TWAS hub - LPIN3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.063	0.0270	4.5e-04	0.009	0.028	0.033	0.029	0.026	2.2e-02	2.2e-04	5.4e-05	1.5e-04	3.5e-04
2	GTEx	Artery Aorta	0.079	0.0340	2.5e-03	0.076	NA	0.076	NA	0.066	5.6e-05	NA	5.4e-05	NA	1.6e-04
3	GTEx	Artery Tibial	0.175	0.0415	1.3e-09	0.130	NA	0.149	NA	0.151	2.2e-10	NA	9.8e-12	NA	6.5e-12
4	GTEx	Heart Atrial Appendage	0.111	0.0530	6.8e-03	0.016	NA	0.014	NA	0.023	6.0e-02	NA	7.4e-02	NA	3.3e-02
5	GTEx	Skin Sun Exposed Lower leg	0.122	0.0380	1.0e-04	0.013	NA	0.015	NA	0.025	2.9e-02	NA	1.8e-02	NA	3.5e-03
6	GTEx	Stomach	0.110	0.0450	3.8e-03	0.053	NA	0.017	NA	0.054	1.5e-03	NA	5.2e-02	NA	1.4e-03
7	GTEx	Thyroid	0.288	0.0820	1.4e-07	0.078	NA	0.019	NA	0.042	1.5e-06	NA	1.2e-02	NA	3.3e-04
8	ROSMAP	Brain Pre-frontal Cortex	0.112	0.0276	1.1e-14	0.096	0.118	0.115	0.112	0.121	2.2e-12	5.9e-15	1.5e-14	3.5e-14	2.5e-15
9	TCGA	Brain Lower Grade Glioma	0.031	0.0167	4.0e-03	0.041	0.018	0.020	NA	0.026	1.8e-05	3.4e-03	2.3e-03	NA	5.5e-04
10	TCGA	Pancreatic Adenocarcinoma	0.105	0.0560	5.5e-03	0.022	0.037	0.059	NA	0.072	4.0e-02	1.2e-02	1.8e-03	NA	6.2e-04
11	TCGA	Thyroid Carcinoma	0.043	0.0220	1.4e-03	0.032	0.039	0.020	NA	0.034	3.8e-04	9.3e-05	4.5e-03	NA	2.5e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
LDL Cholesterol	22.6	35.7	64.8	5.3	6.7	8.1	4.0	3.6	6.4	1.0	7.1	7.0	7.2	5.8
High cholesterol (Self-reported)	13.6	24.0	35.7	4.9	5.6	5.9	3.9	3.7	5.0	1.0	6.0	5.6	5.6	4.6
Medication: Atorvastatin	13.3	16.4	24.6	3.4	4.8	4.8	3.0	4.4	4.9	1.9	5.0	4.6	2.7	3.6
Cholesterol lowering medication	12.1	17.8	30.2	4.0	4.8	4.8	3.5	3.1	4.4	1.1	4.6	4.9	5.5	4.1
Medication: Simvastatin	7.2	10.5	30.3	2.7	3.4	4.0	2.2	1.7	2.3	0.3	3.8	3.7	5.5	3.1
Medication: Cholesterol lowering	5.5	8.5	16.3	2.6	3.2	4.0	1.1	2.4	2.0	1.0	3.9	3.6	3.6	2.7
Supplements: Vitamin C	5.5	6.5	12.7	-1.4	-2.8	-3.1	-1.4	-2.3	-3.6	-1.9	-3.0	-2.6	-1.9	-3.0
Triglycerides	5.4	8.9	15.0	1.9	3.2	3.9	2.3	3.3	2.4	3.2	3.0	3.5	1.8	3.4
Vitamin and mineral supplements	5.4	7.3	12.8	1.8	3.3	3.0	0.8	2.8	3.6	1.4	3.5	3.4	0.6	2.9
Serious illness, injury or assault of a close relative in last 2 years	5.4	6.2	10.6	1.9	2.7	3.1	3.3	1.7	2.3	0.9	2.4	2.5	3.1	2.6
Seen doctor (GP) for nerves, anxiety, tension or depression	4.8	7.3	33.5	2.0	2.2	2.4	2.2	0.7	2.7	-2.9	2.7	1.9	5.8	0.5
Falls in the last year	4.6	6.3	11.6	-0.9	-3.2	-3.4	0.0	-2.9	-2.8	-2.2	-3.2	-3.1	-0.6	-2.3
Smoking status: Previous	4.4	6.6	11.4	-2.0	-2.7	-2.9	-2.6	-2.1	-2.4	-1.4	-3.4	-2.8	-1.7	-3.4
Fasting Glucose	4.3	5.1	10.5	-0.9	-2.3	-2.4	-0.9	-3.2	-1.4	-2.9	-2.4	-2.6	0.3	-3.2
Wears glasses or contact lenses	4.3	5.0	8.4	2.3	2.5	2.6	2.4	2.9	2.7	0.5	2.3	2.1	1.6	1.6
Mineral and other dietary supplements	4.0	5.4	10.3	2.1	2.5	2.7	0.5	1.2	3.2	-0.3	3.0	2.5	2.9	2.1
Crohns Disease (2017)	3.9	8.6	16.7	-1.3	-3.2	-3.5	-0.6	-4.1	-3.8	-3.4	-3.1	-2.6	1.5	-2.8
Waist Hip Ratio (WHR)	3.9	17.6	35.0	3.0	4.5	5.9	3.1	3.9	4.2	1.5	4.6	5.0	5.0	3.7
Angina	3.9	5.1	7.8	2.5	2.1	2.7	0.2	2.8	1.1	2.6	2.4	2.1	2.7	2.2
Breastfed as a baby	3.9	4.8	11.8	1.2	2.0	1.7	1.7	3.4	1.5	3.4	1.8	1.7	-1.0	3.0
Angina (self-reported)	3.9	5.2	8.4	2.7	2.1	2.6	0.3	2.8	1.2	2.4	2.4	2.1	2.9	2.2
Lupus	3.7	5.6	9.7	2.6	2.6	2.8	1.7	1.5	3.1	0.5	2.4	2.6	2.6	2.6
Alcohol usually taken with meals	3.6	5.8	17.1	-2.8	-2.3	-3.0	-2.3	-1.4	-2.1	0.3	-2.3	-2.3	-4.1	-1.3
Rheumatoid Arthritis	3.3	4.6	8.4	-2.9	-2.4	-2.6	-1.7	-2.1	-1.7	-0.5	-2.3	-2.7	-1.4	-2.3
Heel T-Score	3.3	25.9	144.0	2.6	1.3	2.5	1.8	7.6	0.8	12.0	0.5	0.2	-7.0	4.0
Medication: Lansoprazole	3.3	3.7	8.9	-1.9	-1.8	-1.6	-1.2	-2.8	-1.5	-3.0	-1.4	-1.8	1.4	-2.0
Irritable Bowel Disease (IBD)	3.1	7.5	15.4	-1.1	-2.7	-3.0	0.1	-3.9	-3.1	-3.9	-2.5	-2.2	2.5	-2.6
Medication: Ramipril	3.1	4.0	7.7	2.1	2.8	2.6	0.6	2.1	2.0	0.3	2.5	2.6	1.0	1.6
Hair/balding pattern: Pattern 4	3.0	7.2	43.2	-1.8	-0.9	0.4	-2.0	2.5	-1.4	6.6	-0.1	-0.6	-4.1	1.6
Breast cancer (self-reported)	2.9	3.4	5.3	2.1	2.3	2.3	1.4	1.8	1.8	0.8	1.9	2.1	1.6	1.9
Body Mass Index (BMI) (2010)	2.8	3.8	8.4	-1.0	-2.5	-2.6	-1.4	-1.6	-1.6	0.0	-2.9	-2.4	-1.4	-2.2
Headache pain in last month	2.8	4.8	11.9	1.7	2.3	2.7	1.2	1.2	2.3	-1.0	2.5	2.7	3.4	1.8
