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chr16:71,227,328-72,845,749

Best TWAS P=1.18e-18 · Best GWAS P=9.32e-18 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DHODH	0.18	0.13	lasso	5	0.13	5.7e-16	-6.44	6.7	2.2e-11	0.55	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	DHX38	0.31	0.39	enet	41	0.41	3.2e-54	6.19	6.7	2.0e-11	0.73	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	HPR	0.72	0.60	lasso	7	0.61	6.9e-94	8.58	8.6	5.2e-18	1.00	0.00	1.00	FALSE
4	CommonMind	Brain Pre-frontal Cortex	TXNL4B	0.05	0.07	lasso	3	0.06	8.8e-08	8.58	8.0	1.1e-15	0.97	0.00	1.00	FALSE
5	GTEx	Adrenal Gland	DHX38	0.09	-0.01	enet	8	0.00	4.5e-01	-4.21	5.5	3.2e-08	0.41	0.12	0.08	FALSE
6	GTEx	Artery Aorta	DHODH	0.21	0.15	enet	15	0.19	1.7e-10	-6.65	7.0	2.3e-12	0.63	1.00	0.00	FALSE
7	GTEx	Artery Tibial	DHODH	0.34	0.30	lasso	5	0.31	5.9e-25	-6.65	-6.7	1.7e-11	-0.48	1.00	0.00	FALSE
8	GTEx	Brain Cerebellar Hemisphere	DHODH	0.21	0.17	lasso	4	0.15	1.4e-04	-6.69	-5.7	1.5e-08	-0.47	0.08	0.10	TRUE
9	GTEx	Brain Cortex	DHODH	0.21	0.06	enet	14	0.05	1.5e-02	6.19	6.5	8.4e-11	0.81	0.01	0.90	TRUE
10	GTEx	Breast Mammary Tissue (Male)	DHODH	0.03	0.00	lasso	1	0.03	5.9e-02	-6.65	6.7	2.9e-11	0.49	0.04	0.06	FALSE
11	GTEx	Breast Mammary Tissue (Male)	RP11-498D10.5	0.15	0.12	lasso	4	0.17	8.5e-05	5.56	5.2	2.1e-07	0.44	0.04	0.19	FALSE
12	GTEx	Breast Mammary Tissue (Female)	DHODH	0.13	0.04	lasso	4	0.08	2.9e-03	6.29	5.1	2.9e-07	0.56	0.08	0.13	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	DHX38	0.16	0.03	lasso	8	0.03	3.1e-02	6.19	5.7	9.5e-09	0.65	0.15	0.06	FALSE
14	GTEx	Cells Transformed fibroblasts	DHODH	0.33	0.25	lasso	8	0.25	5.8e-19	-6.69	5.9	3.9e-09	0.37	1.00	0.00	FALSE
15	GTEx	Colon Sigmoid	DHODH	0.24	0.26	lasso	6	0.21	6.5e-08	-6.44	6.7	1.5e-11	0.55	0.92	0.03	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	DHODH	0.16	0.14	enet	8	0.09	4.2e-04	-6.65	6.3	3.6e-10	0.58	0.58	0.14	FALSE
17	GTEx	Esophagus Mucosa	DHODH	0.15	0.09	lasso	1	0.08	9.6e-06	-6.69	6.7	2.3e-11	0.48	0.69	0.02	FALSE
18	GTEx	Esophagus Muscularis	DHODH	0.24	0.19	enet	15	0.25	4.4e-15	6.25	6.6	5.1e-11	0.62	1.00	0.00	FALSE
19	GTEx	Esophagus Muscularis	DHX38	0.09	0.07	lasso	7	0.05	4.2e-04	6.25	6.6	5.6e-11	0.69	0.26	0.61	TRUE
20	GTEx	Heart Left Ventricle	DHODH	0.16	0.13	lasso	4	0.12	3.9e-07	-6.69	6.1	1.1e-09	0.51	0.87	0.04	TRUE
