TWAS hub - TRAFD1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0220	0.0150	0.0049	0.028	0.018	0.007	0.019	0.014	2.3e-04	2.6e-03	4.4e-02	2.0e-03	0.00760
2	YFS	Blood	0.0414	0.0212	0.0081	0.016	0.012	0.013	0.012	0.013	4.0e-06	5.3e-05	3.3e-05	7.7e-05	0.00003

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood Eosinophil Count	51.4	395.5	665.6	-11.2	25.8
Hypothyroidism (self reported)	42.8	98.3	182.2	-3.8	13.5
Hypothyroidism/myxoedema (self-reported)	34.7	67.7	121.0	-3.8	11.0
Blood Platelet Count	29.9	346.1	686.4	2.4	26.2
Medication: Levothyroxine sodium	29.8	50.5	75.2	-5.1	8.7
Blood White Count	23.1	171.1	256.0	-9.3	16.0
Medication: Atenolol	12.2	15.2	26.4	-2.0	5.1
Blood Red Count	11.4	109.6	112.0	-10.4	10.6
HbA1C	10.0	11.1	11.4	3.3	-3.4
Systolic Blood Pressure	9.7	48.7	49.3	-7.0	6.9
Diastolic blood pressure, automated reading	9.3	28.7	33.2	-4.9	5.8
Smoking status: Previous	8.6	12.9	14.3	-3.4	3.8
Vascular/heart problems diagnosed by doctor	8.4	23.0	25.2	4.6	-5.0
Coronary Artery Disease (CAD)	8.3	9.9	14.5	-2.3	3.8
Cardiovascular Disease	8.3	27.5	33.2	-4.7	5.8
Birth weight	8.1	17.6	20.1	3.9	-4.5
Allergy or Eczema	7.7	20.2	35.5	2.2	-6.0
High blood pressure	7.6	21.1	22.0	-4.7	4.5
Mean time to correctly identify matches	7.5	14.2	18.7	-4.3	3.1
Primary Biliary Cirrhosis	7.3	10.4	13.9	-2.6	3.7
Medication for cholesterol	7.3	11.0	18.9	1.8	-4.3
Birth weight of first child	7.0	12.8	18.4	2.7	-4.3
Taking other prescription medications	6.8	10.5	17.3	-1.9	4.2
Hayfever, allergic rhinitis or eczema	6.7	14.6	25.0	2.0	-5.0
Number of treatments/medications taken	6.6	11.9	18.2	-2.4	4.3
Medication: Blood pressure	6.6	12.6	17.9	-2.7	4.2
Hypertension (Self-reported)	6.5	18.1	18.4	-4.3	4.2
Number of self-reported non-cancer illnesses	6.5	11.2	17.5	-2.2	4.2
Pulse wave Arterial Stiffness index	6.4	7.4	10.3	-3.2	2.1
Medication: Blood pressure	6.2	10.9	11.5	-3.4	3.2
Irritable Bowel Disease (IBD)	6.1	14.6	28.2	-1.0	5.3
Reaction Time	6.1	11.6	16.6	-4.1	2.6
Rheumatoid Arthritis	6.1	8.4	15.5	-1.2	3.9
Past tobacco smoking	6.1	11.1	11.9	3.4	-3.2
Pulse wave peak to peak time	6.1	7.2	10.6	3.2	-2.0
Systolic blood pressure, automated reading	6.0	17.5	21.4	-4.6	3.7
Heart attack/myocardial infarction (self-reported)	5.8	7.4	8.5	-2.9	2.5
Chronotype (morning person)	5.7	13.1	15.8	-4.0	3.2
Illnesses of siblings	5.7	8.0	10.2	3.2	-2.4
Illnesses of father: None of the above (group 1)	5.6	6.9	7.6	2.8	-2.5
Frequency of tenseness / restlessness in last 2 weeks	5.5	8.6	12.6	2.1	-3.5
Qualifications: NVQ or HND or HNC or equivalent	5.5	6.6	7.8	2.3	-2.8
