TWAS hub - ATXN2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0230	0.013	7.8e-04	0.030	0.023	0.025	0.022	0.023	1.4e-04	7.4e-04	4.8e-04	9.1e-04	7.4e-04
2	YFS	Blood	0.0476	0.020	5.2e-11	0.019	0.037	0.035	0.037	0.031	6.9e-07	2.8e-12	9.1e-12	2.9e-12	1.3e-10

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood Eosinophil Count	72.5	558.5	918.1	30.3	-14.1
Blood White Count	40.2	297.9	449.4	21.2	-12.1
Hypothyroidism (self reported)	37.4	85.9	151.3	12.3	-4.5
Medication: Levothyroxine sodium	37.4	63.3	99.8	10.0	-5.2
Hypothyroidism/myxoedema (self-reported)	32.3	63.1	108.2	10.4	-4.2
Systolic Blood Pressure	24.2	121.1	174.2	13.2	-8.2
Diastolic blood pressure, automated reading	24.2	74.9	121.0	11.0	-5.4
High blood pressure	20.5	57.2	73.4	8.6	-6.4
Cardiovascular Disease	19.6	64.7	92.2	9.6	-6.1
Vascular/heart problems diagnosed by doctor	19.6	53.4	73.3	-8.6	5.8
Hypertension (Self-reported)	18.5	51.4	67.7	8.2	-5.9
Blood Red Count	15.8	152.8	215.7	14.7	-9.5
Systolic blood pressure, automated reading	15.1	44.0	61.9	7.9	-5.1
Medication: Blood pressure	15.1	26.7	41.0	6.4	-3.5
Reaction Time	14.6	27.8	36.3	6.0	-4.4
Smoking status: Previous	14.3	21.4	28.6	5.3	-3.8
Mean time to correctly identify matches	13.5	25.7	33.8	5.8	-4.2
Medication: Atenolol	12.9	16.1	26.3	5.1	-2.4
Medication: Blood pressure	12.3	23.5	29.8	5.5	-4.1
Medication: Allopurinol	12.2	16.2	22.0	4.7	-3.2
Primary Biliary Cirrhosis	11.6	16.5	22.8	4.8	-3.2
Past tobacco smoking	11.4	21.0	30.6	-5.5	3.4
Illnesses of father: None of the above (group 1)	11.4	14.0	19.4	-4.4	2.9
Number of self-reported non-cancer illnesses	11.1	19.3	26.5	5.1	-3.5
LDL Cholesterol	11.0	17.4	26.4	-5.1	2.9
Birth weight	11.0	23.9	36.2	-6.0	3.4
Qualifications: NVQ or HND or HNC or equivalent	10.6	12.7	15.4	-3.9	3.2
Taking other prescription medications	10.3	15.9	27.6	5.2	-2.1
HbA1C	10.2	11.3	14.7	-3.8	2.8
Fed-up feelings	10.0	18.2	25.4	-5.0	3.3
Heart attack/myocardial infarction (self-reported)	9.9	12.8	20.4	4.5	-2.3
Illnesses of siblings	9.8	13.7	17.6	-4.2	3.1
Number of treatments/medications taken	9.5	17.1	27.4	5.2	-2.6
Birth weight of first child	9.5	17.3	28.9	-5.4	2.4
Heart attack	9.0	11.6	18.6	4.3	-2.1
Coronary Artery Disease (CAD)	8.8	10.5	14.0	3.7	-2.7
Gout (self-reported)	8.7	12.0	18.5	4.3	-2.3
Medication: Bendroflumethiazide	8.6	13.1	14.5	3.8	-3.4
Medication: Ramipril	8.5	10.9	14.3	3.8	-2.7
Medication for cholesterol, blood pressure or diabetes	8.1	13.4	22.1	-4.7	2.2
Medication: Aspirin	7.7	10.2	17.3	4.2	-1.7
Father’s age at death	7.5	10.0	17.5	-4.2	1.6