Supplements: Fish oil (including cod liver oil)	2.8	3.6	7.9	-1.7	-1.9	-2.1	-0.7	-1.3	-2.8	-0.6	-2.5	-1.6	-2.6	-1.5
Hair/balding pattern: Pattern 3	2.7	4.0	18.6	-0.6	0.3	0.6	-0.0	2.6	0.7	4.3	0.3	0.1	-4.1	1.0
Pain type(s) experienced in last month: Hip pain	2.6	3.3	8.3	-2.2	-1.6	-1.3	-2.2	-1.9	-1.5	-2.9	-1.5	-0.9	0.2	-2.3
Crohns Disease (2012)	2.5	4.1	7.4	-1.8	-2.3	-2.7	-0.6	-2.4	-2.7	-2.0	-2.3	-1.6	1.0	-1.8
Multivitamins +/- minerals	2.5	3.1	5.7	-1.4	-2.4	-1.8	-0.5	-2.0	-2.1	-0.6	-2.4	-2.4	-0.1	-1.8
Hearing difficulty/problems with background noise	2.5	4.1	9.9	-1.7	-2.3	-2.6	-1.8	-0.7	-1.4	0.8	-2.6	-3.1	-2.3	-1.3
Heart attack	2.5	3.2	8.5	0.5	1.8	2.9	0.3	2.3	1.8	1.9	2.3	1.9	0.6	1.4
Migraine (self-reported)	2.4	2.9	5.3	0.2	2.1	2.3	0.5	1.7	2.1	0.6	2.3	2.2	1.3	1.7
Supplements: Calcium	2.4	2.6	5.3	-1.1	-1.9	-1.9	0.3	-1.8	-1.6	-1.0	-2.3	-2.0	-0.6	-2.0
Type 2 Diabetes (T2D) (2012)	2.3	2.6	12.1	-1.0	-1.0	-1.2	-1.1	-2.2	-0.5	-3.5	-1.2	-0.8	0.6	-2.1
Diabetes (mother)	2.3	2.9	12.5	-1.3	-0.9	-0.4	-1.9	-2.1	-0.4	-3.5	-0.7	-0.7	2.4	-1.4
Illness, injury, bereavement, stress in last 2 years	2.3	2.8	5.0	-1.2	-1.8	-2.0	-2.1	-1.6	-1.5	-0.8	-1.7	-1.7	-2.2	-1.3
Ulcerative Colitis (UC)	2.2	4.1	13.9	-1.2	-1.6	-1.9	0.2	-2.9	-1.4	-3.7	-1.5	-1.3	2.3	-2.0
Bilateral oophorectomy (both ovaries removed)	2.2	2.6	12.6	0.7	1.1	1.5	0.7	1.7	1.4	3.5	0.7	1.1	-1.2	1.8
Commuting to job workplace: Car/motor vehicle	2.2	2.5	5.4	-0.4	-1.8	-1.9	0.2	-0.7	-1.3	-1.1	-2.1	-1.8	-2.0	-2.3
HbA1C	2.1	2.3	3.8	-1.0	-1.9	-1.9	-1.4	-1.1	-1.7	-0.4	-1.8	-1.8	-1.4	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	2.1	4.7	23.5	1.2	0.8	1.0	2.0	2.8	0.3	4.8	0.3	0.5	-3.0	1.8
Intelligence (Savage-Jansen 2018)	2.0	6.0	12.4	2.2	3.2	2.3	3.5	2.4	2.4	0.2	2.8	2.8	1.3	2.3
Diabetes (father)	2.0	2.5	4.5	-1.5	-1.5	-1.3	-2.1	-1.7	-2.0	-1.9	-1.4	-1.1	-0.3	-1.7
Current tobacco smoking	2.0	3.3	6.9	1.4	2.3	2.5	1.0	1.2	1.8	-0.3	2.6	2.4	1.7	1.2
Smoking status: Current	2.0	3.2	6.2	1.8	2.2	2.5	1.1	1.1	1.7	-0.5	2.4	2.3	1.9	1.1
Guilty feelings	2.0	3.0	14.4	0.5	1.3	1.0	0.7	-0.4	2.1	-2.8	1.3	1.0	3.8	0.3
Past tobacco smoking	1.9	3.4	8.9	0.7	1.6	2.0	1.2	1.9	1.5	2.4	2.3	1.8	0.4	3.0
Hair/balding pattern: Pattern 2	1.9	2.5	10.7	0.9	1.1	0.7	1.5	-0.8	1.7	-2.7	0.7	0.7	3.3	0.1
Loneliness, isolation	1.9	2.6	5.2	-1.3	-2.0	-1.6	-0.9	-1.8	-1.3	-1.7	-1.6	-1.8	0.1	-2.3
Commuting to job workplace: Walk	1.9	2.1	4.5	0.6	1.3	1.9	0.1	1.2	1.7	2.0	1.5	1.4	0.2	2.1
Osteoarthritis (self-reported)	1.9	2.5	4.0	-0.4	-1.8	-1.7	-1.4	-1.9	-2.0	-1.2	-2.0	-1.7	-1.3	-1.4
Miserableness	1.9	3.3	10.7	0.7	1.9	1.4	2.1	0.7	2.1	-2.0	2.1	1.5	3.3	0.3
Heart attack/myocardial infarction (self-reported)	1.9	2.5	6.7	0.3	1.5	2.6	0.1	2.1	1.6	1.9	2.0	1.5	0.3	1.1
Blood Red Count	1.8	17.1	28.2	3.5	5.2	5.3	2.5	3.3	4.6	-0.1	5.3	5.3	3.7	3.6
Pack years adult smoking proportion	1.8	2.7	5.7	1.1	1.8	1.8	2.2	1.7	1.1	0.9	2.4	1.9	1.3	1.0
Pack years of smoking	1.8	2.7	5.3	1.3	1.7	1.8	2.2	1.8	1.3	1.1	2.3	1.8	1.1	1.0
Stomach or abdominal pain in last month	1.7	2.1	3.4	1.7	1.8	1.5	0.6	1.5	1.4	0.9	1.8	1.5	1.1	1.7
Number of incorrect matches in round	1.7	2.8	8.3	-1.7	-2.0	-0.8	-2.9	-0.4	-1.3	1.8	-1.4	-2.3	-1.6	-0.9
Gout (self-reported)	1.7	2.3	4.6	-1.7	-1.7	-1.5	-1.4	-1.4	-1.2	-1.4	-2.1	-1.2	-1.4	-1.4
Medication: Ibuprofen	1.7	2.0	4.8	-0.4	-1.5	-1.1	-1.2	-1.5	-0.9	-2.2	-1.5	-1.6	0.0	-2.1
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.7	21.8	1.1	0.7	0.7	1.2	2.2	0.7	4.7	0.2	0.2	-2.7	1.6
Comparative body size at age 10	1.6	4.3	9.4	-1.9	-2.0	-2.5	-1.8	-3.1	-1.2	-2.5	-2.1	-1.9	-0.9	-2.2
Alcohol intake frequency.	1.6	3.7	23.8	0.7	1.4	1.9	0.5	0.3	1.2	-1.5	1.8	1.8	4.9	0.6
Comparative height size at age 10	1.6	8.6	20.2	-4.5	-3.1	-3.2	-3.5	-2.7	-3.2	-1.2	-2.8	-2.5	-1.6	-2.5
Suffer from ‘nerves’	1.6	2.5	4.0	-1.2	-1.7	-1.7	-1.8	-1.2	-1.1	-1.7	-1.2	-2.0	1.4	-1.9
Handedness (chirality/laterality): Left-handed	1.6	1.9	4.2	0.6	1.9	1.7	0.7	1.0	1.5	-0.8	2.0	1.4	1.7	0.7
Qualifications: CSEs or equivalent	1.5	2.0	3.5	-0.4	-1.6	-1.8	-1.2	-1.8	-1.1	-1.8	-1.4	-1.3	0.2	-1.9
Supplements: Glucosamine	1.5	1.9	3.1	-1.1	-1.3	-1.7	-0.5	-1.2	-1.5	-1.0	-1.7	-1.4	-1.6	-1.7