Long-standing illness, disability or infirmity	5.5	8.4	16.5	0.5	4.1
LDL Cholesterol	5.3	8.3	10.2	2.5	-3.2
Heart attack	5.3	6.8	7.8	-2.8	2.4
Heart disease (mother)	5.3	6.4	9.2	-3.0	1.9
High blood pressure (siblings)	5.2	7.4	9.2	-2.4	3.0
Medication: Ramipril	5.1	6.5	9.7	-3.1	1.8
Father’s age at death	5.0	6.6	12.7	0.8	-3.6
Allergy	4.9	11.2	20.8	-1.3	4.6
Medication: Bendroflumethiazide	4.9	7.5	9.8	-3.1	2.2
Crohns Disease (2017)	4.6	10.1	20.2	0.0	4.5
Medication: Lansoprazole	4.4	5.0	8.9	-1.1	3.0
Ulcerative Colitis (UC)	4.3	8.0	14.1	-1.4	3.8
Diverticular disease/diverticulitis (self-reported)	4.3	5.1	7.3	1.7	-2.7
Depression (Nagel 2018)	4.2	6.3	10.0	3.2	-1.6
Alcohol usually taken with meals	4.2	6.7	7.3	-2.7	-2.5
Ever highly irritable/argumentative for 2 days	4.2	5.1	6.0	2.0	-2.4
Relative age voice broke	4.1	6.3	8.3	-2.9	2.1
Crohns Disease (2012)	3.9	6.3	12.7	0.1	3.6
Cholesterol lowering medication	3.9	5.8	6.2	-2.5	2.3
Lupus	3.8	5.8	7.6	-2.0	2.8
Back pain experienced in last month	3.8	5.5	8.3	2.9	-1.6
Ever smoked	3.8	6.7	6.9	-2.5	2.6
Frequency of unenthusiasm / disinterest in last 2 weeks	3.7	4.9	6.7	2.6	-1.7
Supplements: Zinc	3.6	4.0	7.8	0.3	-2.8
Medication: Ibuprofen (e.g. Nurofen)	3.6	4.6	6.3	1.7	-2.5
Arm fat-free mass (right)	3.5	17.7	33.6	1.3	-5.8
Illnesses of father: Heart disease	3.5	4.8	5.2	-2.3	2.1
Depressed Affect (Nagel 2018)	3.4	7.2	11.1	1.8	-3.3
Fasting Glucose	3.4	4.1	4.6	-1.9	-2.1
Other serious medical condition/disability diagnosed by doctor	3.4	4.5	8.7	-0.4	3.0
Fed-up feelings	3.4	6.3	9.6	1.7	-3.1
Medication for cholesterol, blood pressure or diabetes	3.4	5.6	5.7	2.4	-2.3
Medication: Aspirin	3.4	4.5	6.9	-1.4	2.6
Arm fat-free mass (left)	3.4	17.1	31.8	1.5	-5.6
Hayfever/allergic rhinitis (self-reported)	3.3	4.4	7.4	1.2	-2.7
Hip circumference	3.3	14.2	24.7	1.9	-5.0
Angina	3.2	4.2	5.3	-1.8	2.3
Arm predicted mass (right)	3.2	16.6	31.7	1.2	-5.6
Commuting to job workplace: Car/motor vehicle	3.2	3.7	5.9	-1.2	-2.4
Medication: Aspirin	3.2	4.1	7.3	-1.0	2.7
Arm predicted mass (left)	3.2	16.3	30.0	1.6	-5.5
Medication: Allopurinol	3.1	4.1	4.4	-2.1	2.0
Loneliness, isolation	3.1	4.2	5.2	1.8	-2.3
Medication: Lisinopril	3.1	4.0	6.9	-1.0	2.6
Body Mass Index (BMI) (2010)	3.0	4.2	8.0	-0.6	-2.8
Ulcerative Colitis	3.0	4.4	8.7	-0.3	3.0
Diabetes (father)	3.0	3.7	6.1	-2.5	1.1
Lung cancer (father)	3.0	3.5	6.3	0.8	-2.5
Angina (self-reported)	3.0	3.9	6.2	-1.3	2.5
Medication: Ibuprofen	3.0	3.6	4.8	1.5	-2.2
Vitamin and mineral supplements	2.9	4.0	7.7	-0.5	2.8
