TWAS hub - ZHX3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0254	0.0133	3.1e-05	0.027	0.021	0.021	NA	0.023	2.0e-06	2.6e-05	3.5e-05	NA	1.2e-05
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0356	0.0219	9.7e-03	0.021	0.014	0.010	NA	0.020	1.7e-03	9.9e-03	2.1e-02	NA	2.4e-03
3	TCGA	Prostate Adenocarcinoma	0.0469	0.0253	2.2e-05	0.061	0.044	0.052	NA	0.054	5.9e-07	2.2e-05	3.4e-06	NA	2.6e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
LDL Cholesterol	32.0	50.7	82.3	-8.3	1.2	-9.1
High cholesterol (Self-reported)	13.0	23.0	38.7	-5.5	0.8	-6.2
Hair/balding pattern: Pattern 4	11.2	27.2	62.5	-1.3	-7.9	4.2
Cholesterol lowering medication	10.8	15.8	26.6	-4.5	1.0	-5.2
Medication: Atorvastatin	10.6	13.1	23.2	-4.8	-1.3	-3.8
Heel T-Score	10.3	81.7	190.4	-3.8	-13.8	6.3
Medication: Simvastatin	9.1	13.4	23.6	-3.9	1.1	-4.9
Hair/balding pattern: Pattern 3	8.3	12.3	26.6	-0.8	-5.2	3.1
Medication: Cholesterol lowering	7.4	11.5	18.1	-4.1	0.1	-4.3
Waist Hip Ratio (WHR)	7.3	33.0	49.6	-7.0	-0.1	-7.0
Diabetes (mother)	6.8	8.7	18.2	0.2	4.3	-2.8
Triglycerides	6.3	10.2	18.7	-4.3	-2.0	-2.8
Heel bone mineral density (BMD) T-score, automated (left)	6.2	14.0	31.8	-1.6	-5.6	2.7
Heel bone mineral density (BMD) T-score, automated (right)	6.1	14.0	31.2	-1.4	-5.6	3.0
Seen doctor (GP) for nerves, anxiety, tension or depression	5.8	8.9	14.6	-2.0	2.8	-3.8
Type 2 Diabetes (T2D) (2012)	5.7	6.5	16.1	1.2	4.0	-1.5
Heart attack	5.5	7.0	13.0	-3.6	-1.5	-2.4
Crohns Disease (2017)	5.2	11.4	16.7	4.1	4.1	1.1
Neuroticism (2016)	5.1	7.4	11.5	-0.3	3.4	-3.2
Hair/balding pattern: Pattern 2	5.1	6.5	10.3	-0.8	3.2	-2.9
Supplements: Vitamin C	5.0	5.9	10.1	3.2	1.6	2.2
Irritable Bowel Disease (IBD)	4.9	11.6	23.1	3.4	4.8	-0.1
Medication: Lansoprazole	4.8	5.4	12.0	2.0	3.5	-0.6
Serious illness, injury or assault of a close relative in last 2 years	4.7	5.4	8.6	-2.9	-0.3	-2.7
Mineral and other dietary supplements	4.7	6.3	11.0	-2.8	0.7	-3.3
Hearing difficulty/problems with background noise	4.5	7.3	12.2	2.5	-1.8	3.5
Heart attack/myocardial infarction (self-reported)	4.5	5.7	10.6	-3.2	-1.6	-2.0
Ulcerative Colitis (UC)	4.4	8.2	19.3	2.0	4.4	-1.1
Alcohol usually taken with meals	4.4	7.1	11.3	3.0	-0.9	3.4
Falls in the last year	4.4	5.9	11.2	3.3	1.9	1.7
Leg fat percentage (right)	4.2	15.1	36.1	2.1	6.0	-2.2
Breastfed as a baby	3.9	4.8	11.7	-1.5	-3.4	0.7
Bilateral oophorectomy (both ovaries removed)	3.8	4.4	9.0	-2.0	-3.0	0.2