Nervous feelings	1.5	2.8	5.9	-1.6	-1.6	-1.5	-1.8	-2.3	-0.7	-2.4	-1.3	-1.7	0.5	-1.9
Mouth/teeth dental problems: Dentures	1.5	2.6	5.6	-1.3	-2.1	-1.3	-0.4	-1.2	-2.1	0.1	-2.4	-2.2	-0.1	-2.0
Tense / ‘highly strung’	1.5	2.5	6.0	-1.4	-1.6	-1.6	-1.0	-1.7	-1.4	-2.4	-1.3	-1.6	1.6	-1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.8	3.5	1.9	1.2	1.5	1.2	1.4	1.6	1.0	0.8	1.3	-0.6	1.6
Had major operations	1.5	1.8	5.2	-1.9	-1.1	-0.7	-2.3	-0.5	-1.0	0.5	-1.0	-1.1	-2.1	-0.8
Medication for cholesterol	1.5	2.2	9.7	-1.5	-1.5	-1.3	-1.2	-1.0	-1.1	0.3	-1.3	-1.4	-3.1	-1.2
Fractured/broken bones in last 5 years	1.5	1.9	4.4	-1.6	-1.2	-1.5	-0.6	-1.0	-0.6	-2.1	-1.3	-1.2	-1.1	-2.0
Cardiovascular Disease	1.4	4.7	9.8	1.9	2.1	2.7	1.2	1.8	0.9	1.7	2.3	2.5	3.1	2.6
Supplements: Zinc	1.4	1.6	5.0	-0.6	-1.6	-0.7	-1.1	-1.7	-2.2	-0.0	-1.4	-1.2	0.6	-1.0
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.1	7.5	-0.1	-0.8	-0.8	-1.2	-2.1	-0.7	-2.7	-0.2	-1.0	2.1	-1.6
Prospective memory result	1.4	1.7	3.6	-0.9	-1.5	-0.9	-0.8	-1.7	-1.9	-1.3	-1.1	-1.0	1.7	-1.2
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	5.0	-1.5	-1.4	-2.2	0.2	-1.4	-0.3	-1.2	-1.8	-1.5	-2.1	-1.7
Birth weight	1.4	3.0	9.2	-2.2	-1.4	-2.3	0.9	-0.3	-1.1	0.6	-1.9	-2.0	-3.0	-1.2
Illnesses of father: Heart disease	1.4	1.9	4.7	1.2	1.5	1.6	0.6	1.4	2.2	1.2	1.3	1.1	1.5	1.3
Depression (Nagel 2018)	1.3	1.9	7.5	-0.8	-0.8	-1.0	-2.0	-1.8	0.1	-2.7	-0.5	-0.6	1.4	-1.4
Blood White Count	1.3	9.7	21.9	-2.0	-2.5	-2.3	-2.2	-4.7	-2.9	-4.7	-2.0	-2.0	4.1	-3.0
Medication: Co-codamol	1.3	1.5	3.7	0.1	1.1	1.6	0.4	1.3	1.5	1.2	1.2	1.0	1.9	0.7
Fluid intelligence score	1.3	2.7	5.1	1.7	2.3	1.4	1.9	1.5	1.9	0.5	2.1	1.9	-0.2	1.5
Pulse rate, automated reading	1.3	4.1	19.4	0.3	-0.8	-1.4	1.0	-2.9	-0.5	-4.4	-1.2	-0.9	2.9	-1.5
Myopia	1.3	1.9	3.0	0.6	1.7	1.5	1.2	1.7	1.4	0.7	1.6	1.5	0.8	1.5
Blood Eosinophil Count	1.2	9.2	16.4	-3.4	-3.3	-4.0	-2.5	-2.7	-3.1	-1.9	-3.6	-3.1	-2.1	-3.0
Average weekly fortified wine intake	1.2	1.5	7.5	0.1	0.7	1.1	0.2	1.7	0.2	2.7	0.8	0.9	-0.8	1.2
Financial difficulties in last 2 years	1.2	1.6	4.2	2.1	1.4	1.2	1.3	0.8	0.6	-0.7	1.1	1.5	1.8	0.6
Mouth/teeth dental problems	1.2	1.8	4.0	0.4	1.2	1.1	0.8	1.8	1.0	1.7	1.1	1.3	-1.6	2.0
Noisy workplace	1.2	1.5	3.7	-1.0	-1.3	-0.5	-1.9	-1.0	-1.6	-1.1	-1.4	-0.8	0.8	-1.6
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	3.4	0.3	-1.3	-1.1	-1.0	-1.3	-0.9	-1.3	-1.4	-1.5	-0.3	-1.8
Leg fat percentage (right)	1.2	4.2	23.4	-0.2	-0.3	-1.1	0.8	-2.3	-0.6	-4.8	-0.4	-0.1	3.5	-1.7
Mouth/teeth dental problems: Loose teeth	1.2	1.4	5.4	0.9	0.7	0.3	1.5	-0.9	0.8	-2.3	0.7	0.7	2.0	-0.8
Emphysema/chronic bronchitis	1.2	1.3	3.0	-0.6	-1.2	-1.2	0.1	-1.2	-1.3	-0.8	-1.5	-1.4	-0.1	-1.7
Mean time to correctly identify matches	1.2	2.3	9.5	-0.3	0.8	0.9	0.0	2.6	1.1	3.1	1.3	0.9	0.3	2.1
Alcohol drinker status: Never	1.2	1.4	2.9	1.6	1.3	1.2	0.7	1.7	1.3	0.0	1.5	0.9	1.1	0.5
Alzheimer’s Disease (in father)	1.1	1.2	2.3	-1.2	-1.3	-0.8	-0.7	-0.8	-1.4	-0.8	-1.5	-1.1	-1.2	-0.3
Reaction Time	1.1	2.1	8.7	-0.6	0.7	0.7	-0.2	2.3	1.1	2.9	1.4	0.8	0.1	1.9
Blood Platelet Count	1.1	12.8	63.8	2.6	3.0	2.6	2.9	-1.4	3.4	-3.5	3.2	2.7	8.0	1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	7.4	0.5	0.2	-0.0	-0.1	-1.0	0.8	-2.7	0.4	0.1	2.4	-0.7
Length of working week for main job	1.1	1.2	4.1	-0.5	-1.0	-0.9	-1.1	-1.0	-1.0	-1.5	-0.7	-0.6	0.9	-2.0
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.9	-0.1	1.5	1.2	1.4	2.0	1.5	0.5	0.9	1.1	-0.1	1.4
Family relationship satisfaction	1.1	1.3	1.9	-1.3	-1.4	-0.8	-1.1	-0.0	-1.3	0.8	-1.3	-1.2	-1.3	-1.3
Medication: Aspirin	1.1	1.5	4.3	2.1	0.8	1.7	0.1	1.0	-0.0	1.6	1.3	1.1	1.0	0.9
Leg fat percentage (left)	1.1	3.8	20.5	-0.5	-0.6	-1.4	0.7	-2.2	-0.8	-4.5	-0.7	-0.4	3.1	-1.8
Ever depressed for a whole week	1.1	1.4	3.5	1.1	1.4	1.0	0.4	0.3	0.7	-1.7	1.3	1.5	1.9	-0.0
Alzheimer’s Disease (including proxy)	1.0	1.4	3.9	-1.5	-1.3	-0.8	0.3	-1.6	-0.7	-2.0	-1.1	-0.9	0.7	-1.2
Major Depression (MDD)	1.0	1.2	4.7	0.3	-0.5	-0.4	-1.3	-2.1	-0.8	-2.2	-0.2	-0.1	0.6	-0.9
Trunk fat percentage	1.0	3.8	17.4	-1.3	-0.9	-1.7	-0.1	-2.7	-1.0	-4.2	-0.8	-0.7	2.5	-2.0
