Hub : Genes

TRAFD1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0220 0.0150 0.0049 0.028 0.018 0.007 0.019 0.014 2.3e-04 2.6e-03 4.4e-02 2.0e-03 0.00760
2 YFS Blood 0.0414 0.0212 0.0081 0.016 0.012 0.013 0.012 0.013 4.0e-06 5.3e-05 3.3e-05 7.7e-05 0.00003

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.2 2.0 3.1 1.8 0.9
Bipolar Disorder or Schizophrenia 0.4 1.0 1.7 1.3 0.5
Depressed Affect (Nagel 2018) 3.4 7.2 11.1 1.8 -3.3
Depression (Nagel 2018) 4.2 6.3 10.0 3.2 -1.6
Intelligence (Savage-Jansen 2018) 0.8 2.3 4.6 -2.1 -0.2
Neuroticism (Nagel 2018) 1.3 3.1 3.2 1.8 -1.7
Schizophrenia (2018) 0.0 0.0 0.1 0.2 -0.0
Schizophrenia vs Biploar Disorder 1.5 2.0 3.6 -1.9 -0.5
Worry (Nagel 2018) 0.7 1.4 2.6 1.6 -0.3
Alzheimer’s Disease (in mother) 0.1 0.2 0.3 0.6 -0.1
Alzheimer’s Disease (in father) 0.7 0.8 1.5 0.2 -1.2
Alzheimer’s Disease (including proxy) 0.9 1.4 1.7 1.0 -1.3
Crohns Disease (2017) 4.6 10.1 20.2 0.0 4.5
Irritable Bowel Disease (IBD) 6.1 14.6 28.2 -1.0 5.3
Ulcerative Colitis (UC) 4.3 8.0 14.1 -1.4 3.8
Major Depression (MDD) 0.1 0.1 0.1 0.2 -0.3
Reaction Time 6.1 11.6 16.6 -4.1 2.6
Verbal and Numeric Reasoning (VNR) 2.1 5.1 6.7 -2.6 -1.9
Breast Cancer 0.0 0.0 0.0 0.0 0.0
Ovarian Cancer 0.2 0.2 0.5 0.0 -0.7
Prostate Cancer 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.1 0.2 0.3 -0.3 0.6
Bipolar Disorder (2011) 0.5 0.5 1.0 1.0 0.0
Body Mass Index (BMI) (2010) 3.0 4.2 8.0 -0.6 -2.8
Coronary Artery Disease (CAD) 8.3 9.9 14.5 -2.3 3.8
Crohns Disease (2012) 3.9 6.3 12.7 0.1 3.6
Mean Putamen Volume 2.1 2.4 4.1 0.9 2.0
Fasting Glucose 3.4 4.1 4.6 -1.9 -2.1
HbA1C 10.0 11.1 11.4 3.3 -3.4
HDL Cholesterol 1.4 2.4 4.1 -0.8 -2.0
LDL Cholesterol 5.3 8.3 10.2 2.5 -3.2
Lupus 3.8 5.8 7.6 -2.0 2.8
Neuroticism (2016) 1.3 1.9 3.8 -0.1 -1.9
Primary Biliary Cirrhosis 7.3 10.4 13.9 -2.6 3.7
Rheumatoid Arthritis 6.1 8.4 15.5 -1.2 3.9
Schizophrenia (2014) 0.2 0.5 0.8 0.9 0.5
Triglycerides 1.0 1.6 2.6 -1.6 -0.8
Type 2 Diabetes (T2D) (2012) 0.8 0.9 1.7 -1.3 0.4
Ulcerative Colitis 3.0 4.4 8.7 -0.3 3.0
Blood Eosinophil Count 51.4 395.5 665.6 -11.2 25.8
Blood Platelet Count 29.9 346.1 686.4 2.4 26.2
Blood Red Count 11.4 109.6 112.0 -10.4 10.6
Blood White Count 23.1 171.1 256.0 -9.3 16.0
Heel T-Score 0.1 0.8 1.7 -0.2 1.3
BMI 1.8 10.6 19.4 1.3 -4.4
Height 0.2 4.2 7.8 0.8 -2.8
Waist Hip Ratio (WHR) 1.5 6.9 7.5 -2.5 2.7
Systolic Blood Pressure 9.7 48.7 49.3 -7.0 6.9
Smoking Status 2.2 5.3 6.6 -2.6 2.0
Allergy or Eczema 7.7 20.2 35.5 2.2 -6.0
Cardiovascular Disease 8.3 27.5 33.2 -4.7 5.8
