TWAS hub - SH2B3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.4560	0.1320	8.1e-03	-0.006	NA	0.027	NA	-0.008	0.54000	NA	4.4e-02	NA	7.5e-01
2	YFS	Blood	0.0458	0.0242	3.5e-07	0.009	0.016	0.020	0.018	0.016	0.00046	4.1e-06	3.3e-07	1e-06	2.9e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood Eosinophil Count	94.5	727.5	1376.4	8.9	37.1
Hypothyroidism (self reported)	57.0	131.0	259.2	1.7	16.1
Hypothyroidism/myxoedema (self-reported)	47.3	92.3	182.2	1.5	13.5
Medication: Levothyroxine sodium	46.3	78.5	156.2	0.9	12.5
Blood White Count	43.7	323.9	576.0	8.5	24.0
Diastolic blood pressure, automated reading	31.6	97.9	179.6	4.0	13.4
Systolic Blood Pressure	26.2	131.0	237.2	5.0	15.4
Blood Platelet Count	22.2	257.7	299.3	-14.7	17.3
Cardiovascular Disease	18.7	61.9	113.7	3.2	10.7
Vascular/heart problems diagnosed by doctor	18.1	49.4	90.9	-2.8	-9.5
Systolic blood pressure, automated reading	17.6	51.0	87.4	3.8	9.3
High blood pressure	17.5	48.9	89.1	3.0	9.4
Mean time to correctly identify matches	16.9	32.1	48.6	4.0	7.0
Hypertension (Self-reported)	15.9	44.2	80.5	2.8	9.0
Birth weight of first child	15.5	28.2	51.5	-2.2	-7.2
Medication: Atenolol	15.4	19.3	32.9	2.4	5.7
Medication: Blood pressure	14.8	26.1	48.5	1.9	7.0
Reaction Time	14.4	27.4	45.1	3.1	6.7
Blood Red Count	14.3	138.6	252.2	5.0	15.9
Medication: Blood pressure	13.3	25.3	45.7	2.2	6.8
Taking other prescription medications	12.5	19.2	38.2	0.5	6.2
Father’s age at death	11.9	16.0	30.7	-1.2	-5.5
Number of self-reported non-cancer illnesses	11.3	19.5	38.8	0.5	6.2
Number of treatments/medications taken	11.2	20.1	37.2	1.7	6.1
Gout (self-reported)	11.0	15.1	21.2	3.0	4.6
LDL Cholesterol	10.8	17.2	25.1	-3.0	-5.0
Primary Biliary Cirrhosis	10.8	15.5	27.8	1.8	5.3
Medication for cholesterol	10.2	15.5	27.6	-1.8	-5.3
Fed-up feelings	10.1	18.4	27.6	-3.0	-5.3
Smoking status: Previous	10.0	15.0	24.9	2.2	5.0
Medication: Lansoprazole	9.9	11.3	12.9	3.1	3.6
Illnesses of siblings	9.5	13.3	25.5	-1.0	-5.0
Illnesses of father: None of the above (group 1)	9.0	11.1	17.9	-2.1	-4.2
Medication: Allopurinol	8.8	11.6	17.1	2.5	4.1
Medication for cholesterol, blood pressure or diabetes	8.6	14.3	27.0	-1.2	-5.2
Medication: Aspirin	8.6	11.3	16.6	2.5	4.1
Heart attack/myocardial infarction (self-reported)	8.5	10.9	19.8	1.4	4.5
Rheumatoid Arthritis	8.4	11.5	23.0	-0.0	4.8
Exposure to tobacco smoke outside home	7.7	10.2	13.5	2.6	3.7
Qualifications: NVQ or HND or HNC or equivalent	7.7	9.2	9.5	-3.1	-3.0
Coronary Artery Disease (CAD)	7.5	9.0	16.9	1.0	4.1
Past tobacco smoking	7.4	13.6	25.5	-1.3	-5.0