Body fat percentage	1.0	3.9	18.9	-1.0	-0.7	-1.5	0.1	-2.7	-0.9	-4.3	-0.7	-0.4	2.9	-1.9
Medication: Aspirin	1.0	1.3	3.5	1.9	0.4	1.5	-0.2	0.6	-0.4	1.5	1.1	0.9	1.6	0.9
Number of self-reported non-cancer illnesses	1.0	1.8	9.2	1.2	1.3	1.2	0.2	0.7	1.1	-0.6	1.2	1.1	3.0	1.1
Diastolic blood pressure, automated reading	1.0	3.1	14.5	-0.4	-1.1	-0.9	-1.4	0.9	-0.8	3.8	-1.1	-1.4	-3.3	0.1
Depressed Affect (Nagel 2018)	0.9	1.9	6.4	-1.1	-1.0	-1.3	-0.1	-1.4	-0.1	-2.5	-0.5	-1.2	2.1	-1.6
Verbal and Numeric Reasoning (VNR)	0.9	2.1	4.1	0.8	2.0	1.5	1.7	1.4	1.4	0.9	1.9	1.9	0.3	1.3
Coronary Artery Disease (CAD)	0.9	1.1	6.9	2.6	0.6	1.2	0.8	0.7	0.4	0.5	0.6	0.9	0.3	-0.1
Medication: Metformin	0.9	1.3	5.5	0.1	1.1	1.2	-0.5	0.2	1.0	-0.7	1.1	1.4	2.4	0.7
Trunk fat mass	0.9	4.0	18.3	-1.8	-0.9	-1.7	-0.1	-2.7	-1.0	-4.3	-0.9	-0.6	2.3	-2.1
Hip circumference	0.9	4.1	15.3	-2.2	-1.2	-2.5	-0.6	-2.7	-0.9	-3.9	-1.4	-1.2	0.6	-2.1
Time employed in main current job	0.9	1.1	4.0	2.0	0.6	0.5	1.7	0.7	0.8	-0.4	0.3	0.5	1.6	0.3
Illnesses of mother	0.9	1.2	9.0	-0.8	-0.2	-0.7	0.0	0.7	-0.4	1.1	-0.3	-0.6	-3.0	-0.5
Pulse wave Arterial Stiffness index	0.9	1.0	2.2	0.9	1.3	1.0	1.1	0.4	0.5	-0.9	1.5	1.4	1.1	0.5
Ever highly irritable/argumentative for 2 days	0.9	1.1	2.5	-0.5	-1.2	-1.0	-1.3	-0.6	-1.6	-0.0	-1.2	-1.2	-0.9	-0.9
Pulse wave peak to peak time	0.9	1.0	1.9	-1.1	-1.2	-1.1	-1.0	-0.4	-0.5	0.9	-1.4	-1.3	-1.2	-0.4
Medication: Allopurinol	0.9	1.2	3.1	-1.0	-1.3	-0.9	-1.1	-1.0	-1.8	-0.7	-1.3	-0.6	-1.0	-0.7
Whole body fat mass	0.9	3.7	17.7	-1.5	-0.7	-1.5	0.1	-2.6	-0.9	-4.2	-0.7	-0.4	2.5	-1.9
Leg fat mass (right)	0.9	3.6	18.3	-1.1	-0.5	-1.2	0.6	-2.4	-0.6	-4.3	-0.4	-0.1	2.9	-1.7
Age at last live birth	0.9	1.2	2.3	-0.5	1.5	1.0	1.2	1.1	1.5	0.8	1.1	1.2	-0.1	1.3
Ever had prostate specific antigen (PSA) test	0.9	1.1	4.0	0.8	0.8	0.7	0.7	2.0	1.3	1.3	0.9	0.6	-0.5	1.1
Alcohol drinker status: Previous	0.9	1.0	4.1	0.5	0.7	1.3	0.6	-0.1	0.6	-0.8	1.0	1.3	2.0	0.7
Leg fat mass (left)	0.9	3.4	17.0	-1.2	-0.5	-1.3	0.6	-2.3	-0.7	-4.1	-0.5	-0.2	2.8	-1.7
Ulcerative Colitis	0.8	1.1	5.2	-0.1	-0.4	-0.5	0.7	-1.1	-0.2	-2.3	-0.5	-0.2	1.7	-1.2
Average weekly spirits intake	0.8	1.0	4.6	0.8	0.7	1.0	-0.5	1.4	0.8	2.1	0.8	0.5	0.3	1.0
Relative age of first facial hair	0.8	1.7	6.9	1.5	1.2	0.2	1.8	-0.7	1.0	-2.6	0.9	1.4	-0.3	0.5
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.1	0.3	-0.9	-0.9	0.4	-1.5	-1.0	-1.3	-1.4	-1.0	-0.4	-0.9
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	1.7	-0.5	-1.0	-1.2	-0.6	-0.7	-1.3	-0.9	-1.1	-1.1	0.2	-1.3
Chronic bronchitis/emphysema (father)	0.8	0.9	5.6	0.0	0.1	0.2	-0.7	-0.7	-0.0	-2.4	0.3	0.0	1.8	-0.8
Pulse rate	0.8	1.4	6.9	0.0	0.7	0.6	0.4	-0.9	1.0	-2.6	0.5	0.6	2.2	-0.5
Depression (self-reported)	0.8	0.9	2.7	0.9	1.2	0.5	0.3	0.7	0.6	-0.8	1.3	1.2	1.7	0.8
Pulse wave reflection index	0.8	1.0	5.9	0.1	0.4	0.4	0.3	1.4	-0.6	2.4	0.5	0.7	-0.6	1.0
Number of full brothers	0.8	1.0	5.9	2.4	0.9	0.4	1.2	0.3	-0.4	-0.6	0.5	1.2	0.7	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	6.3	0.7	0.6	0.8	0.7	0.4	0.4	-0.4	0.7	1.0	2.5	0.2
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	4.3	-2.1	-0.6	-0.6	-1.6	-0.8	0.0	-0.8	-0.4	-1.2	0.2	-1.0
Basal cell carcinoma (self-reported)	0.8	1.0	5.5	0.5	-0.3	-0.5	-0.5	0.7	-0.3	1.7	-0.2	-0.7	-2.4	0.1
Bipolar Disorder or Schizophrenia	0.7	1.6	8.7	1.6	-0.1	-1.8	0.4	-0.5	-0.9	-2.9	-0.7	-0.2	0.1	-1.4
Schizophrenia (2018)	0.7	1.4	10.2	0.8	0.3	-1.1	0.3	-0.5	-0.1	-3.2	-0.2	0.0	0.8	-1.4
Worry (Nagel 2018)	0.7	1.6	2.8	-1.5	-1.2	-1.4	-1.7	-1.4	-0.5	-1.2	-0.6	-1.7	0.9	-1.1
Alzheimer’s Disease (in mother)	0.7	0.8	3.0	-0.9	-0.3	-0.2	0.7	-0.9	0.4	-1.7	-0.1	-0.0	1.7	-0.9
HDL Cholesterol	0.7	1.2	5.2	-0.7	-0.7	-1.2	-0.1	-1.3	-0.5	-2.3	-0.8	-1.2	0.0	-1.4
Neuroticism (2016)	0.7	1.0	7.3	0.5	-0.3	0.1	-0.1	-1.6	-0.4	-2.7	0.1	0.0	0.0	-0.8
Lung FVC	0.7	3.8	8.9	2.7	2.4	2.0	1.8	1.7	3.0	0.6	2.0	1.9	0.7	1.3
Number of treatments/medications taken	0.7	1.3	9.1	0.4	0.8	1.2	0.0	0.0	0.4	-1.1	0.9	0.8	3.0	0.3
Sensitivity / hurt feelings	0.7	1.1	4.6	0.1	1.2	0.5	0.4	1.7	2.1	0.3	1.3	0.4	0.8	0.7
Relative age voice broke	0.7	1.1	2.8	1.5	1.1	0.4	1.5	-0.1	1.1	-1.7	0.8	1.0	0.4	0.6