21	GTEx	Heart Left Ventricle	HP	0.14	0.03	lasso	4	0.03	1.1e-02	4.76	6.1	8.1e-10	0.79	0.04	0.86	FALSE
22	GTEx	Nerve Tibial	DHODH	0.33	0.26	lasso	5	0.26	2.5e-18	-6.65	6.7	1.6e-11	0.54	1.00	0.00	FALSE
23	GTEx	Ovary	IST1	0.31	0.03	enet	37	0.07	1.0e-02	-0.68	-5.5	3.2e-08	-0.48	0.08	0.14	FALSE
24	GTEx	Skin Sun Exposed Lower leg	DHODH	0.13	0.14	enet	13	0.10	2.7e-08	-6.65	5.5	2.9e-08	0.50	1.00	0.00	FALSE
25	GTEx	Testis	DHODH	0.29	0.24	lasso	6	0.21	1.6e-09	-6.65	6.2	6.3e-10	0.43	1.00	0.00	FALSE
26	METSIM	Adipose	DHX38	0.08	0.06	lasso	7	0.09	4.5e-13	-5.57	5.8	5.1e-09	0.54	1.00	0.00	TRUE
27	METSIM	Adipose	HP	0.09	0.10	blup	360	0.09	2.9e-13	3.89	-5.8	4.9e-09	-0.62	1.00	0.00	FALSE
28	NTR	Blood	DHX38	0.02	0.01	blup	355	0.02	6.5e-06	-3.80	5.9	3.1e-09	0.45	0.86	0.09	FALSE
29	YFS	Blood	DHX38	0.07	0.11	lasso	7	0.11	1.1e-33	6.19	5.9	4.3e-09	0.65	1.00	0.00	FALSE
30	The Cancer Genome Atlas	Glioblastoma Multiforme	HPR	0.82	0.49	lasso	3	0.47	3.4e-16	8.58	8.7	4.9e-18	1.00	0.00	1.00	FALSE
31	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HP	0.02	0.01	blup	53	0.02	5.9e-03	3.40	-5.5	3.5e-08	-0.56	0.10	0.21	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DHODH	0.15	0.15	lasso	7	0.14	1.5e-15	-6.65	6.0	1.7e-09	0.51	1.00	0.00	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HP	0.02	0.00	blup	53	0.02	1.5e-03	6.15	-5.5	4.8e-08	-0.55	0.33	0.06	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	DHX38	0.02	0.01	blup	62	0.01	1.7e-02	-3.80	5.5	3.9e-08	0.48	0.04	0.41	FALSE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	HP	0.60	0.42	lasso	5	0.41	3.8e-50	8.58	8.7	3.6e-18	1.00	0.00	1.00	FALSE
36	The Cancer Genome Atlas	Brain Lower Grade Glioma	HPR	0.75	0.56	lasso	4	0.56	6.1e-76	8.58	8.6	1.0e-17	1.00	0.00	1.00	FALSE
37	The Cancer Genome Atlas	Brain Lower Grade Glioma	TXNL4B	0.44	0.29	lasso	4	0.29	3.2e-33	8.58	8.8	1.2e-18	0.99	0.00	1.00	TRUE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	HP	0.05	0.04	blup	53	0.04	9.8e-05	6.19	-7.7	1.6e-14	-0.66	0.43	0.53	TRUE
39	The Cancer Genome Atlas	Soft Tissue Sarcoma	DHODH	0.15	0.12	enet	7	0.12	1.1e-07	-6.65	5.5	3.3e-08	0.54	0.60	0.35	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	DHODH	0.22	0.15	enet	6	0.15	4.3e-14	-6.65	6.0	1.8e-09	0.50	1.00	0.00	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	HP	0.52	0.13	lasso	5	0.22	1.9e-21	-3.09	5.6	1.8e-08	0.12	1.00	0.00	TRUE