TWAS hub - TXNL4B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.05400	0.0240	0.00120	0.065	0.022	0.041	0.043	0.060	2.1e-08	9.0e-04	8.0e-06	5.2e-06	8.8e-08
2	GTEx	Breast Mammary Tissue (Male)	0.00658	0.0380	0.45000	0.005	NA	0.002	NA	0.023	2.4e-01	NA	2.8e-01	NA	9.5e-02
3	GTEx	Nerve Tibial	0.94440	0.0122	0.00000	-0.001	NA	0.328	NA	0.423	4.2e-01	NA	7.5e-24	NA	2.6e-32
4	GTEx	Stomach	0.36700	0.1150	0.00034	0.008	NA	0.030	NA	0.035	1.2e-01	NA	1.4e-02	NA	8.5e-03
5	METSIM	Adipose	0.03050	0.0188	0.01100	0.002	0.011	0.001	0.012	0.004	1.4e-01	6.6e-03	1.8e-01	6.1e-03	7.7e-02
6	TCGA	Brain Lower Grade Glioma	0.43980	0.0701	0.00000	0.286	0.247	0.285	NA	0.290	1.1e-32	9.1e-28	1.6e-32	NA	3.2e-33

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3	4	5	6
LDL Cholesterol	19.6	31.0	96.1	9.1	-1.2	2.3	0.8	9.8
High cholesterol (Self-reported)	15.5	27.4	77.7	8.0	-4.7	0.3	-0.5	8.8
Medication: Cholesterol lowering	9.3	14.4	41.6	5.5	-2.6	2.1	1.9	6.5
Medication: Simvastatin	7.5	11.1	31.3	4.9	-2.9	1.3	0.8	5.6
Cholesterol lowering medication	7.3	10.8	28.8	5.2	-2.7	-0.0	-1.4	5.4
Cardiovascular Disease	5.1	16.8	49.3	6.4	-2.8	1.7	0.1	7.0
Medication: Atorvastatin	4.6	5.6	17.3	3.2	-1.9	1.7	0.0	4.2
Triglycerides	4.4	7.1	19.7	4.4	-1.8	-0.1	-0.8	4.4
Medication for cholesterol	4.0	6.0	15.8	-3.3	2.5	0.2	1.8	-4.0
Alcohol intake frequency.	3.9	9.0	29.6	2.7	0.1	-5.4	-3.5	2.2
Medication for cholesterol, blood pressure or diabetes	3.8	6.3	16.3	-3.5	2.0	-1.9	-1.3	-4.0
Chronotype (morning person)	3.7	8.5	30.0	2.9	-0.0	-5.5	-3.1	1.9
Emphysema/chronic bronchitis	3.3	3.7	7.0	2.6	-0.7	-2.6	-2.1	1.9
Illnesses of siblings	3.0	4.2	12.3	-3.5	0.7	0.4	1.2	-3.3
Average weekly red wine intake	2.9	4.2	8.1	-2.8	1.2	2.0	2.1	-2.7
Exposure to tobacco smoke outside home	2.8	3.7	8.8	2.5	1.7	1.9	0.8	3.0
Alcohol intake versus 10 years previously	2.7	4.0	9.0	2.3	-1.2	-3.0	-1.7	2.3
Ulcerative Colitis	2.6	3.8	12.2	-1.7	-1.7	1.8	3.5	-1.1
Fluid intelligence score	2.6	5.5	12.5	-3.5	2.1	1.4	-1.5	-3.4
Body Mass Index (BMI) (2010)	2.5	3.5	9.1	3.0	-1.3	-1.2	0.0	2.9
Qualifications: None of the above	2.5	5.3	11.5	2.8	-2.0	-3.4	-1.4	2.6
Mineral and other dietary supplements	2.5	3.3	9.0	-1.8	1.2	3.0	2.3	-1.1
Number of self-reported non-cancer illnesses	2.5	4.4	10.2	2.8	-1.8	1.6	1.6	3.2
Intelligence (Savage-Jansen 2018)	2.4	7.4	18.4	-4.3	1.1	3.0	-0.4	-3.9
Blood Red Count	2.4	23.5	70.2	7.3	-4.1	0.9	0.1	8.4
Time employed in main current job	2.4	2.8	8.9	-0.3	1.8	-2.0	-3.0	-0.4
Qualifications: A levels/AS levels or equivalent	2.4	5.4	11.0	-2.8	3.3	2.7	0.0	-2.5
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.6	5.1	2.2	-0.2	1.4	2.1	2.0
Basal cell carcinoma (self-reported)	2.4	2.8	5.8	2.2	-0.6	-1.1	-2.4	2.2
Financial difficulties in last 2 years	2.3	3.2	8.7	1.4	0.3	2.9	2.1	1.9
Qualifications: College or University degree	2.3	7.3	16.4	-3.1	3.1	4.1	0.5	-2.8