Serious illness, injury or assault to yourself	0.7	0.8	3.0	-0.1	0.9	0.8	1.7	1.2	0.8	1.0	0.5	0.8	0.5	0.5
Medication: Atenolol	0.7	0.8	5.8	0.4	-0.1	0.9	-1.2	-0.4	-0.5	0.0	0.4	0.2	2.4	0.3
Had menopause	0.7	0.9	2.7	-0.1	-1.2	-1.2	0.5	-0.5	-0.9	-0.3	-1.4	-1.6	0.3	-1.0
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	4.3	-0.6	-0.3	-0.6	-0.6	-0.8	-1.1	-2.1	-0.0	-0.1	0.8	-0.9
Qualifications: None of the above	0.7	1.5	3.6	-0.4	-1.7	-1.1	-1.9	-1.3	-1.5	-0.2	-1.3	-1.4	0.3	-0.8
Diabetes (self-reported)	0.7	1.1	6.4	0.2	0.8	1.0	-0.2	-0.6	0.1	-1.0	0.7	1.2	2.5	0.2
Diabetes diagnosed by doctor	0.7	1.2	6.2	-0.4	0.6	0.8	-0.7	-0.7	0.3	-1.6	0.7	1.0	2.5	-0.1
Qualifications: nursing, teaching	0.7	1.1	7.0	-0.6	-0.0	-0.6	0.8	-0.9	0.7	-2.6	-0.3	-0.4	-0.5	-1.4
Commuting to job workplace: Public transport	0.7	0.9	4.0	-0.3	0.6	0.5	1.2	0.3	0.1	1.0	0.9	0.5	2.0	1.2
Illnesses of father: High blood pressure	0.7	0.9	1.5	-1.2	-1.2	-0.9	-1.1	-1.2	-0.6	-0.3	-1.1	-1.2	0.1	-1.0
Schizophrenia (2014)	0.6	1.4	8.5	1.8	0.6	-0.8	1.0	-0.3	0.1	-2.9	-0.1	0.4	0.7	-0.9
Hypothyroidism (self reported)	0.6	1.3	4.4	1.3	1.5	0.6	1.0	1.2	2.1	0.6	0.9	1.1	0.7	0.9
Neuroticism	0.6	1.4	7.0	-0.9	-0.5	-0.7	-0.8	-1.3	-0.3	-1.9	0.3	-0.6	2.6	-0.7
Impedance of leg (left)	0.6	2.8	14.0	0.2	-1.0	-1.6	-0.2	-2.3	-1.0	-3.7	-1.1	-1.1	0.9	-1.7
Waist circumference	0.6	2.1	11.3	-0.2	0.9	0.7	1.1	-0.5	1.0	-2.2	0.9	1.3	3.4	0.1
Alcohol intake versus 10 years previously	0.6	0.8	4.3	0.4	0.6	0.7	0.2	-0.0	0.8	-1.3	0.7	1.0	2.1	0.3
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.7	-0.5	-0.5	-0.6	-1.2	-1.1	-0.7	-1.3	0.2	-0.5	1.0	-0.9
Medication: Paracetamol	0.6	1.0	3.9	0.6	1.0	1.1	0.4	0.2	2.0	0.0	1.3	0.3	1.7	0.2
Medication: Amlodipine	0.6	0.8	2.7	-0.6	-0.9	0.2	-1.6	0.1	-0.8	1.1	-0.3	-0.9	1.5	0.5
Eye problems/disorders: None of the above	0.6	0.7	2.3	-0.7	-0.7	-0.5	0.2	-1.3	-1.0	-1.4	-0.1	-0.3	1.5	-0.3
Leg pain on walking	0.6	0.7	4.2	0.6	0.5	-0.0	0.9	0.5	-0.4	-2.0	-0.0	0.8	0.8	-0.7
Ever had bowel cancer screening	0.6	0.7	1.8	-1.4	-0.9	-1.1	-0.4	-0.4	-0.3	-0.3	-1.1	-1.3	-0.5	-0.4
Medication: Paracetamol	0.6	0.9	3.1	0.0	0.8	1.0	-0.4	-0.2	1.6	-0.8	1.3	0.4	1.8	0.0
Average weekly beer plus cider intake	0.6	0.8	3.3	0.1	0.3	0.2	0.9	-1.2	-0.0	-1.6	0.7	0.6	1.8	-0.4
Bipolar Disorder (2018)	0.5	0.8	2.5	1.6	-0.5	-1.4	0.2	-0.2	-1.3	-0.7	-0.9	-0.4	-0.9	-0.7
Neuroticism (Nagel 2018)	0.5	1.2	4.4	-0.9	-0.1	-0.8	-0.3	-0.4	1.0	-2.1	0.3	-0.8	2.1	-0.9
Bipolar Disorder (2011)	0.5	0.5	3.8	1.9	0.4	-0.8	0.1	0.6	-0.5	-0.6	-0.1	0.4	0.0	0.2
Primary Biliary Cirrhosis	0.5	0.7	1.3	-0.3	-0.6	-1.1	-0.9	-0.9	-0.7	-1.1	-0.8	-0.9	-0.5	-1.0
Systolic Blood Pressure	0.5	2.3	11.2	1.4	0.4	0.4	-0.9	1.9	-0.3	3.3	-0.5	0.0	-2.3	1.4
Type 2 Diabetes (T2D) (2018)	0.5	1.0	3.9	-0.3	0.2	0.5	-0.9	-1.2	-0.6	-1.8	0.4	0.7	2.0	-0.4
Impedance of leg (right)	0.5	2.5	16.1	1.0	-0.3	-0.8	0.5	-2.1	-0.5	-4.0	-0.4	-0.3	1.6	-1.4
Townsend deprivation index at recruitment	0.5	0.6	3.4	0.6	0.6	0.9	-0.1	0.0	0.4	-0.3	1.3	0.4	1.8	-0.3
High blood pressure (mother)	0.5	0.7	1.5	-0.4	-0.8	-0.5	-1.0	-0.3	-1.2	-0.5	-1.0	-1.1	1.1	-0.8
Pain all over the body in last month	0.5	0.5	2.3	1.5	0.7	0.6	0.1	0.8	0.6	0.3	0.4	0.3	1.1	0.7
Father’s age at death	0.5	0.6	3.5	-1.1	-0.5	-0.5	0.4	0.2	0.1	1.0	-0.4	-0.7	-1.9	0.5
Birth weight of first child	0.5	0.9	1.8	0.3	1.2	0.8	1.3	1.2	0.5	0.7	1.0	1.0	-1.1	1.1
Loud music exposure frequency	0.5	0.5	1.0	-0.5	-0.9	-0.9	-1.0	-0.5	-1.0	0.2	-0.8	-0.8	0.4	-0.3
Worry too long after embarrassment	0.5	0.8	2.5	-0.1	1.3	0.2	0.3	0.5	1.6	-1.2	1.6	0.7	0.7	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	3.3	-0.7	-0.3	-0.4	-0.0	-0.5	0.4	-1.3	0.2	-0.9	1.8	-0.7
Medication for pain relief, constipation, heartburn	0.5	0.8	4.4	0.0	-0.1	-1.1	1.3	0.8	-0.5	0.6	-0.7	0.0	-2.1	0.4
Eye problems/disorders: Cataract	0.5	0.6	2.7	-0.1	0.9	0.9	0.1	0.6	1.7	0.7	0.7	0.6	0.0	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	4.7	0.3	0.2	0.4	-0.9	-0.4	0.2	-0.4	0.4	0.1	2.2	-0.1
Illnesses of father: None of the above (group 1)	0.5	0.6	4.2	0.6	-0.0	-0.6	0.6	-0.1	-0.9	0.0	0.0	-0.1	-2.0	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.7	0.2	1.0	1.4	0.6	1.6	0.8	1.3	0.9	1.2	0.4	1.3