Ever smoked	7.5	13.2	19.6	4.4	-2.6
Back pain experienced in last month	7.3	10.7	10.8	-3.2	3.3
Ever highly irritable/argumentative for 2 days	7.1	8.5	10.7	-2.5	3.3
Depressed Affect (Nagel 2018)	7.0	14.8	18.9	-4.3	3.3
Blood Platelet Count	7.0	81.3	93.1	8.3	9.7
Illnesses of father: High blood pressure	7.0	8.7	12.4	3.5	-2.2
Heart disease (mother)	6.9	8.5	9.2	2.8	-3.0
Medication for cholesterol	6.9	10.5	14.8	-3.8	2.5
Rheumatoid Arthritis	6.6	9.1	9.2	3.0	-3.0
Frequency of tiredness / lethargy in last 2 weeks	6.6	10.7	11.2	-3.4	3.2
Frequency of unenthusiasm / disinterest in last 2 weeks	6.3	8.3	8.9	-3.0	2.8
Loneliness, isolation	6.3	8.7	11.0	-3.3	2.5
High blood pressure (mother)	6.2	8.6	10.6	3.3	-2.6
Blood clot in the leg (DVT)	6.2	8.0	13.8	3.7	-1.5
Medication: Aspirin	6.2	8.1	14.8	3.8	-1.2
Pain experienced in last month	6.0	10.0	13.7	3.7	-2.5
Illnesses of father: Heart disease	5.8	8.1	12.7	3.6	-1.9
Mood swings	5.8	10.5	13.2	-3.6	2.8
Depression (Nagel 2018)	5.3	7.9	8.7	-2.7	3.0
Lupus	5.2	7.9	13.1	3.6	-1.6
Chronotype (morning person)	5.1	11.7	13.6	3.7	-3.1
Type 2 Diabetes (T2D) (2018)	5.0	9.4	15.5	3.9	-1.8
Deep venous thrombosis (DVT) (self-reported)	5.0	6.5	11.5	3.4	-1.2
Illnesses of mother	4.9	6.1	7.8	-2.8	2.1
Neuroticism score	4.7	9.7	10.0	-3.1	3.2
Smoking status: Current	4.7	7.4	10.1	-2.2	3.2
Frequency of depressed mood in last 2 weeks	4.5	6.3	6.6	-2.4	2.6
Angina	4.4	5.8	6.7	2.6	-2.2
Headache pain in last month	4.4	7.6	10.7	-3.3	2.1
Frequency of tenseness / restlessness in last 2 weeks	4.2	6.6	9.3	-3.0	2.0
Alcohol intake versus 10 years previously	4.2	6.3	8.4	2.9	-2.0
Cholesterol lowering medication	4.2	6.2	8.8	3.0	-1.9
Comparative height size at age 10	4.0	22.3	25.6	-5.1	4.3
Medication: Omeprazole (e.g. Zanprol)	3.9	4.8	7.7	2.8	-1.4
Current tobacco smoking	3.8	6.2	8.6	-2.0	2.9
High blood pressure (siblings)	3.8	5.5	6.2	2.5	-2.2
Medication: Ibuprofen (e.g. Nurofen)	3.7	4.7	5.8	-2.4	1.9
Medication: Lisinopril	3.7	4.7	8.1	2.9	-1.2
Diabetes diagnosed by doctor	3.6	5.9	9.8	3.1	-1.4
High cholesterol (Self-reported)	3.6	6.4	9.4	3.1	-1.9
Verbal and Numeric Reasoning (VNR)	3.4	8.2	11.7	2.2	-3.4
Angina (self-reported)	3.4	4.4	5.1	2.3	-1.9
Migraine (self-reported)	3.4	4.2	5.3	-2.3	1.7
Pulse wave Arterial Stiffness index	3.3	3.8	5.9	2.4	-1.4
Medication: Ibuprofen	3.3	3.9	4.7	-2.2	1.8
Diverticular disease/diverticulitis (self-reported)	3.2	3.8	4.8	-2.2	1.7
Medication: Cholesterol lowering	3.2	5.0	8.2	2.9	-1.4
Mouth/teeth dental problems: Bleeding gums	3.2	4.1	4.3	2.0	-2.1