Hypothyroidism (self reported) 42.8 98.3 182.2 -3.8 13.5
Respiratory disease 1.9 4.2 8.4 0.1 -2.9
Type 2 Diabetes (T2D) (2018) 2.3 4.2 4.3 -2.0 2.1
Lung FEV1/FVC ratio 1.0 4.8 8.4 1.2 -2.9
Lung FVC 1.1 5.7 11.4 0.2 3.4
Neuroticism 0.8 2.0 2.1 1.3 -1.5
Chronotype (morning person) 5.7 13.1 15.8 -4.0 3.2
Hair Pigment 0.3 9.7 16.2 1.8 -4.0
Tanning 0.8 9.3 12.3 -3.5 2.5
Hand grip strength (left) 0.9 2.3 3.4 -1.1 -1.9
Number of treatments/medications taken 6.6 11.9 18.2 -2.4 4.3
Average weekly spirits intake 0.0 0.0 0.1 -0.2 -0.0
Sensitivity / hurt feelings 0.6 1.0 2.0 -0.4 -1.4
Frequency of depressed mood in last 2 weeks 2.6 3.6 5.9 2.4 -1.1
Hearing difficulty/problems: Yes 1.0 1.5 2.6 -0.7 1.6
Relative age of first facial hair 1.8 3.6 4.5 -2.1 1.7
Other serious medical condition/disability diagnosed by doctor 3.4 4.5 8.7 -0.4 3.0
Ever used hormone-replacement therapy (HRT) 0.3 0.4 0.5 0.6 -0.7
Ever had hysterectomy (womb removed) 0.6 0.7 0.9 0.9 -0.7
Systolic blood pressure, automated reading 6.0 17.5 21.4 -4.6 3.7
Eye problems/disorders: Diabetes related eye disease 1.0 1.1 2.0 0.5 1.4
Angina 3.2 4.2 5.3 -1.8 2.3
Medication for hormone replacement therapy 0.7 0.8 1.3 1.1 0.6
Vitamin and mineral supplements 2.9 4.0 7.7 -0.5 2.8
Supplements: Zinc 3.6 4.0 7.8 0.3 -2.8
Medication: Co-codamol 0.2 0.2 0.2 0.4 -0.5
Medication: Metformin 1.8 2.6 3.6 1.9 1.2
Diabetes (father) 3.0 3.7 6.1 -2.5 1.1
Diabetes (mother) 0.1 0.1 0.2 -0.2 -0.5
Severe depression (siblings) 1.3 1.5 2.8 -0.4 -1.7
Pack years adult smoking proportion 1.6 2.5 3.4 1.8 -1.2
Impedance of leg (right) 0.7 3.4 6.4 -0.7 2.5
Leg fat-free mass (left) 2.4 12.6 22.9 1.5 -4.8
Trunk fat percentage 0.3 1.3 2.4 -0.4 -1.6
Hand grip strength (right) 2.0 5.4 9.4 -1.2 -3.1
Townsend deprivation index at recruitment 1.1 1.5 3.0 -0.3 1.7
Current tobacco smoking 0.9 1.4 2.1 0.8 -1.4
Average weekly fortified wine intake 0.1 0.2 0.3 -0.5 0.1
Maternal smoking around birth 0.5 0.8 1.2 -0.6 1.1
Fed-up feelings 3.4 6.3 9.6 1.7 -3.1
Frequency of unenthusiasm / disinterest in last 2 weeks 3.7 4.9 6.7 2.6 -1.7
Relative age voice broke 4.1 6.3 8.3 -2.9 2.1
Taking other prescription medications 6.8 10.5 17.3 -1.9 4.2
Age when periods started (menarche) 0.1 0.3 0.6 -0.8 0.3
Bilateral oophorectomy (both ovaries removed) 2.8 3.3 6.3 -0.5 -2.5
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 0.6 0.5 -0.8
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.4 0.6 0.6
Qualifications: CSEs or equivalent 1.7 2.3 3.4 -1.8 -1.1
Serious illness, injury or assault to yourself 0.6 0.7 1.4 -0.1 1.2