Arm fat mass (left)	0.5	1.9	8.6	-1.1	-0.4	-1.1	0.3	-1.8	-0.5	-2.9	-0.5	-0.2	2.0	-1.2
Average weekly champagne plus white wine intake	0.5	0.6	4.0	-2.0	-0.7	-0.7	-0.6	-0.6	-0.2	-0.2	-0.5	-0.9	0.0	-0.1
Ever taken oral contraceptive pill	0.5	0.6	2.3	0.1	-0.2	-0.3	0.9	0.6	-1.5	1.2	-0.7	0.2	-1.0	0.0
Hearing aid user	0.5	0.6	1.7	0.9	0.8	0.4	1.2	1.1	1.3	0.0	0.3	0.6	-0.1	0.4
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.4	-0.9	-0.9	-0.5	-0.9	-0.2	0.2	-0.2	-0.9	-1.0	-0.8	-1.2
Number of operations (self-reported)	0.5	0.8	2.8	-1.7	-0.6	0.0	-1.6	0.3	-0.1	1.3	-0.5	-0.6	-0.5	0.0
Irritability	0.5	0.8	5.3	0.3	0.3	0.3	0.8	-0.3	0.5	-1.4	0.6	0.2	2.3	-0.3
Age started oral contraceptive pill	0.5	0.7	1.4	-1.0	-0.9	-0.4	-0.7	-0.2	-0.5	1.2	-1.0	-1.1	-0.9	-0.2
Unable to work because of sickness or disability	0.5	0.6	3.2	0.4	0.4	0.5	0.6	0.0	0.6	-1.2	0.7	0.3	1.8	-0.1
Impedance of whole body	0.5	2.4	7.1	-0.5	-1.5	-1.7	-0.8	-2.3	-1.3	-2.7	-1.3	-1.5	0.4	-1.6
Schizophrenia vs Biploar Disorder	0.4	0.5	1.8	-1.1	-0.1	0.3	0.5	-0.8	0.7	-1.1	0.2	-0.2	1.3	-0.2
Breast Cancer	0.4	0.9	5.0	-0.0	0.1	0.5	-0.1	1.4	0.6	2.2	0.1	-0.1	-1.3	0.5
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.7	0.1	-0.5	-0.3	-0.1	-1.1	-0.6	-1.2	0.1	-0.5	1.3	-0.9
Hearing difficulty/problems: Yes	0.4	0.6	1.8	-0.7	-0.8	-0.8	-1.3	-0.7	-0.3	-0.3	-1.2	-0.8	0.4	-0.4
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.3	0.5	0.5	0.9	-1.1	0.5	0.7	0.6	0.5	0.7	-0.2	0.5
Severe depression (siblings)	0.4	0.4	1.9	0.4	0.6	0.4	0.8	-0.0	1.0	-1.4	0.6	0.3	0.1	-0.3
Maternal smoking around birth	0.4	0.6	1.3	0.1	0.6	0.6	-1.1	-0.2	1.1	-1.1	0.9	0.9	1.0	-0.2
Taking other prescription medications	0.4	0.6	4.5	-0.0	0.5	0.3	-0.2	-0.2	0.7	-0.8	0.6	0.4	2.1	0.4
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.5	-1.1	-0.2	-0.4	0.3	-0.5	-0.3	-1.2	-0.2	-0.2	0.9	-0.4
Medication: Levothyroxine sodium	0.4	0.7	1.2	-0.1	-0.7	-0.8	-0.8	-0.9	0.3	-1.0	-1.0	-0.9	0.8	-1.1
Sitting height	0.4	2.9	9.9	-2.1	1.4	0.4	1.0	-0.8	2.0	-3.1	1.9	1.3	1.9	-0.2
Neuroticism score	0.4	0.7	4.6	-0.4	0.3	0.0	0.2	-0.1	0.7	-1.4	0.9	0.0	2.1	-0.1
Weight	0.4	2.1	7.6	-2.4	-0.6	-1.3	-0.4	-1.9	-0.7	-2.8	-0.4	-0.1	1.2	-1.3
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.7	-0.3	-0.7	-1.1	0.8	-1.7	-0.9	-1.4	-0.6	-1.0	0.2	-0.8
Impedance of arm (left)	0.4	2.0	3.2	-1.0	-1.8	-1.8	-1.3	-1.8	-1.3	-1.2	-1.5	-1.8	-0.8	-1.2
Arm fat mass (right)	0.4	1.7	7.8	-1.0	-0.3	-0.9	0.3	-1.8	-0.6	-2.8	-0.2	-0.0	2.1	-1.0
Standing height	0.4	3.9	18.6	-4.3	-1.3	-2.0	-1.7	-2.0	-1.2	-1.8	-0.8	-0.9	-1.9	-1.4
Wheeze or whistling in the chest in last year	0.4	0.6	2.2	0.3	0.9	0.7	0.3	1.4	1.5	-0.4	0.8	0.6	0.6	-0.1
Neck or shoulder pain in last month	0.4	0.6	1.9	-1.4	-0.6	-0.4	0.0	-1.1	-0.5	-0.9	-0.6	-0.6	0.7	-0.8
Medication: Blood pressure	0.4	0.8	2.0	1.0	0.5	1.2	-0.7	1.1	0.1	1.4	0.7	0.5	0.7	0.9
Medication: Omeprazole	0.4	0.5	2.6	-1.6	-0.0	0.1	-1.2	-0.5	0.5	-0.5	0.1	-0.5	0.8	-0.4
Knee pain experienced in last month	0.4	0.6	4.0	-2.0	-0.0	-0.3	-1.1	-0.0	0.2	-0.2	-0.0	0.1	-1.0	-0.3
Arm fat percentage (left)	0.4	1.8	8.2	-0.4	-0.5	-1.0	0.4	-1.7	-0.5	-2.9	-0.5	-0.2	2.3	-1.1
Average weekly red wine intake	0.4	0.6	2.3	0.8	0.4	-0.0	1.5	0.3	0.8	0.2	-0.1	0.1	-1.4	0.9
Mood swings	0.4	0.7	4.5	-0.6	-0.3	-0.8	-0.2	-0.7	-0.2	-2.1	-0.2	-0.2	1.4	-0.2
Back pain experienced in last month	0.4	0.6	3.3	-1.8	0.1	0.4	-1.1	-0.2	-0.3	-0.5	0.4	0.3	1.3	-0.1
Asthma (self-reported)	0.4	0.8	1.5	0.8	0.9	0.4	1.0	0.9	1.2	-0.8	1.0	0.5	1.1	0.4
Mother’s age at death	0.4	0.5	2.9	0.7	-0.2	-0.3	1.7	0.4	-0.0	0.1	-0.9	-0.3	-0.7	-0.2
Eye problems/disorders: Glaucoma	0.4	0.4	1.6	0.3	-0.7	-0.4	-0.0	-0.7	-0.4	-0.4	-0.9	-0.7	0.2	-1.3
Vascular/heart problems diagnosed by doctor	0.4	1.1	8.5	-0.1	0.2	-0.5	0.8	-1.2	0.7	-2.9	0.0	0.1	-0.1	-0.9
Mean Putamen Volume	0.3	0.3	1.3	-0.8	-0.1	-0.1	-1.1	0.4	-0.2	0.6	-0.1	-0.4	-0.5	-0.4
Height	0.3	5.7	29.5	-5.4	-1.5	-2.0	-2.4	-2.0	-1.7	-2.1	-0.8	-0.9	-2.7	-0.8
Smoking Status	0.3	0.6	2.5	-0.3	0.2	0.1	-1.2	-0.5	0.6	-1.6	0.2	0.4	0.7	-1.3
Chronotype (morning person)	0.3	0.7	2.7	0.9	-0.4	-1.0	0.2	-0.7	0.4	-1.6	-0.4	-0.8	0.6	-1.1
