Hub : Genes

TXNL4B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.05400 0.0240 0.00120 0.065 0.022 0.041 0.043 0.060 2.1e-08 9.0e-04 8.0e-06 5.2e-06 8.8e-08
2 GTEx Breast Mammary Tissue (Male) 0.00658 0.0380 0.45000 0.005 NA 0.002 NA 0.023 2.4e-01 NA 2.8e-01 NA 9.5e-02
3 GTEx Nerve Tibial 0.94440 0.0122 0.00000 -0.001 NA 0.328 NA 0.423 4.2e-01 NA 7.5e-24 NA 2.6e-32
4 GTEx Stomach 0.36700 0.1150 0.00034 0.008 NA 0.030 NA 0.035 1.2e-01 NA 1.4e-02 NA 8.5e-03
5 METSIM Adipose 0.03050 0.0188 0.01100 0.002 0.011 0.001 0.012 0.004 1.4e-01 6.6e-03 1.8e-01 6.1e-03 7.7e-02
6 TCGA Brain Lower Grade Glioma 0.43980 0.0701 0.00000 0.286 0.247 0.285 NA 0.290 1.1e-32 9.1e-28 1.6e-32 NA 3.2e-33

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 1.5 2.3 9.8 -0.1 0.0 -0.4 3.1 1.9 0.2
Bipolar Disorder or Schizophrenia 0.6 1.6 6.2 -1.0 0.0 0.5 2.5 1.0 -0.9
Depressed Affect (Nagel 2018) 0.4 0.9 2.6 1.6 0.0 1.3 0.5 0.2 0.8
Depression (Nagel 2018) 0.5 0.8 1.8 1.2 0.0 0.1 0.3 1.3 1.1
Intelligence (Savage-Jansen 2018) 2.4 7.4 18.4 -4.3 0.0 1.1 3.0 -0.4 -3.9
Neuroticism (Nagel 2018) 0.2 0.5 1.5 0.1 0.0 1.2 -0.7 -0.8 -0.5
Schizophrenia (2018) 0.4 0.9 1.7 -1.3 0.0 1.2 0.7 -0.3 -1.3
Schizophrenia vs Biploar Disorder 0.8 1.0 4.0 -0.7 0.0 0.9 -2.0 -0.2 -1.0
Worry (Nagel 2018) 1.0 2.1 4.7 -1.9 0.0 0.8 -1.5 -1.3 -2.2
Alzheimer’s Disease (in mother) 1.3 1.6 3.6 -0.8 0.0 -1.3 -1.7 -1.9 -0.8
Alzheimer’s Disease (in father) 0.9 0.9 4.7 -0.1 0.0 -2.2 -0.9 0.1 -0.1
Alzheimer’s Disease (including proxy) 1.9 2.8 6.2 -0.8 0.0 -2.1 -2.5 -2.1 -0.8
Crohns Disease (2017) 0.7 1.6 5.7 -0.6 0.0 -1.5 -2.4 -0.4 -1.0
Irritable Bowel Disease (IBD) 0.9 2.2 3.4 -1.8 0.0 -1.7 -0.5 1.7 -1.9
Ulcerative Colitis (UC) 2.0 3.8 12.7 -1.8 0.0 -1.3 1.8 3.6 -1.5
Major Depression (MDD) 1.2 1.5 4.8 0.1 0.0 1.3 1.4 2.2 0.4
Reaction Time 0.7 1.3 3.2 -1.1 0.0 1.6 1.8 0.8 -0.6
Verbal and Numeric Reasoning (VNR) 1.7 4.2 10.1 -3.2 0.0 1.2 1.3 -1.6 -3.0
Breast Cancer 0.3 0.7 2.4 0.8 0.0 1.0 0.2 -1.6 0.6
Ovarian Cancer 0.0 0.1 0.2 -0.2 0.0 -0.5 0.0 0.3 0.0
Prostate Cancer 0.4 0.6 3.6 0.2 0.0 -0.1 -1.9 -0.2 -0.2
Age at First Birth 1.7 2.4 6.2 -2.3 0.0 -2.5 0.8 -0.2 -1.5
Bipolar Disorder (2011) 1.3 1.2 2.8 1.7 0.0 -1.4 -0.0 0.3 1.6
Body Mass Index (BMI) (2010) 2.5 3.5 9.1 3.0 0.0 -1.3 -1.2 0.0 2.9
Coronary Artery Disease (CAD) 1.8 2.2 4.9 1.7 0.0 -0.7 -0.3 -2.1 2.2
Crohns Disease (2012) 0.4 0.6 3.1 -0.2 0.0 -0.1 -1.8 -0.3 -0.4
Mean Putamen Volume 0.5 0.5 1.7 0.5 0.0 -0.3 -0.9 -1.3 0.5
Fasting Glucose 1.0 1.2 4.0 -0.6 0.0 -0.5 -1.3 -2.0 -0.8
HbA1C 0.8 0.8 2.1 1.5 0.0 0.9 -0.4 -0.5 1.3
HDL Cholesterol 0.4 0.6 1.7 -0.7 0.0 1.3 1.1 0.1 -0.6
LDL Cholesterol 19.6 31.0 96.1 9.1 0.0 -1.2 2.3 0.8 9.8
Lupus 1.0 1.5 3.5 0.9 0.0 -1.9 0.7 1.8 1.1
Neuroticism (2016) 0.2 0.3 1.1 1.0 0.0 -0.2 -0.2 -0.5 0.6
Primary Biliary Cirrhosis 0.1 0.1 0.4 0.2 0.0 -0.5 -0.3 0.3 0.6
Rheumatoid Arthritis 0.8 1.0 3.7 -1.0 0.0 1.9 0.4 -0.6 -1.0
Schizophrenia (2014) 0.2 0.5 1.2 -0.9 0.0 0.9 0.4 0.1 -1.1
Triglycerides 4.4 7.1 19.7 4.4 0.0 -1.8 -0.1 -0.8 4.4
