TWAS hub

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.9092	0.0249	3.8e-10	0.031	NA	0.028	NA	0.028	1.6e-03	NA	2.5e-03	NA	2.5e-03
2	GTEx	Heart Left Ventricle	0.1357	0.1298	9.4e-03	0.035	NA	0.018	NA	0.029	6.0e-03	NA	3.5e-02	NA	1.1e-02
3	GTEx	Small Intestine Terminal Ileum	0.7410	0.0940	3.8e-04	-0.004	NA	0.055	NA	-0.010	4.1e-01	NA	2.3e-02	NA	6.0e-01
4	METSIM	Adipose	0.0902	0.0292	1.5e-11	0.096	0.089	0.069	0.087	0.089	3.4e-14	2.9e-13	1.8e-10	5.5e-13	3.5e-13
5	NTR	Blood	0.1820	0.0358	0.0e+00	0.073	0.142	0.155	0.142	0.153	1.8e-22	2.1e-43	1.0e-47	2.4e-43	7.7e-47
6	YFS	Blood	0.4178	0.0493	0.0e+00	0.262	0.357	0.376	0.371	0.374	1.7e-85	2.8e-123	2.3e-131	2.2e-129	1.8e-130
7	TCGA	Head and Neck Squamous Cell Carcinoma	0.0181	0.0111	3.3e-03	0.008	0.016	0.007	NA	0.011	3.5e-02	5.9e-03	5.5e-02	NA	1.9e-02
8	TCGA	Kidney Renal Clear Cell Carcinoma	0.0248	0.0152	8.9e-04	0.004	0.022	0.005	NA	0.007	9.9e-02	1.5e-03	8.6e-02	NA	5.3e-02
9	TCGA	Brain Lower Grade Glioma	0.5963	0.0673	0.0e+00	0.415	0.395	0.405	NA	0.411	7.4e-51	1.0e-47	2.4e-49	NA	3.8e-50
10	TCGA	Lung Adenocarcinoma	0.1389	0.0678	2.2e-12	0.082	0.108	0.095	NA	0.105	8.4e-10	1.4e-12	3.4e-11	NA	2.6e-12
11	TCGA	Lung Squamous Cell Carcinoma	0.0563	0.0273	3.6e-05	0.042	0.049	0.044	NA	0.043	1.4e-05	3.1e-06	9.0e-06	NA	1.1e-05
12	TCGA	Prostate Adenocarcinoma	0.0520	0.0284	2.6e-05	0.038	0.036	0.034	NA	0.034	7.6e-05	9.8e-05	1.8e-04	NA	1.5e-04
13	TCGA	Thyroid Carcinoma	0.5240	0.0850	0.0e+00	0.126	0.193	0.222	NA	0.223	3.0e-12	1.5e-18	2.7e-21	NA	1.9e-21

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	4	5	6	7	8	9	10	11	12	13
High cholesterol (Self-reported)	15.9	28.1	75.5	0.5	6.1	-5.8	-4.3	-4.5	-5.5	-5.5	8.7	-4.0	-3.6	-7.7	5.6
LDL Cholesterol	15.0	23.8	94.4	1.5	4.8	-4.2	-2.2	-2.8	-4.9	-4.3	9.7	-2.9	-3.6	-5.5	8.1
Medication: Cholesterol lowering	13.6	21.2	41.6	1.0	5.0	-4.9	-3.1	-3.2	-5.7	-5.6	6.5	-5.2	-5.0	-6.2	3.1
Medication: Simvastatin	10.0	14.7	31.2	0.4	4.4	-4.2	-2.9	-2.9	-4.5	-4.6	5.5	-3.8	-3.7	-5.6	2.6
Medication for cholesterol	7.4	11.2	25.9	-0.6	-4.0	3.5	3.9	4.0	3.7	3.9	-3.9	3.2	2.1	5.1	0.0
Cholesterol lowering medication	6.9	10.2	27.9	0.4	3.6	-3.5	-2.8	-2.8	-3.3	-3.1	5.3	-1.9	-1.8	-4.7	3.7
Medication: Atorvastatin	6.0	7.4	17.0	0.8	3.1	-2.8	-1.5	-1.8	-3.3	-3.3	4.1	-2.6	-2.8	-3.5	2.8
Cardiovascular Disease	5.7	18.8	48.4	1.7	5.1	-4.7	-2.9	-2.9	-5.2	-4.9	7.0	-3.7	-4.0	-5.8	3.7
Medication: Blood pressure	5.6	10.6	17.2	0.7	3.9	-3.6	-3.7	-3.7	-3.8	-4.1	3.0	-3.8	-2.7	-4.1	-1.5
Medication for cholesterol, blood pressure or diabetes	5.5	9.1	16.4	-1.5	-3.0	2.9	1.3	1.5	3.9	3.7	-4.1	3.6	3.8	4.0	-2.2
Number of treatments/medications taken	5.0	8.9	19.8	0.6	3.3	-3.0	-2.1	-2.3	-3.8	-4.0	2.8	-4.0	-3.4	-4.5	-0.6
Coronary Artery Disease (CAD)	4.9	5.8	10.6	-0.1	3.3	-3.3	-1.8	-2.2	-2.8	-3.1	2.3	-2.8	-1.9	-3.1	-1.4
Ever had prostate specific antigen (PSA) test	4.9	5.6	9.7	-0.6	-3.1	3.1	1.7	2.1	2.8	3.1	-1.8	2.9	2.1	2.9	2.1
Commuting to job workplace: Public transport	4.3	5.1	12.1	1.2	1.7	-2.7	-1.2	-1.0	-3.0	-3.2	-0.7	-3.4	-3.5	-1.6	-2.4
Number of self-reported non-cancer illnesses	4.2	7.3	15.0	0.3	3.0	-2.4	-1.7	-1.9	-3.8	-3.5	3.3	-2.8	-3.0	-3.9	2.1
Hearing difficulty/problems: Yes	4.0	6.1	12.0	-1.1	-2.7	2.9	2.0	2.1	2.9	3.3	-1.6	3.5	3.0	2.9	1.5
Smoking status: Current	3.9	6.1	12.7	0.8	3.2	-1.5	-1.5	-1.9	-3.2	-3.6	2.4	-3.3	-2.6	-3.0	-2.2
Triglycerides	3.4	5.6	20.7	-0.3	3.3	-2.3	-1.7	-2.3	-2.7	-2.6	4.5	-1.8	-1.4	-2.7	0.9
Smoking Status	3.3	7.9	16.6	0.4	3.6	-1.9	-0.9	-1.5	-4.1	-4.1	3.0	-3.7	-3.4	-3.5	-1.8
Birth weight of first child	3.3	6.0	20.5	-1.1	2.5	-1.9	-2.0	-2.3	-2.4	-3.0	0.2	-3.3	-1.8	-2.6	-4.5
Medication: Bendroflumethiazide	3.3	5.0	14.4	1.0	1.8	-1.9	-1.5	-1.3	-3.1	-3.1	0.7	-3.8	-3.5	-2.3	-1.4
Pulse rate, automated reading	3.1	10.1	20.4	-1.1	-3.8	4.5	1.5	2.2	4.3	4.3	-3.5	3.8	3.4	3.4	0.7
Pack years adult smoking proportion	3.0	4.6	12.5	-2.4	2.7	-2.0	-2.4	-2.3	-1.6	-2.3	1.5	-2.2	-0.8	-1.9	-3.5
Current tobacco smoking	3.0	5.0	10.7	0.5	2.9	-1.2	-1.2	-1.6	-3.0	-3.3	2.3	-3.0	-2.6	-2.6	-1.8
Medication: Atenolol	3.0	3.7	7.2	1.3	1.9	-2.1	-1.3	-1.2	-2.5	-2.4	2.2	-2.3	-2.4	-2.7	0.8
Exposure to tobacco smoke outside home	3.0	4.0	9.0	0.9	2.3	-1.7	-0.9	-1.2	-2.6	-2.5	3.0	-2.4	-2.4	-2.4	0.9
Commuting to job workplace: Car/motor vehicle	3.0	3.5	6.6	-2.3	-1.0	2.5	1.4	1.3	2.0	2.2	0.9	2.6	2.5	1.1	2.3