High blood pressure 7.6 21.1 22.0 -4.7 4.5
Hayfever, allergic rhinitis or eczema 6.7 14.6 25.0 2.0 -5.0
Multivitamins +/- minerals 2.7 3.5 6.5 0.7 -2.6
Stomach or abdominal pain in last month 0.0 0.0 0.1 -0.1 0.2
Supplements: Glucosamine 1.1 1.4 2.4 -0.7 -1.5
Diverticular disease/diverticulitis (self-reported) 4.3 5.1 7.3 1.7 -2.7
Medication: Atenolol 12.2 15.2 26.4 -2.0 5.1
Medication: Levothyroxine sodium 29.8 50.5 75.2 -5.1 8.7
Sitting height 0.0 0.1 0.1 -0.4 0.2
Chronic bronchitis/emphysema (father) 0.2 0.2 0.4 0.2 -0.6
High blood pressure (mother) 2.1 2.9 4.3 -2.1 1.2
Body mass index (BMI) 1.3 5.6 10.9 0.5 -3.3
Impedance of leg (left) 0.7 3.4 5.2 -1.2 2.3
Leg predicted mass (left) 2.3 12.3 22.3 1.5 -4.7
Trunk fat mass 0.9 4.0 7.9 0.3 -2.8
Waist circumference 0.9 3.3 5.8 0.9 -2.4
Number of incorrect matches in round 0.9 1.6 3.1 1.8 0.1
Past tobacco smoking 6.1 11.1 11.9 3.4 -3.2
Alcohol usually taken with meals 4.2 6.7 7.3 -2.7 -2.5
Nervous feelings 0.8 1.5 2.3 1.5 -0.8
Frequency of tenseness / restlessness in last 2 weeks 5.5 8.6 12.6 2.1 -3.5
Hearing difficulty/problems with background noise 0.0 0.0 0.0 0.2 -0.1
Hair/balding pattern: Pattern 2 0.4 0.5 1.0 -0.3 -1.0
Had menopause 0.3 0.4 0.7 0.3 0.9
Had other major operations 0.8 0.9 1.9 -1.4 0.1
Forced vital capacity (FVC) 0.2 0.6 1.1 1.1 0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.0 0.0 -0.1 0.2
Ever unenthusiastic/disinterested for a whole week 2.6 3.2 6.4 -0.2 -2.5
Qualifications: None of the above 0.9 1.9 3.5 -0.6 1.9
Financial difficulties in last 2 years 0.3 0.3 0.4 0.5 -0.6
Mouth/teeth dental problems 0.1 0.2 0.4 0.2 0.6
Heart attack 5.3 6.8 7.8 -2.8 2.4
Allergy 4.9 11.2 20.8 -1.3 4.6
Pain all over the body in last month 0.1 0.2 0.3 -0.5 0.2
Diabetes (self-reported) 1.5 2.4 3.7 -1.0 1.9
Hayfever/allergic rhinitis (self-reported) 3.3 4.4 7.4 1.2 -2.7
Medication: Ramipril 5.1 6.5 9.7 -3.1 1.8
Medication: Simvastatin 2.8 4.0 6.5 -1.3 2.5
Fluid intelligence score 0.6 1.3 2.0 -1.4 -0.7
Illnesses of siblings 5.7 8.0 10.2 3.2 -2.4
Neuroticism score 1.6 3.4 4.2 2.1 -1.6
Weight 2.3 11.3 21.4 1.1 -4.6
Impedance of arm (right) 2.4 11.1 22.2 -0.3 4.7
Arm fat percentage (right) 0.2 1.0 1.9 0.3 -1.4
Trunk fat-free mass 2.7 15.7 27.3 2.0 -5.2
Hip circumference 3.3 14.2 24.7 1.9 -5.0
Time employed in main current job 0.0 0.0 0.0 0.0 0.2
Alcohol intake versus 10 years previously 1.5 2.2 2.7 -1.6 1.4
Father’s age at death 5.0 6.6 12.7 0.8 -3.6
Worrier / anxious feelings 0.4 0.8 0.8 0.9 -0.8
