[Hub]/) : Traits : High cholesterol (Self-reported) : ← →

chr19:48,464,978-50,108,983

Best TWAS P=8.01e-17 · Best GWAS P=3.35e-16 conditioned to 0.037

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adrenal Gland	RASIP1	0.20	0.11	lasso	4	0.10	2.4e-04	-4.8	5.4	6.2e-08	0.68	0.24	0.50	FALSE
2	GTEx	Cells Transformed fibroblasts	RASIP1	0.19	0.14	lasso	6	0.20	6.1e-15	7.8	7.9	3.6e-15	0.92	0.03	0.97	FALSE
3	GTEx	Esophagus Mucosa	RASIP1	0.13	0.13	lasso	4	0.13	9.0e-09	-5.7	6.5	7.0e-11	0.77	0.84	0.16	FALSE
4	GTEx	Heart Atrial Appendage	MAMSTR	0.24	0.13	lasso	2	0.13	1.3e-06	-5.5	6.2	7.7e-10	0.74	0.41	0.51	FALSE
5	GTEx	Heart Atrial Appendage	NUCB1-AS1	0.16	0.04	lasso	3	0.07	5.3e-04	-7.5	-6.0	2.5e-09	-0.59	0.04	0.56	FALSE
6	GTEx	Heart Left Ventricle	MAMSTR	0.26	0.18	lasso	6	0.21	3.4e-11	-5.3	6.5	5.6e-11	0.79	0.29	0.71	FALSE
7	GTEx	Skin Not Sun Exposed Suprapubic	RASIP1	0.15	0.04	lasso	6	0.08	2.9e-05	6.7	5.6	2.0e-08	0.71	0.42	0.31	FALSE
8	GTEx	Skin Not Sun Exposed Suprapubic	NTN5	0.19	0.07	lasso	5	0.08	2.5e-05	7.9	7.8	6.2e-15	0.93	0.03	0.97	FALSE
9	GTEx	Skin Sun Exposed Lower leg	RASIP1	0.21	0.13	enet	19	0.17	1.1e-13	-6.0	6.0	2.0e-09	0.72	0.98	0.02	FALSE
10	GTEx	Skin Sun Exposed Lower leg	NTN5	0.11	0.09	enet	18	0.05	6.2e-05	7.8	7.0	1.8e-12	0.87	0.02	0.98	FALSE
11	GTEx	Testis	RASIP1	0.29	0.20	lasso	8	0.30	7.5e-14	-5.9	6.7	1.9e-11	0.79	0.64	0.36	FALSE
12	GTEx	Thyroid	NTN5	0.14	0.02	enet	26	0.04	4.4e-04	7.9	6.4	1.8e-10	0.63	0.02	0.98	FALSE
13	METSIM	Adipose	FUT1	0.04	0.01	lasso	6	0.02	6.9e-04	-4.6	-5.5	4.4e-08	-0.66	0.05	0.87	FALSE
14	METSIM	Adipose	NTN5	0.13	0.10	bslmm	450	0.14	3.2e-20	7.8	6.0	2.2e-09	0.68	0.03	0.97	FALSE
15	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	FUT2	0.05	0.01	blup	52	0.01	6.1e-02	6.9	-7.0	2.2e-12	-0.81	0.03	0.25	FALSE
16	The Cancer Genome Atlas	Breast Invasive Carcinoma	FUT2	0.03	0.05	blup	54	0.05	1.9e-10	7.8	-7.6	3.9e-14	-0.87	0.02	0.98	FALSE
17	The Cancer Genome Atlas	Breast Invasive Carcinoma	NTN5	0.02	0.01	enet	11	0.01	7.6e-04	8.2	8.3	8.0e-17	0.85	0.01	0.93	TRUE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	RASIP1	0.02	0.02	blup	56	0.03	3.8e-07	7.9	7.4	1.2e-13	0.90	0.01	0.99	FALSE
19	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FUT2	0.10	0.02	blup	55	0.06	6.8e-04	8.2	-7.7	1.5e-14	-0.90	0.01	0.98	FALSE
20	The Cancer Genome Atlas	Colon Adenocarcinoma	FUT2	0.18	0.22	enet	12	0.18	6.8e-11	7.9	-8.1	5.2e-16	-0.95	0.01	0.99	FALSE
21	The Cancer Genome Atlas	Colon Adenocarcinoma	SEC1	0.05	0.04	enet	11	0.01	8.5e-02	7.9	-6.9	4.5e-12	-0.90	0.01	0.90	FALSE
22	The Cancer Genome Atlas	Esophageal Carcinoma	FUT2	0.33	0.27	lasso	3	0.24	3.9e-08	-7.5	-7.7	1.6e-14	-0.79	0.03	0.97	FALSE
23	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FUT2	0.11	0.22	blup	52	0.22	6.3e-24	7.9	-7.7	9.6e-15	-0.90	0.03	0.97	FALSE