Ever taken oral contraceptive pill	2.3	2.5	5.2	-1.2	1.7	2.1	2.3	-1.1
Risk taking	2.3	3.3	9.1	1.3	1.5	3.0	2.3	1.2
Serious illness, injury or assault to yourself	2.2	2.7	10.6	-0.9	-0.5	1.9	3.3	-0.9
Arm fat mass (right)	2.1	8.7	24.0	4.8	-0.4	1.3	1.7	4.9
Eye problems/disorders: Cataract	2.1	2.5	5.5	2.3	-0.2	-1.3	-1.6	2.4
Arm fat mass (left)	2.1	8.8	23.9	4.9	-0.2	1.2	1.9	4.9
Heart disease (siblings)	2.1	2.6	5.7	1.9	-0.6	-1.5	-2.4	1.8
Alcohol drinker status: Previous	2.1	2.4	6.3	2.5	0.0	-0.9	-1.2	2.5
Ulcerative Colitis (UC)	2.0	3.8	12.7	-1.8	-1.3	1.8	3.6	-1.5
Qualifications: CSEs or equivalent	2.0	2.6	6.9	2.6	0.6	0.0	1.4	2.6
Arm fat percentage (right)	2.0	7.8	20.4	4.2	-0.6	2.0	2.0	4.5
Medication: Seretide 50 evohaler	2.0	2.3	4.8	1.9	-2.2	0.3	1.2	2.1
Medication: Aspirin	2.0	2.7	7.5	0.7	-0.5	2.7	2.5	1.1
Osteoarthritis (self-reported)	2.0	2.5	6.1	2.4	-1.8	-0.2	-0.2	2.5
Alzheimer’s Disease (including proxy)	1.9	2.8	6.2	-0.8	-2.1	-2.5	-2.1	-0.8
BMI	1.9	11.2	33.6	5.4	-1.1	1.5	0.9	5.8
Average weekly spirits intake	1.9	2.4	4.2	2.0	-1.8	1.4	1.0	2.0
Nervous feelings	1.9	3.5	7.0	-1.9	1.3	-1.7	-2.6	-2.4
Ever unenthusiastic/disinterested for a whole week	1.9	2.3	6.1	-1.8	-0.0	2.5	1.6	-1.4
Medication: Lansoprazole	1.9	2.2	6.3	2.5	-0.2	-0.9	-1.1	2.2
Medication for pain relief, constipation, heartburn	1.9	3.2	7.0	-2.2	2.0	-0.8	-1.5	-2.6
Neck or shoulder pain in last month	1.9	2.7	8.6	2.9	0.3	-2.0	0.2	1.9
Angina (self-reported)	1.9	2.5	6.0	2.4	-1.3	0.9	1.1	2.4
Whole body fat mass	1.9	8.1	23.9	4.9	-0.7	0.0	1.2	4.8
Illnesses of father: Heart disease	1.9	2.7	6.3	1.4	2.5	-0.8	-2.5	1.0
Arm fat percentage (left)	1.9	7.4	19.1	4.1	-0.5	1.8	2.2	4.4
Medication: Blood pressure	1.9	3.6	8.5	2.3	-1.3	-0.2	-2.5	2.9
Coronary Artery Disease (CAD)	1.8	2.2	4.9	1.7	-0.7	-0.3	-2.1	2.2
Medication: Co-codamol	1.8	2.1	4.8	1.7	0.6	-1.4	-2.2	1.6
Trunk fat mass	1.8	7.6	22.6	4.8	-0.8	-0.1	1.4	4.5
Past tobacco smoking	1.8	3.3	10.8	-1.2	-0.4	-3.3	-2.4	-1.3
Worrier / anxious feelings	1.8	3.4	10.0	-1.5	-0.0	-2.2	-3.2	-1.8
Leg fat mass (right)	1.8	7.0	20.4	4.5	-0.8	-0.0	0.9	4.5
Ever smoked	1.8	3.2	10.0	1.3	0.7	3.2	2.3	1.4
Verbal and Numeric Reasoning (VNR)	1.7	4.2	10.1	-3.2	1.2	1.3	-1.6	-3.0
Age at First Birth	1.7	2.4	6.2	-2.3	-2.5	0.8	-0.2	-1.5
Smoking Status	1.7	4.1	8.6	2.7	-0.2	2.6	1.3	2.9
Angina	1.7	2.2	4.5	2.1	-1.2	1.2	1.2	2.1
Lung cancer (father)	1.7	2.0	6.0	1.2	-2.5	-1.3	-1.0	1.3
Commuting to job workplace: Cycle	1.7	2.0	11.6	-0.1	3.4	0.6	-0.3	-0.2
Leg fat mass (left)	1.7	6.5	19.4	4.4	-0.7	-0.1	0.8	4.3
Trunk fat percentage	1.6	6.5	18.2	4.3	-1.2	0.1	1.2	4.2
Medication: Atenolol	1.6	2.0	4.9	2.1	-1.3	1.1	-0.2	2.2
Hearing difficulty/problems with background noise	1.6	2.6	6.6	-2.1	1.4	-0.4	1.5	-2.6
Pain all over the body in last month	1.6	1.7	2.7	-1.5	-1.5	-0.5	1.6	-1.6
Weight	1.6	7.7	23.5	4.8	0.2	0.1	1.3	4.5