Medication: Ramipril	3.8	4.9	7.7	-2.6	0.6	-2.8
Leg fat percentage (left)	3.7	13.3	31.7	2.3	5.6	-1.6
Migraine (self-reported)	3.5	4.4	6.7	-2.6	-0.3	-2.5
Pulse wave reflection index	3.4	4.2	9.7	-0.7	-3.1	1.6
Body fat percentage	3.4	13.5	32.0	2.4	5.7	-1.7
Diastolic blood pressure, automated reading	3.4	10.6	18.1	0.5	-4.3	3.6
Lupus	3.3	5.1	7.9	-2.8	-0.2	-2.7
Birth weight	3.3	7.1	12.1	2.6	-1.6	3.5
Mouth/teeth dental problems: Loose teeth	3.3	4.0	7.9	-0.0	2.8	-2.0
Alcohol intake frequency.	3.3	7.7	13.3	-1.7	2.6	-3.6
Body Mass Index (BMI) (2010)	3.2	4.3	7.1	2.4	-0.4	2.7
Crohns Disease (2012)	3.2	5.2	9.1	3.0	2.2	1.4
Angina	3.2	4.2	7.2	-2.7	-1.2	-2.0
Trunk fat percentage	3.2	12.9	30.1	2.5	5.5	-1.5
Leg fat mass (right)	3.2	12.3	29.4	2.2	5.4	-1.6
Pulse rate, automated reading	3.2	10.2	24.2	2.0	4.9	-1.6
Vitamin and mineral supplements	3.1	4.3	7.7	-2.8	-1.1	-2.0
Pulse rate	3.1	5.3	10.4	-0.1	3.2	-2.3
Headache pain in last month	3.1	5.4	9.4	-2.3	1.3	-3.1
Trunk fat mass	3.0	13.0	30.1	2.7	5.5	-1.2
Angina (self-reported)	3.0	3.9	6.6	-2.6	-1.1	-2.0
Wears glasses or contact lenses	3.0	3.4	5.9	-2.4	-0.4	-2.0
Leg fat mass (left)	3.0	11.7	28.0	2.3	5.3	-1.4
Whole body fat mass	2.9	12.3	28.8	2.5	5.4	-1.3
Smoking status: Current	2.9	4.6	7.1	-2.7	0.3	-2.6
Guilty feelings	2.8	4.3	6.5	-0.7	2.4	-2.5
Pain type(s) experienced in last month: Hip pain	2.8	3.5	8.5	1.2	2.9	-0.8
Basal cell carcinoma (self-reported)	2.8	3.3	4.9	0.5	-2.2	2.2
Medication for cholesterol, blood pressure or diabetes	2.7	4.5	7.1	2.7	0.5	2.5
Miserableness	2.7	4.7	6.7	-0.9	2.6	-2.6
Fasting Glucose	2.6	3.1	4.6	2.0	2.2	-0.6
Current tobacco smoking	2.6	4.3	7.2	-2.7	-0.0	-2.4
Hip circumference	2.6	11.3	18.7	3.8	4.3	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	2.5	3.3	7.9	0.7	2.8	-1.2
Diabetes diagnosed by doctor	2.5	4.2	6.8	-0.5	2.6	-2.3
Commuting to job workplace: Walk	2.5	2.7	4.9	-2.2	-1.1	-1.4
Medication: Co-codamol	2.4	2.8	5.0	-2.2	-0.3	-1.8
Qualifications: CSEs or equivalent	2.4	3.1	5.9	2.4	1.0	1.6
Alcohol drinker status: Previous	2.4	2.8	4.9	-1.3	1.2	-2.2
Average weekly fortified wine intake	2.3	2.7	4.9	-1.8	-2.2	-0.3
Supplements: Fish oil (including cod liver oil)	2.3	3.0	4.7	2.1	0.0	2.2
Schizophrenia (2018)	2.2	4.5	9.6	2.0	3.1	-0.1
Blood Red Count	2.2	21.0	35.4	-5.0	1.7	-6.0
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.4	8.2	1.0	2.9	-1.0
Illness, injury, bereavement, stress in last 2 years	2.2	2.7	4.5	2.1	0.3	1.9