Whole body water mass	2.9	16.3	29.7	1.7	-5.5
Basal metabolic rate	2.9	15.9	29.5	1.5	-5.4
Bilateral oophorectomy (both ovaries removed)	2.8	3.3	6.3	-0.5	-2.5
Medication: Simvastatin	2.8	4.0	6.5	-1.3	2.5
Whole body fat-free mass	2.8	15.7	28.6	1.7	-5.3
Diabetes diagnosed by doctor	2.8	4.6	7.7	-1.2	2.8
Multivitamins +/- minerals	2.7	3.5	6.5	0.7	-2.6
Trunk fat-free mass	2.7	15.7	27.3	2.0	-5.2
Depression (self-reported)	2.7	3.3	6.2	-0.6	-2.5
Trunk predicted mass	2.7	15.6	27.2	2.0	-5.2
Headache pain in last month	2.7	4.6	8.4	0.9	-2.9
Gout (self-reported)	2.7	3.6	6.0	-1.1	2.4
Fractured/broken bones in last 5 years	2.7	3.4	4.4	-2.1	1.6
Alcohol drinker status: Previous	2.7	3.1	6.2	0.3	2.5
Frequency of depressed mood in last 2 weeks	2.6	3.6	5.9	2.4	-1.1
Ever unenthusiastic/disinterested for a whole week	2.6	3.2	6.4	-0.2	-2.5
Pain experienced in last month	2.6	4.3	6.6	-1.4	2.6
Miserableness	2.5	4.3	8.1	0.7	-2.8
Hearing aid user	2.5	2.8	5.5	-0.1	2.4
Illnesses of father: High blood pressure	2.5	3.1	4.0	-1.5	2.0
Leg fat-free mass (left)	2.4	12.6	22.9	1.5	-4.8
Impedance of arm (right)	2.4	11.1	22.2	-0.3	4.7
High cholesterol (Self-reported)	2.4	4.2	5.4	-2.3	1.7
Myopia	2.4	3.5	6.9	-0.2	2.6
Type 2 Diabetes (T2D) (2018)	2.3	4.2	4.3	-2.0	2.1
Leg predicted mass (left)	2.3	12.3	22.3	1.5	-4.7
Weight	2.3	11.3	21.4	1.1	-4.6
Comparative height size at age 10	2.3	12.9	19.4	2.5	-4.4
Smoking Status	2.2	5.3	6.6	-2.6	2.0
Impedance of arm (left)	2.2	10.3	19.6	-1.0	4.4
Blood clot in the leg (DVT)	2.2	2.8	4.7	-1.0	2.2
Leg fat-free mass (right)	2.2	11.7	22.1	1.2	-4.7
Leg predicted mass (right)	2.2	11.6	21.9	1.1	-4.7
Verbal and Numeric Reasoning (VNR)	2.1	5.1	6.7	-2.6	-1.9
Mean Putamen Volume	2.1	2.4	4.1	0.9	2.0
High blood pressure (mother)	2.1	2.9	4.3	-2.1	1.2
Risk taking	2.1	3.1	4.0	1.5	-2.0
Ever depressed for a whole week	2.1	2.6	5.1	-0.1	-2.3
Hand grip strength (right)	2.0	5.4	9.4	-1.2	-3.1
Had major operations	2.0	2.3	3.4	-1.9	1.1
Mood swings	2.0	3.6	3.6	1.9	-1.9
Respiratory disease	1.9	4.2	8.4	0.1	-2.9
Medication: Cholesterol lowering	1.9	2.9	3.3	-1.6	1.8
Leg fat mass (right)	1.9	7.2	14.0	0.6	-3.7
Illnesses of siblings: Diabetes	1.9	2.3	2.3	-1.5	1.5
Mouth/teeth dental problems: Mouth ulcers	1.9	3.1	6.1	-0.1	-2.5
Leg fat mass (left)	1.9	7.2	14.3	0.4	-3.8
BMI	1.8	10.6	19.4	1.3	-4.4
Relative age of first facial hair	1.8	3.6	4.5	-2.1	1.7
Medication: Metformin	1.8	2.6	3.6	1.9	1.2
Tense / ‘highly strung’	1.8	3.0	3.1	1.8	-1.7
Qualifications: CSEs or equivalent	1.7	2.3	3.4	-1.8	-1.1
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	3.8	-1.9	-0.3