Body Mass Index (BMI) (2010)	2.9	3.9	10.3	-0.4	2.5	-1.8	-2.0	-2.2	-1.7	-2.1	2.9	-2.2	-0.9	-3.2	-0.8
Pain all over the body in last month	2.9	3.1	6.5	-2.3	-2.3	1.7	1.2	1.4	2.6	2.1	-1.7	1.8	1.8	1.7	0.4
Forced expiratory volume in 1-second (FEV1)	2.9	9.9	26.5	-0.8	-2.8	2.9	1.4	1.8	4.2	4.7	-0.8	5.0	5.1	3.6	1.5
Eye problems/disorders: Cataract	2.8	3.3	6.4	0.2	2.2	-2.5	-2.4	-2.5	-1.6	-1.8	2.5	-1.9	-0.3	-2.0	-0.5
Hearing difficulty/problems with background noise	2.5	4.0	7.2	-0.1	-2.7	2.4	1.8	2.1	1.8	2.4	-2.4	2.2	1.8	2.6	1.2
Arm fat percentage (right)	2.5	10.0	22.8	0.8	4.0	-1.9	-1.6	-2.1	-4.0	-4.2	4.4	-3.7	-3.6	-4.8	-0.2
Eye problems/disorders: None of the above	2.5	2.9	6.0	-0.4	-2.4	1.8	2.4	2.5	1.5	1.6	-1.9	1.7	0.1	1.6	1.7
Medication for pain relief, constipation, heartburn	2.5	4.3	11.0	1.4	-2.5	1.0	0.8	1.3	2.0	2.7	-2.4	2.8	2.3	3.3	1.9
Chest pain or discomfort	2.5	3.6	7.4	-0.0	2.3	-2.7	-2.7	-2.3	-2.2	-2.2	0.9	-1.9	-0.6	-2.3	-1.5
Illnesses of father: Heart disease	2.5	3.5	7.4	-0.2	2.1	-2.2	-1.7	-1.7	-2.4	-2.3	1.3	-2.7	-1.6	-2.0	-2.1
Pack years of smoking	2.5	3.7	9.8	-2.4	2.4	-1.7	-2.1	-1.9	-1.4	-2.1	1.3	-1.9	-0.8	-1.6	-3.1
BMI	2.4	14.1	33.2	-0.9	5.1	-2.2	-2.3	-3.1	-4.8	-4.8	5.8	-4.1	-3.3	-5.5	-0.4
Financial difficulties in last 2 years	2.4	3.3	7.3	0.5	2.3	-1.5	-0.6	-0.9	-2.4	-2.7	1.9	-1.9	-2.3	-2.7	-0.7
Hypertension (Self-reported)	2.4	6.8	12.5	2.0	2.7	-2.5	-2.1	-1.8	-3.4	-3.5	2.5	-3.5	-3.4	-3.0	-0.5
Townsend deprivation index at recruitment	2.3	3.2	7.1	1.4	2.4	-1.2	-1.0	-1.1	-2.1	-2.5	1.7	-2.3	-1.6	-2.7	-1.4
High blood pressure	2.3	6.5	11.5	1.9	2.7	-2.5	-2.2	-2.0	-3.3	-3.4	2.4	-3.3	-3.1	-2.9	-0.6
Forced vital capacity (FVC)	2.2	8.3	28.6	-0.7	-2.2	1.9	0.5	1.0	3.9	4.4	0.4	4.7	5.3	2.9	1.9
Emphysema/chronic bronchitis	2.2	2.5	5.1	-0.7	1.8	-1.6	-2.3	-2.1	-1.0	-1.3	1.9	-1.8	0.1	-2.0	-1.6
Arm fat percentage (left)	2.2	8.7	21.4	0.7	3.7	-1.7	-1.7	-2.1	-3.5	-3.9	4.3	-3.3	-3.2	-4.6	-0.2
Back pain experienced in last month	2.2	3.3	13.1	0.1	-1.2	1.9	-0.1	0.2	2.3	2.6	0.1	2.9	3.6	1.4	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.5	11.0	-0.6	-2.2	1.9	1.6	1.7	2.3	2.9	-1.9	3.0	2.6	3.3	0.7
Blood Red Count	2.1	20.1	158.8	1.7	2.3	-1.9	-1.4	-1.6	-1.9	-0.9	8.0	1.1	-0.7	-3.9	12.6
Waist circumference	2.1	7.8	17.3	0.1	3.9	-1.8	-2.3	-2.5	-3.3	-3.5	4.2	-2.9	-1.9	-4.2	-1.3
Medication: Ramipril	2.1	2.7	6.6	-0.9	1.4	-1.6	-0.8	-0.8	-2.2	-2.3	1.2	-2.6	-2.2	-2.3	-0.1
Angina (self-reported)	2.1	2.8	10.2	0.2	1.6	-1.6	-1.1	-0.9	-1.5	-1.8	2.3	-1.5	-1.4	-3.2	1.9
Irritable Bowel Disease (IBD)	2.0	4.8	12.3	-2.0	-3.1	2.4	1.4	1.9	3.5	2.9	-2.2	2.0	1.9	2.1	-0.1
Chronotype (morning person)	2.0	4.6	17.6	0.1	0.2	-1.8	-4.2	-3.0	1.9	1.6	1.9	1.2	4.2	-0.3	-1.1
Multivitamins +/- minerals	2.0	2.6	6.2	2.5	2.0	-2.1	-1.5	-1.7	-1.6	-1.5	1.6	-1.6	-0.7	-1.2	-1.5
Arm fat mass (right)	2.0	8.2	23.2	0.1	3.8	-1.4	-1.8	-2.2	-3.4	-3.5	4.8	-3.0	-2.5	-4.3	-0.3
Leg fat percentage (right)	2.0	7.1	16.4	-0.3	3.6	-2.0	-2.6	-2.7	-2.9	-3.2	3.8	-2.9	-1.7	-4.0	-1.1
Mood swings	2.0	3.6	7.7	-0.6	2.8	-1.6	-2.0	-2.0	-2.3	-2.3	2.3	-1.8	-0.7	-2.4	-1.8
Ever had hysterectomy (womb removed)	1.9	2.2	5.8	-2.4	1.7	-1.5	-0.7	-1.0	-1.9	-1.7	1.9	-1.5	-1.2	-1.4	0.3
Body fat percentage	1.9	7.4	18.1	0.1	3.6	-1.8	-2.3	-2.5	-2.9	-3.2	4.2	-2.9	-2.0	-4.2	-0.9
Wheeze or whistling in the chest in last year	1.9	3.4	7.1	-0.7	1.9	-2.0	-2.7	-2.4	-1.9	-1.9	2.6	-1.9	-0.8	-2.2	0.4
Arm fat mass (left)	1.9	7.8	23.1	0.2	3.7	-1.3	-1.9	-2.2	-3.3	-3.4	4.8	-2.9	-2.3	-4.3	-0.1
Leg fat percentage (left)	1.9	6.9	15.8	-0.4	3.5	-1.9	-2.5	-2.6	-3.0	-3.2	3.6	-2.9	-1.7	-4.0	-1.3
Crohns Disease (2017)	1.8	3.9	11.9	-2.2	-2.2	1.9	0.3	0.7	3.5	2.9	-1.3	1.9	2.6	1.9	-0.9
Medication: Co-codamol	1.8	2.1	6.8	-0.8	2.0	-1.4	-2.4	-2.6	-0.8	-0.9	1.6	-0.3	0.9	-1.3	-1.2
Body mass index (BMI)	1.8	7.7	17.8	0.4	3.6	-1.1	-1.5	-2.0	-3.5	-3.6	4.2	-3.2	-2.8	-4.2	-0.2
Depression (self-reported)	1.8	2.1	6.4	0.0	1.6	-1.4	-0.3	-0.4	-2.5	-2.3	-0.2	-1.9	-2.0	-1.0	-1.4
Medication: Paracetamol	1.8	2.9	9.1	0.6	2.3	-1.0	-2.1	-2.2	-1.1	-1.8	1.8	-1.7	-0.3	-3.0	-1.6
Forced vital capacity (FVC), Best measure	1.8	6.5	20.4	-0.6	-1.9	1.7	0.8	1.0	3.3	3.9	0.4	4.3	4.5	2.7	2.1
Medication: Paracetamol	1.8	2.7	7.1	1.2	2.0	-1.2	-2.0	-2.0	-1.2	-1.8	1.2	-1.9	-0.4	-2.7	-2.0
Ever smoked	1.8	3.2	9.6	0.9	2.1	-0.7	-0.2	-0.7	-3.1	-2.6	1.6	-1.6	-2.4	-2.4	1.4
Vascular/heart problems diagnosed by doctor	1.8	4.9	9.5	-1.6	-2.3	2.1	1.5	1.3	2.9	3.1	-2.1	2.8	3.1	2.8	-0.1