Number of treatments/medications taken	2.1	3.8	6.7	-1.4	1.7	-2.6
Smoking status: Previous	2.1	3.1	5.6	2.4	0.8	1.7
Breast cancer (self-reported)	2.1	2.6	4.7	-2.2	-0.5	-1.6
Bipolar Disorder or Schizophrenia	2.0	4.9	7.0	2.6	2.6	0.9
Ulcerative Colitis	2.0	2.9	6.8	0.4	2.6	-1.4
Commuting to job workplace: Car/motor vehicle	2.0	2.3	3.7	1.7	0.2	1.9
Mood swings	2.0	3.6	8.3	1.4	2.9	-0.7
Depression (Nagel 2018)	1.9	2.9	6.2	1.6	2.5	0.2
Bipolar Disorder (2011)	1.9	1.8	2.8	1.6	0.2	1.7
HbA1C	1.9	2.1	3.3	1.8	-0.0	1.8
Schizophrenia (2014)	1.9	4.2	9.4	1.7	3.1	-0.4
Blood Platelet Count	1.9	22.1	35.2	-2.1	5.2	-5.9
Relative age of first facial hair	1.9	3.8	8.0	0.2	2.8	-1.9
Waist circumference	1.9	7.0	13.5	-0.2	3.7	-2.7
Diabetes (self-reported)	1.9	3.0	4.5	-0.7	2.0	-2.1
Illnesses of mother	1.9	2.4	3.7	0.7	-1.7	1.9
Tense / ‘highly strung’	1.9	3.1	6.4	1.7	2.5	-0.2
Comparative body size at age 10	1.9	5.2	7.5	2.7	2.7	0.9
Rheumatoid Arthritis	1.8	2.5	3.9	2.0	-0.2	1.9
Cardiovascular Disease	1.8	6.1	9.2	-3.0	-0.2	-3.0
Type 2 Diabetes (T2D) (2018)	1.8	3.5	6.1	-0.4	2.5	-2.0
Impedance of leg (right)	1.8	8.8	19.5	1.0	4.4	-2.4
Coronary Artery Disease (CAD)	1.7	2.0	3.3	-1.8	0.0	-1.7
Blood White Count	1.7	12.5	29.1	2.5	5.4	-1.5
Supplements: Glucosamine	1.7	2.2	3.8	2.0	0.8	1.5
Chronic bronchitis/emphysema (father)	1.7	2.0	4.2	0.2	2.0	-1.3
Medication for cholesterol	1.7	2.6	4.3	1.0	-1.6	2.1
Supplements: Calcium	1.7	1.9	3.4	1.8	0.8	1.3
Depressed Affect (Nagel 2018)	1.6	3.3	6.8	1.7	2.6	-0.1
Medication: Metformin	1.6	2.3	4.0	-1.0	1.4	-2.0
Eye problems/disorders: None of the above	1.6	1.8	4.1	1.0	2.0	-0.6
Mean time to correctly identify matches	1.6	3.0	7.4	-0.6	-2.7	1.1
Arm fat percentage (left)	1.6	6.4	15.3	1.7	3.9	-1.0
Qualifications: nursing, teaching	1.6	2.5	6.0	0.7	2.5	-0.9
Arm fat mass (left)	1.6	6.5	14.8	2.0	3.9	-0.7
Irritability	1.6	2.7	4.7	-0.4	2.2	-1.8
Reaction Time	1.5	2.9	6.9	-0.2	-2.6	1.4
Impedance of leg (left)	1.5	7.1	16.3	1.6	4.0	-1.5
Financial difficulties in last 2 years	1.5	2.0	3.5	-1.3	0.9	-1.9
Arm fat mass (right)	1.5	6.2	14.5	1.7	3.8	-1.0
Length of working week for main job	1.5	1.6	3.1	1.3	1.8	0.1
Medication for pain relief, constipation, heartburn	1.5	2.5	4.5	1.6	-0.5	2.1
Illnesses of father: Heart disease	1.5	2.0	3.5	-1.9	-1.3	-0.9
Medication: Aspirin	1.5	1.9	3.3	-1.8	-1.1	-1.1
Ever depressed for a whole week	1.5	1.8	3.0	-0.9	1.2	-1.7
Medication: Atenolol	1.4	1.8	3.4	-1.3	0.6	-1.9