Friendships satisfaction	1.7	2.2	4.0	0.6	-2.0
Pack years adult smoking proportion	1.6	2.5	3.4	1.8	-1.2
Neuroticism score	1.6	3.4	4.2	2.1	-1.6
Deep venous thrombosis (DVT) (self-reported)	1.6	2.1	3.5	-0.8	1.9
Impedance of whole body	1.6	8.1	14.5	-1.3	3.8
Schizophrenia vs Biploar Disorder	1.5	2.0	3.6	-1.9	-0.5
Waist Hip Ratio (WHR)	1.5	6.9	7.5	-2.5	2.7
Diabetes (self-reported)	1.5	2.4	3.7	-1.0	1.9
Alcohol intake versus 10 years previously	1.5	2.2	2.7	-1.6	1.4
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	3.2	-0.6	1.8
HDL Cholesterol	1.4	2.4	4.1	-0.8	-2.0
Pulse rate	1.4	2.4	4.8	-2.2	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.6	3.3	-1.8	0.1
Suffer from ‘nerves’	1.4	2.1	3.8	2.0	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.4	1.7	3.2	-0.4	1.8
Asthma (self-reported)	1.4	2.7	5.1	0.5	-2.3
Arm fat mass (left)	1.4	5.6	11.0	0.3	-3.3
Financial situation satisfaction	1.4	1.7	3.0	0.6	1.7
Pack years of smoking	1.4	2.0	2.8	1.7	-1.1
Neuroticism (Nagel 2018)	1.3	3.1	3.2	1.8	-1.7
Neuroticism (2016)	1.3	1.9	3.8	-0.1	-1.9
Severe depression (siblings)	1.3	1.5	2.8	-0.4	-1.7
Body mass index (BMI)	1.3	5.6	10.9	0.5	-3.3
Exposure to tobacco smoke at home	1.3	1.5	1.6	-1.3	1.2
Migraine (self-reported)	1.3	1.6	2.1	1.1	-1.4
Family relationship satisfaction	1.3	1.6	3.1	-0.1	-1.8
Bipolar Disorder (2018)	1.2	2.0	3.1	1.8	0.9
Frequency of tiredness / lethargy in last 2 weeks	1.2	1.9	2.5	1.1	-1.6
Asthma	1.2	2.3	4.5	0.5	-2.1
Illnesses of mother	1.2	1.5	2.4	1.5	-0.8
Arm fat mass (right)	1.2	5.1	10.0	0.4	-3.2
Pulse wave reflection index	1.2	1.5	1.9	-1.0	1.4
Qualifications: O levels/GCSEs or equivalent	1.2	2.0	3.9	-0.0	-2.0
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	2.8	-1.7	-0.6
Medication for pain relief, constipation, heartburn	1.2	2.1	3.2	1.8	-1.0
Whole body fat mass	1.2	4.9	9.5	0.5	-3.1
Age at last live birth	1.2	1.7	2.2	-1.1	-1.5
Average weekly red wine intake	1.2	1.7	3.4	0.2	-1.9
Commuting to job workplace: Walk	1.2	1.3	2.4	-0.5	1.5
Smoking status: Current	1.2	2.0	3.0	1.0	-1.7
Average weekly champagne plus white wine intake	1.2	1.6	2.8	-1.7	-0.7
Age started oral contraceptive pill	1.2	1.5	2.5	-0.8	1.6
Lung FVC	1.1	5.7	11.4	0.2	3.4
Townsend deprivation index at recruitment	1.1	1.5	3.0	-0.3	1.7
Supplements: Glucosamine	1.1	1.4	2.4	-0.7	-1.5
Tinnitus: Yes, now most or all of the time	1.1	1.3	1.4	1.1	1.2
Number of operations (self-reported)	1.1	1.6	3.2	-1.8	-0.3
Average weekly beer plus cider intake	1.1	1.5	3.0	1.7	-0.3
Triglycerides	1.0	1.6	2.6	-1.6	-0.8