Alzheimer’s Disease (in mother)	1.7	2.0	4.1	-0.6	0.9	-2.0	-1.9	-1.5	-1.1	-1.6	-0.7	-1.9	-1.1	-1.7	-1.9
Hand grip strength (left)	1.7	4.4	12.2	-1.3	-1.8	2.0	-0.4	-0.1	3.1	2.8	-1.5	1.8	3.5	2.2	-2.8
Average weekly spirits intake	1.7	2.1	4.8	-0.2	1.9	-0.8	-0.3	-0.8	-2.2	-2.0	2.0	-1.8	-2.0	-1.5	0.1
Medication: Metformin	1.7	2.4	5.4	1.3	1.8	-1.7	-2.2	-1.8	-1.2	-1.4	2.2	-0.8	-0.3	-2.3	0.7
Past tobacco smoking	1.7	3.1	8.9	-1.2	-1.7	0.6	-0.6	-0.0	3.0	2.5	-1.4	1.8	2.9	2.0	-1.5
Forced expiratory volume in 1-second (FEV1), Best measure	1.7	5.3	14.1	-0.8	-2.0	1.9	1.2	1.4	2.9	3.4	-0.4	3.8	3.7	2.7	1.2
Birth weight	1.7	3.8	11.1	-0.3	2.5	-2.4	-0.6	-1.0	-3.3	-2.8	1.2	-2.6	-2.1	-1.5	-1.4
Leg fat mass (right)	1.7	6.7	19.5	-0.5	3.5	-1.6	-2.4	-2.5	-2.7	-2.9	4.4	-2.6	-1.5	-4.0	-0.8
Financial situation satisfaction	1.7	2.1	5.7	-0.2	1.9	-1.6	-1.2	-1.3	-2.4	-2.1	1.3	-1.5	-1.4	-1.2	-0.8
Leg fat mass (left)	1.7	6.5	18.1	-0.6	3.4	-1.5	-2.4	-2.4	-2.7	-2.9	4.3	-2.6	-1.4	-3.9	-0.9
Angina	1.6	2.1	7.9	0.5	1.3	-1.3	-0.7	-0.4	-1.3	-1.5	2.0	-1.2	-1.3	-2.8	2.1
Hand grip strength (right)	1.6	4.4	13.8	-0.7	-1.4	2.0	-0.6	-0.5	2.7	2.6	-1.7	2.1	3.7	2.3	-3.2
Length of working week for main job	1.6	1.8	8.4	1.6	0.2	-0.3	1.0	0.9	-1.5	-1.6	-0.4	-2.0	-2.9	-1.0	-0.2
Whole body fat mass	1.6	6.6	21.7	-0.3	3.5	-1.4	-2.2	-2.4	-2.7	-2.8	4.7	-2.5	-1.5	-3.9	-0.8
Alcohol intake frequency.	1.6	3.6	13.5	1.0	1.3	-1.6	-3.1	-3.1	1.3	0.9	2.1	1.3	3.7	-0.8	-0.5
Medication: Aspirin	1.6	2.2	10.0	-0.2	0.7	-1.0	0.8	0.7	-1.9	-1.9	1.1	-2.1	-3.2	-1.4	0.9
Pain experienced in last month	1.6	2.6	10.8	1.3	1.7	-1.5	0.2	0.1	-2.3	-2.3	0.8	-2.2	-3.3	-0.7	-0.6
Ulcerative Colitis (UC)	1.5	2.9	6.8	-1.1	-2.6	2.0	2.1	2.3	2.2	1.8	-1.9	1.3	0.2	1.2	1.1
Ulcerative Colitis	1.5	2.1	4.3	-1.4	-1.9	1.8	2.0	2.1	1.7	1.4	-1.5	1.2	0.0	1.0	1.1
Type 2 Diabetes (T2D) (2018)	1.5	2.9	6.0	1.8	1.9	-1.8	-2.3	-1.9	-1.4	-1.3	2.4	-0.7	-0.1	-2.5	1.4
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.3	4.8	-0.7	1.8	-1.6	-1.8	-1.9	-1.3	-1.6	0.9	-1.6	-0.6	-2.2	-1.9
Number of live births	1.5	2.2	4.9	-1.4	-1.8	1.6	0.2	0.9	2.2	2.1	-1.0	1.9	2.0	0.8	1.0
Pulse rate	1.5	2.6	5.0	-1.8	-1.8	2.2	0.7	1.3	2.2	2.1	-1.0	2.0	1.8	1.7	0.7
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	4.0	-0.0	1.8	-1.1	-1.5	-1.3	-2.0	-1.8	1.2	-1.5	-1.2	-2.0	-0.3
Medication: Seretide 50 evohaler	1.5	1.7	4.8	-0.6	1.1	-0.9	-1.0	-0.9	-0.8	-1.5	1.8	-2.0	-1.3	-2.2	-0.7
Handedness (chirality/laterality): Left-handed	1.5	1.8	3.6	-1.9	-1.4	1.1	-0.1	0.3	1.8	1.7	-0.4	1.9	1.8	1.4	1.2
Osteoarthritis (self-reported)	1.5	2.0	6.1	-0.3	1.5	-1.3	-1.5	-1.7	-1.2	-1.0	2.5	-0.5	-0.3	-2.0	1.9
Miserableness	1.5	2.6	7.9	0.6	1.9	-0.9	0.2	-0.2	-2.8	-2.5	1.2	-2.1	-2.7	-1.3	-0.3
Neuroticism (2016)	1.4	2.1	3.7	-0.2	1.9	-1.9	-1.5	-1.6	-1.9	-1.8	0.9	-1.6	-0.8	-1.9	-0.8
Trunk fat percentage	1.4	5.7	16.5	0.1	3.1	-1.4	-1.9	-2.1	-2.4	-2.8	4.1	-2.5	-1.7	-3.9	-0.6
Comparative body size at age 10	1.4	3.9	8.0	0.5	2.1	-1.4	-1.9	-2.3	-1.8	-2.5	1.2	-2.6	-1.7	-2.8	-2.5
Age at last live birth	1.4	2.0	5.9	1.2	1.1	-1.3	0.4	-0.2	-2.3	-2.0	-0.3	-2.1	-2.4	-0.6	-1.0
Average weekly red wine intake	1.4	2.1	7.3	2.2	-1.4	1.8	1.5	1.5	0.6	0.6	-2.7	0.2	-0.8	1.6	-1.0
Illnesses of siblings	1.3	1.8	11.0	-0.4	-1.5	0.5	0.9	0.7	1.4	0.9	-3.3	0.6	0.4	1.2	-2.0
Diabetes diagnosed by doctor	1.3	2.2	5.2	1.5	1.6	-1.4	-1.8	-1.3	-1.6	-1.6	1.8	-1.1	-0.8	-2.3	1.1
Medication: Lisinopril	1.3	1.7	4.8	2.1	0.4	-1.3	0.3	0.3	-1.8	-1.6	-0.5	-1.9	-2.2	-0.2	-1.1
Basal cell carcinoma (self-reported)	1.3	1.5	5.0	-0.5	2.2	-1.4	-1.4	-1.7	-1.0	-0.7	2.2	0.2	0.7	-1.0	0.3
Relative age of first facial hair	1.2	2.5	8.5	-0.6	1.6	-2.1	-0.5	-0.7	-1.5	-1.9	1.7	-2.2	-1.3	-2.9	-1.1
Medication for hormone replacement therapy	1.2	1.3	3.4	1.0	1.0	-0.8	-1.9	-1.6	-1.0	-1.0	1.1	-1.2	-0.4	-1.8	-0.7
Trunk fat mass	1.2	5.3	19.5	-0.5	3.1	-1.2	-1.9	-2.1	-2.3	-2.5	4.4	-2.2	-1.2	-3.5	-0.7
Hip circumference	1.2	5.2	19.4	-0.1	3.2	-1.2	-2.0	-2.2	-2.6	-2.6	4.4	-2.0	-1.4	-3.0	-0.1
Alcohol intake versus 10 years previously	1.2	1.8	4.8	-0.8	1.2	-1.4	-2.2	-1.9	0.4	0.0	2.2	0.5	1.5	-1.4	0.9
Medication: Lansoprazole	1.2	1.4	4.9	-0.0	1.5	-1.4	-1.8	-1.5	-0.7	-0.6	2.2	0.2	0.6	-1.2	0.9
Ever highly irritable/argumentative for 2 days	1.2	1.5	6.5	-0.6	-0.2	1.7	-0.8	-0.6	1.5	1.4	0.4	1.7	2.5	0.8	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	4.0	0.7	0.9	-1.2	-2.0	-1.7	-0.3	0.1	1.7	0.6	1.6	-1.0	1.4