Nervous feelings	1.4	2.6	5.9	1.3	2.4	-0.5
Suffer from ‘nerves’	1.4	2.1	3.5	1.9	1.6	0.6
Breast Cancer	1.3	3.2	7.4	-1.1	-2.7	1.0
Blood Eosinophil Count	1.3	9.9	17.8	4.2	1.2	3.2
Average weekly spirits intake	1.3	1.7	3.2	-1.3	-1.8	0.2
Relative age voice broke	1.3	2.0	3.8	0.0	2.0	-1.5
Weight	1.3	6.2	13.8	2.1	3.7	-0.5
Illnesses of siblings: Diabetes	1.3	1.6	2.9	-0.3	1.7	-1.4
Bipolar Disorder (2018)	1.2	1.9	3.0	1.7	0.3	1.6
Neuroticism	1.2	2.8	6.2	1.4	2.5	-0.6
Diabetes (father)	1.2	1.5	3.0	1.2	1.7	0.0
Multivitamins +/- minerals	1.2	1.6	2.8	1.7	0.6	1.3
Arm fat percentage (right)	1.2	4.8	11.4	1.4	3.4	-0.9
Happiness	1.2	1.5	2.4	-1.1	0.9	-1.5
Family relationship satisfaction	1.2	1.5	2.5	0.3	-1.4	1.6
Medication: Aspirin	1.2	1.5	2.6	-1.6	-0.8	-1.2
Unable to work because of sickness or disability	1.2	1.6	2.5	-0.3	1.6	-1.5
Schizophrenia vs Biploar Disorder	1.1	1.4	2.3	-0.2	1.5	-1.4
Alzheimer’s Disease (in mother)	1.1	1.3	2.8	0.1	1.7	-1.0
Alzheimer’s Disease (including proxy)	1.1	1.6	3.8	0.3	1.9	-1.0
Diverticular disease/diverticulitis (self-reported)	1.1	1.4	2.2	1.5	0.6	1.2
Number of incorrect matches in round	1.1	1.9	4.3	-0.6	-2.1	1.0
Gout (self-reported)	1.1	1.5	2.7	1.6	1.3	0.5
Handedness (chirality/laterality): Left-handed	1.1	1.4	2.3	-1.3	0.4	-1.5
Ever had bowel cancer screening	1.1	1.2	2.0	1.1	-0.6	1.4
Number of self-reported non-cancer illnesses	1.1	1.9	3.6	-0.9	1.2	-1.9
Ever taken oral contraceptive pill	1.1	1.2	1.8	0.5	-1.2	1.3
Neuroticism (Nagel 2018)	1.0	2.3	4.6	1.5	2.2	-0.2
Systolic Blood Pressure	1.0	4.9	11.8	-0.8	-3.4	1.5
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.5	0.4	1.6	-0.7
Past tobacco smoking	1.0	1.9	3.0	-1.6	-1.7	-0.3
Mouth/teeth dental problems	1.0	1.6	3.7	-0.9	-1.9	0.4
Prospective memory result	1.0	1.2	2.5	1.0	1.6	-0.3
Glaucoma (self-reported)	1.0	1.2	2.0	-1.2	0.6	-1.4
Comparative height size at age 10	1.0	5.5	10.2	3.2	1.4	2.1
Leg pain on walking	1.0	1.3	3.2	0.4	1.8	-0.6
Eye problems/disorders: Cataract	1.0	1.2	2.1	-1.4	-0.8	-0.9
Medication: Paracetamol	1.0	1.5	2.5	-1.4	0.3	-1.6
HDL Cholesterol	0.9	1.5	2.5	1.4	1.6	0.2
Townsend deprivation index at recruitment	0.9	1.2	2.0	-1.0	0.7	-1.4
Alcohol intake versus 10 years previously	0.9	1.4	2.2	-0.6	1.2	-1.5
Peak expiratory flow (PEF)	0.9	2.2	4.8	-0.8	-2.2	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	1.6	0.2	-1.2	1.2
Medication: Ibuprofen	0.9	1.1	2.5	0.7	1.6	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	1.8	-1.3	-0.9	-0.8