Frequency of tiredness / lethargy in last 2 weeks 1.2 1.9 2.5 1.1 -1.6
Falls in the last year 0.1 0.2 0.3 0.0 -0.6
Hair/balding pattern: Pattern 3 0.0 0.0 0.0 -0.2 0.0
Number of live births 0.3 0.4 0.8 -0.4 0.9
Forced expiratory volume in 1-second (FEV1) 0.0 0.2 0.3 0.5 -0.2
Pulse rate 1.4 2.4 4.8 -2.2 0.1
Happiness 0.5 0.7 1.2 0.3 -1.1
Noisy workplace 0.4 0.5 0.7 -0.9 -0.6
Qualifications: A levels/AS levels or equivalent 0.4 0.9 1.2 1.1 -0.7
Serious illness, injury or assault of a close relative in last 2 years 1.7 1.9 3.8 -1.9 -0.3
Mouth/teeth dental problems: Dentures 0.8 1.4 2.3 -0.6 1.5
Asthma 1.2 2.3 4.5 0.5 -2.1
Medication: Ibuprofen (e.g. Nurofen) 3.6 4.6 6.3 1.7 -2.5
Medication: Cholesterol lowering 1.9 2.9 3.3 -1.6 1.8
Depression (self-reported) 2.7 3.3 6.2 -0.6 -2.5
Medication: Lansoprazole 4.4 5.0 8.9 -1.1 3.0
Prospective memory result 0.8 1.0 1.6 1.3 -0.6
Lung cancer (father) 3.0 3.5 6.3 0.8 -2.5
Illnesses of mother 1.2 1.5 2.4 1.5 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.3 0.6 0.8 0.2
Pulse wave Arterial Stiffness index 6.4 7.4 10.3 -3.2 2.1
Impedance of arm (left) 2.2 10.3 19.6 -1.0 4.4
Arm fat mass (right) 1.2 5.1 10.0 0.4 -3.2
Trunk predicted mass 2.7 15.6 27.2 2.0 -5.2
Standing height 0.6 5.6 9.9 1.2 -3.1
Length of working week for main job 0.1 0.2 0.3 0.6 0.0
Exposure to tobacco smoke at home 1.3 1.5 1.6 -1.3 1.2
Breastfed as a baby 0.6 0.7 1.2 0.4 1.1
Tense / ‘highly strung’ 1.8 3.0 3.1 1.8 -1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 0.7 1.1 1.2 1.0 -1.1
Hair/balding pattern: Pattern 4 0.6 1.4 2.7 -0.2 1.6
Birth weight of first child 7.0 12.8 18.4 2.7 -4.3
Peak expiratory flow (PEF) 0.2 0.4 0.5 -0.7 0.5
Pulse wave reflection index 1.2 1.5 1.9 -1.0 1.4
Ever highly irritable/argumentative for 2 days 4.2 5.1 6.0 2.0 -2.4
Loud music exposure frequency 0.2 0.3 0.3 -0.5 0.6
Qualifications: O levels/GCSEs or equivalent 1.2 2.0 3.9 -0.0 -2.0
Mouth/teeth dental problems: Bleeding gums 1.2 1.6 2.8 -1.7 -0.6
Blood clot in the leg (DVT) 2.2 2.8 4.7 -1.0 2.2
Medication: Paracetamol 0.7 1.2 2.2 -1.5 0.5
Headache pain in last month 2.7 4.6 8.4 0.9 -2.9
Medication for cholesterol, blood pressure or diabetes 3.4 5.6 5.7 2.4 -2.3
Glaucoma (self-reported) 0.1 0.1 0.2 -0.2 -0.5
Gout (self-reported) 2.7 3.6 6.0 -1.1 2.4
Hypothyroidism/myxoedema (self-reported) 34.7 67.7 121.0 -3.8 11.0
Medication: Amlodipine 0.3 0.5 0.7 -0.8 0.5
Medication: Ventolin 100micrograms inhaler 0.3 0.4 0.6 0.4 -0.8
Birth weight 8.1 17.6 20.1 3.9 -4.5
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.3 0.1 1.1
