Hub : Traits :

Glaucoma (self-reported)

26 significantly associated models · 8 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	164933115	166462417	3	1	2.1e-27	2.2e-29	1.0e+00	100	TMCO1
2	4	7060959	8640389	2	1	2.0e-09	4.1e-13	5.7e-07	52	AFAP1
3	9	21303958	22705094	1	1	5.7e-12	1.3e-14	4.2e-04	79	CDKN2B
4	14	60168943	61664530	1	1	2.4e-07	1.0e-10	5.3e-05	61	C14orf39
5	17	9114358	10799013	1	1	1.3e-09	1.2e-12	1.5e-04	71	GAS7

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Eye problems/disorders: Glaucoma	51.71	5	5	11.1	1	0.00015	AFAP1 C14orf39 CDKN2B GAS7 TMCO1
Coronary Artery Disease (CAD)	15.74	1	1	2.2	0	1.00000	CDKN2B
Angina	15.17	1	1	2.2	0	1.00000	CDKN2B
Angina (self-reported)	15.03	1	1	2.2	0	1.00000	CDKN2B
Illnesses of father: Heart disease	14.01	1	1	2.2	0	1.00000	CDKN2B
Heart attack/myocardial infarction (self-reported)	12.26	1	1	2.2	0	1.00000	CDKN2B
Heart attack	11.89	1	1	2.2	0	1.00000	CDKN2B
Eye problems/disorders: None of the above	7.30	2	0	0.0	0	1.00000	AFAP1 TMCO1
Heart disease (mother)	7.06	1	1	2.2	0	1.00000	CDKN2B
Medication: Aspirin	6.57	1	1	2.2	0	1.00000	CDKN2B
Medication: Aspirin	6.35	1	1	2.2	0	1.00000	CDKN2B
Standing height	5.56	3	3	6.7	0	1.00000	AFAP1 C14orf39 GAS7
Illnesses of father: None of the above (group 1)	5.23	1	1	2.2	0	1.00000	CDKN2B
Height	5.22	3	3	6.7	0	1.00000	AFAP1 C14orf39 GAS7
Trunk predicted mass	5.22	3	1	2.2	0	1.00000	AFAP1 C14orf39 GAS7
Trunk fat-free mass	5.08	3	1	2.2	0	1.00000	AFAP1 C14orf39 GAS7
Myopia	4.93	2	0	0.0	0	1.00000	C14orf39 TMCO1
Medication: Atorvastatin	4.75	1	1	2.2	0	1.00000	CDKN2B
Forced expiratory volume in 1-second (FEV1), predicted	4.65	3	0	0.0	0	1.00000	AFAP1 C14orf39 GAS7
Whole body fat-free mass	4.34	1	1	2.2	0	1.00000	C14orf39
Sitting height	4.31	3	3	6.7	0	1.00000	AFAP1 C14orf39 GAS7
Father's age at death	4.31	1	0	0.0	0	1.00000	CDKN2B
Arm fat-free mass (left)	4.28	1	1	2.2	0	1.00000	C14orf39
Whole body water mass	4.23	1	1	2.2	0	1.00000	C14orf39
Arm predicted mass (left)	4.20	1	1	2.2	0	1.00000	C14orf39
Basal cell carcinoma (self-reported)	4.16	1	0	0.0	0	1.00000	CDKN2B
Arm predicted mass (right)	3.97	1	1	2.2	0	1.00000	C14orf39
Heel bone mineral density (BMD) T-score, automated (left)	3.92	2	0	0.0	0	1.00000	C14orf39 GAS7
Arm fat-free mass (right)	3.80	1	1	2.2	0	1.00000	C14orf39
Basal metabolic rate	3.75	1	1	2.2	0	1.00000	C14orf39
Heel bone mineral density (BMD) T-score, automated (right)	3.58	1	0	0.0	0	1.00000	C14orf39
Medication: Cholesterol lowering	3.17	1	0	0.0	0	1.00000	CDKN2B
Age when periods started (menarche)	3.16	1	1	2.2	0	1.00000	C14orf39
Hand grip strength (right)	3.10	2	0	0.0	0	1.00000	AFAP1 C14orf39
Leg predicted mass (right)	3.10	1	1	2.2	0	1.00000	C14orf39
Leg fat-free mass (right)	3.09	1	1	2.2	0	1.00000	C14orf39
Breast cancer (self-reported)	3.04	1	0	0.0	0	1.00000	CDKN2B
Heel T-Score	3.03	2	2	4.4	0	1.00000	C14orf39 GAS7