Hip circumference	1.6	6.9	20.2	4.3	-0.1	0.6	1.4	4.5
Length of working week for main job	1.6	1.8	8.5	-0.7	0.4	2.9	1.3	-0.4
Body fat percentage	1.6	6.4	18.4	4.2	-1.0	0.1	0.9	4.3
Number of full brothers	1.6	2.1	5.5	2.3	-1.5	-0.5	0.3	2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	3.4	1.8	1.6	-1.4	-1.1	1.6
Had major operations	1.6	1.8	4.5	-1.4	-0.1	0.9	2.1	-1.9
Supplements: Fish oil (including cod liver oil)	1.6	2.1	6.7	1.1	-1.0	-2.6	-1.8	0.6
Average weekly beer plus cider intake	1.6	2.3	6.1	1.5	-2.5	0.5	1.4	1.9
Bipolar Disorder (2018)	1.5	2.3	9.8	-0.1	-0.4	3.1	1.9	0.2
Number of treatments/medications taken	1.5	2.8	7.7	2.4	-1.2	0.9	1.0	2.8
Body mass index (BMI)	1.5	6.4	18.5	4.0	-0.2	1.5	1.5	4.3
Waist circumference	1.5	5.5	17.5	3.9	0.4	0.5	0.7	4.2
Alcohol usually taken with meals	1.5	2.5	6.1	-1.6	2.5	-0.5	-1.5	-1.9
Noisy workplace	1.5	1.9	4.5	2.1	-0.6	-1.4	-0.3	2.1
Pulse wave peak to peak time	1.5	1.7	3.7	1.3	-1.0	-1.9	-1.7	1.1
Heart disease (mother)	1.5	1.8	4.2	2.0	1.1	0.8	0.8	2.0
Medication: Aspirin	1.5	1.9	6.3	0.2	-0.1	2.5	2.2	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.5	3.2	5.3	-1.5	1.7	-2.2	-2.3	-2.0
Ever depressed for a whole week	1.5	1.8	3.5	-1.9	0.8	1.3	1.7	-1.5
Current tobacco smoking	1.4	2.3	5.1	1.8	-1.1	1.7	1.1	2.3
Multivitamins +/- minerals	1.4	1.7	3.3	1.7	1.2	-1.0	-1.8	1.4
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	5.1	2.3	-0.8	-2.1	0.1	1.9
Falls in the last year	1.4	1.9	8.1	0.1	0.6	2.9	1.8	0.1
Illnesses of mother	1.4	1.7	3.5	-1.7	-0.6	1.2	1.4	-1.9
Medication: Paracetamol	1.4	2.3	3.8	1.9	-1.8	-1.5	-1.1	1.9
Eye problems/disorders: None of the above	1.4	1.7	3.1	-1.7	-0.6	1.6	1.0	-1.8
Illnesses of siblings: Diabetes	1.4	1.7	5.0	1.8	-0.1	1.2	0.8	2.2
Smoking status: Current	1.4	2.2	5.7	1.9	-1.0	1.5	0.8	2.4
Heart attack/myocardial infarction (self-reported)	1.4	1.8	4.3	0.2	-1.3	2.0	2.1	0.7
Alzheimer’s Disease (in mother)	1.3	1.6	3.6	-0.8	-1.3	-1.7	-1.9	-0.8
Bipolar Disorder (2011)	1.3	1.2	2.8	1.7	-1.4	-0.0	0.3	1.6
Medication: Metformin	1.3	1.8	5.1	2.0	-1.2	-0.6	-0.4	2.3
Fed-up feelings	1.3	2.4	8.1	2.8	0.8	-1.1	-0.8	2.0
High blood pressure (siblings)	1.3	1.9	5.5	2.3	-0.2	0.6	-0.2	2.3
Leg fat percentage (right)	1.3	4.7	14.5	3.6	-0.7	-0.2	-0.0	3.8
Wheeze or whistling in the chest in last year	1.3	2.4	6.7	2.6	-0.5	-0.9	-0.1	2.6
Age at first live birth	1.3	2.2	4.7	-2.2	1.4	1.8	-0.0	-1.9
Pulse rate, automated reading	1.3	4.3	11.2	-3.1	-0.5	-1.4	1.8	-3.3
Pain type(s) experienced in last month: Hip pain	1.3	1.7	3.6	1.9	0.4	-1.9	0.3	1.6
Major Depression (MDD)	1.2	1.5	4.8	0.1	1.3	1.4	2.2	0.4
Type 2 Diabetes (T2D) (2018)	1.2	2.3	5.7	2.2	-1.6	-0.4	-0.6	2.4
Sitting height	1.2	8.4	28.6	5.3	0.7	-2.1	-0.6	4.1
Heart attack	1.2	1.6	3.8	0.4	-1.3	1.7	1.9	0.8
Pulse wave Arterial Stiffness index	1.2	1.4	2.9	-1.1	0.7	1.6	1.7	-1.0