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	1.9	-0.9	0.0	-0.2	-0.2	0.5	-0.0	0.8	-0.3	-0.5	-1.4	0.5
Ever had hysterectomy (womb removed)	0.3	0.4	2.3	-0.3	-0.4	0.3	-0.3	0.6	-0.3	1.5	-0.6	-0.5	0.8	0.1
Systolic blood pressure, automated reading	0.3	0.9	4.1	0.8	-0.4	-0.7	-0.4	0.5	-0.3	1.2	-1.2	-0.7	-2.0	-0.2
Medication for hormone replacement therapy	0.3	0.3	1.2	0.4	-0.4	-0.3	0.5	-0.4	-1.0	-1.1	-0.7	-0.4	0.2	-0.3
Fed-up feelings	0.3	0.5	1.7	-0.1	-0.6	-0.4	0.3	-0.6	-0.7	-1.3	-0.4	-0.8	1.3	-0.6
High blood pressure	0.3	0.8	4.7	-0.1	-0.5	-0.2	-0.9	0.9	-0.9	2.2	-0.6	-0.6	-0.4	0.4
Impedance of arm (right)	0.3	1.4	2.5	-1.1	-1.6	-1.4	-1.5	-1.2	-1.4	-0.3	-1.2	-1.4	-0.9	-0.7
Arm fat percentage (right)	0.3	1.2	5.1	-0.4	-0.3	-0.7	0.4	-1.3	-0.6	-2.3	-0.3	-0.0	2.1	-0.7
Worrier / anxious feelings	0.3	0.5	1.8	0.2	0.7	0.7	-0.5	0.2	1.3	-0.5	1.1	0.2	1.0	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	2.0	0.4	0.3	0.5	-1.4	0.3	0.5	-0.4	0.8	0.2	1.3	-0.0
Happiness	0.3	0.4	1.9	1.4	0.1	0.7	0.5	0.1	0.2	-0.7	0.3	0.2	0.4	-1.0
Asthma	0.3	0.5	1.4	0.9	0.8	0.2	1.2	0.8	0.9	-0.6	0.7	0.3	0.7	0.2
Exposure to tobacco smoke at home	0.3	0.3	1.6	-0.4	-0.2	0.3	-0.1	0.3	-0.4	1.2	0.3	-0.3	1.0	0.1
Peak expiratory flow (PEF)	0.3	0.7	3.2	-0.7	0.4	0.6	0.3	0.9	0.4	1.8	0.7	0.4	-1.1	0.4
Exposure to tobacco smoke outside home	0.3	0.4	1.5	0.3	0.4	0.3	0.5	1.2	-0.4	0.6	0.5	0.4	0.9	0.8
Number of children fathered	0.3	0.3	1.6	-0.4	-0.2	-0.3	0.8	0.1	-0.5	0.3	-0.6	0.1	-1.3	-0.5
Health satisfaction	0.3	0.4	0.7	-0.2	0.7	0.9	-0.2	0.6	0.5	-0.6	0.8	0.7	0.6	-0.6
Medication: Seretide 50 evohaler	0.3	0.4	1.4	-1.2	-0.5	-0.7	-1.1	-0.4	-0.3	0.3	-0.3	-0.7	0.3	-0.2
Heart disease (mother)	0.3	0.4	1.6	0.4	-0.2	-0.4	-1.0	-0.7	0.4	-0.7	0.2	-0.7	1.3	0.0
Number of full sisters	0.3	0.3	1.1	-0.2	-0.3	-0.3	-0.4	0.5	-0.8	1.0	-0.4	-0.6	-0.6	0.7
Overall health rating	0.3	0.5	1.4	-0.5	-0.6	-0.6	-1.0	-0.4	-1.2	-0.2	-0.6	-0.6	1.0	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.1	-0.4	0.6	0.7	0.5	1.0	0.1	0.1	0.8	0.5	0.4	0.7
Illnesses of siblings: Diabetes	0.3	0.3	1.4	-0.3	-0.1	0.2	0.1	-0.3	0.4	-1.1	0.3	-0.2	1.2	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	3.5	-1.1	-0.4	-0.5	-0.7	0.1	-0.5	0.9	0.0	-0.1	-1.9	-0.2
Leg fat-free mass (right)	0.3	1.4	9.6	-3.1	-0.8	-1.3	-0.9	-0.9	-0.8	-0.5	-0.4	-0.3	-0.7	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	1.6	-1.3	0.1	-0.3	-0.7	0.2	0.4	0.8	0.1	0.1	0.2	0.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	2.6	0.7	-0.3	-0.2	0.5	-0.6	0.2	-1.2	-0.3	-0.3	1.6	-0.6
Leg predicted mass (right)	0.3	1.5	9.5	-3.1	-0.8	-1.4	-0.9	-1.0	-0.9	-0.6	-0.6	-0.4	-0.8	-0.8
Financial situation satisfaction	0.3	0.4	1.0	0.3	0.2	0.0	0.8	0.9	-0.3	1.0	-0.2	0.6	-0.7	0.6
Medication: Blood pressure	0.3	0.5	2.2	-0.7	-0.7	-0.6	-1.5	0.2	-0.3	0.5	-0.8	-0.9	0.3	-0.3
Medication: Bendroflumethiazide	0.3	0.5	1.5	-0.4	-0.7	-0.5	-1.2	0.0	-0.8	0.7	-0.6	-0.6	-0.8	-0.5
Ever smoked	0.3	0.5	2.2	0.2	-0.3	-0.4	0.2	-0.8	-0.5	-1.5	-0.8	-0.2	-0.4	-1.3
Commuting to job workplace: Cycle	0.3	0.4	1.3	-1.1	-0.3	0.0	-1.1	-0.5	1.1	-0.1	0.2	-0.4	-0.5	-0.3
Pain experienced in last month	0.3	0.6	2.0	1.4	-0.5	-0.7	0.6	0.1	-0.6	0.5	-0.5	-0.9	-1.3	-0.1
Heart disease (siblings)	0.3	0.4	1.7	-0.9	-0.1	-0.3	-0.1	0.6	0.6	1.3	-0.4	-0.1	0.3	0.9
Ovarian Cancer	0.2	0.2	1.3	-0.9	-0.0	-0.2	-0.4	0.1	-0.0	0.5	0.2	0.3	-1.1	0.1
Prostate Cancer	0.2	0.3	1.2	-0.1	0.6	0.6	0.1	0.7	0.8	0.2	1.1	0.4	0.1	0.6
Age at First Birth	0.2	0.4	0.9	0.4	0.5	0.4	0.1	0.7	0.9	0.9	0.3	0.4	-0.7	0.6
BMI	0.2	1.0	3.1	-0.7	-0.4	-0.5	0.6	-1.3	-0.9	-1.8	-0.4	0.1	1.7	-1.1
Hand grip strength (left)	0.2	0.4	1.7	0.5	-0.6	-0.3	0.2	-0.9	-1.3	-0.2	-0.3	0.1	-0.9	-0.8
Leg fat-free mass (left)	0.2	1.1	7.1	-2.7	-0.6	-1.1	-0.5	-1.0	-0.7	-1.0	-0.3	-0.0	-0.1	-0.7
Hand grip strength (right)	0.2	0.4	2.5	0.0	-0.4	-0.3	0.6	-0.3	-0.8	0.6	-0.3	-0.1	-1.6	-0.6
Age when periods started (menarche)	0.2	0.6	3.3	-0.8	-0.4	-0.8	-0.2	-0.0	-0.0	0.0	-0.2	-0.6	-1.8	-1.0
Body mass index (BMI)	0.2	0.9	4.3	-0.4	0.0	-0.4	0.6	-1.0	-0.2	-1.9	-0.0	0.3	2.1	-0.7
Leg predicted mass (left)	0.2	1.1	7.3	-2.7	-0.5	-1.1	-0.4	-1.0	-0.7	-1.1	-0.2	-0.0	-0.1	-0.7