Number of full sisters	0.9	1.1	2.1	0.2	-1.5	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.8	0.4	-1.0	1.3
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	3.0	0.3	1.7	-1.1
Number of operations (self-reported)	0.9	1.3	3.2	-0.9	-1.8	0.2
Worry (Nagel 2018)	0.8	1.7	3.1	1.7	1.3	0.5
Major Depression (MDD)	0.8	1.0	2.3	0.6	1.5	-0.6
Chronotype (morning person)	0.8	1.9	4.0	1.3	2.0	-0.2
Severe depression (siblings)	0.8	0.9	1.1	-0.6	1.1	-1.0
Qualifications: A levels/AS levels or equivalent	0.8	1.8	3.5	1.3	1.9	0.1
Pulse wave Arterial Stiffness index	0.8	0.9	1.4	-0.7	0.8	-1.2
Pulse wave peak to peak time	0.8	0.9	1.5	0.8	-0.7	1.2
Medication: Blood pressure	0.8	1.4	2.5	-1.6	-0.8	-1.0
Loneliness, isolation	0.8	1.1	1.9	1.4	1.0	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	2.8	-1.7	-1.3	-0.6
Fractured/broken bones in last 5 years	0.8	1.0	1.7	1.3	0.6	1.0
Myopia	0.8	1.2	1.8	-1.3	-0.4	-1.2
Impedance of whole body	0.8	4.2	9.1	1.7	3.0	-0.7
Ever had hysterectomy (womb removed)	0.7	0.8	1.6	-0.8	-1.3	0.3
Taking other prescription medications	0.7	1.1	1.8	-0.1	1.4	-1.3
Stomach or abdominal pain in last month	0.7	0.9	1.4	-1.2	-0.7	-0.9
Sitting height	0.7	5.3	11.6	0.6	3.4	-2.0
Body mass index (BMI)	0.7	3.1	7.5	1.2	2.7	-0.6
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	1.7	0.9	1.3	-0.1
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.9	1.0	1.4	-0.0
Health satisfaction	0.7	0.9	1.3	-0.9	0.8	-1.2
Osteoarthritis (self-reported)	0.7	0.9	1.9	1.4	0.6	0.7
Illnesses of father: None of the above (group 1)	0.7	0.9	1.5	1.1	-0.1	1.2
Hearing aid user	0.7	0.8	1.4	-0.0	-1.2	1.0
Average weekly beer plus cider intake	0.7	1.1	2.6	0.3	1.6	-0.7
Pain experienced in last month	0.7	1.1	1.7	0.7	-1.1	1.3
Primary Biliary Cirrhosis	0.6	0.8	1.5	1.2	0.9	0.4
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.9	0.7	1.4	-0.2
Ever used hormone-replacement therapy (HRT)	0.6	0.7	1.5	0.8	1.2	-0.1
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.2	-1.1	-0.4	-0.7
Allergy	0.6	1.3	2.3	-1.3	0.1	-1.5
Neuroticism score	0.6	1.2	2.8	0.5	1.7	-0.8
Father’s age at death	0.6	0.9	1.5	0.3	-1.2	1.0
Ever highly irritable/argumentative for 2 days	0.6	0.8	1.4	0.7	-0.6	1.2
Medication: Paracetamol	0.6	1.0	1.6	-1.3	-0.2	-1.2
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.2	-1.1	-0.9	-0.4
Arm fat-free mass (right)	0.6	3.0	5.6	1.8	2.4	0.2
Medication: Seretide 50 evohaler	0.6	0.7	1.2	0.8	-0.4	1.1