Pulse wave peak to peak time	3.2	3.8	5.7	-2.4	1.4
Allergy or Eczema	3.1	8.1	13.6	-3.7	1.6
Trunk fat-free mass	3.1	17.5	27.3	-5.2	2.8
Trunk predicted mass	3.1	17.9	27.9	-5.3	2.8
Arm fat-free mass (left)	3.0	15.0	25.4	-5.0	2.1
Neuroticism (Nagel 2018)	2.9	6.8	7.4	-2.7	2.5
Illnesses of siblings: Diabetes	2.9	3.6	6.6	2.6	-0.7
Risk taking	2.9	4.3	7.0	-2.7	1.2
Arm predicted mass (left)	2.9	14.9	24.8	-5.0	2.2
Smoking Status	2.8	6.6	12.5	3.5	-0.9
Diabetes (self-reported)	2.8	4.3	7.4	2.7	-1.1
Mother’s age at death	2.8	3.5	6.8	-2.6	0.6
Medication for pain relief, constipation, heartburn	2.7	4.6	7.5	-2.7	1.3
Ulcerative Colitis (UC)	2.6	4.8	8.1	2.9	-1.2
Multivitamins +/- minerals	2.6	3.3	6.2	-2.5	0.7
Fluid intelligence score	2.6	5.4	8.3	1.6	-2.9
Alcohol drinker status: Previous	2.6	3.0	4.1	2.0	-1.3
Type 2 Diabetes (T2D) (2012)	2.5	2.9	5.2	0.8	-2.3
Pack years adult smoking proportion	2.5	3.8	4.8	-1.7	2.2
Medication: Simvastatin	2.5	3.6	6.0	2.4	-1.2
Medication: Omeprazole	2.5	3.0	4.4	2.1	-1.3
Mouth/teeth dental problems: Mouth ulcers	2.5	4.0	7.3	-2.7	0.9
Ever depressed for a whole week	2.5	3.1	4.2	-2.0	1.4
Hayfever, allergic rhinitis or eczema	2.4	5.2	8.6	-2.9	1.4
Medication: Lansoprazole	2.4	2.7	4.7	2.2	-0.8
Arm fat-free mass (right)	2.4	12.1	20.5	-4.5	1.9
Arm predicted mass (right)	2.4	12.0	20.9	-4.6	1.8
Irritable Bowel Disease (IBD)	2.3	5.5	9.3	3.0	-1.3
Miserableness	2.3	3.9	5.5	-2.3	1.5
Vitamin and mineral supplements	2.2	3.0	5.8	2.4	-0.5
Relative age voice broke	2.2	3.3	4.1	2.0	-1.6
Hip circumference	2.2	9.6	14.5	-3.8	2.2
Comparative body size at age 10	2.2	6.0	7.8	2.0	-2.8
Whole body water mass	2.2	12.6	20.2	-4.5	2.2
Heart disease (siblings)	2.2	2.7	3.5	1.9	-1.4
Neuroticism	2.1	5.1	5.2	-2.3	2.2
Other serious medical condition/disability diagnosed by doctor	2.1	2.7	4.3	2.1	-1.0
Medication: Amlodipine	2.1	2.9	3.5	1.9	-1.5
Whole body fat-free mass	2.1	12.3	19.5	-4.4	2.2
Basal metabolic rate	2.1	11.5	18.1	-4.3	2.2
Pack years of smoking	2.1	3.1	4.0	-1.5	2.0
Intelligence (Savage-Jansen 2018)	2.0	6.2	8.4	2.0	-2.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.3	2.8	1.7	-1.4
Suffer from ‘nerves’	2.0	3.1	3.6	-1.6	1.9
Ever unenthusiastic/disinterested for a whole week	1.9	2.4	4.0	-2.0	0.8
Reason for reducing amount of alcohol drunk: Health precaution	1.9	2.2	3.2	1.8	-1.1
Guilty feelings	1.8	2.7	3.2	-1.8	1.5
Age started oral contraceptive pill	1.8	2.2	3.4	1.0	-1.8
Medication for hormone replacement therapy	1.7	1.9	2.0	-1.4	1.4
Exposure to tobacco smoke outside home	1.7	2.3	4.2	2.1	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	3.4	1.9	-0.7