Comparative height size at age 10	3.03	2	1	2.2	0	1.00000	C14orf39 GAS7
Leg fat-free mass (left)	2.93	1	1	2.2	0	1.00000	C14orf39
Leg predicted mass (left)	2.89	1	1	2.2	0	1.00000	C14orf39
Hand grip strength (left)	2.87	2	0	0.0	0	1.00000	AFAP1 C14orf39
Type 2 Diabetes (T2D) (2012)	2.82	1	0	0.0	0	1.00000	CDKN2B
Long-standing illness, disability or infirmity	2.81	1	0	0.0	0	1.00000	CDKN2B
Number of operations (self-reported)	2.77	1	0	0.0	0	1.00000	C14orf39
Age at first live birth	2.73	1	0	0.0	0	1.00000	GAS7
Shortness of breath walking on level ground	2.73	1	0	0.0	0	1.00000	AFAP1
Medication: Atenolol	2.72	1	0	0.0	0	1.00000	CDKN2B
Age at last live birth	2.70	1	0	0.0	0	1.00000	AFAP1
Medication: Simvastatin	2.52	1	0	0.0	0	1.00000	CDKN2B
Forced expiratory volume in 1-second (FEV1)	2.52	1	0	0.0	0	1.00000	AFAP1
Miserableness	2.51	1	0	0.0	0	1.00000	AFAP1
Smoking Status	2.48	1	0	0.0	0	1.00000	C14orf39
Average weekly spirits intake	2.48	1	0	0.0	0	1.00000	AFAP1
Mouth/teeth dental problems	2.46	1	0	0.0	0	1.00000	CDKN2B
Medication: Metformin	2.45	1	0	0.0	0	1.00000	CDKN2B
Forced vital capacity (FVC)	2.43	2	0	0.0	0	1.00000	AFAP1 GAS7
Forced expiratory volume in 1-second (FEV1), Best measure	2.39	1	0	0.0	0	1.00000	AFAP1
Illnesses of mother	2.33	1	0	0.0	0	1.00000	CDKN2B
Hearing difficulty/problems: Yes	2.32	1	0	0.0	0	1.00000	AFAP1
Breast Cancer	2.22	1	0	0.0	0	1.00000	CDKN2B
Lung FEV1/FVC ratio	2.12	1	1	2.2	0	1.00000	AFAP1
Weight	2.05	1	1	2.2	0	1.00000	C14orf39
Forced vital capacity (FVC), Best measure	2.01	1	0	0.0	0	1.00000	AFAP1
Heart disease (siblings)	2.01	1	0	0.0	0	1.00000	CDKN2B
Waist Hip Ratio (WHR)	1.98	2	0	0.0	0	1.00000	C14orf39 TMCO1
Fed-up feelings	1.93	1	0	0.0	0	1.00000	AFAP1
Neuroticism score	1.88	1	0	0.0	0	1.00000	AFAP1
Cholesterol lowering medication	1.81	1	0	0.0	0	1.00000	CDKN2B
Osteoarthritis (self-reported)	1.80	1	0	0.0	0	1.00000	GAS7
Chronotype (morning person)	1.77	1	0	0.0	0	1.00000	C14orf39
Chest pain or discomfort	1.70	1	0	0.0	0	1.00000	CDKN2B
Depressed Affect (Nagel 2018)	1.68	1	0	0.0	0	1.00000	AFAP1
Systolic Blood Pressure	1.57	1	1	2.2	0	1.00000	AFAP1
Nervous feelings	1.56	1	0	0.0	0	1.00000	C14orf39
Neuroticism	1.55	1	0	0.0	0	1.00000	AFAP1
Arm fat percentage (right)	1.41	1	0	0.0	0	1.00000	AFAP1
Hip circumference	1.41	1	1	2.2	0	1.00000	C14orf39
Arm fat percentage (left)	1.39	1	0	0.0	0	1.00000	AFAP1
Vascular/heart problems diagnosed by doctor	1.33	1	0	0.0	0	1.00000	CDKN2B
Cardiovascular Disease	1.29	1	0	0.0	0	1.00000	TMCO1
Diastolic blood pressure, automated reading	1.26	1	0	0.0	0	1.00000	CDKN2B
Impedance of leg (right)	1.23	1	0	0.0	0	1.00000	C14orf39
Leg fat percentage (right)	1.11	1	0	0.0	0	1.00000	AFAP1
Body fat percentage	1.08	1	0	0.0	0	1.00000	AFAP1
Impedance of leg (left)	1.07	1	0	0.0	0	1.00000	C14orf39
Trunk fat mass	1.02	1	0	0.0	0	1.00000	C14orf39