Birth weight	7.4	16.0	31.7	0.6	-5.6
High blood pressure (siblings)	7.2	10.4	20.4	0.5	4.5
Heart attack	7.1	9.1	16.4	1.4	4.0
Loneliness, isolation	6.6	9.1	16.6	-1.3	-4.1
Illnesses of father: High blood pressure	6.5	8.1	15.7	0.7	4.0
Medication: Bendroflumethiazide	6.3	9.6	17.4	1.3	4.2
Medication: Aspirin	6.1	7.9	12.7	1.8	3.6
Medication: Lisinopril	6.0	7.7	14.3	1.1	3.8
Depressed Affect (Nagel 2018)	5.9	12.4	17.8	-2.6	-4.2
Frequency of tiredness / lethargy in last 2 weeks	5.9	9.6	11.9	-2.7	-3.5
Illnesses of father: Heart disease	5.9	8.1	15.1	1.1	3.9
Type 2 Diabetes (T2D) (2018)	5.7	10.7	18.1	1.8	4.2
Smoking status: Current	5.7	9.1	9.7	-3.1	-2.9
Pain experienced in last month	5.5	9.2	15.3	1.8	3.9
Blood clot in the leg (DVT)	5.4	7.0	14.0	-0.0	3.7
Mother’s age at death	5.4	6.7	10.4	-1.7	-3.2
Diabetes diagnosed by doctor	5.2	8.5	12.4	2.1	3.5
Mouth/teeth dental problems: Mouth ulcers	5.2	8.3	16.2	0.6	-4.0
Chronotype (morning person)	5.1	11.9	16.1	4.0	2.8
Qualifications: nursing, teaching	5.1	7.9	12.0	-2.0	-3.5
Deep venous thrombosis (DVT) (self-reported)	5.1	6.6	13.0	-0.3	3.6
Heart disease (siblings)	5.1	6.2	8.6	2.0	2.9
Medication: Ramipril	4.9	6.3	12.5	0.4	3.5
Ever smoked	4.9	8.6	17.1	-0.0	4.1
Current tobacco smoking	4.7	7.7	8.4	-2.9	-2.6
Alcohol drinker status: Previous	4.7	5.3	5.5	2.3	2.4
Mood swings	4.5	8.1	11.8	-2.1	-3.4
Arm fat-free mass (left)	4.5	22.9	44.9	-1.0	-6.7
Ever highly irritable/argumentative for 2 days	4.4	5.3	7.3	-1.8	-2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.3	5.0	8.0	1.4	2.8
Back pain experienced in last month	4.3	6.3	12.4	0.4	-3.5
Arm predicted mass (left)	4.3	22.1	43.0	-1.0	-6.6
Average weekly red wine intake	4.2	6.2	10.7	-3.3	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	4.1	5.4	9.9	-1.0	-3.1
Medication for pain relief, constipation, heartburn	4.1	7.0	7.2	-2.6	-2.7
Lupus	4.0	6.0	11.8	0.5	3.4
Pulse wave Arterial Stiffness index	4.0	4.7	9.3	0.0	3.0
Pulse wave peak to peak time	4.0	4.7	9.3	-0.0	-3.0
Comparative height size at age 10	4.0	21.9	43.7	-0.3	-6.6
Medication: Omeprazole (e.g. Zanprol)	4.0	4.9	8.6	1.1	2.9
Trunk fat-free mass	3.9	22.1	43.3	-1.0	-6.6
Pulse rate	3.9	6.5	9.0	2.0	3.0
Illnesses of mother	3.9	4.8	9.5	-0.4	-3.1
Trunk predicted mass	3.9	22.1	43.4	-1.0	-6.6
Arm fat-free mass (right)	3.9	19.8	39.0	-0.7	-6.2
Arm predicted mass (right)	3.9	19.7	39.1	-0.6	-6.3
Migraine (self-reported)	3.8	4.7	4.9	-2.1	-2.2
Frequency of depressed mood in last 2 weeks	3.7	5.2	6.1	-2.1	-2.5
High blood pressure (mother)	3.7	5.2	10.1	0.5	3.2