Qualifications: nursing, teaching	1.7	2.6	5.2	-2.3	0.1
Medication: Gliclazide	1.7	1.9	2.6	1.6	-1.1
Commuting to job workplace: Public transport	1.7	2.0	3.3	1.8	-0.9
Weight	1.6	7.9	11.7	-3.4	2.0
Mouth/teeth dental problems: Loose teeth	1.6	1.9	2.8	-0.9	1.7
Mean Putamen Volume	1.5	1.7	2.4	-1.0	1.5
Knee pain experienced in last month	1.5	2.3	3.0	-1.7	1.2
Long-standing illness, disability or infirmity	1.5	2.2	4.5	2.1	0.1
Supplements: Calcium	1.5	1.7	1.8	1.4	-1.3
Schizophrenia vs Biploar Disorder	1.4	1.8	3.6	1.9	-0.2
Crohns Disease (2012)	1.4	2.2	4.3	2.1	-0.5
Relative age of first facial hair	1.4	2.8	2.9	1.7	-1.7
Standing height	1.4	13.7	16.8	-4.1	3.2
Hair/balding pattern: Pattern 4	1.4	3.3	5.3	2.3	-1.1
Fractured/broken bones in last 5 years	1.4	1.9	2.5	1.1	-1.6
Impedance of arm (left)	1.3	6.0	11.9	3.4	-0.3
Pulse wave reflection index	1.3	1.6	2.5	1.6	-0.8
Waist Hip Ratio (WHR)	1.2	5.3	10.2	3.2	-0.7
Tanning	1.2	14.9	16.7	4.1	-3.6
Leg fat-free mass (left)	1.2	6.5	9.7	-3.1	1.8
Leg predicted mass (left)	1.2	6.3	9.4	-3.1	1.8
Had other major operations	1.2	1.5	1.6	1.3	-1.1
Mouth/teeth dental problems	1.2	1.8	2.5	1.0	-1.6
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	3.0	-1.7	0.4
Triglycerides	1.1	1.9	2.3	1.5	-1.2
Alcohol usually taken with meals	1.1	1.8	3.6	0.2	-1.9
Qualifications: A levels/AS levels or equivalent	1.1	2.4	4.4	-2.1	0.7
Exposure to tobacco smoke at home	1.1	1.3	2.1	1.4	-0.7
Crohns Disease (2017)	1.0	2.1	4.0	2.0	-0.5
Stomach or abdominal pain in last month	1.0	1.3	1.4	-1.2	1.1
Waist circumference	1.0	3.8	4.1	-2.0	1.9
Lung cancer (father)	1.0	1.1	2.0	-1.4	0.5
Health satisfaction	1.0	1.3	2.6	0.1	1.6
Alcohol intake frequency.	1.0	2.3	3.1	1.2	-1.8
Average weekly beer plus cider intake	1.0	1.4	2.2	-0.8	1.5
Worry (Nagel 2018)	0.9	2.0	3.5	-0.7	1.9
Major Depression (MDD)	0.9	1.1	1.3	-0.9	1.1
Ulcerative Colitis	0.9	1.3	2.5	1.6	-0.2
Height	0.9	18.1	22.7	-4.8	3.7
Qualifications: None of the above	0.9	2.0	3.9	2.0	-0.1
Financial difficulties in last 2 years	0.9	1.2	1.8	-1.4	0.7
Chronic bronchitis/emphysema (mother)	0.9	1.1	2.1	1.4	0.0
Number of full brothers	0.9	1.2	1.9	-1.4	0.6
Leg fat mass (right)	0.9	3.4	4.8	-2.2	1.4
Leg fat-free mass (right)	0.9	4.6	7.6	-2.8	1.3
Irritability	0.9	1.5	1.7	-1.2	1.3
Ever used hormone-replacement therapy (HRT)	0.8	1.0	1.5	-1.2	0.7
Severe depression (siblings)	0.8	0.9	1.6	-1.3	-0.4
Average weekly fortified wine intake	0.8	1.0	1.9	-1.4	-0.3
Age when periods started (menarche)	0.8	1.9	2.1	1.4	-1.3
Allergy	0.8	1.9	3.0	1.7	-1.0