Had other major operations	0.2	0.3	0.9	-0.1	0.5	-0.1	0.7	-0.1	0.7	-1.0	0.3	0.1	0.6	-0.6
Forced vital capacity (FVC)	0.2	0.9	2.5	-1.4	1.1	0.6	-0.4	0.1	1.5	-0.1	1.6	1.0	-0.5	0.3
Illnesses of siblings	0.2	0.2	0.8	-0.5	-0.0	-0.1	0.4	-0.5	-0.9	-0.6	0.4	0.5	-0.7	-0.1
Number of live births	0.2	0.3	1.5	-1.2	-0.1	-0.2	0.1	-0.7	0.2	-1.0	-0.3	-0.0	0.4	-0.3
Lung cancer (father)	0.2	0.3	0.7	0.8	0.5	0.3	0.3	0.6	-0.3	0.5	0.3	0.7	0.1	0.8
Blood clot in the leg (DVT)	0.2	0.2	0.9	-1.0	-0.1	0.0	-0.0	0.7	0.4	0.9	0.2	-0.4	-0.0	-0.0
Glaucoma (self-reported)	0.2	0.3	1.3	0.7	0.1	0.6	0.1	-0.4	0.6	-0.3	0.1	0.1	1.2	-0.4
Hypothyroidism/myxoedema (self-reported)	0.2	0.5	2.1	0.9	0.7	0.1	-0.1	0.1	1.4	-0.5	0.2	0.5	1.0	0.3
High blood pressure (siblings)	0.2	0.3	0.9	0.8	0.2	0.4	-0.4	0.6	0.6	1.0	-0.1	-0.4	0.5	0.2
Arm fat-free mass (right)	0.2	1.0	4.2	-1.8	-0.2	-1.0	0.2	-1.1	-0.2	-2.0	-0.2	-0.0	0.3	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.8	-0.2	-0.0	-0.2	0.8	0.9	-0.0	0.7	-0.3	-0.5	-0.2	-0.0
Age at first live birth	0.2	0.4	1.2	-0.8	0.9	0.2	0.2	0.1	0.8	0.1	0.7	0.4	-1.1	0.5
Shortness of breath walking on level ground	0.2	0.2	1.0	0.5	0.3	0.5	-0.3	1.0	0.4	0.1	0.2	0.3	0.5	-0.5
Qualifications: College or University degree	0.2	0.6	3.1	-0.7	0.5	-0.1	1.8	0.1	1.5	-0.4	0.4	0.0	-0.1	0.2
Arm predicted mass (right)	0.2	1.2	4.8	-2.0	-0.3	-1.1	0.1	-1.3	-0.3	-2.2	-0.3	-0.1	0.2	-1.1
Chest pain or discomfort	0.2	0.2	1.5	0.0	0.4	0.3	0.0	0.6	0.4	0.2	0.4	-0.1	1.2	0.0
Hypertension (Self-reported)	0.2	0.6	3.0	0.2	-0.6	-0.3	-1.2	0.6	-0.8	1.7	-0.7	-0.6	0.3	0.2
Whole body fat-free mass	0.2	1.1	7.3	-2.7	-0.5	-1.1	-0.5	-0.7	-0.6	-0.8	-0.3	-0.2	-0.7	-0.6
Long-standing illness, disability or infirmity	0.2	0.2	1.1	-0.1	-0.2	-0.5	-0.0	-0.0	-0.5	-0.4	-0.6	-0.6	1.1	-0.3
Medication: Gliclazide	0.2	0.2	0.5	0.5	0.4	0.0	-0.5	-0.3	-0.1	-0.7	0.3	0.5	0.7	0.2
Whole body water mass	0.2	1.1	7.0	-2.6	-0.5	-1.2	-0.6	-0.7	-0.6	-0.9	-0.4	-0.2	-0.8	-0.7
Basal metabolic rate	0.2	1.3	7.3	-2.7	-0.6	-1.3	-0.5	-1.1	-0.7	-1.5	-0.4	-0.2	-0.2	-0.8
Arm fat-free mass (left)	0.2	1.2	4.3	-2.1	-0.4	-1.2	-0.2	-1.3	-0.5	-2.0	-0.3	-0.1	0.4	-0.9
Risk taking	0.2	0.3	1.8	-1.3	-0.2	-0.3	-0.9	0.1	0.1	0.3	-0.3	-0.1	-0.5	0.0
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.7	-0.8	-0.3	-0.2	-0.0	0.6	0.1	0.6	-0.1	-0.6	-0.5	-0.2
Arm predicted mass (left)	0.2	0.8	3.7	-1.9	-0.2	-0.9	-0.0	-0.8	-0.4	-1.6	-0.1	0.0	0.2	-0.7
Allergy or Eczema	0.1	0.3	1.0	0.2	-0.7	-0.5	-0.3	-0.2	-0.1	-0.3	-0.9	-1.0	-0.2	0.0
Respiratory disease	0.1	0.3	1.4	-0.4	-0.1	-0.5	-0.5	-0.0	0.6	-0.3	0.1	-0.5	1.2	-0.1
Lung FEV1/FVC ratio	0.1	0.3	1.3	0.1	-0.3	-0.2	0.5	0.8	-1.0	1.1	-0.1	-0.1	-0.3	0.2
Hair Pigment	0.1	1.8	5.0	1.5	1.5	1.4	2.2	1.3	1.0	0.1	1.1	1.5	-0.1	1.3
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.3	0.5	-0.4	-0.6	-0.3	-0.3	-0.1	-0.5	-0.6	-0.5	-0.1	-0.1
Allergy	0.1	0.1	0.3	-0.5	0.1	0.5	-0.2	-0.1	-0.1	0.5	0.1	0.5	-0.4	0.1
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.9	0.4	0.3	-0.3	1.0	0.1	0.0	-0.2	-0.1	0.1	0.6	0.3
Trunk fat-free mass	0.1	0.8	6.3	-2.5	-0.3	-0.9	-0.4	-0.3	-0.4	-0.5	-0.2	-0.1	-1.1	-0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.7	-1.1	0.7	0.3	-0.3	-0.0	1.0	-0.3	1.3	0.7	0.1	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.4	1.6	-1.3	0.6	0.3	-0.0	0.1	0.6	-0.1	1.0	0.8	0.4	0.2
Trunk predicted mass	0.1	0.8	6.2	-2.5	-0.3	-0.8	-0.4	-0.3	-0.5	-0.4	-0.2	-0.0	-1.2	-0.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.7	-0.4	-0.1	-0.5	0.1	-0.7	-0.3	-0.8	0.3	-0.2	-0.4	-0.4
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.7	-0.8	0.0	-0.1	-0.4	-0.0	-0.2	0.1	0.2	0.2	0.2	0.1
Forced vital capacity (FVC), Best measure	0.1	0.5	1.9	-1.4	0.7	0.3	-0.3	-0.4	0.9	-0.6	1.1	0.8	0.2	-0.1
Friendships satisfaction	0.1	0.2	0.5	0.7	-0.3	0.3	0.2	0.4	-0.1	0.1	-0.4	-0.5	0.3	-0.7
Osteoporosis (self-reported)	0.1	0.1	0.4	-0.4	0.1	0.4	-0.6	-0.3	-0.1	0.3	-0.0	0.1	0.1	0.5
Medication: Lisinopril	0.1	0.2	0.7	-0.8	-0.1	0.5	-0.2	0.1	0.4	0.4	-0.0	-0.3	0.8	0.0
Tanning	0.0	0.2	0.8	-0.9	0.1	-0.5	-0.0	0.6	0.3	0.1	-0.2	0.0	0.4	0.6

Hub : Genes

LPIN3

Models

Trait associations