Type 2 Diabetes (T2D) (2012) 0.2 0.2 1.0 -0.2 0.0 0.0 -0.1 -1.0 0.2
Ulcerative Colitis 2.6 3.8 12.2 -1.7 0.0 -1.7 1.8 3.5 -1.1
Blood Eosinophil Count 0.5 3.6 14.8 1.0 0.0 -3.9 -0.7 1.2 1.9
Blood Platelet Count 0.7 8.4 25.2 -4.7 0.0 1.4 -1.2 -0.3 -5.0
Blood Red Count 2.4 23.5 70.2 7.3 0.0 -4.1 0.9 0.1 8.4
Blood White Count 0.5 3.7 12.0 1.7 0.0 -1.8 -3.5 -1.4 1.5
Heel T-Score 0.3 2.7 9.0 0.5 0.0 -0.2 -3.0 -2.7 0.2
BMI 1.9 11.2 33.6 5.4 0.0 -1.1 1.5 0.9 5.8
Height 0.3 6.1 22.8 3.2 0.0 0.5 -4.8 -1.0 1.4
Waist Hip Ratio (WHR) 0.3 1.3 6.4 -0.2 0.0 2.5 -0.4 -0.9 -0.4
Systolic Blood Pressure 0.6 2.9 8.4 -2.0 0.0 -0.4 -0.8 -2.9 -2.1
Smoking Status 1.7 4.1 8.6 2.7 0.0 -0.2 2.6 1.3 2.9
Allergy or Eczema 0.3 0.7 2.2 -1.5 0.0 -0.1 -0.0 0.2 -1.4
Cardiovascular Disease 5.1 16.8 49.3 6.4 0.0 -2.8 1.7 0.1 7.0
Hypothyroidism (self reported) 0.4 0.9 2.9 1.3 0.0 0.2 0.5 0.7 1.7
Respiratory disease 0.8 1.9 5.4 2.3 0.0 0.2 0.0 0.9 2.2
Type 2 Diabetes (T2D) (2018) 1.2 2.3 5.7 2.2 0.0 -1.6 -0.4 -0.6 2.4
Lung FEV1/FVC ratio 0.9 4.5 11.0 -3.1 0.0 2.5 0.6 -0.3 -3.3
Lung FVC 0.4 1.9 6.9 0.1 0.0 0.0 -2.6 -2.0 -0.6
Neuroticism 0.5 1.2 4.9 0.5 0.0 2.2 -0.8 -1.1 -0.2
Chronotype (morning person) 3.7 8.5 30.0 2.9 0.0 -0.0 -5.5 -3.1 1.9
Hair Pigment 0.1 4.1 10.5 2.9 0.0 -1.2 1.6 -1.4 3.2
Tanning 0.2 2.1 10.4 -0.5 0.0 -0.8 -3.2 0.7 -1.0
Hand grip strength (left) 1.1 2.8 11.8 -0.2 0.0 -0.1 -3.4 -1.9 -1.3
Number of treatments/medications taken 1.5 2.8 7.7 2.4 0.0 -1.2 0.9 1.0 2.8
Average weekly spirits intake 1.9 2.4 4.2 2.0 0.0 -1.8 1.4 1.0 2.0
Sensitivity / hurt feelings 0.9 1.6 6.1 0.5 0.0 0.9 -2.5 -1.5 0.3
Frequency of depressed mood in last 2 weeks 0.3 0.5 1.3 1.2 0.0 -0.5 -0.6 0.4 0.9
Hearing difficulty/problems: Yes 0.8 1.2 2.3 -1.3 0.0 0.9 -1.5 -0.3 -1.5
Relative age of first facial hair 0.5 1.0 3.0 1.6 0.0 0.2 0.3 -0.5 1.7
Other serious medical condition/disability diagnosed by doctor 0.1 0.1 0.3 -0.4 0.0 0.5 0.2 0.3 -0.4
Ever used hormone-replacement therapy (HRT) 0.2 0.2 0.7 0.4 0.0 -0.1 -0.2 -0.9 0.6
Ever had hysterectomy (womb removed) 1.0 1.1 3.4 1.7 0.0 0.3 0.2 -0.5 1.9
Systolic blood pressure, automated reading 0.6 1.7 6.4 -1.0 0.0 0.3 -1.0 -2.5 -1.2
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.1 0.1 0.0 0.3 0.2 -0.2 0.1
Angina 1.7 2.2 4.5 2.1 0.0 -1.2 1.2 1.2 2.1
Medication for hormone replacement therapy 0.6 0.7 1.5 1.2 0.0 0.8 0.2 -0.8 1.2
Vitamin and mineral supplements 1.1 1.4 2.6 -1.5 0.0 -0.6 1.4 1.6 -1.1
Supplements: Zinc 0.9 0.9 4.1 -0.3 0.0 2.0 -0.4 -0.5 -1.0
Medication: Co-codamol 1.8 2.1 4.8 1.7 0.0 0.6 -1.4 -2.2 1.6
Medication: Metformin 1.3 1.8 5.1 2.0 0.0 -1.2 -0.6 -0.4 2.3
Diabetes (father) 0.1 0.1 0.3 -0.0 0.0 -0.0 0.6 0.6 0.4
Diabetes (mother) 1.0 1.3 2.1 1.5 0.0 0.9 -1.4 -0.9 1.3
Severe depression (siblings) 0.4 0.4 1.3 -1.0 0.0 0.2 -0.2 0.5 -1.1
Pack years adult smoking proportion 0.6 0.9 2.2 1.1 0.0 -1.4 -0.4 0.3 1.5
Impedance of leg (right) 0.7 3.3 11.4 0.1 0.0 -1.4 -3.4 -2.6 -0.0