Medication: Aspirin	1.2	1.5	7.7	0.1	-0.1	-0.5	1.4	1.4	-1.4	-1.2	0.5	-1.5	-2.8	-0.7	1.3
Rheumatoid Arthritis	1.1	1.5	2.8	1.6	-1.1	1.7	1.3	1.3	0.6	1.2	-0.9	1.2	0.8	1.5	1.5
Respiratory disease	1.1	2.5	5.2	0.4	1.5	-1.3	-1.0	-0.8	-2.0	-1.7	2.3	-1.7	-1.7	-2.1	1.9
Number of incorrect matches in round	1.1	1.8	4.2	-0.8	1.6	-1.6	-1.6	-1.7	-1.2	-1.7	0.2	-1.2	-0.4	-2.0	-1.2
Qualifications: None of the above	1.1	2.3	6.1	-1.4	1.5	-0.7	-2.4	-2.2	0.1	-0.6	2.4	-0.4	1.3	-2.5	-0.7
Hayfever/allergic rhinitis (self-reported)	1.1	1.4	2.8	-1.0	-1.6	1.7	0.9	1.2	1.2	1.4	-1.0	0.9	0.6	1.6	1.1
Illnesses of mother	1.1	1.4	4.3	-0.4	-1.8	1.7	1.6	1.4	1.2	0.8	-2.1	0.1	-0.4	0.7	-0.1
Heart disease (mother)	1.1	1.3	4.8	1.3	1.0	-1.1	0.3	0.3	-1.4	-0.7	2.2	-0.5	-0.8	-0.4	2.2
Had major operations	1.1	1.3	3.1	-0.7	-1.6	1.0	1.7	1.6	0.6	0.9	-1.8	0.4	-0.2	1.8	0.3
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	2.6	-0.0	-1.6	1.3	1.5	1.3	1.2	1.3	-1.0	1.1	0.7	1.2	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.0	-0.2	-1.2	1.7	1.2	1.5	1.2	1.4	0.4	1.0	0.8	1.6	1.0
Heart attack/myocardial infarction (self-reported)	1.1	1.4	6.1	-1.0	0.2	-0.8	0.8	1.1	-1.0	-1.4	0.5	-1.7	-2.5	-1.5	0.6
Alcohol drinker status: Previous	1.1	1.3	6.1	-1.0	1.9	-0.7	-1.0	-1.3	-0.9	-0.8	2.5	-0.1	0.5	-0.6	-0.2
Breast Cancer	1.0	2.3	7.8	0.8	1.5	-2.8	-2.3	-2.4	-1.1	-1.3	0.6	-1.1	0.2	-1.6	-0.9
Crohns Disease (2012)	1.0	1.6	7.3	-2.7	-0.5	0.8	-0.1	0.1	1.8	1.3	-0.6	0.7	1.5	1.0	-2.0
Lung FVC	1.0	5.0	14.4	0.4	-2.2	1.6	0.9	1.0	2.5	3.2	-0.5	3.8	3.3	2.2	3.0
Fed-up feelings	1.0	1.9	5.0	-0.0	2.2	-1.1	-1.7	-1.7	-1.4	-1.1	2.2	-0.5	0.6	-1.7	-0.7
Qualifications: CSEs or equivalent	1.0	1.3	6.0	0.7	1.5	-0.8	-1.4	-1.4	-0.4	-0.6	2.4	-0.2	0.6	-1.6	0.6
Serious illness, injury or assault to yourself	1.0	1.2	2.5	1.0	-1.5	1.6	1.4	1.5	0.9	0.8	-0.9	0.8	-0.2	0.9	1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	9.4	1.2	-0.1	0.7	-0.6	-0.7	1.7	2.0	0.5	2.7	3.1	1.3	1.1
Weight	1.0	4.8	20.2	-1.0	3.0	-0.8	-1.8	-2.0	-2.2	-2.2	4.5	-1.9	-0.8	-3.0	-0.8
Father’s age at death	1.0	1.4	4.0	-0.5	-1.4	0.5	1.2	1.3	1.2	1.2	-1.7	1.1	0.7	2.0	-1.0
Falls in the last year	1.0	1.4	4.7	0.1	1.2	-0.3	0.1	-0.0	-2.2	-1.8	0.2	-1.7	-2.0	-1.1	0.0
Noisy workplace	1.0	1.2	4.5	-0.6	1.2	-0.4	-1.6	-1.8	-0.1	-0.4	2.1	-0.6	1.0	-0.8	-1.1
Asthma	1.0	2.0	4.7	2.2	1.2	-0.9	-1.1	-0.9	-1.8	-1.7	1.3	-1.6	-1.7	-1.6	1.0
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	2.7	-0.6	1.3	-0.3	-0.1	-0.3	-1.1	-1.5	0.7	-1.5	-1.6	-1.6	-1.7
Lung cancer (father)	1.0	1.2	4.7	-2.2	1.1	-0.6	-1.5	-1.8	-0.1	-0.3	1.3	-0.1	0.9	-0.9	-0.6
Medication: Blood pressure	1.0	1.8	7.1	1.6	0.6	-0.5	0.2	0.3	-1.6	-1.6	1.2	-2.1	-2.7	-1.3	0.5
Eye problems/disorders: Glaucoma	1.0	1.2	2.8	1.3	1.5	-1.5	-1.7	-1.6	-0.7	-0.8	1.2	-0.8	-0.0	-1.0	-0.7
Supplements: Fish oil (including cod liver oil)	1.0	1.3	3.9	0.0	-1.0	0.5	-1.2	-0.9	1.5	1.7	0.5	1.1	2.0	1.4	0.6
Risk taking	1.0	1.5	6.0	-0.8	0.6	0.1	1.1	1.1	-1.5	-1.5	1.1	-1.5	-2.4	-1.2	0.4
Intelligence (Savage-Jansen 2018)	0.9	2.9	12.4	3.1	-0.7	-0.5	0.8	0.5	-1.6	-1.0	-3.5	-1.1	-2.4	1.6	-1.0
Fasting Glucose	0.9	1.0	2.5	0.7	-1.2	0.9	-0.0	0.0	1.4	1.5	-0.7	1.6	1.3	1.3	0.7
Heel T-Score	0.9	7.0	23.2	1.1	-2.1	1.8	-0.4	-0.0	3.1	3.5	0.2	4.1	4.0	1.6	4.8
Vitamin and mineral supplements	0.9	1.2	3.8	-1.2	-1.4	2.0	1.2	1.3	1.0	0.8	-1.3	0.9	-0.1	0.8	0.6
Average weekly fortified wine intake	0.9	1.0	3.2	0.6	-0.3	1.6	0.1	-0.3	1.1	1.3	0.1	1.7	1.8	0.7	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.0	7.1	1.2	-0.3	0.7	0.0	-0.2	1.4	1.9	0.5	2.6	2.7	1.5	1.7
Heart attack	0.9	1.2	5.0	-0.9	0.1	-0.8	0.6	1.0	-0.8	-1.2	0.6	-1.5	-2.2	-1.4	0.7
Diabetes (self-reported)	0.9	1.4	3.4	1.3	1.0	-0.4	-1.5	-1.0	-1.0	-0.9	1.8	-0.6	-0.5	-1.8	1.6
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	3.7	-0.2	1.6	-0.9	-1.9	-1.8	-0.5	-0.5	1.9	0.0	1.2	-1.5	-0.4
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	3.9	2.0	1.0	-1.5	-0.7	-0.7	-1.7	-1.4	-0.1	-1.5	-1.5	-0.4	-0.7
Medication: Ventolin 100micrograms inhaler	0.9	1.1	2.3	0.7	0.8	-0.9	-0.6	-0.8	-1.2	-1.2	1.5	-1.3	-1.3	-1.4	1.0
Knee pain experienced in last month	0.9	1.4	4.5	-0.4	1.1	0.4	-2.1	-2.0	0.3	0.1	1.2	0.4	1.8	-1.3	-1.1
Illnesses of siblings: Diabetes	0.9	1.1	5.3	0.8	0.6	0.1	-0.1	-0.0	-1.0	-0.8	2.1	-0.4	-1.0	-1.1	2.3
Commuting to job workplace: Walk	0.9	1.0	3.1	1.8	-1.1	0.9	0.8	0.8	1.0	0.8	-1.5	0.8	0.2	1.2	0.2