Long-standing illness, disability or infirmity	3.7	5.7	11.1	-0.5	3.3
Number of full brothers	3.6	4.5	6.0	-2.4	-1.7
Body Mass Index (BMI) (2010)	3.4	4.7	9.3	-0.1	-3.0
Angina	3.2	4.1	7.8	-0.7	2.8
Diverticular disease/diverticulitis (self-reported)	3.2	3.8	6.0	-1.3	-2.4
Frequency of tenseness / restlessness in last 2 weeks	3.2	5.0	7.7	-1.5	-2.8
Number of operations (self-reported)	3.2	4.8	9.6	-3.1	-0.2
Allergy or Eczema	3.1	8.3	15.6	1.0	-4.0
Hayfever, allergic rhinitis or eczema	3.1	6.6	10.4	1.7	-3.2
Heart disease (mother)	3.1	3.8	6.0	1.3	2.4
Whole body fat-free mass	3.1	17.6	34.3	-1.0	-5.9
Whole body water mass	3.1	18.0	35.1	-0.9	-5.9
Basal metabolic rate	3.0	16.4	31.8	-1.0	-5.6
Multivitamins +/- minerals	2.9	3.7	7.3	-0.4	-2.7
Medication: Cholesterol lowering	2.9	4.5	8.8	-0.3	3.0
Headache pain in last month	2.9	4.9	8.0	-1.4	-2.8
Angina (self-reported)	2.9	3.8	6.8	-0.9	2.6
HbA1C	2.8	3.1	5.9	-0.6	-2.4
Other serious medical condition/disability diagnosed by doctor	2.8	3.6	6.4	-0.9	2.5
Diabetes (self-reported)	2.8	4.3	7.6	1.0	2.8
Hip circumference	2.8	11.9	22.9	-1.0	-4.8
Chronic bronchitis/emphysema (mother)	2.8	3.2	4.8	1.3	2.2
Irritable Bowel Disease (IBD)	2.7	6.5	12.6	0.6	3.5
Neuroticism score	2.7	5.7	8.0	-1.8	-2.8
Depression (Nagel 2018)	2.6	3.9	7.3	-0.7	-2.7
Medication: Simvastatin	2.6	3.8	7.6	0.1	2.8
Medication: Ibuprofen (e.g. Nurofen)	2.6	3.2	6.1	0.6	-2.5
Pulse rate, automated reading	2.6	8.4	11.0	3.3	2.4
Ulcerative Colitis (UC)	2.5	4.7	8.2	1.1	2.9
Qualifications: A levels/AS levels or equivalent	2.5	5.6	7.3	-1.9	-2.7
Medication: Ibuprofen	2.4	2.8	5.6	-0.2	-2.4
Cholesterol lowering medication	2.4	3.6	6.9	0.5	2.6
Alzheimer’s Disease (in mother)	2.3	2.7	5.3	2.3	0.2
Neuroticism (Nagel 2018)	2.2	5.2	7.2	-1.8	-2.7
Qualifications: None of the above	2.2	4.8	5.4	2.0	2.3
Impedance of arm (left)	2.2	10.3	20.7	-0.0	4.5
Reason for reducing amount of alcohol drunk: Health precaution	2.2	2.5	3.1	-1.4	1.8
Miserableness	2.2	3.8	4.9	-1.6	-2.2
Relative age voice broke	2.1	3.1	4.0	-2.0	1.5
Number of incorrect matches in round	2.1	3.5	4.0	2.0	1.7
Risk taking	2.1	3.1	5.9	-0.6	-2.4
Crohns Disease (2012)	2.0	3.3	4.8	1.3	2.2
Ulcerative Colitis	2.0	2.9	4.7	1.1	2.2
Allergy	2.0	4.5	8.1	-1.0	2.8
Mouth/teeth dental problems: Bleeding gums	2.0	2.6	4.8	0.5	2.2
High cholesterol (Self-reported)	2.0	3.5	6.9	-0.3	2.6
Triglycerides	1.9	3.1	5.4	-2.3	0.8
Weight	1.9	9.1	17.9	-0.6	-4.2
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.2	4.0	-0.6	-2.0
Medication: Amlodipine	1.9	2.6	3.9	1.2	2.0
Ever had prostate specific antigen (PSA) test	1.9	2.2	3.7	-1.9	-0.8