Leg fat-free mass (left) 0.7 3.9 9.9 3.1 0.0 0.4 0.8 2.3 2.8
Trunk fat percentage 1.6 6.5 18.2 4.3 0.0 -1.2 0.1 1.2 4.2
Hand grip strength (right) 1.0 2.8 8.7 -0.6 0.0 1.1 -2.9 -1.9 -1.7
Townsend deprivation index at recruitment 0.7 1.0 2.9 1.5 0.0 -0.6 0.7 0.4 1.7
Current tobacco smoking 1.4 2.3 5.1 1.8 0.0 -1.1 1.7 1.1 2.3
Average weekly fortified wine intake 0.1 0.1 0.4 0.3 0.0 0.6 0.3 0.0 0.2
Maternal smoking around birth 1.0 1.4 4.0 1.7 0.0 -0.9 0.6 -0.3 2.0
Fed-up feelings 1.3 2.4 8.1 2.8 0.0 0.8 -1.1 -0.8 2.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 2.8 1.7 0.0 0.8 -0.5 -0.1 1.4
Relative age voice broke 0.4 0.6 3.7 0.4 0.0 -0.0 -1.9 0.2 -0.1
Taking other prescription medications 0.7 1.1 2.4 1.0 0.0 -1.3 0.0 1.5 1.2
Age when periods started (menarche) 0.4 1.1 2.6 1.4 0.0 0.6 -1.6 -0.9 0.8
Bilateral oophorectomy (both ovaries removed) 0.8 0.9 2.8 1.3 0.0 -0.7 0.4 0.4 1.7
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 4.1 0.6 0.0 -0.6 -1.7 -2.0 0.4
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.5 -0.3 0.0 -0.3 -0.1 -0.7 -0.0
Qualifications: CSEs or equivalent 2.0 2.6 6.9 2.6 0.0 0.6 0.0 1.4 2.6
Serious illness, injury or assault to yourself 2.2 2.7 10.6 -0.9 0.0 -0.5 1.9 3.3 -0.9
High blood pressure 0.9 2.5 5.5 1.9 0.0 -2.2 0.8 -0.3 2.4
Hayfever, allergic rhinitis or eczema 0.5 1.1 2.6 -1.6 0.0 -0.8 -0.7 0.6 -1.6
Multivitamins +/- minerals 1.4 1.7 3.3 1.7 0.0 1.2 -1.0 -1.8 1.4
Stomach or abdominal pain in last month 0.9 1.2 3.9 -0.7 0.0 2.0 -1.2 0.7 -1.0
Supplements: Glucosamine 0.3 0.4 1.0 0.8 0.0 -1.0 -0.5 -0.5 0.6
Diverticular disease/diverticulitis (self-reported) 0.1 0.2 0.3 -0.6 0.0 0.5 0.2 -0.3 -0.5
Medication: Atenolol 1.6 2.0 4.9 2.1 0.0 -1.3 1.1 -0.2 2.2
Medication: Levothyroxine sodium 1.0 1.7 4.4 1.3 0.0 -0.8 2.1 0.6 1.7
Sitting height 1.2 8.4 28.6 5.3 0.0 0.7 -2.1 -0.6 4.1
Chronic bronchitis/emphysema (father) 0.3 0.3 1.3 0.4 0.0 0.1 -1.1 0.2 0.6
High blood pressure (mother) 0.3 0.4 0.9 0.5 0.0 0.7 -0.7 -0.9 0.6
Body mass index (BMI) 1.5 6.4 18.5 4.0 0.0 -0.2 1.5 1.5 4.3
Impedance of leg (left) 0.7 3.4 11.8 0.1 0.0 -1.1 -3.4 -2.7 -0.2
Leg predicted mass (left) 0.7 3.8 9.7 3.1 0.0 0.5 0.7 2.2 2.8
Trunk fat mass 1.8 7.6 22.6 4.8 0.0 -0.8 -0.1 1.4 4.5
Waist circumference 1.5 5.5 17.5 3.9 0.0 0.4 0.5 0.7 4.2
Number of incorrect matches in round 0.5 0.8 2.7 -0.4 0.0 -1.0 -0.8 -1.6 0.2
Past tobacco smoking 1.8 3.3 10.8 -1.2 0.0 -0.4 -3.3 -2.4 -1.3
Alcohol usually taken with meals 1.5 2.5 6.1 -1.6 0.0 2.5 -0.5 -1.5 -1.9
Nervous feelings 1.9 3.5 7.0 -1.9 0.0 1.3 -1.7 -2.6 -2.4
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.2 2.9 1.3 0.0 -0.2 -1.3 -1.7 0.9
Hearing difficulty/problems with background noise 1.6 2.6 6.6 -2.1 0.0 1.4 -0.4 1.5 -2.6
Hair/balding pattern: Pattern 2 0.8 1.0 2.7 0.8 0.0 -1.4 -1.6 -0.6 0.6
Had menopause 1.1 1.3 2.3 1.2 0.0 -1.2 -1.3 -1.5 1.0
Had other major operations 0.1 0.1 0.5 0.4 0.0 0.2 -0.7 0.4 -0.3
Forced vital capacity (FVC) 1.1 4.1 16.2 1.4 0.0 1.2 -4.0 -2.2 0.5