Asthma (self-reported)	0.9	1.9	2.9	1.6	1.3	-1.1	-1.1	-0.9	-1.7	-1.6	1.5	-1.6	-1.6	-1.7	1.1
Illnesses of father: None of the above (group 1)	0.9	1.1	2.8	0.2	-0.9	1.2	0.9	0.8	1.1	1.2	-1.5	1.7	0.9	1.4	0.3
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.7	-1.7	1.1	0.2	-1.4	-1.4	-0.5	-0.7	0.5	-0.5	0.3	-0.9	-1.6
Severe depression (siblings)	0.8	0.9	2.0	1.2	-1.4	1.4	0.4	0.6	1.0	1.2	-1.2	0.8	0.5	1.3	-0.0
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	5.0	-2.2	0.9	1.0	-0.3	-0.7	-0.2	-0.3	1.5	0.3	0.5	-1.0	0.7
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	1.5	0.7	1.0	-1.2	-1.0	-1.2	-1.2	-1.2	0.1	-1.0	-0.5	-1.2	-0.2
Chronic bronchitis/emphysema (father)	0.8	0.9	2.3	-0.8	-0.4	0.9	0.6	0.7	1.3	1.3	0.4	1.5	1.5	1.2	0.4
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	3.0	-0.5	-0.7	1.3	1.7	1.5	-0.6	-0.4	-1.3	-0.4	-1.6	0.8	-0.1
Fluid intelligence score	0.8	1.6	9.4	1.8	-1.5	-0.3	0.5	0.7	-0.2	0.5	-3.1	0.4	-0.4	2.2	-0.1
Qualifications: A levels/AS levels or equivalent	0.8	1.9	7.0	0.6	-0.3	-0.7	1.0	1.0	-1.8	-1.3	-2.2	-1.6	-2.6	1.0	-1.0
Prospective memory result	0.8	0.9	3.3	0.3	-0.5	1.4	-0.5	-0.5	1.6	1.3	0.1	1.2	1.8	0.5	-0.3
Peak expiratory flow (PEF)	0.8	2.0	4.5	-0.2	-1.2	1.5	1.1	1.2	1.2	2.0	0.7	2.1	1.8	1.3	1.9
High blood pressure (siblings)	0.8	1.1	5.2	0.2	1.0	-0.5	-0.4	-0.3	-1.3	-1.2	2.3	-1.3	-1.4	-0.9	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	3.8	-0.8	-0.7	1.8	2.0	1.4	0.2	0.4	-1.3	0.7	-0.0	1.1	-0.1
Number of children fathered	0.8	0.9	3.3	-0.1	-1.4	0.9	1.1	1.4	0.1	0.7	-1.8	0.5	-0.1	1.2	0.4
Neck or shoulder pain in last month	0.8	1.1	4.2	-1.4	0.4	0.4	-0.3	-0.4	0.1	0.7	2.0	0.9	1.9	-0.6	1.4
Medication: Allopurinol	0.8	1.0	2.0	1.4	1.2	-0.1	-0.6	-0.6	-0.9	-1.4	-0.3	-1.2	-1.3	-1.4	-1.2
Overall health rating	0.8	1.8	6.3	-1.4	1.4	-0.9	-1.6	-1.3	-0.7	-0.9	2.3	-0.4	0.6	-2.5	0.9
Pain type(s) experienced in last month: Hip pain	0.8	0.9	2.5	0.2	-0.1	-0.0	-1.5	-1.2	1.1	0.8	1.4	0.5	1.6	-0.9	1.1
Illnesses of father: High blood pressure	0.8	1.0	4.3	0.0	-1.3	-0.1	0.9	1.2	-0.7	-0.4	-1.2	-1.0	-2.1	0.4	1.3
Irritability	0.8	1.3	5.9	-0.1	1.4	-0.6	-1.4	-1.5	-0.8	-1.0	0.7	-1.0	0.4	-1.1	-2.4
Age started oral contraceptive pill	0.8	1.0	2.9	-0.7	1.1	-1.7	-0.3	-0.8	-1.5	-1.2	0.8	-1.3	-0.9	-0.4	-0.7
Commuting to job workplace: Cycle	0.8	1.0	7.5	2.7	0.5	-0.1	1.0	0.7	-1.0	-0.7	-0.1	-0.6	-1.1	0.3	-0.1
Bipolar Disorder or Schizophrenia	0.7	1.6	4.9	-1.1	-0.5	1.9	2.2	2.1	0.2	0.8	-0.8	1.5	-0.0	1.3	1.1
Schizophrenia (2018)	0.7	1.4	2.8	-1.7	-1.0	1.3	1.5	1.5	0.7	1.2	-1.2	1.4	0.8	1.4	0.5
Type 2 Diabetes (T2D) (2012)	0.7	0.9	1.8	-0.0	1.0	-1.1	-0.7	-0.9	-1.1	-1.2	0.2	-1.2	-0.6	-1.2	-1.4
Frequency of depressed mood in last 2 weeks	0.7	0.9	4.1	-0.3	1.5	-0.5	-1.0	-1.1	-0.6	-0.9	0.8	-0.7	-0.1	-1.1	-2.0
Nervous feelings	0.7	1.2	6.4	0.4	0.1	0.1	-0.6	-0.8	-0.1	0.3	-2.0	0.6	1.7	1.3	-2.5
Hair/balding pattern: Pattern 2	0.7	1.0	3.8	-1.4	-0.3	-0.0	-2.0	-1.3	1.2	0.8	0.3	0.7	1.4	-0.5	0.3
Had menopause	0.7	0.8	2.4	-1.5	0.9	-0.8	-1.4	-1.2	-0.8	-0.6	1.1	-0.6	0.2	-1.0	0.4
Happiness	0.7	0.8	1.9	1.2	1.3	-0.8	-0.7	-1.0	-1.4	-1.1	0.4	-0.7	-0.4	-0.5	-1.2
Tense / ‘highly strung’	0.7	1.2	9.9	-0.3	-0.2	0.3	-0.4	-0.2	0.7	0.5	-1.4	0.3	1.5	0.7	-3.1
Gout (self-reported)	0.7	1.0	3.2	1.3	0.8	0.1	0.1	0.3	-1.0	-1.4	-0.4	-1.3	-1.8	-1.1	-1.0
Pulse wave peak to peak time	0.7	0.8	2.1	-0.3	0.9	-0.3	-1.5	-1.4	0.6	0.2	1.0	0.4	1.4	-0.6	-1.3
Medication: Ibuprofen	0.7	0.8	2.9	-0.0	0.4	0.1	0.4	0.5	-0.6	-1.0	-0.1	-1.3	-1.6	-1.0	-1.7
Mean time to correctly identify matches	0.7	1.4	4.5	-0.3	-1.2	1.2	2.1	1.9	-0.0	0.3	-1.5	0.4	-1.1	1.7	0.9
Comparative height size at age 10	0.7	3.6	12.5	-2.9	-0.0	2.1	-0.6	-0.3	2.5	2.2	1.3	2.5	3.5	1.0	-1.3
Leg pain on walking	0.7	0.8	3.7	0.6	-0.5	1.1	0.7	0.9	0.5	0.8	0.8	1.3	0.7	0.5	1.9
Smoking status: Previous	0.7	1.1	3.1	0.2	1.0	-0.5	0.7	0.2	-1.6	-1.2	0.9	-0.6	-1.5	-1.2	1.8
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	3.8	1.0	0.8	-0.3	-0.5	-0.4	-0.8	-0.8	1.9	-0.8	-0.8	-0.9	0.6
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	4.0	-1.1	1.1	-2.0	-0.9	-1.1	-1.0	-1.0	0.8	-1.1	-0.4	-1.0	-0.9
Mineral and other dietary supplements	0.7	1.0	3.2	0.4	0.2	0.7	1.8	1.4	-1.0	-1.0	-1.1	-0.4	-1.7	-0.4	0.1
Medication: Gliclazide	0.7	0.8	3.5	0.5	0.9	-0.4	-0.5	-0.4	-0.7	-1.1	1.4	-0.8	-0.8	-1.9	0.2
Ever taken oral contraceptive pill	0.7	0.8	2.1	-1.0	0.0	1.4	1.4	1.2	0.3	0.2	-1.1	0.5	-0.1	1.1	-1.1