Lung FEV1/FVC ratio	1.0	4.8	8.4	1.2	-2.9
Hearing difficulty/problems: Yes	1.0	1.5	2.6	-0.7	1.6
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.0	0.5	1.4
Exposure to tobacco smoke outside home	1.0	1.3	2.5	0.3	1.6
Wheeze or whistling in the chest in last year	1.0	1.7	2.9	-1.7	-0.8
Medication: Seretide 50 evohaler	1.0	1.1	2.0	-1.4	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	1.4	-1.2	-1.0
Leg fat percentage (left)	1.0	3.6	7.2	-0.1	-2.7
Medication: Omeprazole (e.g. Zanprol)	1.0	1.3	1.8	-1.4	0.8
Alzheimer’s Disease (including proxy)	0.9	1.4	1.7	1.0	-1.3
Hand grip strength (left)	0.9	2.3	3.4	-1.1	-1.9
Current tobacco smoking	0.9	1.4	2.1	0.8	-1.4
Trunk fat mass	0.9	4.0	7.9	0.3	-2.8
Waist circumference	0.9	3.3	5.8	0.9	-2.4
Number of incorrect matches in round	0.9	1.6	3.1	1.8	0.1
Qualifications: None of the above	0.9	1.9	3.5	-0.6	1.9
Leg fat percentage (right)	0.9	3.3	6.5	0.3	-2.5
Supplements: Vitamin C	0.9	1.0	2.0	-0.3	-1.4
Intelligence (Savage-Jansen 2018)	0.8	2.3	4.6	-2.1	-0.2
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.7	-1.3	0.4
Neuroticism	0.8	2.0	2.1	1.3	-1.5
Tanning	0.8	9.3	12.3	-3.5	2.5
Nervous feelings	0.8	1.5	2.3	1.5	-0.8
Had other major operations	0.8	0.9	1.9	-1.4	0.1
Mouth/teeth dental problems: Dentures	0.8	1.4	2.3	-0.6	1.5
Prospective memory result	0.8	1.0	1.6	1.3	-0.6
Number of full brothers	0.8	1.0	1.9	0.4	-1.4
Osteoporosis (self-reported)	0.8	1.0	1.7	-1.3	-0.6
Ever taken oral contraceptive pill	0.8	0.9	1.7	-1.3	-0.1
Mother’s age at death	0.8	1.0	1.5	0.7	-1.2
Worry (Nagel 2018)	0.7	1.4	2.6	1.6	-0.3
Alzheimer’s Disease (in father)	0.7	0.8	1.5	0.2	-1.2
Medication for hormone replacement therapy	0.7	0.8	1.3	1.1	0.6
Impedance of leg (right)	0.7	3.4	6.4	-0.7	2.5
Impedance of leg (left)	0.7	3.4	5.2	-1.2	2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.2	1.0	-1.1
Medication: Paracetamol	0.7	1.2	2.2	-1.5	0.5
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.0	1.0	-0.8
Medication: Gliclazide	0.7	0.7	1.4	-0.3	1.2
Guilty feelings	0.7	1.1	2.0	1.4	0.4
Heart disease (siblings)	0.7	0.8	1.1	-1.0	0.7
Sensitivity / hurt feelings	0.6	1.0	2.0	-0.4	-1.4
Ever had hysterectomy (womb removed)	0.6	0.7	0.9	0.9	-0.7
Serious illness, injury or assault to yourself	0.6	0.7	1.4	-0.1	1.2
Fluid intelligence score	0.6	1.3	2.0	-1.4	-0.7
Standing height	0.6	5.6	9.9	1.2	-3.1
Breastfed as a baby	0.6	0.7	1.2	0.4	1.1
Hair/balding pattern: Pattern 4	0.6	1.4	2.7	-0.2	1.6
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.3	0.1	1.1
Number of full sisters	0.6	0.7	1.4	0.3	1.2