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.1 5.9 0.8 0.0 -0.7 -2.4 -2.3 0.5
Ever unenthusiastic/disinterested for a whole week 1.9 2.3 6.1 -1.8 0.0 -0.0 2.5 1.6 -1.4
Qualifications: None of the above 2.5 5.3 11.5 2.8 0.0 -2.0 -3.4 -1.4 2.6
Financial difficulties in last 2 years 2.3 3.2 8.7 1.4 0.0 0.3 2.9 2.1 1.9
Mouth/teeth dental problems 0.5 0.7 2.0 -0.3 0.0 0.7 1.4 1.4 -0.2
Heart attack 1.2 1.6 3.8 0.4 0.0 -1.3 1.7 1.9 0.8
Allergy 0.0 0.1 0.4 0.0 0.0 -0.7 0.1 -0.4 0.1
Pain all over the body in last month 1.6 1.7 2.7 -1.5 0.0 -1.5 -0.5 1.6 -1.6
Diabetes (self-reported) 0.9 1.4 3.7 1.6 0.0 -1.4 0.2 0.5 1.9
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 1.6 -0.7 0.0 0.4 0.7 1.3 -1.0
Medication: Ramipril 0.5 0.6 1.3 0.9 0.0 -0.8 0.9 0.4 1.1
Medication: Simvastatin 7.5 11.1 31.3 4.9 0.0 -2.9 1.3 0.8 5.6
Fluid intelligence score 2.6 5.5 12.5 -3.5 0.0 2.1 1.4 -1.5 -3.4
Illnesses of siblings 3.0 4.2 12.3 -3.5 0.0 0.7 0.4 1.2 -3.3
Neuroticism score 0.6 1.3 3.2 0.8 0.0 1.0 -1.8 -1.8 0.1
Weight 1.6 7.7 23.5 4.8 0.0 0.2 0.1 1.3 4.5
Impedance of arm (right) 0.1 0.3 0.7 -0.4 0.0 -0.8 0.5 0.5 -0.6
Arm fat percentage (right) 2.0 7.8 20.4 4.2 0.0 -0.6 2.0 2.0 4.5
Trunk fat-free mass 0.4 2.4 7.6 2.8 0.0 0.6 -0.8 0.9 2.2
Hip circumference 1.6 6.9 20.2 4.3 0.0 -0.1 0.6 1.4 4.5
Time employed in main current job 2.4 2.8 8.9 -0.3 0.0 1.8 -2.0 -3.0 -0.4
Alcohol intake versus 10 years previously 2.7 4.0 9.0 2.3 0.0 -1.2 -3.0 -1.7 2.3
Father’s age at death 0.8 1.0 3.3 -1.5 0.0 0.7 -0.3 0.0 -1.8
Worrier / anxious feelings 1.8 3.4 10.0 -1.5 0.0 -0.0 -2.2 -3.2 -1.8
Frequency of tiredness / lethargy in last 2 weeks 1.4 2.3 5.1 2.3 0.0 -0.8 -2.1 0.1 1.9
Falls in the last year 1.4 1.9 8.1 0.1 0.0 0.6 2.9 1.8 0.1
Hair/balding pattern: Pattern 3 0.4 0.6 2.1 0.6 0.0 -0.3 0.7 1.4 0.6
Number of live births 1.0 1.5 4.6 -0.4 0.0 -1.8 -2.1 -0.1 -0.8
Forced expiratory volume in 1-second (FEV1) 0.7 2.5 9.4 0.1 0.0 1.5 -3.1 -1.6 -0.7
Pulse rate 0.4 0.6 1.7 -1.0 0.0 -0.2 -0.4 1.3 -0.9
Happiness 0.6 0.7 2.1 0.6 0.0 1.4 -0.2 -1.4 0.2
Noisy workplace 1.5 1.9 4.5 2.1 0.0 -0.6 -1.4 -0.3 2.1
Qualifications: A levels/AS levels or equivalent 2.4 5.4 11.0 -2.8 0.0 3.3 2.7 0.0 -2.5
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 1.2 -1.1 0.0 -0.5 0.4 0.3 -0.5
Mouth/teeth dental problems: Dentures 0.2 0.4 1.0 0.9 0.0 -0.4 -1.0 -0.1 0.6
Asthma 0.4 0.7 1.6 1.1 0.0 -0.4 0.6 1.1 1.2
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.1 0.7 0.0 -0.3 1.1 1.1 0.9
Medication: Cholesterol lowering 9.3 14.4 41.6 5.5 0.0 -2.6 2.1 1.9 6.5
Depression (self-reported) 0.4 0.4 1.5 -0.6 0.0 0.7 1.2 0.0 -0.5
Medication: Lansoprazole 1.9 2.2 6.3 2.5 0.0 -0.2 -0.9 -1.1 2.2
Prospective memory result 0.8 1.0 4.7 0.5 0.0 -0.9 -2.2 -0.0 0.2
Lung cancer (father) 1.7 2.0 6.0 1.2 0.0 -2.5 -1.3 -1.0 1.3
Illnesses of mother 1.4 1.7 3.5 -1.7 0.0 -0.6 1.2 1.4 -1.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.3 7.2 0.2 0.0 1.8 -2.7 -1.8 -0.4
Pulse wave Arterial Stiffness index 1.2 1.4 2.9 -1.1 0.0 0.7 1.6 1.7 -1.0