Ever depressed for a whole week	0.7	0.8	2.5	-0.4	-0.7	1.5	1.3	0.9	0.2	0.0	-1.6	-0.1	-0.6	0.9	-1.2
Unable to work because of sickness or disability	0.7	0.9	3.2	1.0	-0.7	1.4	1.8	1.7	0.6	0.5	0.1	0.7	-0.2	0.9	0.5
Heart disease (siblings)	0.7	0.9	4.0	-0.1	0.6	-1.0	-1.0	-0.7	-0.6	0.0	2.0	0.3	0.7	-0.3	2.0
Worry (Nagel 2018)	0.6	1.4	3.9	1.3	-0.9	0.7	0.2	0.2	1.0	1.2	-2.0	1.6	1.9	1.5	-0.6
Major Depression (MDD)	0.6	0.7	2.2	0.2	1.2	0.3	0.5	0.2	-1.3	-1.3	0.5	-0.8	-1.5	-0.9	0.2
Primary Biliary Cirrhosis	0.6	0.9	3.0	-1.7	0.8	-0.9	-1.1	-1.0	-0.5	-0.7	0.6	-0.8	-0.2	-0.6	-1.4
Schizophrenia (2014)	0.6	1.3	2.9	-1.7	-0.9	1.6	1.0	1.2	0.8	1.3	-1.0	1.5	1.2	1.1	0.5
Sensitivity / hurt feelings	0.6	1.1	3.4	1.0	1.4	-0.9	-1.8	-1.6	-0.2	0.0	0.5	0.7	1.6	-0.1	-1.1
Diabetes (mother)	0.6	0.7	2.3	0.9	0.9	-0.8	-1.2	-0.8	-0.5	-0.1	1.5	0.1	0.8	-0.6	1.2
Relative age voice broke	0.6	0.9	5.6	-0.1	-0.1	-0.2	-0.7	-0.5	1.3	0.6	-0.2	0.0	1.5	-0.7	-2.4
Sitting height	0.6	4.3	16.6	-2.4	-0.0	0.1	-0.1	0.1	1.0	2.0	4.1	2.2	2.7	1.1	3.8
Time employed in main current job	0.6	0.7	1.8	1.3	0.4	-1.1	-1.3	-1.3	-0.4	-0.2	-0.2	-0.8	0.5	0.1	-1.0
Hair/balding pattern: Pattern 3	0.6	0.8	3.4	1.9	-0.4	1.0	1.0	0.8	0.5	0.7	0.6	1.1	0.4	0.7	1.3
Mouth/teeth dental problems: Dentures	0.6	1.0	2.0	-0.7	-0.7	0.5	0.6	0.7	1.3	1.4	0.5	1.4	1.4	1.4	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.4	-1.0	1.3	-0.6	-0.2	-0.7	-1.5	-1.4	0.0	-1.2	-0.6	-0.8	-1.4
Age at first live birth	0.6	1.1	4.0	0.8	0.0	-0.6	1.1	0.6	-1.4	-1.0	-1.7	-0.9	-2.0	0.7	-0.3
Loneliness, isolation	0.6	0.9	5.7	2.4	1.1	-0.5	-0.1	-0.2	-1.2	-0.8	0.7	-0.7	-0.4	-0.3	-1.0
Osteoporosis (self-reported)	0.6	0.7	1.7	-1.2	0.9	-0.9	-0.8	-0.5	-1.0	-1.0	1.3	-1.0	-0.6	-0.9	-0.1
Wears glasses or contact lenses	0.6	0.7	2.9	0.3	0.7	-0.8	-0.6	-0.7	-1.7	-1.2	-0.2	-0.9	-1.0	0.0	-0.4
Alcohol drinker status: Never	0.6	0.7	2.2	0.7	-0.8	0.3	-0.9	-0.8	1.5	0.9	-1.0	0.9	1.2	0.3	-0.2
Average weekly beer plus cider intake	0.6	0.9	3.2	0.0	1.0	-0.2	-0.4	-0.6	-1.1	-1.3	1.8	-1.1	-1.1	-1.1	0.5
Fractured/broken bones in last 5 years	0.6	0.8	2.2	-0.7	1.1	-0.9	-0.8	-0.4	-1.1	-1.1	0.4	-1.1	-0.7	-0.5	-1.5
Bipolar Disorder (2018)	0.5	0.8	3.0	0.5	0.4	1.5	1.7	1.4	-0.5	-0.3	0.2	0.6	-1.0	0.4	1.1
Depressed Affect (Nagel 2018)	0.5	1.0	4.2	0.6	1.6	-0.5	-0.1	-0.3	-2.0	-1.4	1.2	-0.7	-0.8	-0.6	-0.4
Verbal and Numeric Reasoning (VNR)	0.5	1.2	7.0	1.3	-0.9	-0.6	-0.2	-0.3	-0.8	-0.1	-2.6	-0.3	-0.9	1.8	-0.5
Prostate Cancer	0.5	0.6	2.1	1.5	-0.6	0.7	-0.8	-0.3	0.9	1.0	-0.2	1.1	1.2	0.4	0.4
Age at First Birth	0.5	0.7	2.4	-0.5	-0.9	0.8	1.2	0.9	0.2	0.1	-1.5	-0.0	-0.9	1.5	-0.4
HbA1C	0.5	0.5	2.0	1.4	1.0	0.1	0.2	-0.0	-0.6	-0.2	1.4	0.3	-0.1	-0.0	1.0
HDL Cholesterol	0.5	0.8	3.6	1.9	0.3	-1.3	-0.7	-0.4	-1.0	-0.8	-0.5	-0.7	-0.8	-0.9	0.7
Blood White Count	0.5	3.6	11.3	0.8	1.8	-1.8	-3.4	-3.0	-0.2	-1.0	1.4	-1.0	1.2	-2.9	-2.3
Height	0.5	8.7	33.6	-5.2	-1.1	0.6	-1.7	-0.8	3.3	3.7	1.4	3.0	5.8	2.5	-2.3
Lung FEV1/FVC ratio	0.5	2.7	21.0	-0.6	-0.6	1.4	0.8	0.6	0.0	-0.1	-3.1	-0.6	-0.1	1.0	-4.6
Tanning	0.5	6.0	16.5	0.2	-2.9	3.2	1.1	1.3	4.1	3.6	-1.3	3.1	3.2	2.4	0.6
Maternal smoking around birth	0.5	0.8	3.7	-0.2	1.3	-0.8	0.4	-0.1	-1.2	-1.0	1.9	-0.6	-0.9	-0.5	0.1
Age when periods started (menarche)	0.5	1.1	6.7	0.2	0.7	-2.6	-1.4	-1.2	-0.8	-0.7	1.0	-0.6	0.1	-1.2	0.5
High blood pressure (mother)	0.5	0.7	2.9	1.7	0.6	-1.0	-1.4	-1.1	-0.5	-0.5	0.6	-0.5	-0.1	-0.3	-0.7
Alcohol usually taken with meals	0.5	0.7	3.1	1.2	-0.0	-0.9	-0.8	-0.7	-0.3	-0.0	-1.7	-0.1	0.2	0.4	-1.8
Pulse wave Arterial Stiffness index	0.5	0.6	1.7	-0.0	-0.9	0.2	1.3	1.3	-0.3	-0.0	-0.9	-0.3	-1.1	0.6	1.0
Standing height	0.5	4.5	18.7	-3.2	-0.5	0.6	-1.0	-0.4	2.4	2.7	1.4	2.5	4.3	1.9	-1.6
Loud music exposure frequency	0.5	0.5	1.9	-1.4	0.7	1.1	-0.1	-0.3	0.4	0.2	1.4	0.3	0.6	-0.4	-0.3
Glaucoma (self-reported)	0.5	0.6	1.7	0.7	0.7	-0.7	-0.5	-0.6	-0.7	-0.9	0.2	-1.3	-1.0	-0.7	-1.2
Medication: Omeprazole	0.5	0.6	3.9	-2.0	-0.6	0.8	0.5	0.6	0.4	0.1	-1.0	0.1	-0.4	-0.1	-0.7
Qualifications: nursing, teaching	0.5	0.8	2.2	-1.1	-0.1	-1.0	0.6	0.5	-1.2	-0.7	-0.5	-1.0	-1.5	1.3	-0.4
Average weekly champagne plus white wine intake	0.5	0.7	2.2	-0.3	1.3	-1.0	-0.0	-0.3	-1.5	-1.1	1.1	-0.7	-0.8	-0.2	0.3
Schizophrenia vs Biploar Disorder	0.4	0.5	1.6	-1.3	-1.0	0.3	-0.3	0.1	0.5	0.8	-0.8	0.5	1.2	0.6	-0.2
Alzheimer’s Disease (including proxy)	0.4	0.5	2.3	-0.9	-0.3	-1.0	-1.0	-0.5	0.3	-0.1	-0.8	-0.7	0.2	-0.5	-1.5
