[Hub]/) : Traits : High cholesterol (Self-reported) : ←

chr20:61,800,907-62,912,463

Best TWAS P=1.15e-12 · Best GWAS P=3.21e-12 conditioned to 0.0262

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TPD52L2	0.13	0.07	bslmm	418	0.08	4.5e-10	-3.5	5.1	3.0e-07	0.27	0.99	0.01	FALSE
2	GTEx	Adrenal Gland	OPRL1	0.48	0.29	enet	21	0.22	1.5e-08	-6.0	-5.7	1.2e-08	-0.78	0.02	0.98	FALSE
3	GTEx	Adrenal Gland	RGS19	0.32	0.20	lasso	8	0.21	5.8e-08	-6.0	-5.2	1.6e-07	-0.79	0.10	0.80	FALSE
4	GTEx	Artery Aorta	OPRL1	0.27	0.19	lasso	4	0.17	1.4e-09	-6.0	-6.2	6.3e-10	-0.80	0.19	0.81	FALSE
5	GTEx	Artery Aorta	TCEA2	0.09	0.04	lasso	3	0.03	1.3e-02	-6.0	5.5	3.5e-08	0.76	0.01	0.98	FALSE
6	GTEx	Artery Tibial	OPRL1	0.10	0.10	lasso	2	0.06	1.1e-05	-6.0	-6.2	4.6e-10	-0.88	0.04	0.96	FALSE
7	GTEx	Artery Tibial	RGS19	0.12	0.07	lasso	2	0.07	2.8e-06	6.6	-6.7	2.8e-11	-0.95	0.01	0.99	FALSE
8	GTEx	Brain Cerebellar Hemisphere	OPRL1	0.27	0.14	lasso	7	0.17	4.4e-05	-6.0	-6.0	2.5e-09	-0.77	0.02	0.75	FALSE
9	GTEx	Brain Cerebellar Hemisphere	RGS19	0.36	0.10	lasso	5	0.07	8.2e-03	-5.9	-5.3	9.3e-08	-0.59	0.02	0.59	FALSE
10	GTEx	Brain Cerebellum	RGS19	0.28	0.22	lasso	4	0.18	7.2e-06	-6.0	-5.8	5.1e-09	-0.81	0.02	0.91	FALSE
11	GTEx	Cells Transformed fibroblasts	OPRL1	0.25	0.07	enet	13	0.12	5.5e-09	5.8	-6.2	4.9e-10	-0.72	0.20	0.80	FALSE
12	GTEx	Cells Transformed fibroblasts	RGS19	0.37	0.28	lasso	8	0.29	3.2e-22	6.6	-7.1	1.4e-12	-0.93	0.01	0.99	FALSE
13	GTEx	Colon Sigmoid	RGS19	0.27	0.07	enet	33	0.09	3.8e-04	-5.7	-6.9	6.0e-12	-0.61	0.04	0.93	FALSE
14	GTEx	Esophagus Mucosa	RGS19	0.43	0.28	enet	17	0.34	7.9e-24	-6.0	-6.6	4.5e-11	-0.91	0.00	1.00	FALSE
15	GTEx	Esophagus Muscularis	OPRL1	0.17	0.14	lasso	1	0.13	4.7e-08	-6.0	-6.0	2.5e-09	-0.84	0.07	0.93	FALSE
16	GTEx	Esophagus Muscularis	RGS19	0.22	0.10	lasso	4	0.10	1.6e-06	-6.0	-6.4	1.1e-10	-0.80	0.09	0.90	FALSE
17	GTEx	Muscle Skeletal	RGS19	0.26	0.16	lasso	4	0.16	5.1e-15	6.6	-6.7	1.6e-11	-0.94	0.01	0.99	FALSE
18	GTEx	Nerve Tibial	OPRL1	0.20	0.15	lasso	3	0.14	3.3e-10	-6.0	-6.1	1.3e-09	-0.82	0.27	0.73	FALSE
19	GTEx	Pancreas	OPRL1	0.39	0.27	lasso	5	0.32	6.9e-14	-6.0	-6.7	1.9e-11	-0.90	0.02	0.98	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	RGS19	0.51	0.28	enet	28	0.32	4.3e-18	-6.0	-6.4	2.0e-10	-0.80	0.01	0.99	FALSE