Impedance of arm (left) 0.1 0.2 0.6 -0.3 0.0 -0.8 -0.2 0.6 -0.6
Arm fat mass (right) 2.1 8.7 24.0 4.8 0.0 -0.4 1.3 1.7 4.9
Trunk predicted mass 0.4 2.3 7.1 2.7 0.0 0.7 -0.8 1.0 2.1
Standing height 0.4 3.6 11.6 2.8 0.0 0.8 -3.4 -0.5 1.4
Length of working week for main job 1.6 1.8 8.5 -0.7 0.0 0.4 2.9 1.3 -0.4
Exposure to tobacco smoke at home 0.1 0.1 0.2 0.4 0.0 -0.3 -0.1 0.5 0.5
Breastfed as a baby 0.4 0.5 2.1 0.3 0.0 1.4 -0.1 -0.6 -0.5
Tense / ‘highly strung’ 0.7 1.1 2.5 -1.1 0.0 0.8 -1.6 -0.5 -1.6
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.7 -0.2 0.0 0.5 0.0 -0.8 -0.2
Hair/balding pattern: Pattern 4 0.3 0.7 2.8 -0.2 0.0 0.8 0.9 1.7 -0.0
Birth weight of first child 0.2 0.3 0.8 -0.2 0.0 0.9 -0.3 -0.9 0.1
Peak expiratory flow (PEF) 0.3 0.8 1.7 1.3 0.0 1.3 -0.1 -0.8 0.7
Pulse wave reflection index 0.7 0.8 2.9 -0.7 0.0 0.9 1.7 0.7 -0.3
Ever highly irritable/argumentative for 2 days 0.8 1.0 3.8 0.6 0.0 -1.0 -2.0 -0.7 0.4
Loud music exposure frequency 1.2 1.3 3.5 1.9 0.0 -1.2 -0.8 -0.0 1.5
Qualifications: O levels/GCSEs or equivalent 0.5 0.7 2.1 -0.4 0.0 1.4 1.0 -1.1 -0.2
Mouth/teeth dental problems: Bleeding gums 0.3 0.5 1.2 0.8 0.0 0.0 0.5 -0.8 1.1
Blood clot in the leg (DVT) 0.7 0.9 2.8 0.9 0.0 1.7 0.1 0.9 0.9
Medication: Paracetamol 1.4 2.3 3.8 1.9 0.0 -1.8 -1.5 -1.1 1.9
Headache pain in last month 0.7 1.2 3.3 -1.6 0.0 -0.2 -0.8 0.5 -1.8
Medication for cholesterol, blood pressure or diabetes 3.8 6.3 16.3 -3.5 0.0 2.0 -1.9 -1.3 -4.0
Glaucoma (self-reported) 0.2 0.2 0.7 0.4 0.0 0.4 -0.9 -0.3 0.2
Gout (self-reported) 1.0 1.4 3.5 -1.2 0.0 0.1 1.9 1.9 -0.4
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 2.3 1.2 0.0 0.2 1.3 0.8 1.5
Medication: Amlodipine 1.0 1.4 5.1 0.2 0.0 -2.2 1.1 1.5 0.3
Medication: Ventolin 100micrograms inhaler 0.8 1.0 2.4 1.5 0.0 -0.6 0.4 1.0 1.5
Birth weight 0.8 1.7 5.2 0.6 0.0 2.3 1.5 -1.3 0.8
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.2 -0.1 0.0 -0.5 -0.2 -0.5 0.2
High blood pressure (siblings) 1.3 1.9 5.5 2.3 0.0 -0.2 0.6 -0.2 2.3
Forced vital capacity (FVC), Best measure 1.0 3.8 14.4 1.2 0.0 1.3 -3.8 -2.1 0.5
Body fat percentage 1.6 6.4 18.4 4.2 0.0 -1.0 0.1 0.9 4.3
Leg fat percentage (right) 1.3 4.7 14.5 3.6 0.0 -0.7 -0.2 -0.0 3.8
Arm fat-free mass (right) 0.6 2.9 8.5 2.9 0.0 0.5 -1.6 0.5 2.4
Exposure to tobacco smoke outside home 2.8 3.7 8.8 2.5 0.0 1.7 1.9 0.8 3.0
Comparative body size at age 10 0.6 1.6 5.7 1.2 0.0 -2.4 -0.7 0.7 1.2
Number of full brothers 1.6 2.1 5.5 2.3 0.0 -1.5 -0.5 0.3 2.1
Worry too long after embarrassment 0.7 1.2 4.7 0.2 0.0 -0.3 -1.5 -2.2 0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.1 2.2 -1.5 0.0 0.4 0.8 1.3 -1.4
Wheeze or whistling in the chest in last year 1.3 2.4 6.7 2.6 0.0 -0.5 -0.9 -0.1 2.6
Number of children fathered 1.0 1.2 4.4 -1.3 0.0 0.3 0.4 0.8 -2.1
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 4.2 -0.7 0.0 -2.0 -1.0 -1.1 -0.4
Age at first live birth 1.3 2.2 4.7 -2.2 0.0 1.4 1.8 -0.0 -1.9