Reaction Time	0.4	0.8	2.5	1.0	-0.3	0.5	1.6	1.5	-0.7	-0.5	-0.5	-0.3	-1.5	0.8	0.9
Mean Putamen Volume	0.4	0.5	1.6	0.4	0.6	-1.3	-1.3	-1.0	0.1	-0.0	0.5	-0.1	0.6	-0.9	-0.1
Blood Platelet Count	0.4	4.9	24.2	-2.7	-2.1	0.9	1.2	1.2	1.3	0.8	-4.9	-0.2	0.3	1.5	-4.5
Supplements: Zinc	0.4	0.5	1.3	1.1	-0.7	0.1	1.0	0.9	0.2	0.6	-0.7	0.1	0.3	1.1	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.6	-0.1	1.3	-0.2	-0.4	-0.5	-0.4	-0.7	1.3	-0.7	-0.1	-1.2	-1.2
Taking other prescription medications	0.4	0.7	2.5	-0.3	0.6	0.2	-1.0	-0.9	-0.1	-0.3	1.1	0.4	0.4	-1.6	1.5
Neuroticism score	0.4	0.8	1.9	0.7	1.4	-0.7	-1.1	-1.3	-0.8	-0.5	0.4	0.1	1.0	-0.2	-1.3
Pulse wave reflection index	0.4	0.5	1.5	0.6	-0.5	-0.0	1.2	1.0	-0.5	-0.1	-0.2	-0.2	-1.1	1.0	1.1
Number of full brothers	0.4	0.5	3.9	-0.1	0.9	-0.5	-0.2	-0.4	0.1	-0.0	2.0	0.4	0.6	-0.5	0.7
Qualifications: College or University degree	0.4	1.3	5.8	0.2	-0.5	0.2	1.6	1.3	-1.2	-0.5	-2.4	0.0	-1.6	1.4	-0.0
Family relationship satisfaction	0.4	0.4	2.1	1.5	0.5	-0.4	-0.6	-0.7	-0.7	-0.5	0.6	-0.8	-0.3	-0.4	-0.6
Supplements: Vitamin C	0.4	0.5	2.4	0.1	0.5	-0.5	-0.5	-0.8	-0.4	0.0	1.6	0.3	0.9	-0.1	1.0
Ever had bowel cancer screening	0.4	0.5	3.1	-0.2	-0.3	0.4	-0.5	-0.5	1.1	0.9	-0.2	0.9	1.8	-0.2	-0.2
Breast cancer (self-reported)	0.4	0.5	2.0	-0.6	-0.4	1.4	1.3	1.2	0.2	0.2	0.0	0.0	-0.7	0.6	0.3
Guilty feelings	0.4	0.7	2.6	-0.2	0.7	-0.5	-1.1	-1.3	0.5	0.4	0.3	0.9	1.6	0.1	-0.9
Tinnitus: Yes, now most or all of the time	0.4	0.5	3.2	-1.8	-0.7	0.3	-0.3	-0.3	0.6	0.4	-0.8	0.1	0.4	-0.0	-0.8
Diastolic blood pressure, automated reading	0.4	1.2	5.5	0.4	-0.3	0.3	0.8	1.0	-1.1	-0.6	0.5	-0.9	-2.4	1.0	2.0
Ovarian Cancer	0.3	0.4	2.1	0.2	0.5	-1.1	-1.5	-0.9	-0.3	-0.5	0.1	-0.0	0.0	-0.6	0.3
Bipolar Disorder (2011)	0.3	0.3	2.0	0.6	0.6	0.5	-0.2	0.1	0.2	0.1	1.4	0.5	-0.1	0.1	1.0
Lupus	0.3	0.4	2.9	-1.7	-0.1	-0.3	-0.3	-0.1	0.3	-0.1	0.8	-0.5	-0.4	-1.0	0.8
Hypothyroidism (self reported)	0.3	0.6	2.3	0.7	1.0	0.3	-0.3	-0.6	0.1	-0.0	1.5	1.1	0.9	-0.7	1.0
Hair Pigment	0.3	9.9	20.8	1.0	3.6	-4.2	-2.2	-2.4	-4.6	-4.1	3.5	-3.6	-3.3	-3.5	0.7
Hayfever, allergic rhinitis or eczema	0.3	0.8	2.7	1.3	-1.6	0.7	0.2	0.7	0.7	0.7	-1.6	-0.1	-0.4	0.3	0.9
Medication: Levothyroxine sodium	0.3	0.6	2.6	-0.2	1.4	0.2	-0.2	-0.4	-0.6	-0.8	1.6	0.2	-0.3	-1.1	0.4
Mouth/teeth dental problems	0.3	0.5	3.8	1.9	-0.1	0.3	0.4	0.3	-0.4	-0.4	-0.3	-0.4	-0.8	-0.2	0.7
Allergy	0.3	0.7	4.0	-2.0	0.0	-0.0	0.3	-0.1	0.8	0.7	0.0	1.3	1.3	0.5	-0.6
Worrier / anxious feelings	0.3	0.6	2.3	0.7	-0.3	-1.0	-0.8	-0.6	0.1	0.3	-1.5	0.2	0.9	0.7	-1.1
Breastfed as a baby	0.3	0.4	1.1	0.1	-0.6	0.8	1.1	0.9	0.2	0.7	-0.4	0.6	0.3	0.8	-0.2
Headache pain in last month	0.3	0.6	2.9	0.8	-0.8	0.3	0.3	0.2	0.2	0.2	-1.7	-0.4	0.2	0.4	-1.5
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.6	0.9	0.3	0.6	-0.3	-0.5	0.4	0.3	0.2	1.1	1.3	0.1	0.3
Arm fat-free mass (right)	0.3	1.7	5.5	-2.3	1.0	0.3	-1.4	-1.4	0.1	0.2	2.4	0.1	1.8	-0.6	-1.4
Worry too long after embarrassment	0.3	0.5	1.5	0.3	0.8	-0.9	-1.0	-1.2	-0.2	0.0	0.2	0.6	1.1	-0.2	-0.1
Health satisfaction	0.3	0.4	1.7	-0.5	1.0	-0.1	-0.6	-0.5	-0.5	-0.5	0.9	0.3	0.4	-1.3	0.8
Migraine (self-reported)	0.3	0.4	1.3	1.1	0.6	-0.8	-0.2	-0.3	-0.6	-0.7	-0.3	-0.6	-0.5	-0.5	-0.9
Arm predicted mass (right)	0.3	1.6	5.6	-2.2	1.1	0.2	-1.4	-1.3	-0.0	0.1	2.4	0.0	1.6	-0.8	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.5	2.0	0.7	0.2	-0.0	-0.6	-0.3	0.8	0.7	1.4	0.7	1.4	-0.1	-0.5
Friendships satisfaction	0.3	0.3	2.8	1.7	-0.3	-0.1	0.1	0.2	-0.7	-0.1	-0.3	-0.2	-0.5	0.4	0.6
Basal metabolic rate	0.3	1.5	9.0	-1.6	1.4	0.2	-1.0	-1.0	-0.8	-0.6	3.0	-0.6	0.4	-1.3	-0.7
Arm fat-free mass (left)	0.3	1.6	9.0	-2.1	1.3	0.3	-1.2	-1.2	-0.5	-0.2	3.0	-0.1	1.2	-0.8	-0.7
Number of operations (self-reported)	0.3	0.4	1.4	-0.8	-0.7	1.0	0.1	-0.1	0.6	0.5	-1.2	0.2	0.5	0.4	-0.7
Myopia	0.3	0.4	1.0	0.2	0.4	-1.0	-0.7	-0.6	-1.0	-0.8	0.3	-1.0	-0.5	-0.7	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	3.4	-1.8	-0.2	0.1	-0.2	-0.1	0.3	-0.0	-0.5	0.2	-0.0	-0.1	-0.6
Depression (Nagel 2018)	0.2	0.2	0.9	-0.3	0.9	0.5	0.3	-0.1	-0.2	-0.3	0.9	0.2	0.2	-0.6	-0.5
Blood Eosinophil Count	0.2	1.2	4.4	-1.6	1.0	-0.3	-1.3	-1.0	-0.1	-0.8	1.6	-0.8	-0.5	-2.1	0.4
Systolic Blood Pressure	0.2	1.1	3.9	1.7	-1.2	-0.1	-0.5	0.2	0.9	1.0	-2.0	0.7	0.5	1.7	0.3
Allergy or Eczema	0.2	0.6	2.2	1.0	-1.0	0.3	0.4	0.7	-0.3	-0.2	-1.4	-1.1	-1.5	-0.1	0.5