24	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RASIP1	0.04	0.01	enet	10	0.02	2.3e-03	-5.5	5.8	6.7e-09	0.65	0.16	0.57	FALSE
25	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FUT2	0.10	0.01	blup	51	0.05	9.8e-04	7.8	-7.4	1.1e-13	-0.88	0.01	0.93	FALSE
26	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	NTN5	0.11	0.02	blup	41	0.07	1.2e-04	-5.5	6.3	3.7e-10	0.71	0.03	0.70	FALSE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	FAM83E	0.06	0.04	lasso	4	0.06	6.1e-07	-4.9	5.2	2.1e-07	0.59	0.00	0.99	FALSE
28	The Cancer Genome Atlas	Brain Lower Grade Glioma	FUT2	0.02	0.04	lasso	1	0.03	1.8e-04	-5.5	-5.5	2.9e-08	-0.66	0.15	0.13	FALSE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	MAMSTR	0.04	0.04	blup	47	0.06	3.9e-07	-4.8	6.8	1.5e-11	0.78	0.52	0.47	FALSE
30	The Cancer Genome Atlas	Brain Lower Grade Glioma	NTN5	0.05	0.04	lasso	2	0.02	6.7e-04	7.9	7.9	2.2e-15	0.97	0.01	0.99	FALSE
31	The Cancer Genome Atlas	Lung Adenocarcinoma	FUT2	0.09	0.12	blup	52	0.12	4.2e-14	8.2	-7.5	5.5e-14	-0.93	0.01	0.99	FALSE
32	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FUT2	0.05	0.08	lasso	2	0.08	6.7e-09	7.8	-7.9	2.1e-15	-0.96	0.02	0.98	FALSE
33	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RASIP1	0.04	0.03	enet	8	0.03	1.7e-04	-4.2	5.2	2.6e-07	0.47	0.07	0.10	FALSE
34	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	FUT2	0.06	0.00	blup	53	0.05	3.5e-04	6.9	-7.6	2.7e-14	-0.89	0.02	0.83	FALSE
35	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FUT2	0.08	0.12	lasso	4	0.11	2.5e-05	7.8	-7.8	5.7e-15	-0.92	0.02	0.95	FALSE
36	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	IZUMO1	0.16	0.17	lasso	7	0.15	1.4e-06	-5.7	5.8	8.3e-09	0.67	0.42	0.53	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	FUT2	0.05	0.06	blup	52	0.06	8.6e-07	7.9	-8.0	1.1e-15	-0.94	0.01	0.99	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	NTN5	0.06	0.03	blup	41	0.03	2.1e-04	8.2	5.7	9.2e-09	0.76	0.01	0.88	FALSE
39	The Cancer Genome Atlas	Rectum Adenocarcinoma	FUT2	0.26	0.28	lasso	10	0.22	5.2e-06	7.9	-8.0	1.9e-15	-0.96	0.01	0.99	FALSE
40	The Cancer Genome Atlas	Soft Tissue Sarcoma	RASIP1	0.05	0.06	blup	54	0.04	1.4e-03	-7.5	7.0	1.9e-12	0.78	0.03	0.62	FALSE
41	The Cancer Genome Atlas	Stomach Adenocarcinoma	FUT2	0.14	0.16	lasso	8	0.14	4.9e-10	7.8	-8.1	6.9e-16	-0.96	0.01	0.99	FALSE
42	The Cancer Genome Atlas	Testicular Germ Cell Tumors	FUT2	0.22	0.09	lasso	8	0.13	3.0e-05	-4.9	-7.0	2.8e-12	-0.76	0.02	0.97	FALSE
43	The Cancer Genome Atlas	Thyroid Carcinoma	FUT2	0.06	0.04	blup	54	0.06	1.1e-06	-7.5	-7.8	8.7e-15	-0.87	0.02	0.98	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	NTN5	0.11	0.07	blup	43	0.09	2.6e-09	8.2	8.1	8.0e-16	0.89	0.00	1.00	FALSE