Pulse wave peak to peak time 1.5 1.7 3.7 1.3 0.0 -1.0 -1.9 -1.7 1.1
Health satisfaction 0.3 0.3 0.7 0.8 0.0 0.4 0.1 0.7 0.8
Shortness of breath walking on level ground 0.5 0.6 1.3 1.1 0.0 -0.3 -0.2 1.1 1.0
Qualifications: College or University degree 2.3 7.3 16.4 -3.1 0.0 3.1 4.1 0.5 -2.8
Eye problems/disorders: None of the above 1.4 1.7 3.1 -1.7 0.0 -0.6 1.6 1.0 -1.8
Mouth/teeth dental problems: Loose teeth 0.9 1.1 2.2 -1.2 0.0 -1.5 1.0 1.3 -0.7
Emphysema/chronic bronchitis 3.3 3.7 7.0 2.6 0.0 -0.7 -2.6 -2.1 1.9
Medication for pain relief, constipation, heartburn 1.9 3.2 7.0 -2.2 0.0 2.0 -0.8 -1.5 -2.6
Neck or shoulder pain in last month 1.9 2.7 8.6 2.9 0.0 0.3 -2.0 0.2 1.9
Medication: Blood pressure 0.9 1.5 2.7 1.0 0.0 -1.5 1.6 1.3 1.2
Angina (self-reported) 1.9 2.5 6.0 2.4 0.0 -1.3 0.9 1.1 2.4
Migraine (self-reported) 0.3 0.4 1.7 -0.4 0.0 1.3 0.5 0.4 -0.3
Medication: Ibuprofen 0.4 0.5 1.7 0.1 0.0 0.4 1.3 1.0 0.1
Medication: Allopurinol 0.3 0.4 1.2 -0.7 0.0 0.2 1.1 0.8 -0.2
Medication: Omeprazole 0.8 1.0 2.7 -1.2 0.0 -1.0 0.3 1.6 -0.8
Medication: Seretide 50 evohaler 2.0 2.3 4.8 1.9 0.0 -2.2 0.3 1.2 2.1
Mean time to correctly identify matches 1.0 1.9 4.0 -2.0 0.0 1.2 1.7 0.6 -1.6
Heart disease (mother) 1.5 1.8 4.2 2.0 0.0 1.1 0.8 0.8 2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.6 1.9 3.4 1.8 0.0 1.6 -1.4 -1.1 1.6
Whole body fat mass 1.9 8.1 23.9 4.9 0.0 -0.7 0.0 1.2 4.8
Leg fat mass (right) 1.8 7.0 20.4 4.5 0.0 -0.8 -0.0 0.9 4.5
Arm predicted mass (right) 0.6 2.8 8.5 2.9 0.0 0.3 -1.6 0.6 2.4
Pulse rate, automated reading 1.3 4.3 11.2 -3.1 0.0 -0.5 -1.4 1.8 -3.3
Alcohol intake frequency. 3.9 9.0 29.6 2.7 0.0 0.1 -5.4 -3.5 2.2
Comparative height size at age 10 0.5 2.5 5.7 2.4 0.0 -0.4 -2.3 1.2 1.6
Number of full sisters 0.9 1.1 1.9 1.4 0.0 -1.2 0.0 1.3 1.2
Suffer from ‘nerves’ 0.2 0.3 0.6 -0.8 0.0 0.7 -0.2 -0.4 -0.7
Overall health rating 1.2 2.5 5.8 2.4 0.0 -0.8 -1.4 1.2 2.3
Chest pain or discomfort 0.3 0.4 0.8 0.6 0.0 0.5 -0.6 -0.9 0.6
Had major operations 1.6 1.8 4.5 -1.4 0.0 -0.1 0.9 2.1 -1.9
Age at last live birth 0.9 1.3 5.8 -0.6 0.0 2.4 1.2 0.0 -0.5
Family relationship satisfaction 0.9 1.1 3.0 0.7 0.0 1.3 -1.1 -1.7 0.5
Leg pain on walking 0.6 0.8 1.9 0.7 0.0 1.4 0.9 0.7 1.0
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.2 -0.7 0.0 0.1 0.8 1.1 -0.9
Commuting to job workplace: Car/motor vehicle 1.0 1.2 2.2 1.4 0.0 -1.4 0.2 1.5 1.1
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 4.2 -0.5 0.0 0.8 -1.9 -2.1 -0.7
Medication: Aspirin 2.0 2.7 7.5 0.7 0.0 -0.5 2.7 2.5 1.1
Supplements: Vitamin C 0.9 1.1 3.7 1.9 0.0 0.7 -0.4 -0.0 1.4
Knee pain experienced in last month 1.0 1.5 3.9 1.4 0.0 -1.1 -2.0 0.2 1.3
Hypertension (Self-reported) 0.9 2.6 6.2 2.1 0.0 -2.0 0.8 -0.4 2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 1.5 0.0 0.0 -0.1 -1.2 -0.7 0.2
Illnesses of father: Heart disease 1.9 2.7 6.3 1.4 0.0 2.5 -0.8 -2.5 1.0
Illnesses of siblings: Diabetes 1.4 1.7 5.0 1.8 0.0 -0.1 1.2 0.8 2.2