Loud music exposure frequency	1.2	1.3	3.5	1.9	-1.2	-0.8	-0.0	1.5
Overall health rating	1.2	2.5	5.8	2.4	-0.8	-1.4	1.2	2.3
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	4.2	-0.5	0.8	-1.9	-2.1	-0.7
Loneliness, isolation	1.2	1.6	4.2	1.2	1.9	-0.2	-2.1	0.5
Mouth/teeth dental problems: Mouth ulcers	1.2	1.8	7.7	0.5	-0.0	-1.7	-2.8	0.6
Medication: Gliclazide	1.2	1.4	2.7	1.1	-1.6	0.1	1.4	1.6
Guilty feelings	1.2	1.8	6.0	0.3	-0.4	-2.5	-2.2	0.2
Eye problems/disorders: Glaucoma	1.2	1.5	3.5	1.5	0.6	-1.9	-1.1	1.2
Leg fat percentage (left)	1.2	4.2	12.7	3.5	-0.5	-0.3	-0.0	3.6
Hand grip strength (left)	1.1	2.8	11.8	-0.2	-0.1	-3.4	-1.9	-1.3
Vitamin and mineral supplements	1.1	1.4	2.6	-1.5	-0.6	1.4	1.6	-1.1
Had menopause	1.1	1.3	2.3	1.2	-1.2	-1.3	-1.5	1.0
Forced vital capacity (FVC)	1.1	4.1	16.2	1.4	1.2	-4.0	-2.2	0.5
Friendships satisfaction	1.1	1.3	5.7	-0.2	2.4	0.5	-1.3	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	5.2	0.8	1.1	0.8	2.3	0.4
Illnesses of father: High blood pressure	1.1	1.3	3.0	-1.3	-0.2	1.7	1.2	-1.3
Worry (Nagel 2018)	1.0	2.1	4.7	-1.9	0.8	-1.5	-1.3	-2.2
Fasting Glucose	1.0	1.2	4.0	-0.6	-0.5	-1.3	-2.0	-0.8
Lupus	1.0	1.5	3.5	0.9	-1.9	0.7	1.8	1.1
Ever had hysterectomy (womb removed)	1.0	1.1	3.4	1.7	0.3	0.2	-0.5	1.9
Diabetes (mother)	1.0	1.3	2.1	1.5	0.9	-1.4	-0.9	1.3
Hand grip strength (right)	1.0	2.8	8.7	-0.6	1.1	-2.9	-1.9	-1.7
Maternal smoking around birth	1.0	1.4	4.0	1.7	-0.9	0.6	-0.3	2.0
Medication: Levothyroxine sodium	1.0	1.7	4.4	1.3	-0.8	2.1	0.6	1.7
Number of live births	1.0	1.5	4.6	-0.4	-1.8	-2.1	-0.1	-0.8
Gout (self-reported)	1.0	1.4	3.5	-1.2	0.1	1.9	1.9	-0.4
Medication: Amlodipine	1.0	1.4	5.1	0.2	-2.2	1.1	1.5	0.3
Forced vital capacity (FVC), Best measure	1.0	3.8	14.4	1.2	1.3	-3.8	-2.1	0.5
Number of children fathered	1.0	1.2	4.4	-1.3	0.3	0.4	0.8	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	4.2	-0.7	-2.0	-1.0	-1.1	-0.4
Mean time to correctly identify matches	1.0	1.9	4.0	-2.0	1.2	1.7	0.6	-1.6
Commuting to job workplace: Car/motor vehicle	1.0	1.2	2.2	1.4	-1.4	0.2	1.5	1.1
Knee pain experienced in last month	1.0	1.5	3.9	1.4	-1.1	-2.0	0.2	1.3
Mood swings	1.0	1.9	6.3	2.5	-0.1	-0.7	-0.6	2.0
Osteoporosis (self-reported)	1.0	1.3	3.6	1.2	-1.9	0.6	0.9	1.2
Alcohol drinker status: Never	1.0	1.2	3.5	-1.0	-1.9	-1.4	-0.1	-0.8
Alzheimer’s Disease (in father)	0.9	0.9	4.7	-0.1	-2.2	-0.9	0.1	-0.1
Irritable Bowel Disease (IBD)	0.9	2.2	3.4	-1.8	-1.7	-0.5	1.7	-1.9
Lung FEV1/FVC ratio	0.9	4.5	11.0	-3.1	2.5	0.6	-0.3	-3.3
Sensitivity / hurt feelings	0.9	1.6	6.1	0.5	0.9	-2.5	-1.5	0.3
Supplements: Zinc	0.9	0.9	4.1	-0.3	2.0	-0.4	-0.5	-1.0
High blood pressure	0.9	2.5	5.5	1.9	-2.2	0.8	-0.3	2.4
Stomach or abdominal pain in last month	0.9	1.2	3.9	-0.7	2.0	-1.2	0.7	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	5.9	0.8	-0.7	-2.4	-2.3	0.5