Arm predicted mass (right)	0.6	3.3	6.2	1.9	2.5	0.2
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.8	1.2	-0.9	0.6	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.2	0.5	-1.2	1.5
Arm fat-free mass (left)	0.6	3.2	6.0	1.9	2.4	0.1
Age started oral contraceptive pill	0.6	0.7	1.9	-0.3	-1.4	0.5
Pack years of smoking	0.6	0.9	1.7	-1.3	-0.8	-0.6
Allergy or Eczema	0.5	1.3	2.3	1.1	-0.6	1.5
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	1.3	0.2	-1.1	0.7
Pack years adult smoking proportion	0.5	0.7	1.4	-1.2	-0.6	-0.7
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.1	1.1	-0.2	1.4
Worrier / anxious feelings	0.5	0.9	1.5	-0.6	0.8	-1.2
Loud music exposure frequency	0.5	0.5	1.1	1.0	0.4	0.6
Number of full brothers	0.5	0.7	1.3	-0.1	1.1	-0.9
Emphysema/chronic bronchitis	0.5	0.5	0.8	0.9	0.6	0.6
Medication: Allopurinol	0.5	0.6	1.2	1.1	0.7	0.3
Back pain experienced in last month	0.5	0.7	1.2	-0.2	1.1	-1.0
Medication: Gliclazide	0.5	0.6	1.3	0.6	1.1	-0.4
Medication: Lisinopril	0.5	0.6	0.9	-0.9	0.1	-1.0
Basal metabolic rate	0.5	2.6	3.8	1.9	1.9	0.7
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.2	-0.2	-1.1	0.5
Vascular/heart problems diagnosed by doctor	0.5	1.4	3.1	1.0	1.8	-0.1
Intelligence (Savage-Jansen 2018)	0.4	1.2	1.9	-1.4	-0.1	-1.3
BMI	0.4	2.2	5.5	1.0	2.3	-0.4
Respiratory disease	0.4	0.9	1.6	0.8	-0.6	1.3
Systolic blood pressure, automated reading	0.4	1.1	1.7	0.7	-1.0	1.3
Leg fat-free mass (left)	0.4	1.9	3.0	1.7	1.5	0.7
Medication: Levothyroxine sodium	0.4	0.7	1.4	0.8	1.2	-0.3
Leg predicted mass (left)	0.4	2.0	3.1	1.8	1.6	0.7
Had menopause	0.4	0.5	1.1	1.0	0.3	0.7
Time employed in main current job	0.4	0.5	0.8	-0.2	0.9	-0.7
Depression (self-reported)	0.4	0.4	1.0	0.4	1.0	-0.4
Impedance of arm (left)	0.4	1.7	3.0	1.7	1.4	0.4
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	0.8	0.9	0.9	0.4
High blood pressure (siblings)	0.4	0.5	0.8	-0.9	-0.5	-0.7
Neck or shoulder pain in last month	0.4	0.5	1.2	0.3	1.1	-0.4
Friendships satisfaction	0.4	0.5	0.9	-1.0	-0.2	-0.6
Leg predicted mass (right)	0.4	2.1	3.6	1.9	0.9	1.3
Alcohol drinker status: Never	0.4	0.5	0.9	-0.9	-0.3	-0.7
Heart disease (siblings)	0.4	0.5	0.9	0.3	-0.9	0.7
Arm predicted mass (left)	0.4	2.2	3.8	1.7	1.9	0.3
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.2	-1.1	-0.7	-0.4
Mean Putamen Volume	0.3	0.4	0.9	-0.3	-0.9	0.3
Smoking Status	0.3	0.7	1.0	-0.6	0.9	-1.0
Lung FVC	0.3	1.6	2.8	-1.7	-1.3	-0.5