Qualifications: O levels/GCSEs or equivalent	0.8	1.2	2.3	-1.5	0.3
Number of children fathered	0.8	0.9	0.9	-1.0	0.9
Emphysema/chronic bronchitis	0.8	0.9	1.8	-0.3	1.3
Ever had bowel cancer screening	0.8	1.0	1.8	-1.3	0.4
Leg predicted mass (right)	0.8	4.3	7.2	-2.7	1.2
Average weekly champagne plus white wine intake	0.8	1.1	1.4	1.2	-0.9
Bipolar Disorder (2018)	0.7	1.2	1.8	-0.7	1.4
Bipolar Disorder (2011)	0.7	0.6	1.2	-1.1	0.3
Lung FEV1/FVC ratio	0.7	3.4	5.7	-2.4	1.0
Lung FVC	0.7	3.6	5.2	2.3	-1.4
Diabetes (father)	0.7	0.9	1.1	1.1	-0.8
Serious illness, injury or assault to yourself	0.7	0.9	1.5	1.2	-0.6
Chronic bronchitis/emphysema (father)	0.7	0.8	1.1	-0.6	1.1
Pulse rate	0.7	1.3	1.5	1.2	-1.0
Leg pain on walking	0.7	0.8	1.2	-0.7	1.1
Friendships satisfaction	0.7	0.8	1.2	-1.1	-0.6
Alzheimer’s Disease (including proxy)	0.6	0.8	1.6	-1.2	0.4
Body Mass Index (BMI) (2010)	0.6	0.9	1.6	-1.3	-0.3
Nervous feelings	0.6	1.1	1.6	-0.8	1.3
Pain all over the body in last month	0.6	0.7	1.3	0.2	-1.2
Impedance of arm (right)	0.6	2.7	5.2	2.3	0.4
Mouth/teeth dental problems: Dentures	0.6	1.0	2.0	0.3	1.4
Prospective memory result	0.6	0.8	1.1	-0.6	1.1
Leg fat percentage (right)	0.6	2.2	3.1	-1.8	1.1
Worry too long after embarrassment	0.6	1.1	1.4	-0.9	1.2
Neck or shoulder pain in last month	0.6	0.8	1.6	-1.2	-0.1
Medication: Seretide 50 evohaler	0.6	0.7	0.7	0.9	-0.8
Whole body fat mass	0.6	2.6	3.3	-1.8	1.4
Age at last live birth	0.6	0.9	1.7	-0.0	-1.3
Average weekly red wine intake	0.6	0.9	1.5	-1.2	0.6
Osteoarthritis (self-reported)	0.6	0.8	1.5	0.4	-1.2
Impedance of whole body	0.6	3.2	6.4	2.5	-0.3
Leg fat mass (left)	0.6	2.4	3.7	-1.9	1.1
Respiratory disease	0.5	1.2	2.1	0.5	-1.5
Hair Pigment	0.5	14.3	22.1	-4.7	2.5
Medication: Metformin	0.5	0.7	1.4	0.1	1.2
Trunk fat mass	0.5	2.2	2.6	-1.6	1.3
Worrier / anxious feelings	0.5	1.0	1.6	-0.7	1.3
Number of live births	0.5	0.7	1.0	-0.7	1.0
Arm fat mass (right)	0.5	2.0	2.9	-1.7	1.0
Tense / ‘highly strung’	0.5	0.9	1.2	-1.1	0.8
Medication: Ventolin 100micrograms inhaler	0.5	0.6	0.7	-0.8	0.7
Wheeze or whistling in the chest in last year	0.5	0.9	1.0	1.0	-0.9
Number of full sisters	0.5	0.6	0.8	-0.7	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.1	-1.1	1.0
Handedness (chirality/laterality): Left-handed	0.5	0.6	1.3	-1.1	0.1
Hearing aid user	0.5	0.6	0.9	0.5	-1.0
Bipolar Disorder or Schizophrenia	0.4	0.9	1.5	-0.5	1.2
Age at First Birth	0.4	0.6	0.6	0.7	-0.8
Hearing difficulty/problems: Yes	0.4	0.6	1.1	0.4	-1.0
Ever had hysterectomy (womb removed)	0.4	0.5	0.6	-0.8	0.6