Smoking status: Previous 0.7 1.1 3.1 0.9 0.0 0.1 1.8 1.3 0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.4 3.9 2.0 0.0 0.9 -1.1 0.5 1.5
Whole body fat-free mass 0.5 2.7 8.2 2.9 0.0 0.5 -0.3 1.5 2.4
Leg fat-free mass (right) 0.6 3.4 8.1 2.9 0.0 0.8 0.9 2.3 2.4
Arm fat percentage (left) 1.9 7.4 19.1 4.1 0.0 -0.5 1.8 2.2 4.4
Average weekly red wine intake 2.9 4.2 8.1 -2.8 0.0 1.2 2.0 2.1 -2.7
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.2 -0.0 0.0 -0.2 -0.4 -0.3 -0.3
Mood swings 1.0 1.9 6.3 2.5 0.0 -0.1 -0.7 -0.6 2.0
Loneliness, isolation 1.2 1.6 4.2 1.2 0.0 1.9 -0.2 -2.1 0.5
Long-standing illness, disability or infirmity 0.6 1.0 4.5 0.4 0.0 0.1 0.9 2.1 0.7
Ever had bowel cancer screening 0.6 0.7 4.2 0.2 0.0 -0.3 -2.1 0.2 -0.1
Diabetes diagnosed by doctor 0.8 1.3 3.2 1.4 0.0 -1.5 0.3 0.3 1.8
Ever had stillbirth, spontaneous miscarriage or termination 2.4 2.6 5.1 2.2 0.0 -0.2 1.4 2.1 2.0
Friendships satisfaction 1.1 1.3 5.7 -0.2 0.0 2.4 0.5 -1.3 -0.5
Qualifications: nursing, teaching 0.5 0.7 1.8 -1.4 0.0 0.7 1.1 -0.4 -0.8
Commuting to job workplace: Walk 0.9 1.0 2.8 -1.7 0.0 0.3 0.4 0.9 -1.4
Eye problems/disorders: Cataract 2.1 2.5 5.5 2.3 0.0 -0.2 -1.3 -1.6 2.4
Mouth/teeth dental problems: Mouth ulcers 1.2 1.8 7.7 0.5 0.0 -0.0 -1.7 -2.8 0.6
Medication for cholesterol 4.0 6.0 15.8 -3.3 0.0 2.5 0.2 1.8 -4.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 5.2 0.8 0.0 1.1 0.8 2.3 0.4
Back pain experienced in last month 0.9 1.3 6.3 1.0 0.0 0.7 -2.5 0.0 0.2
Mineral and other dietary supplements 2.5 3.3 9.0 -1.8 0.0 1.2 3.0 2.3 -1.1
Breast cancer (self-reported) 0.5 0.6 1.9 0.2 0.0 -1.1 0.7 1.4 0.2
Asthma (self-reported) 0.4 0.7 2.0 1.2 0.0 -0.4 0.3 0.8 1.4
Osteoporosis (self-reported) 1.0 1.3 3.6 1.2 0.0 -1.9 0.6 0.9 1.2
Osteoarthritis (self-reported) 2.0 2.5 6.1 2.4 0.0 -1.8 -0.2 -0.2 2.5
Medication: Aspirin 1.5 1.9 6.3 0.2 0.0 -0.1 2.5 2.2 0.5
Medication: Gliclazide 1.2 1.4 2.7 1.1 0.0 -1.6 0.1 1.4 1.6
Illnesses of father: None of the above (group 1) 0.9 1.1 2.7 -1.6 0.0 -0.2 1.0 0.7 -1.5
Smoking status: Current 1.4 2.2 5.7 1.9 0.0 -1.0 1.5 0.8 2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.5 3.2 5.3 -1.5 0.0 1.7 -2.2 -2.3 -2.0
Whole body water mass 0.5 2.8 8.2 2.9 0.0 0.6 -0.2 1.6 2.4
Leg predicted mass (right) 0.6 3.4 7.8 2.8 0.0 0.8 0.9 2.4 2.3
Arm fat mass (left) 2.1 8.8 23.9 4.9 0.0 -0.2 1.2 1.9 4.9
Number of self-reported non-cancer illnesses 2.5 4.4 10.2 2.8 0.0 -1.8 1.6 1.6 3.2
Average weekly champagne plus white wine intake 0.5 0.7 2.2 0.8 0.0 1.5 0.6 -0.5 0.9
Miserableness 0.7 1.2 4.5 1.1 0.0 0.3 2.1 0.6 1.1
Guilty feelings 1.2 1.8 6.0 0.3 0.0 -0.4 -2.5 -2.2 0.2
Wears glasses or contact lenses 0.6 0.7 1.9 -0.5 0.0 0.7 1.4 -1.0 -0.5
Ever taken oral contraceptive pill 2.3 2.5 5.2 -1.2 0.0 1.7 2.1 2.3 -1.1
Hearing aid user 0.2 0.2 1.2 0.2 0.0 -0.1 -0.3 -1.1 -0.2
Mother’s age at death 0.8 1.0 3.6 -0.6 0.0 -0.1 -1.1 -1.9 -0.7
Financial situation satisfaction 0.4 0.5 1.1 0.8 0.0 -0.8 0.2 -0.7 1.0
Tinnitus: Yes, now most or all of the time 0.4 0.5 1.7 -0.5 0.0 -1.3 -0.6 -0.1 -0.8