Ever unenthusiastic/disinterested for a whole week	1.8	2.2	4.0	-0.7	-2.0
Pulse wave reflection index	1.8	2.2	4.3	0.3	2.1
Lung FVC	1.7	8.9	16.9	0.9	4.1
Neuroticism	1.7	4.2	6.0	-1.5	-2.5
Diabetes (father)	1.7	2.1	2.6	1.6	1.2
Impedance of arm (right)	1.7	7.8	14.8	-0.9	3.8
Leg fat-free mass (right)	1.7	9.1	17.6	-0.8	-4.2
Eye problems/disorders: Cataract	1.7	2.0	3.4	-1.8	-0.7
Leg predicted mass (right)	1.7	8.9	17.1	-0.8	-4.1
Crohns Disease (2017)	1.6	3.5	7.0	0.2	2.6
Severe depression (siblings)	1.6	1.8	3.5	0.1	-1.9
Leg fat-free mass (left)	1.6	8.5	16.5	-0.7	-4.1
Leg predicted mass (left)	1.6	8.2	16.0	-0.7	-4.0
Hair/balding pattern: Pattern 2	1.6	2.1	2.2	-1.5	-1.4
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	2.5	1.3	-1.6
Age when periods started (menarche)	1.5	3.7	4.3	-2.1	1.8
Standing height	1.5	15.2	29.6	-0.9	-5.4
Length of working week for main job	1.5	1.7	3.3	0.1	-1.8
Knee pain experienced in last month	1.5	2.3	4.4	-0.5	-2.1
Alzheimer’s Disease (including proxy)	1.4	2.1	3.8	1.9	-0.6
Prospective memory result	1.4	1.8	3.5	1.9	0.1
Hair/balding pattern: Pattern 4	1.4	3.4	6.1	-0.9	2.5
Illnesses of siblings: Diabetes	1.4	1.7	3.1	0.5	1.8
Average weekly champagne plus white wine intake	1.4	2.0	3.9	0.0	2.0
Ever taken oral contraceptive pill	1.4	1.5	2.1	-1.0	-1.4
Ever depressed for a whole week	1.4	1.7	2.7	-0.8	-1.6
Hair Pigment	1.3	36.2	46.8	-5.1	-6.8
Supplements: Zinc	1.3	1.4	1.4	-1.2	-1.2
Alcohol intake versus 10 years previously	1.3	1.9	3.6	-0.5	1.9
Number of children fathered	1.3	1.4	2.5	-0.6	-1.6
Number of full sisters	1.3	1.6	1.8	-1.4	-1.1
Commuting to job workplace: Public transport	1.3	1.6	2.2	-1.0	1.5
Height	1.2	22.3	42.6	-1.4	-6.5
Vitamin and mineral supplements	1.2	1.7	3.2	-0.5	1.8
Irritability	1.2	2.0	3.0	-1.7	-1.0
Commuting to job workplace: Cycle	1.2	1.5	2.8	-1.7	-0.3
Bipolar Disorder (2011)	1.1	1.0	1.3	-0.9	-1.1
Tanning	1.1	13.2	22.2	2.0	4.7
Average weekly fortified wine intake	1.1	1.3	1.6	-1.0	-1.2
Serious illness, injury or assault to yourself	1.1	1.4	2.7	-0.2	1.6
Chronic bronchitis/emphysema (father)	1.1	1.2	2.1	-0.6	-1.5
Exposure to tobacco smoke at home	1.1	1.2	2.3	-0.2	1.5
Loud music exposure frequency	1.1	1.2	2.2	0.4	1.5
Medication: Gliclazide	1.1	1.3	2.5	0.2	1.6
Wears glasses or contact lenses	1.1	1.3	2.1	1.4	0.7
Tinnitus: Yes, now most or all of the time	1.1	1.3	1.8	0.9	1.3
Waist Hip Ratio (WHR)	1.0	4.3	8.5	0.3	2.9
Stomach or abdominal pain in last month	1.0	1.3	2.4	-1.6	-0.3
Medication: Omeprazole	1.0	1.2	2.4	0.3	1.6