Ever had bowel cancer screening	0.6	0.7	1.3	0.3	1.1
Supplements: Calcium	0.6	0.7	1.1	-0.5	1.1
Bipolar Disorder (2011)	0.5	0.5	1.0	1.0	0.0
Maternal smoking around birth	0.5	0.8	1.2	-0.6	1.1
Happiness	0.5	0.7	1.2	0.3	-1.1
Worry too long after embarrassment	0.5	0.9	1.6	1.3	0.5
Age at first live birth	0.5	0.8	1.4	-0.4	-1.2
Health satisfaction	0.5	0.7	1.0	1.0	0.6
Neck or shoulder pain in last month	0.5	0.6	1.1	-0.5	-1.0
Medication: Omeprazole	0.5	0.6	0.7	-0.7	0.8
Wears glasses or contact lenses	0.5	0.6	1.1	-1.0	0.4
Bipolar Disorder or Schizophrenia	0.4	1.0	1.7	1.3	0.5
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.4	0.6	0.6
Hair/balding pattern: Pattern 2	0.4	0.5	1.0	-0.3	-1.0
Worrier / anxious feelings	0.4	0.8	0.8	0.9	-0.8
Noisy workplace	0.4	0.5	0.7	-0.9	-0.6
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.2	1.1	-0.7
Body fat percentage	0.4	1.6	3.1	-0.2	-1.8
Alcohol intake frequency.	0.4	1.0	1.3	-1.2	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.3	1.1	-0.5
Commuting to job workplace: Cycle	0.4	0.5	0.7	0.8	0.6
Basal cell carcinoma (self-reported)	0.4	0.5	0.7	0.6	-0.8
Hair Pigment	0.3	9.7	16.2	1.8	-4.0
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.5	0.6	-0.7
Trunk fat percentage	0.3	1.3	2.4	-0.4	-1.6
Had menopause	0.3	0.4	0.7	0.3	0.9
Financial difficulties in last 2 years	0.3	0.3	0.4	0.5	-0.6
Number of live births	0.3	0.4	0.8	-0.4	0.9
Medication: Amlodipine	0.3	0.5	0.7	-0.8	0.5
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.6	0.4	-0.8
Forced vital capacity (FVC), Best measure	0.3	1.1	1.3	0.9	1.1
Comparative body size at age 10	0.3	1.0	1.9	-1.4	0.2
Knee pain experienced in last month	0.3	0.5	1.0	0.2	-1.0
Arm fat percentage (left)	0.3	1.4	2.7	0.2	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.4	0.4	0.6
Osteoarthritis (self-reported)	0.3	0.3	0.7	-0.8	-0.1
Commuting to job workplace: Public transport	0.3	0.4	0.7	-0.2	0.8
Alcohol drinker status: Never	0.3	0.4	0.5	-0.6	-0.7
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.6	-0.8	-0.4
Ovarian Cancer	0.2	0.2	0.5	0.0	-0.7
Schizophrenia (2014)	0.2	0.5	0.8	0.9	0.5
Height	0.2	4.2	7.8	0.8	-2.8
Medication: Co-codamol	0.2	0.2	0.2	0.4	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.6	0.5	-0.8
Chronic bronchitis/emphysema (father)	0.2	0.2	0.4	0.2	-0.6
Forced vital capacity (FVC)	0.2	0.6	1.1	1.1	0.3
Arm fat percentage (right)	0.2	1.0	1.9	0.3	-1.4
Peak expiratory flow (PEF)	0.2	0.4	0.5	-0.7	0.5
Loud music exposure frequency	0.2	0.3	0.3	-0.5	0.6
Shortness of breath walking on level ground	0.2	0.2	0.3	0.6	0.2