Diabetes (self-reported)	0.9	1.4	3.7	1.6	-1.4	0.2	0.5	1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	2.2	-1.5	0.4	0.8	1.3	-1.4
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.2	-1.2	-1.5	1.0	1.3	-0.7
Medication: Blood pressure	0.9	1.5	2.7	1.0	-1.5	1.6	1.3	1.2
Number of full sisters	0.9	1.1	1.9	1.4	-1.2	0.0	1.3	1.2
Age at last live birth	0.9	1.3	5.8	-0.6	2.4	1.2	0.0	-0.5
Family relationship satisfaction	0.9	1.1	3.0	0.7	1.3	-1.1	-1.7	0.5
Supplements: Vitamin C	0.9	1.1	3.7	1.9	0.7	-0.4	-0.0	1.4
Hypertension (Self-reported)	0.9	2.6	6.2	2.1	-2.0	0.8	-0.4	2.5
Commuting to job workplace: Walk	0.9	1.0	2.8	-1.7	0.3	0.4	0.9	-1.4
Back pain experienced in last month	0.9	1.3	6.3	1.0	0.7	-2.5	0.0	0.2
Illnesses of father: None of the above (group 1)	0.9	1.1	2.7	-1.6	-0.2	1.0	0.7	-1.5
Commuting to job workplace: Public transport	0.9	1.1	2.6	-1.6	0.9	1.6	-0.1	-0.9
Vascular/heart problems diagnosed by doctor	0.9	2.3	4.5	-1.7	2.0	-1.6	-0.7	-2.1
Pain experienced in last month	0.9	1.5	6.9	0.1	1.1	2.6	-0.7	0.8
Schizophrenia vs Biploar Disorder	0.8	1.0	4.0	-0.7	0.9	-2.0	-0.2	-1.0
HbA1C	0.8	0.8	2.1	1.5	0.9	-0.4	-0.5	1.3
Rheumatoid Arthritis	0.8	1.0	3.7	-1.0	1.9	0.4	-0.6	-1.0
Respiratory disease	0.8	1.9	5.4	2.3	0.2	0.0	0.9	2.2
Hearing difficulty/problems: Yes	0.8	1.2	2.3	-1.3	0.9	-1.5	-0.3	-1.5
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	2.8	1.3	-0.7	0.4	0.4	1.7
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	2.9	1.3	-0.2	-1.3	-1.7	0.9
Hair/balding pattern: Pattern 2	0.8	1.0	2.7	0.8	-1.4	-1.6	-0.6	0.6
Father’s age at death	0.8	1.0	3.3	-1.5	0.7	-0.3	0.0	-1.8
Prospective memory result	0.8	1.0	4.7	0.5	-0.9	-2.2	-0.0	0.2
Ever highly irritable/argumentative for 2 days	0.8	1.0	3.8	0.6	-1.0	-2.0	-0.7	0.4
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.4	1.5	-0.6	0.4	1.0	1.5
Birth weight	0.8	1.7	5.2	0.6	2.3	1.5	-1.3	0.8
Medication: Omeprazole	0.8	1.0	2.7	-1.2	-1.0	0.3	1.6	-0.8
Diabetes diagnosed by doctor	0.8	1.3	3.2	1.4	-1.5	0.3	0.3	1.8
Mother’s age at death	0.8	1.0	3.6	-0.6	-0.1	-1.1	-1.9	-0.7
Arm fat-free mass (left)	0.8	3.8	12.5	3.5	0.5	-0.9	0.7	3.0
Number of operations (self-reported)	0.8	1.1	4.6	-0.9	0.4	0.3	2.1	-1.1
Crohns Disease (2017)	0.7	1.6	5.7	-0.6	-1.5	-2.4	-0.4	-1.0
Reaction Time	0.7	1.3	3.2	-1.1	1.6	1.8	0.8	-0.6
Blood Platelet Count	0.7	8.4	25.2	-4.7	1.4	-1.2	-0.3	-5.0
Impedance of leg (right)	0.7	3.3	11.4	0.1	-1.4	-3.4	-2.6	-0.0
Leg fat-free mass (left)	0.7	3.9	9.9	3.1	0.4	0.8	2.3	2.8
Townsend deprivation index at recruitment	0.7	1.0	2.9	1.5	-0.6	0.7	0.4	1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.8	1.7	0.8	-0.5	-0.1	1.4
Taking other prescription medications	0.7	1.1	2.4	1.0	-1.3	0.0	1.5	1.2
Impedance of leg (left)	0.7	3.4	11.8	0.1	-1.1	-3.4	-2.7	-0.2
Leg predicted mass (left)	0.7	3.8	9.7	3.1	0.5	0.7	2.2	2.8