Fractured/broken bones in last 5 years	1.0	1.3	2.3	-0.5	1.5
Supplements: Calcium	1.0	1.1	1.6	0.8	1.3
Schizophrenia vs Biploar Disorder	0.9	1.2	1.4	1.2	1.0
Type 2 Diabetes (T2D) (2012)	0.9	1.1	1.7	-1.3	-0.6
Smoking Status	0.9	2.2	4.2	-0.5	2.1
Ever had hysterectomy (womb removed)	0.9	1.0	1.3	1.1	-0.9
Townsend deprivation index at recruitment	0.9	1.3	2.2	-1.5	0.6
Supplements: Glucosamine	0.9	1.2	1.4	1.2	-1.0
Friendships satisfaction	0.9	1.1	1.4	1.2	-0.9
Breast cancer (self-reported)	0.9	1.1	2.2	-0.0	-1.5
Age started oral contraceptive pill	0.9	1.2	2.0	1.4	0.6
Impedance of whole body	0.9	4.4	8.9	-0.0	3.0
Sensitivity / hurt feelings	0.8	1.5	2.9	1.7	-0.2
Fluid intelligence score	0.8	1.8	1.9	-1.3	1.4
Hair/balding pattern: Pattern 3	0.8	1.1	2.1	1.5	0.4
Happiness	0.8	0.9	1.1	-0.9	-1.1
Lung cancer (father)	0.8	1.0	1.0	-1.0	-1.0
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	2.6	0.2	-1.6
Had major operations	0.8	0.9	1.5	-1.2	0.5
Family relationship satisfaction	0.8	1.0	1.7	-0.6	-1.3
Leg pain on walking	0.8	1.0	1.3	-1.1	-0.8
Guilty feelings	0.8	1.2	2.4	0.1	-1.6
HDL Cholesterol	0.7	1.2	2.1	0.5	-1.5
Waist circumference	0.7	2.7	5.3	-0.4	-2.3
Falls in the last year	0.7	0.9	1.6	-1.3	-0.4
Asthma	0.7	1.3	2.6	-0.3	-1.6
Peak expiratory flow (PEF)	0.7	1.6	1.9	1.4	1.1
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.2	-1.1	-0.6
Neck or shoulder pain in last month	0.7	1.0	1.2	-1.1	-0.9
Leg fat mass (right)	0.7	2.7	5.3	-0.4	-2.3
Chest pain or discomfort	0.7	1.0	1.9	-1.4	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	1.7	-1.1	-1.3
Leg fat mass (left)	0.7	2.8	5.4	-0.5	-2.3
Bipolar Disorder (2018)	0.6	1.0	1.9	1.4	-0.1
Alzheimer’s Disease (in father)	0.6	0.7	1.4	1.2	0.1
Age at First Birth	0.6	0.8	1.4	-1.2	0.5
Lung FEV1/FVC ratio	0.6	3.1	6.0	0.5	-2.5
Ever used hormone-replacement therapy (HRT)	0.6	0.8	0.9	-0.9	-0.9
Pack years adult smoking proportion	0.6	1.0	1.9	-0.1	-1.4
Had menopause	0.6	0.8	1.5	1.2	0.2
Tense / ‘highly strung’	0.6	0.9	1.1	-0.9	-1.0
Medication: Ventolin 100micrograms inhaler	0.6	0.7	1.5	0.1	-1.2
Health satisfaction	0.6	0.8	1.3	0.6	1.1
Medication: Seretide 50 evohaler	0.6	0.7	1.1	0.6	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	0.7	0.8	0.8
Pack years of smoking	0.6	0.9	1.7	0.1	-1.3
Bipolar Disorder or Schizophrenia	0.5	1.1	2.1	1.4	-0.5
Worry (Nagel 2018)	0.5	1.1	1.3	-1.1	-0.9
Neuroticism (2016)	0.5	0.7	1.3	0.2	-1.1
Medication: Metformin	0.5	0.7	1.0	0.7	1.0
Worrier / anxious feelings	0.5	0.9	1.1	-0.8	-1.1
Mouth/teeth dental problems: Dentures	0.5	0.9	1.5	-0.6	1.2