Systolic blood pressure, automated reading	0.2	0.5	2.1	0.6	-0.7	0.3	-0.5	0.1	0.6	0.8	-1.1	0.7	0.7	1.5	-0.3
Diabetes (father)	0.2	0.2	0.7	0.6	0.3	0.2	-0.4	-0.0	-0.4	-0.6	0.3	-0.6	-0.9	-0.6	0.3
Impedance of leg (right)	0.2	1.0	3.9	0.4	0.2	-1.5	-1.7	-1.2	1.2	0.8	-0.1	0.6	2.0	-0.2	-0.6
Leg fat-free mass (left)	0.2	1.0	7.1	-1.1	1.1	0.4	-0.6	-0.6	-0.7	-0.6	2.7	-0.5	-0.1	-1.3	-0.2
Stomach or abdominal pain in last month	0.2	0.3	2.1	1.4	-0.5	-0.0	0.1	0.0	0.3	0.4	-0.9	-0.2	0.5	-0.2	-0.4
Supplements: Glucosamine	0.2	0.3	0.6	0.6	-0.3	0.6	-0.1	0.2	0.4	0.7	0.6	0.6	0.6	0.8	0.5
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.8	0.2	-0.2	-0.2	0.1	0.5	-0.0	-0.3	-0.7	-0.3	-0.6	-0.9	-0.4
Impedance of leg (left)	0.2	1.1	3.8	0.3	0.2	-1.7	-1.8	-1.2	1.0	0.7	-0.2	0.4	1.9	-0.2	-0.9
Leg predicted mass (left)	0.2	1.0	7.0	-1.0	1.0	0.4	-0.5	-0.6	-0.7	-0.6	2.6	-0.5	-0.1	-1.2	-0.2
Had other major operations	0.2	0.2	0.9	-0.3	-0.4	0.3	-0.6	-0.1	0.4	0.5	-0.3	0.6	1.0	-0.1	0.4
Trunk fat-free mass	0.2	1.2	5.3	-2.3	0.9	0.5	-0.8	-0.8	-0.1	0.1	2.2	0.1	1.3	-0.2	-1.2
Trunk predicted mass	0.2	1.2	5.5	-2.4	0.8	0.6	-0.7	-0.8	-0.1	0.2	2.1	0.1	1.3	-0.1	-1.2
Blood clot in the leg (DVT)	0.2	0.3	1.0	-0.1	0.8	-0.3	-0.3	-0.4	-0.5	-0.6	1.0	-0.5	-0.3	-0.6	-0.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	2.0	0.6	1.2	0.0	-0.2	-0.5	-0.4	-0.4	1.4	0.5	0.3	-0.6	0.6
Shortness of breath walking on level ground	0.2	0.2	1.1	-0.8	-0.1	1.0	-0.2	0.1	0.4	0.2	0.8	-0.1	0.2	0.1	-0.4
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.6	-0.3	-0.4	0.5	0.5	0.6	0.0	-0.2	-0.8	-0.3	-0.7	-0.2	-0.3
Number of full sisters	0.2	0.3	1.2	0.9	0.3	-0.2	-0.3	0.0	0.1	-0.1	1.1	0.0	0.2	-1.1	0.7
Suffer from ‘nerves’	0.2	0.3	2.6	1.6	-0.2	0.3	0.7	0.2	-0.3	-0.1	-0.6	-0.1	-0.2	0.7	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	1.0	-0.3	-0.1	-0.4	-1.0	-0.8	0.3	-0.0	0.1	-0.4	0.3	-0.5	-0.1
Whole body fat-free mass	0.2	1.0	5.3	-2.0	0.9	0.6	-0.7	-0.7	-0.2	-0.1	2.3	-0.1	0.9	-0.6	-0.9
Long-standing illness, disability or infirmity	0.2	0.2	0.7	-0.1	0.2	0.6	0.1	0.0	-0.5	-0.4	0.6	-0.4	-0.5	-0.8	0.8
Whole body water mass	0.2	1.0	5.4	-2.0	0.8	0.6	-0.6	-0.6	-0.3	-0.1	2.3	-0.1	0.8	-0.5	-0.9
Hearing aid user	0.2	0.2	0.8	0.3	-0.0	-0.7	0.5	0.4	-0.8	-0.4	-0.1	-0.7	-0.9	0.2	0.1
Arm predicted mass (left)	0.2	1.1	5.8	-1.9	1.0	0.5	-0.9	-0.9	-0.4	-0.0	2.4	0.0	1.2	-0.6	-0.7
Neuroticism (Nagel 2018)	0.1	0.4	1.3	0.3	1.1	-0.4	-0.4	-0.5	-1.0	-0.4	-0.1	0.3	0.5	0.0	-1.0
Alzheimer’s Disease (in father)	0.1	0.1	0.3	-0.6	-0.3	0.2	0.1	0.5	0.5	0.2	-0.2	-0.1	0.1	-0.2	-0.5
Waist Hip Ratio (WHR)	0.1	0.3	1.6	0.7	0.4	-0.4	-0.0	0.0	-0.4	-0.4	-0.3	-0.3	0.2	-0.7	-1.3
Neuroticism	0.1	0.2	0.9	0.5	0.6	0.1	-0.1	-0.2	-0.5	-0.0	0.0	0.5	1.0	0.2	-0.8
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.7	-0.8	-0.2	0.4	-0.0	0.0	-0.4	-0.0	-0.3	0.3	0.2	-0.4	0.7
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.5	-0.6	-0.1	0.2	0.2	0.5	0.1	0.4	0.2	0.5	0.2	0.7	0.6
Impedance of arm (right)	0.1	0.3	1.3	1.1	-0.6	-0.8	0.4	0.7	0.4	0.1	-0.7	0.0	-0.8	-0.0	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.3	0.1	0.0	0.0	-0.3	-0.2	0.1	0.0	-0.5	0.5	0.0	0.6	-0.0
Impedance of arm (left)	0.1	0.3	1.1	0.9	-0.6	-0.7	0.0	0.4	1.1	0.6	-0.8	0.6	0.1	-0.0	0.2
Hair/balding pattern: Pattern 4	0.1	0.3	1.4	0.3	0.2	-0.6	0.3	0.2	-0.8	-0.7	-0.0	-0.8	-1.2	-0.3	0.3
Medication: Amlodipine	0.1	0.2	0.5	-0.6	0.0	0.7	0.7	0.6	-0.1	-0.2	0.2	-0.1	-0.7	0.0	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.4	-0.2	-0.1	-0.0	-0.6	-0.7	0.5	0.2	-0.5	0.5	0.5	-0.3	0.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.6	0.2	-0.3	-0.7	-0.2	-0.3	0.0	0.2	-0.6	-0.5	0.3	0.5	-0.6
Leg fat-free mass (right)	0.1	0.7	5.3	-1.1	0.7	0.7	-0.2	-0.2	-0.5	-0.3	2.3	-0.2	0.1	-0.8	-0.1
Leg predicted mass (right)	0.1	0.6	5.1	-1.1	0.7	0.6	-0.2	-0.2	-0.5	-0.4	2.2	-0.3	0.0	-0.8	-0.1
Mother’s age at death	0.1	0.1	0.5	-0.1	-0.3	-0.1	0.2	0.1	0.0	0.4	-0.5	0.6	0.3	0.7	0.2
Supplements: Calcium	0.1	0.1	0.7	-0.8	-0.1	-0.5	0.1	0.3	-0.4	-0.1	-0.1	-0.2	-0.2	0.6	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.7	-0.3	0.6	-0.1	-0.3	-0.4	-0.1	-0.2	0.8	-0.1	0.2	-0.3	-0.0
Impedance of whole body	0.1	0.6	1.8	0.7	-0.5	-1.0	-0.6	-0.2	1.3	1.0	-0.6	0.9	1.3	0.3	-0.0
Exposure to tobacco smoke at home	0.0	0.1	0.2	-0.2	0.1	-0.1	-0.1	-0.4	0.3	-0.0	0.4	-0.0	0.1	-0.4	0.3

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