[Hub]/) : Traits : High cholesterol (Self-reported) : ← →

chr17:44,788,310-46,474,610

Best TWAS P=3.7e-09 · Best GWAS P=4.25e-09 conditioned to 0.348

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	TBKBP1	0.08	0.09	lasso	4	0.11	3.8e-09	-4.9	-5.4	5.4e-08	0.89	0.17	0.83	FALSE
2	GTEx	Artery Coronary	TBKBP1	0.20	0.20	lasso	5	0.18	1.3e-06	-4.9	-5.6	2.1e-08	0.93	0.05	0.95	FALSE
3	GTEx	Artery Tibial	TBKBP1	0.23	0.32	lasso	2	0.30	1.3e-23	-4.9	-5.2	2.1e-07	0.90	0.70	0.30	FALSE
4	GTEx	Artery Tibial	MRPL45P2	0.05	0.06	lasso	2	0.06	3.8e-05	-5.7	5.7	1.1e-08	-0.96	0.04	0.95	FALSE
5	GTEx	Cells EBV-transformed lymphocytes	AC002558.1	0.28	0.04	enet	22	0.07	2.2e-03	5.7	-5.6	2.5e-08	0.45	0.03	0.65	FALSE
6	GTEx	Cells EBV-transformed lymphocytes	MRPL45P2	0.37	0.41	lasso	5	0.42	5.3e-15	-5.6	5.6	1.9e-08	-0.96	0.04	0.96	FALSE
7	GTEx	Cells Transformed fibroblasts	NPEPPS	0.05	0.03	lasso	4	0.01	6.6e-02	4.9	5.2	2.2e-07	-0.86	0.06	0.89	FALSE
8	GTEx	Cells Transformed fibroblasts	MRPL45P2	0.14	0.14	lasso	6	0.13	1.1e-09	-5.6	5.5	2.9e-08	-0.94	0.04	0.96	FALSE
9	GTEx	Colon Transverse	EFCAB13	0.23	0.06	enet	35	0.08	1.5e-04	5.6	5.5	2.9e-08	-0.55	0.06	0.87	FALSE
10	GTEx	Esophagus Mucosa	MRPL45P2	0.11	0.13	enet	12	0.11	1.1e-07	-5.6	5.9	3.7e-09	-0.94	0.04	0.96	TRUE
11	GTEx	Esophagus Muscularis	EFCAB13	0.13	0.14	lasso	4	0.10	6.6e-07	5.6	5.6	2.7e-08	-0.81	0.04	0.96	FALSE
12	GTEx	Esophagus Muscularis	MRPL45P2	0.10	0.06	lasso	3	0.05	6.4e-04	-5.6	5.7	1.3e-08	-0.94	0.04	0.95	FALSE
13	GTEx	Liver	EFCAB13	0.20	0.04	enet	22	0.06	1.1e-02	5.0	5.5	4.9e-08	-0.61	0.05	0.84	FALSE
14	GTEx	Muscle Skeletal	MRPL45P2	0.09	0.10	lasso	4	0.10	9.8e-10	5.6	5.7	1.0e-08	-0.92	0.04	0.96	FALSE
15	GTEx	Pituitary	NPEPPS	0.20	0.10	enet	10	0.05	2.6e-02	4.4	5.8	7.7e-09	-0.71	0.05	0.63	FALSE
16	GTEx	Pituitary	EFCAB13	0.39	0.19	enet	23	0.26	3.5e-07	5.5	5.7	1.3e-08	-0.79	0.04	0.96	FALSE
17	GTEx	Skin Sun Exposed Lower leg	MRPL45P2	0.17	0.17	lasso	5	0.17	3.8e-14	-5.6	5.7	9.7e-09	-0.95	0.04	0.96	FALSE
18	GTEx	Skin Sun Exposed Lower leg	RP11-580I16.2	0.04	0.04	lasso	2	0.03	1.5e-03	5.7	-5.7	1.2e-08	0.89	0.03	0.95	FALSE
19	GTEx	Stomach	EFCAB13	0.22	0.14	enet	36	0.18	3.2e-09	4.7	5.1	2.7e-07	-0.51	0.08	0.92	FALSE
20	GTEx	Stomach	MRPL45P2	0.15	0.14	lasso	7	0.14	3.8e-07	-5.6	5.7	1.5e-08	-0.96	0.04	0.96	FALSE
21	GTEx	Whole Blood	TBKBP1	0.21	0.15	lasso	7	0.14	1.4e-12	-4.8	-5.2	1.8e-07	0.89	0.61	0.39	FALSE
22	YFS	Blood	KPNB1	0.01	0.01	lasso	3	0.01	4.6e-04	5.5	5.6	2.4e-08	-0.84	0.03	0.96	FALSE
23	YFS	Blood	TBKBP1	0.21	0.30	enet	11	0.30	3.2e-99	-4.8	-5.1	2.9e-07	0.87	0.72	0.27	FALSE
24	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C17orf57	0.06	0.08	enet	7	0.07	2.1e-06	5.5	5.5	3.1e-08	-0.88	0.01	0.99	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	TBKBP1	0.02	0.03	lasso	2	0.03	3.0e-06	5.0	-5.2	2.5e-07	0.81	0.02	0.98	FALSE
26	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC100272146	0.04	0.03	enet	19	0.03	1.1e-04	-5.6	5.5	3.8e-08	-0.87	0.01	0.97	FALSE
27	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C17orf57	0.28	0.16	lasso	6	0.15	1.4e-07	5.5	5.3	1.3e-07	-0.76	0.01	0.99	FALSE
28	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TBKBP1	0.08	0.04	blup	46	0.04	5.9e-03	5.7	-5.2	2.0e-07	0.84	0.01	0.69	FALSE
29	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TBKBP1	0.03	0.04	blup	47	0.04	5.3e-04	5.6	-5.6	2.7e-08	0.93	0.01	0.97	FALSE
30	The Cancer Genome Atlas	Soft Tissue Sarcoma	C17orf57	0.17	0.13	blup	73	0.12	1.7e-07	5.6	5.3	9.2e-08	-0.65	0.01	0.99	FALSE
31	The Cancer Genome Atlas	Stomach Adenocarcinoma	C17orf57	0.11	0.05	lasso	3	0.05	8.2e-05	5.6	5.4	5.1e-08	-0.87	0.01	0.97	FALSE
32	The Cancer Genome Atlas	Stomach Adenocarcinoma	TBKBP1	0.10	0.12	enet	15	0.11	2.5e-08	-4.9	-5.3	1.4e-07	0.81	0.28	0.71	FALSE
33	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TBKBP1	0.11	0.04	blup	45	0.03	5.3e-02	5.0	-5.2	2.2e-07	0.89	0.02	0.70	FALSE