Breastfed as a baby	0.5	0.6	0.7	-0.7	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.4	-1.2	0.1
Whole body fat mass	0.5	2.2	3.9	-0.7	-2.0
Age at last live birth	0.5	0.7	0.9	0.7	0.9
Ever had bowel cancer screening	0.5	0.6	1.1	0.2	-1.0
Asthma (self-reported)	0.5	1.0	1.9	-0.2	-1.4
Hearing aid user	0.5	0.6	1.1	-0.2	1.1
Supplements: Fish oil (including cod liver oil)	0.5	0.7	1.3	-1.2	-0.0
Unable to work because of sickness or disability	0.5	0.6	1.2	-0.1	1.1
Intelligence (Savage-Jansen 2018)	0.4	1.2	1.8	-1.4	0.8
Major Depression (MDD)	0.4	0.5	0.9	0.1	-1.0
Verbal and Numeric Reasoning (VNR)	0.4	1.1	1.2	-1.1	1.0
Respiratory disease	0.4	0.9	1.4	0.6	-1.2
Average weekly spirits intake	0.4	0.4	0.5	0.6	-0.7
Relative age of first facial hair	0.4	0.8	1.7	-0.2	1.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	0.6	-0.8	0.6
Body mass index (BMI)	0.4	1.6	3.1	-0.3	-1.8
Hearing difficulty/problems with background noise	0.4	0.7	1.4	0.1	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	1.0	-0.9	-1.0
Financial difficulties in last 2 years	0.4	0.5	0.9	-0.5	-0.9
Mouth/teeth dental problems	0.4	0.6	1.1	1.1	0.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.2	1.6	1.3	0.9
Arm fat mass (right)	0.4	1.8	3.0	-0.7	-1.7
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	0.9	0.9	0.2
Supplements: Vitamin C	0.4	0.5	0.9	0.9	0.3
Basal cell carcinoma (self-reported)	0.4	0.4	0.8	-0.9	-0.2
Ovarian Cancer	0.3	0.4	0.7	0.9	-0.2
Diabetes (mother)	0.3	0.3	0.4	-0.7	-0.5
Trunk fat mass	0.3	1.4	2.6	-0.3	-1.6
Alcohol usually taken with meals	0.3	0.5	0.9	-0.9	0.2
Pain all over the body in last month	0.3	0.3	0.6	-0.2	-0.8
Time employed in main current job	0.3	0.4	0.7	-0.9	0.2
Noisy workplace	0.3	0.3	0.4	0.6	0.5
Forced vital capacity (FVC), Best measure	0.3	1.1	1.1	1.0	1.1
Leg fat percentage (right)	0.3	1.1	2.1	-0.2	-1.5
Worry too long after embarrassment	0.3	0.4	0.9	0.1	-0.9
Eye problems/disorders: None of the above	0.3	0.3	0.6	0.8	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	0.5	0.5	0.7
Alcohol intake frequency.	0.3	0.6	1.0	0.4	1.0
Suffer from ‘nerves’	0.3	0.5	0.6	-0.6	-0.8
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.8	0.1	-0.9
Commuting to job workplace: Walk	0.3	0.3	0.4	-0.6	-0.4
Osteoarthritis (self-reported)	0.3	0.4	0.4	-0.7	-0.5
Arm fat mass (left)	0.3	1.3	2.5	-0.3	-1.6
Financial situation satisfaction	0.3	0.4	0.7	-0.8	0.3
Leg fat percentage (left)	0.3	1.3	2.4	-0.3	-1.6
Average weekly beer plus cider intake	0.3	0.4	0.7	-0.8	-0.4
Schizophrenia (2018)	0.2	0.4	0.5	0.7	-0.5
Mean Putamen Volume	0.2	0.2	0.3	-0.3	-0.5
