Best TWAS P=8.63e-10 · Best GWAS P=4.47e-16 conditioned to 7.64e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ATXN2 | 0.02 | 0.03 | enet | 8 | 0.02 | 4.8e-04 | -3.5 | 5.1 | 2.9e-07 | 0.57 | 0.22 | 0.70 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | HECTD4 | 0.06 | 0.00 | enet | 15 | 0.02 | 1.0e-02 | -3.1 | 5.9 | 2.9e-09 | 0.66 | 0.07 | 0.81 | FALSE |
| 3 | GTEx | Artery Tibial | HECTD4 | 0.05 | 0.02 | lasso | 3 | 0.01 | 3.1e-02 | 6.8 | 6.1 | 8.6e-10 | 0.81 | 0.02 | 0.91 | TRUE |
| 4 | YFS | Blood | SH2B3 | 0.05 | 0.01 | enet | 22 | 0.02 | 3.3e-07 | -4.3 | 5.7 | 9.6e-09 | 0.66 | 0.37 | 0.63 | FALSE |
| 5 | YFS | Blood | TRAFD1 | 0.04 | 0.02 | lasso | 2 | 0.01 | 2.9e-05 | 4.3 | 5.1 | 2.7e-07 | 0.54 | 0.09 | 0.85 | FALSE |