Commuting to job workplace: Public transport 0.9 1.1 2.6 -1.6 0.0 0.9 1.6 -0.1 -0.9
Eye problems/disorders: Glaucoma 1.2 1.5 3.5 1.5 0.0 0.6 -1.9 -1.1 1.2
Medication: Blood pressure 1.9 3.6 8.5 2.3 0.0 -1.3 -0.2 -2.5 2.9
Pain type(s) experienced in last month: Hip pain 1.3 1.7 3.6 1.9 0.0 0.4 -1.9 0.3 1.6
Supplements: Fish oil (including cod liver oil) 1.6 2.1 6.7 1.1 0.0 -1.0 -2.6 -1.8 0.6
High cholesterol (Self-reported) 15.5 27.4 77.7 8.0 0.0 -4.7 0.3 -0.5 8.8
Medication: Bendroflumethiazide 0.7 1.1 3.1 0.0 0.0 -1.8 0.9 -1.4 0.6
Medication: Paracetamol 0.7 1.1 2.0 1.4 0.0 -0.5 -1.3 -1.0 1.3
Medication: Lisinopril 0.4 0.5 1.0 -1.0 0.0 0.8 0.7 -0.2 -0.8
Medication: Atorvastatin 4.6 5.6 17.3 3.2 0.0 -1.9 1.7 0.0 4.2
Illnesses of father: High blood pressure 1.1 1.3 3.0 -1.3 0.0 -0.2 1.7 1.2 -1.3
Alcohol drinker status: Never 1.0 1.2 3.5 -1.0 0.0 -1.9 -1.4 -0.1 -0.8
Ever smoked 1.8 3.2 10.0 1.3 0.0 0.7 3.2 2.3 1.4
Basal metabolic rate 0.7 4.1 12.5 3.5 0.0 0.5 -0.1 1.6 3.1
Leg fat percentage (left) 1.2 4.2 12.7 3.5 0.0 -0.5 -0.3 -0.0 3.6
Arm fat-free mass (left) 0.8 3.8 12.5 3.5 0.0 0.5 -0.9 0.7 3.0
Number of operations (self-reported) 0.8 1.1 4.6 -0.9 0.0 0.4 0.3 2.1 -1.1
Average weekly beer plus cider intake 1.6 2.3 6.1 1.5 0.0 -2.5 0.5 1.4 1.9
Irritability 0.4 0.7 1.9 1.4 0.0 0.5 -1.3 0.1 0.6
Risk taking 2.3 3.3 9.1 1.3 0.0 1.5 3.0 2.3 1.2
Ever had prostate specific antigen (PSA) test 0.7 0.8 2.7 -1.0 0.0 0.5 0.1 1.1 -1.6
Fractured/broken bones in last 5 years 0.4 0.5 1.9 0.4 0.0 0.5 0.6 1.4 0.3
Age started oral contraceptive pill 0.2 0.3 1.2 0.4 0.0 0.2 -0.3 -1.1 0.6
Diastolic blood pressure, automated reading 0.5 1.5 7.2 0.2 0.0 1.0 2.7 0.8 0.5
Ever depressed for a whole week 1.5 1.8 3.5 -1.9 0.0 0.8 1.3 1.7 -1.5
Unable to work because of sickness or disability 0.7 0.9 4.5 0.0 0.0 -0.0 0.8 2.1 0.1
Commuting to job workplace: Cycle 1.7 2.0 11.6 -0.1 0.0 3.4 0.6 -0.3 -0.2
Myopia 0.0 0.1 0.2 0.5 0.0 -0.1 -0.1 0.2 0.2
Vascular/heart problems diagnosed by doctor 0.9 2.3 4.5 -1.7 0.0 2.0 -1.6 -0.7 -2.1
Cholesterol lowering medication 7.3 10.8 28.8 5.2 0.0 -2.7 -0.0 -1.4 5.4
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 1.3 -0.4 0.0 -1.1 -0.4 0.8 -0.4
Pain experienced in last month 0.9 1.5 6.9 0.1 0.0 1.1 2.6 -0.7 0.8
Supplements: Calcium 0.2 0.2 0.5 0.0 0.0 -0.4 0.5 -0.7 -0.3
Basal cell carcinoma (self-reported) 2.4 2.8 5.8 2.2 0.0 -0.6 -1.1 -2.4 2.2
Heart attack/myocardial infarction (self-reported) 1.4 1.8 4.3 0.2 0.0 -1.3 2.0 2.1 0.7
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 2.9 0.9 0.0 1.7 -0.3 0.9 0.8
Heart disease (siblings) 2.1 2.6 5.7 1.9 0.0 -0.6 -1.5 -2.4 1.8
Alcohol drinker status: Previous 2.1 2.4 6.3 2.5 0.0 0.0 -0.9 -1.2 2.5
Pack years of smoking 0.6 0.9 3.2 0.9 0.0 -1.8 -0.3 0.0 1.3
Impedance of whole body 0.2 1.1 3.9 -0.1 0.0 -0.9 -2.0 -1.2 -0.5
Leg fat mass (left) 1.7 6.5 19.4 4.4 0.0 -0.7 -0.1 0.8 4.3
Arm predicted mass (left) 0.5 2.6 8.3 2.9 0.0 0.4 -0.9 0.7 2.4