Schizophrenia (2014)	0.2	0.4	0.6	0.8	-0.5
BMI	0.2	1.1	2.1	-0.3	-1.4
Medication: Co-codamol	0.2	0.2	0.3	-0.5	-0.4
Maternal smoking around birth	0.2	0.2	0.5	-0.7	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.5	0.9	0.1	-1.0
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	-0.5	0.5
Forced vital capacity (FVC)	0.2	1.0	1.0	1.0	1.0
Depression (self-reported)	0.2	0.3	0.6	-0.1	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	1.2	1.1	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.5	-0.7	-0.5
Glaucoma (self-reported)	0.2	0.3	0.4	0.4	-0.7
Comparative body size at age 10	0.2	0.5	0.7	0.6	0.8
Emphysema/chronic bronchitis	0.2	0.2	0.4	0.6	-0.3
Overall health rating	0.2	0.3	0.5	-0.7	-0.4
Osteoporosis (self-reported)	0.2	0.2	0.4	0.2	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.6	0.7	0.7
Eye problems/disorders: Glaucoma	0.2	0.2	0.3	0.6	0.1
Medication: Atorvastatin	0.2	0.2	0.3	-0.6	0.3
Fasting Glucose	0.1	0.1	0.2	0.1	-0.5
Heel T-Score	0.1	1.0	1.9	-0.1	1.4
Hearing difficulty/problems: Yes	0.1	0.1	0.3	-0.1	0.5
Medication for hormone replacement therapy	0.1	0.1	0.1	-0.3	-0.4
Impedance of leg (right)	0.1	0.5	0.9	0.1	1.0
Hand grip strength (right)	0.1	0.2	0.4	0.2	-0.6
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.3	-0.6	-0.0
Sitting height	0.1	0.7	0.8	0.8	-0.9
Had other major operations	0.1	0.1	0.2	0.3	0.4
Arm fat percentage (right)	0.1	0.2	0.3	-0.6	0.3
Medication: Paracetamol	0.1	0.1	0.2	0.4	0.4
Wheeze or whistling in the chest in last year	0.1	0.2	0.3	0.5	-0.4
Age at first live birth	0.1	0.2	0.2	0.4	0.4
Shortness of breath walking on level ground	0.1	0.2	0.3	0.5	0.3
Qualifications: College or University degree	0.1	0.4	0.7	-0.4	-0.9
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.1	-0.2	-0.3
Myopia	0.1	0.2	0.3	-0.5	0.2
Breast Cancer	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Hand grip strength (left)	0.0	0.1	0.1	-0.2	-0.4
Trunk fat percentage	0.0	0.0	0.0	-0.2	0.0
Qualifications: CSEs or equivalent	0.0	0.1	0.1	0.1	-0.3
Impedance of leg (left)	0.0	0.1	0.2	-0.2	0.5
Nervous feelings	0.0	0.0	0.0	-0.1	0.2
Number of live births	0.0	0.1	0.1	-0.3	0.1
Body fat percentage	0.0	0.1	0.1	-0.2	-0.3
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.0	-0.0	-0.1
Arm fat percentage (left)	0.0	0.1	0.2	-0.2	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.1	-0.1	-0.3
Mineral and other dietary supplements	0.0	0.1	0.1	0.2	0.3
Medication: Paracetamol	0.0	0.1	0.1	0.3	-0.2
Alcohol drinker status: Never	0.0	0.0	0.0	-0.2	0.1

Hub : Genes

SH2B3

Models

Trait associations