Townsend deprivation index at recruitment	0.4	0.5	0.8	0.5	-0.9
Supplements: Glucosamine	0.4	0.5	1.0	0.2	-1.0
Body mass index (BMI)	0.4	1.7	2.9	-1.7	0.7
Hearing difficulty/problems with background noise	0.4	0.6	1.1	-1.1	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.0	-0.0	-1.0
Depression (self-reported)	0.4	0.5	0.9	-1.0	-0.3
Shortness of breath walking on level ground	0.4	0.5	0.9	-0.2	1.0
Pulse rate, automated reading	0.4	1.1	2.1	1.4	-0.5
Had major operations	0.4	0.5	0.5	0.7	-0.7
Mineral and other dietary supplements	0.4	0.5	1.0	0.2	1.0
Pain type(s) experienced in last month: Hip pain	0.4	0.6	0.8	-0.6	0.9
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.8	-0.9	-0.0
Commuting to job workplace: Cycle	0.4	0.5	0.9	-1.0	-0.1
Basal cell carcinoma (self-reported)	0.4	0.4	0.8	-0.9	0.0
Fasting Glucose	0.3	0.4	0.4	0.6	-0.6
HDL Cholesterol	0.3	0.6	1.1	-1.0	-0.2
Schizophrenia (2014)	0.3	0.7	0.9	-0.7	1.0
Heel T-Score	0.3	2.7	3.7	1.9	-1.3
Supplements: Zinc	0.3	0.4	0.8	-0.9	0.1
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.8	-0.0	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.0	-1.0	0.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.5	-0.3	0.7
Hair/balding pattern: Pattern 2	0.3	0.4	0.5	-0.7	0.6
Falls in the last year	0.3	0.4	0.6	-0.8	0.5
Breastfed as a baby	0.3	0.4	0.7	-0.1	0.9
Peak expiratory flow (PEF)	0.3	0.6	0.6	0.8	-0.8
Overall health rating	0.3	0.6	1.3	0.0	1.1
Chest pain or discomfort	0.3	0.4	0.7	-0.3	0.8
Eye problems/disorders: Cataract	0.3	0.3	0.4	-0.6	0.6
Arm fat mass (left)	0.3	1.3	2.1	-1.4	0.7
Wears glasses or contact lenses	0.3	0.3	0.5	0.7	-0.4
Leg fat percentage (left)	0.3	1.1	1.8	-1.4	0.6
Ovarian Cancer	0.2	0.2	0.4	0.6	-0.2
Neuroticism (2016)	0.2	0.3	0.5	-0.7	0.4
BMI	0.2	0.9	1.8	-1.4	0.1
Medication: Co-codamol	0.2	0.2	0.4	-0.2	0.7
Diabetes (mother)	0.2	0.3	0.5	0.7	-0.3
Number of incorrect matches in round	0.2	0.3	0.3	0.5	0.6
Happiness	0.2	0.2	0.3	-0.6	0.3
Noisy workplace	0.2	0.3	0.3	0.5	-0.6
Glaucoma (self-reported)	0.2	0.3	0.5	-0.7	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.4	-0.4	-0.7
Age at first live birth	0.2	0.4	0.8	0.1	-0.9
Family relationship satisfaction	0.2	0.3	0.3	-0.5	-0.6
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.4	0.1	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.3	0.5	0.2
Number of operations (self-reported)	0.2	0.3	0.4	0.3	-0.7
Schizophrenia (2018)	0.1	0.1	0.2	-0.0	0.5
Alzheimer’s Disease (in mother)	0.1	0.1	0.2	-0.5	-0.2
Hand grip strength (left)	0.1	0.3	0.4	0.3	-0.7
Average weekly spirits intake	0.1	0.1	0.1	0.4	-0.1