High blood pressure (siblings) 5.2 7.4 9.2 -2.4 3.0
Forced vital capacity (FVC), Best measure 0.3 1.1 1.3 0.9 1.1
Body fat percentage 0.4 1.6 3.1 -0.2 -1.8
Leg fat percentage (right) 0.9 3.3 6.5 0.3 -2.5
Arm fat-free mass (right) 3.5 17.7 33.6 1.3 -5.8
Exposure to tobacco smoke outside home 1.0 1.3 2.5 0.3 1.6
Comparative body size at age 10 0.3 1.0 1.9 -1.4 0.2
Number of full brothers 0.8 1.0 1.9 0.4 -1.4
Worry too long after embarrassment 0.5 0.9 1.6 1.3 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.2 0.3 0.4
Wheeze or whistling in the chest in last year 1.0 1.7 2.9 -1.7 -0.8
Number of children fathered 0.1 0.1 0.2 -0.0 0.5
Reason for reducing amount of alcohol drunk: Health precaution 1.5 1.8 3.2 -0.6 1.8
Age at first live birth 0.5 0.8 1.4 -0.4 -1.2
Pulse wave peak to peak time 6.1 7.2 10.6 3.2 -2.0
Health satisfaction 0.5 0.7 1.0 1.0 0.6
Shortness of breath walking on level ground 0.2 0.2 0.3 0.6 0.2
Qualifications: College or University degree 0.2 0.6 0.9 1.0 -0.5
Eye problems/disorders: None of the above 0.1 0.1 0.2 -0.3 -0.4
Mouth/teeth dental problems: Loose teeth 0.7 0.8 1.0 1.0 -0.8
Emphysema/chronic bronchitis 0.2 0.2 0.2 -0.3 -0.5
Medication for pain relief, constipation, heartburn 1.2 2.1 3.2 1.8 -1.0
Neck or shoulder pain in last month 0.5 0.6 1.1 -0.5 -1.0
Medication: Blood pressure 6.2 10.9 11.5 -3.4 3.2
Angina (self-reported) 3.0 3.9 6.2 -1.3 2.5
Migraine (self-reported) 1.3 1.6 2.1 1.1 -1.4
Medication: Ibuprofen 3.0 3.6 4.8 1.5 -2.2
Medication: Allopurinol 3.1 4.1 4.4 -2.1 2.0
Medication: Omeprazole 0.5 0.6 0.7 -0.7 0.8
Medication: Seretide 50 evohaler 1.0 1.1 2.0 -1.4 -0.5
Mean time to correctly identify matches 7.5 14.2 18.7 -4.3 3.1
Heart disease (mother) 5.3 6.4 9.2 -3.0 1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.6 3.3 -1.8 0.1
Whole body fat mass 1.2 4.9 9.5 0.5 -3.1
Leg fat mass (right) 1.9 7.2 14.0 0.6 -3.7
Arm predicted mass (right) 3.2 16.6 31.7 1.2 -5.6
Pulse rate, automated reading 0.1 0.3 0.6 -0.8 -0.2
Alcohol intake frequency. 0.4 1.0 1.3 -1.2 0.8
Comparative height size at age 10 2.3 12.9 19.4 2.5 -4.4
Number of full sisters 0.6 0.7 1.4 0.3 1.2
Suffer from ‘nerves’ 1.4 2.1 3.8 2.0 -0.6
Overall health rating 0.1 0.2 0.3 0.2 0.6
Chest pain or discomfort 0.0 0.0 0.0 0.1 -0.2
Had major operations 2.0 2.3 3.4 -1.9 1.1
Age at last live birth 1.2 1.7 2.2 -1.1 -1.5
Family relationship satisfaction 1.3 1.6 3.1 -0.1 -1.8
Leg pain on walking 0.2 0.3 0.4 0.3 0.7
Qualifications: NVQ or HND or HNC or equivalent 5.5 6.6 7.8 2.3 -2.8
