Best TWAS P=5.01e-10 · Best GWAS P=4.46e-10 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | LPIN3 | 0.08 | 0.08 | enet | 4 | 0.08 | 5.4e-05 | 5.4 | 5.6 | 2.2e-08 | 0.59 | 0.23 | 0.70 | FALSE |
| 2 | GTEx | Artery Tibial | LPIN3 | 0.17 | 0.13 | lasso | 6 | 0.15 | 6.5e-12 | 5.4 | 5.9 | 3.7e-09 | 0.67 | 0.14 | 0.86 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | LPIN3 | 0.11 | 0.10 | lasso | 8 | 0.12 | 2.5e-15 | 5.4 | 6.0 | 2.3e-09 | 0.59 | 0.46 | 0.54 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ZHX3 | 0.03 | 0.03 | lasso | 4 | 0.02 | 1.2e-05 | 5.4 | -5.5 | 4.7e-08 | -0.69 | 0.24 | 0.74 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LPIN3 | 0.03 | 0.04 | lasso | 2 | 0.03 | 5.5e-04 | 5.4 | 5.6 | 2.2e-08 | 0.63 | 0.04 | 0.82 | FALSE |
| 6 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | LPIN3 | 0.10 | 0.02 | lasso | 5 | 0.07 | 6.1e-04 | 5.4 | 5.6 | 2.5e-08 | 0.68 | 0.01 | 0.68 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZHX3 | 0.05 | 0.06 | lasso | 2 | 0.05 | 2.6e-06 | 6.2 | -6.2 | 5.0e-10 | -0.97 | 0.01 | 0.99 | TRUE |