21	GTEx	Skin Sun Exposed Lower leg	OPRL1	0.14	0.10	lasso	6	0.11	4.4e-09	6.6	-6.9	5.7e-12	-0.93	0.01	0.99	FALSE
22	GTEx	Skin Sun Exposed Lower leg	RGS19	0.42	0.26	lasso	6	0.33	4.6e-28	-6.0	-6.8	9.8e-12	-0.95	0.00	1.00	FALSE
23	GTEx	Stomach	OPRL1	0.36	0.23	enet	16	0.19	1.3e-09	-6.0	-5.8	8.6e-09	-0.75	0.18	0.82	FALSE
24	GTEx	Stomach	RGS19	0.18	0.25	lasso	2	0.25	2.2e-12	-6.0	-6.0	2.4e-09	-0.84	0.40	0.60	FALSE
25	GTEx	Thyroid	RGS19	0.23	0.14	enet	11	0.19	3.3e-14	6.6	-6.7	1.7e-11	-0.92	0.00	1.00	FALSE
26	GTEx	Vagina	RGS19	0.39	0.08	lasso	8	0.03	7.5e-02	6.6	-6.7	2.3e-11	-0.91	0.01	0.85	FALSE
27	GTEx	Whole Blood	OPRL1	0.09	0.06	enet	8	0.07	4.3e-07	7.0	7.0	2.8e-12	0.92	0.00	1.00	FALSE
28	ROSMAP	Brain Pre-frontal Cortex	C20orf201	0.10	0.09	enet	9	0.10	9.9e-13	-5.9	6.9	5.4e-12	0.68	0.20	0.80	FALSE
29	YFS	Blood	OPRL1	0.07	0.07	lasso	5	0.09	5.0e-27	-6.0	6.5	6.6e-11	0.82	0.19	0.81	FALSE
30	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C20orf201	0.05	0.00	enet	12	0.01	6.8e-02	3.7	5.8	6.6e-09	0.57	0.01	0.32	FALSE
31	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RGS19	0.04	0.04	blup	48	0.03	1.1e-03	-6.0	-5.2	1.9e-07	-0.71	0.01	0.84	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	C20orf201	0.03	0.01	lasso	4	0.01	2.3e-03	-5.9	6.0	1.7e-09	0.61	0.27	0.28	FALSE
33	The Cancer Genome Atlas	Colon Adenocarcinoma	RGS19	0.09	0.04	enet	4	0.04	2.8e-03	-5.6	-5.8	6.7e-09	-0.59	0.06	0.75	FALSE
34	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RGS19	0.06	0.06	blup	47	0.05	1.4e-06	-6.0	-6.4	2.1e-10	-0.80	0.00	1.00	FALSE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	OPRL1	0.03	0.02	lasso	1	0.01	3.5e-02	-6.0	-6.0	2.5e-09	-0.84	0.01	0.86	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RGS19	0.05	0.02	blup	48	0.02	1.1e-03	4.6	-5.7	1.4e-08	-0.75	0.01	0.97	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	OPRL1	0.07	0.08	lasso	4	0.08	7.8e-09	-5.9	-6.4	1.9e-10	-0.68	0.51	0.49	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	RGS19	0.07	0.05	blup	48	0.07	1.1e-07	-5.9	-7.1	1.1e-12	-0.79	0.03	0.97	TRUE
39	The Cancer Genome Atlas	Testicular Germ Cell Tumors	RGS19	0.18	0.08	enet	10	0.07	2.2e-03	4.6	-6.1	1.4e-09	-0.61	0.12	0.28	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	RGS19	0.07	0.04	blup	48	0.06	8.4e-07	5.5	-5.4	5.0e-08	-0.60	0.28	0.67	FALSE