Forced expiratory volume in 1-second (FEV1)	0.7	2.5	9.4	0.1	1.5	-3.1	-1.6	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	7.2	0.2	1.8	-2.7	-1.8	-0.4
Tense / ‘highly strung’	0.7	1.1	2.5	-1.1	0.8	-1.6	-0.5	-1.6
Pulse wave reflection index	0.7	0.8	2.9	-0.7	0.9	1.7	0.7	-0.3
Blood clot in the leg (DVT)	0.7	0.9	2.8	0.9	1.7	0.1	0.9	0.9
Headache pain in last month	0.7	1.2	3.3	-1.6	-0.2	-0.8	0.5	-1.8
Worry too long after embarrassment	0.7	1.2	4.7	0.2	-0.3	-1.5	-2.2	0.1
Smoking status: Previous	0.7	1.1	3.1	0.9	0.1	1.8	1.3	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	3.9	2.0	0.9	-1.1	0.5	1.5
Miserableness	0.7	1.2	4.5	1.1	0.3	2.1	0.6	1.1
Medication: Bendroflumethiazide	0.7	1.1	3.1	0.0	-1.8	0.9	-1.4	0.6
Medication: Paracetamol	0.7	1.1	2.0	1.4	-0.5	-1.3	-1.0	1.3
Basal metabolic rate	0.7	4.1	12.5	3.5	0.5	-0.1	1.6	3.1
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.7	-1.0	0.5	0.1	1.1	-1.6
Unable to work because of sickness or disability	0.7	0.9	4.5	0.0	-0.0	0.8	2.1	0.1
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.9	0.9	1.7	-0.3	0.9	0.8
Bipolar Disorder or Schizophrenia	0.6	1.6	6.2	-1.0	0.5	2.5	1.0	-0.9
Systolic Blood Pressure	0.6	2.9	8.4	-2.0	-0.4	-0.8	-2.9	-2.1
Systolic blood pressure, automated reading	0.6	1.7	6.4	-1.0	0.3	-1.0	-2.5	-1.2
Medication for hormone replacement therapy	0.6	0.7	1.5	1.2	0.8	0.2	-0.8	1.2
Pack years adult smoking proportion	0.6	0.9	2.2	1.1	-1.4	-0.4	0.3	1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	4.1	0.6	-0.6	-1.7	-2.0	0.4
Neuroticism score	0.6	1.3	3.2	0.8	1.0	-1.8	-1.8	0.1
Happiness	0.6	0.7	2.1	0.6	1.4	-0.2	-1.4	0.2
Arm fat-free mass (right)	0.6	2.9	8.5	2.9	0.5	-1.6	0.5	2.4
Comparative body size at age 10	0.6	1.6	5.7	1.2	-2.4	-0.7	0.7	1.2
Arm predicted mass (right)	0.6	2.8	8.5	2.9	0.3	-1.6	0.6	2.4
Leg pain on walking	0.6	0.8	1.9	0.7	1.4	0.9	0.7	1.0
Leg fat-free mass (right)	0.6	3.4	8.1	2.9	0.8	0.9	2.3	2.4
Long-standing illness, disability or infirmity	0.6	1.0	4.5	0.4	0.1	0.9	2.1	0.7
Ever had bowel cancer screening	0.6	0.7	4.2	0.2	-0.3	-2.1	0.2	-0.1
Leg predicted mass (right)	0.6	3.4	7.8	2.8	0.8	0.9	2.4	2.3
Wears glasses or contact lenses	0.6	0.7	1.9	-0.5	0.7	1.4	-1.0	-0.5
Pack years of smoking	0.6	0.9	3.2	0.9	-1.8	-0.3	0.0	1.3
Depression (Nagel 2018)	0.5	0.8	1.8	1.2	0.1	0.3	1.3	1.1
Mean Putamen Volume	0.5	0.5	1.7	0.5	-0.3	-0.9	-1.3	0.5
Blood Eosinophil Count	0.5	3.6	14.8	1.0	-3.9	-0.7	1.2	1.9
Blood White Count	0.5	3.7	12.0	1.7	-1.8	-3.5	-1.4	1.5
Neuroticism	0.5	1.2	4.9	0.5	2.2	-0.8	-1.1	-0.2
Relative age of first facial hair	0.5	1.0	3.0	1.6	0.2	0.3	-0.5	1.7
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.6	-1.6	-0.8	-0.7	0.6	-1.6
Number of incorrect matches in round	0.5	0.8	2.7	-0.4	-1.0	-0.8	-1.6	0.2
Mouth/teeth dental problems	0.5	0.7	2.0	-0.3	0.7	1.4	1.4	-0.2
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.6	-0.7	0.4	0.7	1.3	-1.0