Medication for hormone replacement therapy	0.3	0.4	1.1	0.2	1.0	-0.3
Maternal smoking around birth	0.3	0.5	0.8	-0.4	0.8	-0.9
Fed-up feelings	0.3	0.5	1.3	0.5	1.1	-0.3
Serious illness, injury or assault to yourself	0.3	0.4	0.9	-0.9	-0.3	-0.6
Had other major operations	0.3	0.3	0.7	0.3	0.9	-0.5
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	0.6	0.6	-0.2	0.8
Noisy workplace	0.3	0.4	0.6	-0.5	0.6	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.6	0.7	0.8	0.1
Standing height	0.3	3.1	4.8	2.2	2.1	0.5
Birth weight of first child	0.3	0.5	1.1	-0.7	-1.1	-0.0
Blood clot in the leg (DVT)	0.3	0.4	0.9	-0.3	-0.9	0.5
Medication: Amlodipine	0.3	0.5	1.0	-0.7	-0.1	-1.0
Had major operations	0.3	0.3	0.7	-0.1	-0.8	0.5
Age at last live birth	0.3	0.4	0.6	-0.8	-0.6	-0.3
Whole body fat-free mass	0.3	1.7	2.9	1.7	1.1	1.0
Leg fat-free mass (right)	0.3	1.9	3.2	1.8	0.9	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.7	-0.3	0.4	-0.9
Whole body water mass	0.3	1.7	3.0	1.7	1.0	1.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.7	0.0	-0.8	0.7
Ovarian Cancer	0.2	0.2	0.4	0.2	-0.6	0.5
Age at First Birth	0.2	0.3	0.5	-0.5	-0.7	-0.1
Height	0.2	3.6	6.8	1.9	2.6	0.5
Hearing difficulty/problems: Yes	0.2	0.3	0.5	0.7	0.0	0.6
Hand grip strength (right)	0.2	0.5	0.8	0.1	-0.9	0.9
Age when periods started (menarche)	0.2	0.5	1.1	0.7	-0.2	1.0
High blood pressure	0.2	0.5	1.2	-0.1	-1.1	0.5
Fluid intelligence score	0.2	0.3	0.6	-0.8	-0.6	-0.2
Trunk fat-free mass	0.2	0.9	1.5	1.2	0.5	0.9
Number of live births	0.2	0.3	0.5	-0.2	0.7	-0.7
Exposure to tobacco smoke at home	0.2	0.2	0.3	-0.6	-0.5	-0.4
Number of children fathered	0.2	0.3	0.4	-0.0	-0.6	0.6
Shortness of breath walking on level ground	0.2	0.2	0.3	-0.5	0.1	-0.5
Knee pain experienced in last month	0.2	0.2	0.4	0.6	0.5	0.3
Long-standing illness, disability or infirmity	0.2	0.3	0.4	0.6	0.7	0.0
Osteoporosis (self-reported)	0.2	0.2	0.3	-0.6	-0.4	-0.4
Average weekly champagne plus white wine intake	0.2	0.3	0.5	0.7	0.1	0.6
Financial situation satisfaction	0.2	0.3	0.6	-0.3	-0.7	0.5
Commuting to job workplace: Public transport	0.2	0.2	0.5	-0.2	0.2	-0.7
Illnesses of father: High blood pressure	0.2	0.2	0.4	0.6	0.6	-0.0
Ever smoked	0.2	0.4	0.9	-0.0	0.9	-0.6
Risk taking	0.2	0.3	0.5	0.1	-0.7	0.7
Alzheimer’s Disease (in father)	0.1	0.1	0.1	0.2	0.4	-0.2
Prostate Cancer	0.1	0.1	0.2	-0.4	-0.3	-0.3
Lung FEV1/FVC ratio	0.1	0.4	0.8	0.4	-0.6	0.9