Qualifications: College or University degree	0.2	0.6	0.9	1.0	-0.5
Emphysema/chronic bronchitis	0.2	0.2	0.2	-0.3	-0.5
Leg pain on walking	0.2	0.3	0.4	0.3	0.7
Medication: Paracetamol	0.2	0.3	0.4	-0.6	0.4
Irritability	0.2	0.4	0.6	0.3	-0.8
Unable to work because of sickness or disability	0.2	0.3	0.4	0.7	0.4
Alzheimer’s Disease (in mother)	0.1	0.2	0.3	0.6	-0.1
Major Depression (MDD)	0.1	0.1	0.1	0.2	-0.3
Age at First Birth	0.1	0.2	0.3	-0.3	0.6
Heel T-Score	0.1	0.8	1.7	-0.2	1.3
Diabetes (mother)	0.1	0.1	0.2	-0.2	-0.5
Average weekly fortified wine intake	0.1	0.2	0.3	-0.5	0.1
Age when periods started (menarche)	0.1	0.3	0.6	-0.8	0.3
Mouth/teeth dental problems	0.1	0.2	0.4	0.2	0.6
Pain all over the body in last month	0.1	0.2	0.3	-0.5	0.2
Falls in the last year	0.1	0.2	0.3	0.0	-0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.3	0.6	0.8	0.2
Length of working week for main job	0.1	0.2	0.3	0.6	0.0
Glaucoma (self-reported)	0.1	0.1	0.2	-0.2	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.3	0.4
Number of children fathered	0.1	0.1	0.2	-0.0	0.5
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.3	-0.4
Pulse rate, automated reading	0.1	0.3	0.6	-0.8	-0.2
Overall health rating	0.1	0.2	0.3	0.2	0.6
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.1	0.3	-0.2
Qualifications: nursing, teaching	0.1	0.2	0.4	0.6	-0.2
Breast cancer (self-reported)	0.1	0.1	0.2	0.1	-0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.1	-0.1	0.4
Medication: Atorvastatin	0.1	0.2	0.3	-0.1	0.6
Schizophrenia (2018)	0.0	0.0	0.1	0.2	-0.0
Breast Cancer	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Average weekly spirits intake	0.0	0.0	0.1	-0.2	-0.0
Stomach or abdominal pain in last month	0.0	0.0	0.1	-0.1	0.2
Sitting height	0.0	0.1	0.1	-0.4	0.2
Hearing difficulty/problems with background noise	0.0	0.0	0.0	0.2	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.0	-0.1	0.2
Time employed in main current job	0.0	0.0	0.0	0.0	0.2
Hair/balding pattern: Pattern 3	0.0	0.0	0.0	-0.2	0.0
Forced expiratory volume in 1-second (FEV1)	0.0	0.2	0.3	0.5	-0.2
Chest pain or discomfort	0.0	0.0	0.0	0.1	-0.2
Handedness (chirality/laterality): Left-handed	0.0	0.0	0.0	0.1	-0.2
Eye problems/disorders: Cataract	0.0	0.0	0.0	-0.1	0.0
Mineral and other dietary supplements	0.0	0.0	0.0	0.2	0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.0	0.1	0.1	0.3	0.2
Eye problems/disorders: Glaucoma	0.0	0.1	0.1	0.1	-0.3
Pain type(s) experienced in last month: Hip pain	0.0	0.1	0.1	0.2	-0.3

Hub : Genes

TRAFD1

Models

Trait associations