Leg fat percentage (left)	1.01	1	0	0.0	0	1.00000	AFAP1
Trunk fat percentage	1.00	1	0	0.0	0	1.00000	AFAP1
Arm fat mass (right)	1.00	1	0	0.0	0	1.00000	C14orf39
Body mass index (BMI)	0.90	1	0	0.0	0	1.00000	AFAP1
Impedance of whole body	0.90	1	0	0.0	0	1.00000	C14orf39
Impedance of arm (right)	0.80	1	0	0.0	0	1.00000	CDKN2B
Hair Pigment	0.62	1	1	2.2	0	1.00000	CDKN2B
Blood Red Count	0.53	2	0	0.0	0	1.00000	C14orf39 CDKN2B
Blood White Count	0.52	1	0	0.0	0	1.00000	CDKN2B
Blood Platelet Count	0.46	1	0	0.0	0	1.00000	CDKN2B
Tanning	0.19	1	0	0.0	0	1.00000	GAS7

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.3
GTEx	Adipose Subcutaneous	0	0.000	1.2
GTEx	Adipose Visceral Omentum	0	0.000	1.2
GTEx	Adrenal Gland	0	0.000	1.2
GTEx	Artery Aorta	1	0.034	1.2
GTEx	Artery Coronary	0	0.000	1.2
GTEx	Artery Tibial	2	0.053	1.2
GTEx	Brain Caudate basal ganglia	0	0.000	1.2
GTEx	Brain Cerebellar Hemisphere	2	0.134	1.2
GTEx	Brain Cerebellum	1	0.050	1.2
GTEx	Brain Cortex	0	0.000	1.2
GTEx	Brain Hippocampus	0	0.000	1.2
GTEx	Brain Hypothalamus	0	0.000	1.2
GTEx	Breast Mammary Tissue	0	0.000	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.2
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.2
GTEx	Cells Transformed fibroblasts	2	0.048	1.2
GTEx	Colon Sigmoid	1	0.068	1.2
GTEx	Colon Transverse	0	0.000	1.2
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.2
GTEx	Esophagus Mucosa	0	0.000	1.2
GTEx	Esophagus Muscularis	0	0.000	1.2
GTEx	Heart Atrial Appendage	0	0.000	1.2
GTEx	Heart Left Ventricle	0	0.000	1.2
GTEx	Liver	0	0.000	1.2
GTEx	Lung	1	0.035	1.2
GTEx	Nerve Tibial	1	0.023	1.2
GTEx	Ovary	0	0.000	1.2
GTEx	Pancreas	0	0.000	1.2
GTEx	Pituitary	0	0.000	1.2
GTEx	Prostate	0	0.000	1.2
GTEx	Skin Not Sun Exposed Suprapubic	2	0.081	1.2
GTEx	Skin Sun Exposed Lower leg	2	0.055	1.2
GTEx	Small Intestine Terminal Ileum	0	0.000	1.2
GTEx	Spleen	0	0.000	1.2
GTEx	Stomach	1	0.069	1.2
GTEx	Testis	0	0.000	1.2
GTEx	Thyroid	0	0.000	1.2
GTEx	Uterus	0	0.000	1.2
GTEx	Vagina	0	0.000	1.2
GTEx	Whole Blood	0	0.000	1.2
NTR	Blood	1	0.042	1.2
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.2
YFS	Blood	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	1	0.019	1.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	1	0.049	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	1	0.023	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	1	0.060	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.2
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	1	0.019	1.2
GTEx	Brain Frontal Cortex BA9	0	0.000	1.1
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.1
GTEx	Brain Putamen basal ganglia	0	0.000	1.1
GTEx	Muscle Skeletal	2	0.069	1.1
METSIM	Adipose	1	0.022	1.1
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Prostate Adenocarcinoma	1	0.022	1.1
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.1
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.1