Commuting to job workplace: Car/motor vehicle 3.2 3.7 5.9 -1.2 -2.4
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.1 0.3 -0.2
Medication: Aspirin 3.4 4.5 6.9 -1.4 2.6
Supplements: Vitamin C 0.9 1.0 2.0 -0.3 -1.4
Knee pain experienced in last month 0.3 0.5 1.0 0.2 -1.0
Hypertension (Self-reported) 6.5 18.1 18.4 -4.3 4.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.4 1.7 3.2 -0.4 1.8
Illnesses of father: Heart disease 3.5 4.8 5.2 -2.3 2.1
Illnesses of siblings: Diabetes 1.9 2.3 2.3 -1.5 1.5
Smoking status: Previous 8.6 12.9 14.3 -3.4 3.8
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 1.3 1.1 -0.5
Whole body fat-free mass 2.8 15.7 28.6 1.7 -5.3
Leg fat-free mass (right) 2.2 11.7 22.1 1.2 -4.7
Arm fat percentage (left) 0.3 1.4 2.7 0.2 -1.6
Average weekly red wine intake 1.2 1.7 3.4 0.2 -1.9
Handedness (chirality/laterality): Left-handed 0.0 0.0 0.0 0.1 -0.2
Mood swings 2.0 3.6 3.6 1.9 -1.9
Loneliness, isolation 3.1 4.2 5.2 1.8 -2.3
Long-standing illness, disability or infirmity 5.5 8.4 16.5 0.5 4.1
Ever had bowel cancer screening 0.6 0.7 1.3 0.3 1.1
Diabetes diagnosed by doctor 2.8 4.6 7.7 -1.2 2.8
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.4 0.4 0.6
Friendships satisfaction 1.7 2.2 4.0 0.6 -2.0
Qualifications: nursing, teaching 0.1 0.2 0.4 0.6 -0.2
Commuting to job workplace: Walk 1.2 1.3 2.4 -0.5 1.5
Eye problems/disorders: Cataract 0.0 0.0 0.0 -0.1 0.0
Mouth/teeth dental problems: Mouth ulcers 1.9 3.1 6.1 -0.1 -2.5
Medication for cholesterol 7.3 11.0 18.9 1.8 -4.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.0 1.2 1.4 -1.2 -1.0
Back pain experienced in last month 3.8 5.5 8.3 2.9 -1.6
Mineral and other dietary supplements 0.0 0.0 0.0 0.2 0.2
Breast cancer (self-reported) 0.1 0.1 0.2 0.1 -0.4
Asthma (self-reported) 1.4 2.7 5.1 0.5 -2.3
Osteoporosis (self-reported) 0.8 1.0 1.7 -1.3 -0.6
Osteoarthritis (self-reported) 0.3 0.3 0.7 -0.8 -0.1
Medication: Aspirin 3.2 4.1 7.3 -1.0 2.7
Medication: Gliclazide 0.7 0.7 1.4 -0.3 1.2
Illnesses of father: None of the above (group 1) 5.6 6.9 7.6 2.8 -2.5
Smoking status: Current 1.2 2.0 3.0 1.0 -1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.0 0.1 0.1 0.3 0.2
Whole body water mass 2.9 16.3 29.7 1.7 -5.5
Leg predicted mass (right) 2.2 11.6 21.9 1.1 -4.7
Arm fat mass (left) 1.4 5.6 11.0 0.3 -3.3
Number of self-reported non-cancer illnesses 6.5 11.2 17.5 -2.2 4.2
Average weekly champagne plus white wine intake 1.2 1.6 2.8 -1.7 -0.7
Miserableness 2.5 4.3 8.1 0.7 -2.8
Guilty feelings 0.7 1.1 2.0 1.4 0.4