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.1	-0.2	-0.3
Impedance of leg (right)	0.1	0.4	0.8	0.3	0.9
Hand grip strength (right)	0.1	0.2	0.3	0.3	-0.6
Qualifications: CSEs or equivalent	0.1	0.2	0.3	-0.3	-0.5
Impedance of leg (left)	0.1	0.3	0.7	0.8	0.1
Had menopause	0.1	0.1	0.1	-0.1	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.5	-0.7	0.3
Arm fat percentage (right)	0.1	0.2	0.3	-0.3	0.6
Time employed in main current job	0.1	0.1	0.2	-0.4	0.2
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.4	0.6	-0.4
Asthma	0.1	0.1	0.3	-0.5	-0.1
Length of working week for main job	0.1	0.1	0.1	-0.3	0.3
Loud music exposure frequency	0.1	0.1	0.2	-0.1	0.4
Medication: Paracetamol	0.1	0.1	0.2	0.3	-0.4
Body fat percentage	0.1	0.2	0.3	-0.4	0.5
Qualifications: College or University degree	0.1	0.5	0.9	-0.1	-0.9
Eye problems/disorders: None of the above	0.1	0.1	0.2	0.0	-0.4
Supplements: Vitamin C	0.1	0.1	0.2	-0.3	-0.4
Commuting to job workplace: Walk	0.1	0.1	0.1	-0.3	0.4
Breast cancer (self-reported)	0.1	0.1	0.1	-0.4	-0.1
Asthma (self-reported)	0.1	0.2	0.3	-0.6	-0.3
Osteoporosis (self-reported)	0.1	0.1	0.1	0.3	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.2	-0.4	0.2
Ever taken oral contraceptive pill	0.1	0.2	0.3	-0.0	0.6
Financial situation satisfaction	0.1	0.1	0.1	0.3	-0.2
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.1	0.3	-0.3
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	0.0	-0.4
Medication: Paracetamol	0.1	0.1	0.2	-0.5	0.2
Medication: Atorvastatin	0.1	0.1	0.2	0.5	0.2
Alcohol drinker status: Never	0.1	0.2	0.3	0.2	-0.5
Unable to work because of sickness or disability	0.1	0.1	0.2	0.4	0.3
Alzheimer’s Disease (in father)	0.0	0.0	0.1	0.1	-0.3
Breast Cancer	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0
Sensitivity / hurt feelings	0.0	0.0	0.1	-0.1	-0.3
Trunk fat percentage	0.0	0.1	0.1	-0.1	0.4
Maternal smoking around birth	0.0	0.0	0.0	0.1	0.0
Sitting height	0.0	0.0	0.0	0.1	0.2
Forced vital capacity (FVC)	0.0	0.2	0.3	0.6	0.1
Hair/balding pattern: Pattern 3	0.0	0.0	0.0	-0.1	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.2	0.2	-0.4	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.1	-0.3	-0.1
Forced vital capacity (FVC), Best measure	0.0	0.1	0.2	0.2	0.4
Commuting to job workplace: Car/motor vehicle	0.0	0.0	0.1	-0.1	-0.2
Arm fat percentage (left)	0.0	0.1	0.1	0.1	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.0	0.2	-0.0
Eye problems/disorders: Glaucoma	0.0	0.1	0.1	-0.3	0.2
Myopia	0.0	0.0	0.1	0.0	0.3

Hub : Genes

ATXN2

Models

Trait associations