Sensitivity / hurt feelings	0.1	0.2	0.5	-0.2	-0.7	0.1
Supplements: Zinc	0.1	0.1	0.2	0.4	0.1	0.2
High blood pressure (mother)	0.1	0.1	0.3	0.2	0.6	-0.2
Qualifications: None of the above	0.1	0.2	0.4	0.7	0.2	0.2
Pain all over the body in last month	0.1	0.1	0.1	-0.4	-0.2	-0.4
Illnesses of siblings	0.1	0.2	0.3	0.4	-0.0	0.6
Impedance of arm (right)	0.1	0.6	1.2	1.1	0.6	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.3	0.4	-0.6
Mouth/teeth dental problems: Dentures	0.1	0.1	0.2	0.4	0.1	0.5
Asthma	0.1	0.2	0.4	0.5	0.0	0.6
Trunk predicted mass	0.1	0.8	1.5	1.2	0.5	0.9
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.3	0.0	0.5	-0.5
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.2	0.4	0.2
Exposure to tobacco smoke outside home	0.1	0.2	0.2	0.4	-0.4	0.4
Worry too long after embarrassment	0.1	0.2	0.3	0.6	0.6	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.3	0.5	0.6	-0.0
Wheeze or whistling in the chest in last year	0.1	0.2	0.4	-0.6	-0.3	-0.3
Qualifications: College or University degree	0.1	0.4	0.8	0.6	0.9	0.2
Medication: Omeprazole	0.1	0.1	0.2	-0.2	0.2	-0.5
Heart disease (mother)	0.1	0.1	0.4	0.6	0.2	0.1
Overall health rating	0.1	0.3	0.6	0.5	0.7	-0.1
Chest pain or discomfort	0.1	0.1	0.2	-0.4	0.0	-0.5
Hypertension (Self-reported)	0.1	0.2	0.4	0.0	-0.6	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.2	-0.4	-0.0	-0.3
Average weekly red wine intake	0.1	0.2	0.3	0.6	0.0	0.4
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.3	0.1	-0.5	0.5
Eye problems/disorders: Glaucoma	0.1	0.2	0.4	-0.3	0.6	-0.3
Medication: Blood pressure	0.1	0.2	0.4	0.6	0.2	0.3
Medication: Bendroflumethiazide	0.1	0.2	0.3	0.5	0.2	0.6
Commuting to job workplace: Cycle	0.1	0.2	0.3	-0.5	-0.3	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.3	0.5	0.4	0.2
Hypothyroidism (self reported)	0.0	0.1	0.2	-0.3	-0.4	-0.2
Hair Pigment	0.0	0.3	0.6	-0.8	0.2	-0.6
Tanning	0.0	0.4	0.9	1.0	0.6	0.3
Hand grip strength (left)	0.0	0.0	0.1	0.1	-0.2	0.3
Forced vital capacity (FVC)	0.0	0.2	0.3	-0.2	-0.6	0.4
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.2	0.2	-0.1	0.4
Lung cancer (father)	0.0	0.0	0.1	-0.2	-0.0	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.3	0.2	-0.2	0.5
Forced vital capacity (FVC), Best measure	0.0	0.0	0.1	0.1	0.1	0.3
Age at first live birth	0.0	0.1	0.2	-0.1	-0.4	0.2
Asthma (self-reported)	0.0	0.0	0.0	0.2	0.2	0.2
Mother’s age at death	0.0	0.0	0.1	0.2	0.2	0.2

Hub : Genes

ZHX3

Models

Trait associations