
Impedance of whole body 0.90 1 0 0.0 0 1.00000 C14orf39
Arm predicted mass (left) 4.20 1 1 2.2 0 1.00000 C14orf39

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.2
GTEx Adipose Visceral Omentum 0 0.000 1.2
GTEx Adrenal Gland 0 0.000 1.2
GTEx Artery Aorta 1 0.034 1.2
GTEx Artery Coronary 0 0.000 1.2
GTEx Artery Tibial 2 0.053 1.2
GTEx Brain Caudate basal ganglia 0 0.000 1.2
GTEx Brain Cerebellar Hemisphere 2 0.134 1.2
GTEx Brain Cerebellum 1 0.050 1.2
GTEx Brain Cortex 0 0.000 1.2
GTEx Brain Frontal Cortex BA9 0 0.000 1.1
GTEx Brain Hippocampus 0 0.000 1.2
GTEx Brain Hypothalamus 0 0.000 1.2
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.1
GTEx Brain Putamen basal ganglia 0 0.000 1.1
GTEx Breast Mammary Tissue 0 0.000 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.2
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.2
GTEx Cells Transformed fibroblasts 2 0.048 1.2
GTEx Colon Sigmoid 1 0.068 1.2
GTEx Colon Transverse 0 0.000 1.2
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.2
GTEx Esophagus Mucosa 0 0.000 1.2
GTEx Esophagus Muscularis 0 0.000 1.2
GTEx Heart Atrial Appendage 0 0.000 1.2
GTEx Heart Left Ventricle 0 0.000 1.2
GTEx Liver 0 0.000 1.2
GTEx Lung 1 0.035 1.2
GTEx Muscle Skeletal 2 0.069 1.1
GTEx Nerve Tibial 1 0.023 1.2
GTEx Ovary 0 0.000 1.2
GTEx Pancreas 0 0.000 1.2
GTEx Pituitary 0 0.000 1.2
GTEx Prostate 0 0.000 1.2
GTEx Skin Not Sun Exposed Suprapubic 2 0.081 1.2
GTEx Skin Sun Exposed Lower leg 2 0.055 1.2
GTEx Small Intestine Terminal Ileum 0 0.000 1.2
GTEx Spleen 0 0.000 1.2
GTEx Stomach 1 0.069 1.2
GTEx Testis 0 0.000 1.2
GTEx Thyroid 0 0.000 1.2
GTEx Uterus 0 0.000 1.2
GTEx Vagina 0 0.000 1.2
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 1 0.022 1.1
NTR Blood 1 0.042 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.2
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 1 0.019 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 1 0.049 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 1 0.023 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Pancreatic Adenocarcinoma 1 0.060 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 1 0.022 1.1
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.1
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.2
The Cancer Genome Atlas Thyroid Carcinoma 1 0.019 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.1