Wears glasses or contact lenses 0.5 0.6 1.1 -1.0 0.4
Ever taken oral contraceptive pill 0.8 0.9 1.7 -1.3 -0.1
Hearing aid user 2.5 2.8 5.5 -0.1 2.4
Mother’s age at death 0.8 1.0 1.5 0.7 -1.2
Financial situation satisfaction 1.4 1.7 3.0 0.6 1.7
Tinnitus: Yes, now most or all of the time 1.1 1.3 1.4 1.1 1.2
Commuting to job workplace: Public transport 0.3 0.4 0.7 -0.2 0.8
Eye problems/disorders: Glaucoma 0.0 0.1 0.1 0.1 -0.3
Medication: Blood pressure 6.6 12.6 17.9 -2.7 4.2
Pain type(s) experienced in last month: Hip pain 0.0 0.1 0.1 0.2 -0.3
Supplements: Fish oil (including cod liver oil) 0.1 0.1 0.1 -0.1 0.4
High cholesterol (Self-reported) 2.4 4.2 5.4 -2.3 1.7
Medication: Bendroflumethiazide 4.9 7.5 9.8 -3.1 2.2
Medication: Paracetamol 0.2 0.3 0.4 -0.6 0.4
Medication: Lisinopril 3.1 4.0 6.9 -1.0 2.6
Medication: Atorvastatin 0.1 0.2 0.3 -0.1 0.6
Illnesses of father: High blood pressure 2.5 3.1 4.0 -1.5 2.0
Alcohol drinker status: Never 0.3 0.4 0.5 -0.6 -0.7
Ever smoked 3.8 6.7 6.9 -2.5 2.6
Basal metabolic rate 2.9 15.9 29.5 1.5 -5.4
Leg fat percentage (left) 1.0 3.6 7.2 -0.1 -2.7
Arm fat-free mass (left) 3.4 17.1 31.8 1.5 -5.6
Number of operations (self-reported) 1.1 1.6 3.2 -1.8 -0.3
Average weekly beer plus cider intake 1.1 1.5 3.0 1.7 -0.3
Irritability 0.2 0.4 0.6 0.3 -0.8
Risk taking 2.1 3.1 4.0 1.5 -2.0
Ever had prostate specific antigen (PSA) test 0.3 0.4 0.6 -0.8 -0.4
Fractured/broken bones in last 5 years 2.7 3.4 4.4 -2.1 1.6
Age started oral contraceptive pill 1.2 1.5 2.5 -0.8 1.6
Diastolic blood pressure, automated reading 9.3 28.7 33.2 -4.9 5.8
Ever depressed for a whole week 2.1 2.6 5.1 -0.1 -2.3
Unable to work because of sickness or disability 0.2 0.3 0.4 0.7 0.4
Commuting to job workplace: Cycle 0.4 0.5 0.7 0.8 0.6
Myopia 2.4 3.5 6.9 -0.2 2.6
Vascular/heart problems diagnosed by doctor 8.4 23.0 25.2 4.6 -5.0
Cholesterol lowering medication 3.9 5.8 6.2 -2.5 2.3
Medication: Omeprazole (e.g. Zanprol) 1.0 1.3 1.8 -1.4 0.8
Pain experienced in last month 2.6 4.3 6.6 -1.4 2.6
Supplements: Calcium 0.6 0.7 1.1 -0.5 1.1
Basal cell carcinoma (self-reported) 0.4 0.5 0.7 0.6 -0.8
Heart attack/myocardial infarction (self-reported) 5.8 7.4 8.5 -2.9 2.5
Deep venous thrombosis (DVT) (self-reported) 1.6 2.1 3.5 -0.8 1.9
Heart disease (siblings) 0.7 0.8 1.1 -1.0 0.7
Alcohol drinker status: Previous 2.7 3.1 6.2 0.3 2.5
Pack years of smoking 1.4 2.0 2.8 1.7 -1.1
Impedance of whole body 1.6 8.1 14.5 -1.3 3.8
Leg fat mass (left) 1.9 7.2 14.3 0.4 -3.8
Arm predicted mass (left) 3.2 16.3 30.0 1.6 -5.5