Medication: Ramipril	0.5	0.6	1.3	0.9	-0.8	0.9	0.4	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.1	0.7	-0.3	1.1	1.1	0.9
Qualifications: O levels/GCSEs or equivalent	0.5	0.7	2.1	-0.4	1.4	1.0	-1.1	-0.2
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.3	1.2	0.2	1.3	0.8	1.5
Shortness of breath walking on level ground	0.5	0.6	1.3	1.1	-0.3	-0.2	1.1	1.0
Comparative height size at age 10	0.5	2.5	5.7	2.4	-0.4	-2.3	1.2	1.6
Whole body fat-free mass	0.5	2.7	8.2	2.9	0.5	-0.3	1.5	2.4
Qualifications: nursing, teaching	0.5	0.7	1.8	-1.4	0.7	1.1	-0.4	-0.8
Breast cancer (self-reported)	0.5	0.6	1.9	0.2	-1.1	0.7	1.4	0.2
Whole body water mass	0.5	2.8	8.2	2.9	0.6	-0.2	1.6	2.4
Average weekly champagne plus white wine intake	0.5	0.7	2.2	0.8	1.5	0.6	-0.5	0.9
Diastolic blood pressure, automated reading	0.5	1.5	7.2	0.2	1.0	2.7	0.8	0.5
Arm predicted mass (left)	0.5	2.6	8.3	2.9	0.4	-0.9	0.7	2.4
Depressed Affect (Nagel 2018)	0.4	0.9	2.6	1.6	1.3	0.5	0.2	0.8
Schizophrenia (2018)	0.4	0.9	1.7	-1.3	1.2	0.7	-0.3	-1.3
Prostate Cancer	0.4	0.6	3.6	0.2	-0.1	-1.9	-0.2	-0.2
Crohns Disease (2012)	0.4	0.6	3.1	-0.2	-0.1	-1.8	-0.3	-0.4
HDL Cholesterol	0.4	0.6	1.7	-0.7	1.3	1.1	0.1	-0.6
Hypothyroidism (self reported)	0.4	0.9	2.9	1.3	0.2	0.5	0.7	1.7
Lung FVC	0.4	1.9	6.9	0.1	0.0	-2.6	-2.0	-0.6
Severe depression (siblings)	0.4	0.4	1.3	-1.0	0.2	-0.2	0.5	-1.1
Relative age voice broke	0.4	0.6	3.7	0.4	-0.0	-1.9	0.2	-0.1
Age when periods started (menarche)	0.4	1.1	2.6	1.4	0.6	-1.6	-0.9	0.8
Trunk fat-free mass	0.4	2.4	7.6	2.8	0.6	-0.8	0.9	2.2
Hair/balding pattern: Pattern 3	0.4	0.6	2.1	0.6	-0.3	0.7	1.4	0.6
Pulse rate	0.4	0.6	1.7	-1.0	-0.2	-0.4	1.3	-0.9
Asthma	0.4	0.7	1.6	1.1	-0.4	0.6	1.1	1.2
Depression (self-reported)	0.4	0.4	1.5	-0.6	0.7	1.2	0.0	-0.5
Trunk predicted mass	0.4	2.3	7.1	2.7	0.7	-0.8	1.0	2.1
Standing height	0.4	3.6	11.6	2.8	0.8	-3.4	-0.5	1.4
Breastfed as a baby	0.4	0.5	2.1	0.3	1.4	-0.1	-0.6	-0.5
Medication: Ibuprofen	0.4	0.5	1.7	0.1	0.4	1.3	1.0	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.2	-0.7	0.1	0.8	1.1	-0.9
Asthma (self-reported)	0.4	0.7	2.0	1.2	-0.4	0.3	0.8	1.4
Financial situation satisfaction	0.4	0.5	1.1	0.8	-0.8	0.2	-0.7	1.0
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.7	-0.5	-1.3	-0.6	-0.1	-0.8
Medication: Lisinopril	0.4	0.5	1.0	-1.0	0.8	0.7	-0.2	-0.8
Irritability	0.4	0.7	1.9	1.4	0.5	-1.3	0.1	0.6
Fractured/broken bones in last 5 years	0.4	0.5	1.9	0.4	0.5	0.6	1.4	0.3
Breast Cancer	0.3	0.7	2.4	0.8	1.0	0.2	-1.6	0.6
Heel T-Score	0.3	2.7	9.0	0.5	-0.2	-3.0	-2.7	0.2
Height	0.3	6.1	22.8	3.2	0.5	-4.8	-1.0	1.4
Waist Hip Ratio (WHR)	0.3	1.3	6.4	-0.2	2.5	-0.4	-0.9	-0.4
Allergy or Eczema	0.3	0.7	2.2	-1.5	-0.1	-0.0	0.2	-1.4
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.3	1.2	-0.5	-0.6	0.4	0.9
Supplements: Glucosamine	0.3	0.4	1.0	0.8	-1.0	-0.5	-0.5	0.6
Chronic bronchitis/emphysema (father)	0.3	0.3	1.3	0.4	0.1	-1.1	0.2	0.6
High blood pressure (mother)	0.3	0.4	0.9	0.5	0.7	-0.7	-0.9	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.2	-1.1	-0.5	0.4	0.3	-0.5
Hair/balding pattern: Pattern 4	0.3	0.7	2.8	-0.2	0.8	0.9	1.7	-0.0
Peak expiratory flow (PEF)	0.3	0.8	1.7	1.3	1.3	-0.1	-0.8	0.7
Mouth/teeth dental problems: Bleeding gums	0.3	0.5	1.2	0.8	0.0	0.5	-0.8	1.1
Health satisfaction	0.3	0.3	0.7	0.8	0.4	0.1	0.7	0.8
Migraine (self-reported)	0.3	0.4	1.7	-0.4	1.3	0.5	0.4	-0.3
Medication: Allopurinol	0.3	0.4	1.2	-0.7	0.2	1.1	0.8	-0.2
Chest pain or discomfort	0.3	0.4	0.8	0.6	0.5	-0.6	-0.9	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	1.5	0.0	-0.1	-1.2	-0.7	0.2
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.3	-0.4	-1.1	-0.4	0.8	-0.4
Neuroticism (Nagel 2018)	0.2	0.5	1.5	0.1	1.2	-0.7	-0.8	-0.5
Neuroticism (2016)	0.2	0.3	1.1	1.0	-0.2	-0.2	-0.5	0.6
Schizophrenia (2014)	0.2	0.5	1.2	-0.9	0.9	0.4	0.1	-1.1
Type 2 Diabetes (T2D) (2012)	0.2	0.2	1.0	-0.2	0.0	-0.1	-1.0	0.2
Tanning	0.2	2.1	10.4	-0.5	-0.8	-3.2	0.7	-1.0
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.7	0.4	-0.1	-0.2	-0.9	0.6
Mouth/teeth dental problems: Dentures	0.2	0.4	1.0	0.9	-0.4	-1.0	-0.1	0.6
Birth weight of first child	0.2	0.3	0.8	-0.2	0.9	-0.3	-0.9	0.1
Glaucoma (self-reported)	0.2	0.2	0.7	0.4	0.4	-0.9	-0.3	0.2
Suffer from ‘nerves’	0.2	0.3	0.6	-0.8	0.7	-0.2	-0.4	-0.7
Hearing aid user	0.2	0.2	1.2	0.2	-0.1	-0.3	-1.1	-0.2
Age started oral contraceptive pill	0.2	0.3	1.2	0.4	0.2	-0.3	-1.1	0.6
Supplements: Calcium	0.2	0.2	0.5	0.0	-0.4	0.5	-0.7	-0.3
Impedance of whole body	0.2	1.1	3.9	-0.1	-0.9	-2.0	-1.2	-0.5
Primary Biliary Cirrhosis	0.1	0.1	0.4	0.2	-0.5	-0.3	0.3	0.6
Hair Pigment	0.1	4.1	10.5	2.9	-1.2	1.6	-1.4	3.2
Other serious medical condition/disability diagnosed by doctor	0.1	0.1	0.3	-0.4	0.5	0.2	0.3	-0.4
Diabetes (father)	0.1	0.1	0.3	-0.0	-0.0	0.6	0.6	0.4
Average weekly fortified wine intake	0.1	0.1	0.4	0.3	0.6	0.3	0.0	0.2
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.5	-0.3	-0.3	-0.1	-0.7	-0.0
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.3	-0.6	0.5	0.2	-0.3	-0.5
Had other major operations	0.1	0.1	0.5	0.4	0.2	-0.7	0.4	-0.3
Impedance of arm (right)	0.1	0.3	0.7	-0.4	-0.8	0.5	0.5	-0.6
Impedance of arm (left)	0.1	0.2	0.6	-0.3	-0.8	-0.2	0.6	-0.6
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.4	-0.3	-0.1	0.5	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.7	-0.2	0.5	0.0	-0.8	-0.2
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	-0.1	-0.5	-0.2	-0.5	0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.0	-0.2	-0.4	-0.3	-0.3
Ovarian Cancer	0.0	0.1	0.2	-0.2	-0.5	0.0	0.3	0.0
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.1	0.1	0.3	0.2	-0.2	0.1
Allergy	0.0	0.1	0.4	0.0	-0.7	0.1	-0.4	0.1
Myopia	0.0	0.1	0.2	0.5	-0.1	-0.1	0.2	0.2

Hub : Genes

TXNL4B

Models

Trait associations