Hub : Traits :

Medication: Atenolol

26 significantly associated models · 5 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 12 111154626 113517494 4 1 8.6e-10 4.5e-16 7.6e-08 56 HECTD4
2 15 90730363 92135418 1 1 7.8e-12 1.7e-09 8.5e-01 100 FES

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 3.70 1 0 0.0 0 1 FES
Bipolar Disorder or Schizophrenia 12.61 1 1 2.2 0 1 FES
Neuroticism (Nagel 2018) 2.56 1 0 0.0 0 1 FES
Schizophrenia (2018) 13.38 1 1 2.2 0 1 FES
Crohns Disease (2017) 5.57 2 0 0.0 0 1 FES HECTD4
Irritable Bowel Disease (IBD) 6.34 2 0 0.0 0 1 FES HECTD4
Ulcerative Colitis (UC) 3.99 1 0 0.0 0 1 HECTD4
Reaction Time 13.44 1 1 2.2 0 1 HECTD4
Breast Cancer 8.31 1 0 0.0 0 1 FES
Ovarian Cancer 3.65 1 0 0.0 0 1 FES
Body Mass Index (BMI) (2010) 3.84 1 0 0.0 0 1 HECTD4
Coronary Artery Disease (CAD) 18.54 1 0 0.0 0 1 HECTD4
Crohns Disease (2012) 4.25 1 0 0.0 0 1 FES
LDL Cholesterol 10.78 1 1 2.2 0 1 HECTD4
Lupus 8.57 1 0 0.0 0 1 HECTD4
Primary Biliary Cirrhosis 9.55 1 0 0.0 0 1 HECTD4
Rheumatoid Arthritis 6.30 1 0 0.0 0 1 HECTD4
Schizophrenia (2014) 12.30 1 1 2.2 0 1 FES
Blood Eosinophil Count 88.55 1 1 2.2 0 1 HECTD4
Blood Platelet Count 36.03 1 1 2.2 0 1 HECTD4
Blood Red Count 12.23 2 1 2.2 0 1 FES HECTD4
Blood White Count 38.19 2 2 4.4 0 1 FES HECTD4
BMI 2.27 1 0 0.0 0 1 HECTD4
Height 1.86 2 2 4.4 0 1 FES HECTD4
Waist Hip Ratio (WHR) 2.11 1 0 0.0 0 1 HECTD4
Systolic Blood Pressure 43.63 2 2 4.4 0 1 FES HECTD4
Smoking Status 4.95 1 0 0.0 0 1 FES
Allergy or Eczema 9.09 2 1 2.2 0 1 FES HECTD4
Cardiovascular Disease 33.45 2 2 4.4 0 1 FES HECTD4
Hypothyroidism (self reported) 69.10 1 1 2.2 0 1 HECTD4
Respiratory disease 3.67 1 0 0.0 0 1 FES
Lung FEV1/FVC ratio 1.01 1 0 0.0 0 1 HECTD4
Lung FVC 2.80 1 0 0.0 0 1 HECTD4
Neuroticism 2.38 1 0 0.0 0 1 FES
Chronotype (morning person) 3.26 1 0 0.0 0 1 HECTD4
Hair Pigment 1.46 2 2 4.4 0 1 FES HECTD4
Tanning 0.73 1 0 0.0 0 1 HECTD4
Hand grip strength (left) 3.81 1 0 0.0 0 1 FES
Number of treatments/medications taken 12.97 2 1 2.2 0 1 FES HECTD4
Sensitivity / hurt feelings 8.16 1 1 2.2 0 1 FES
Other serious medical condition/disability diagnosed by doctor 4.59 1 0 0.0 0 1 HECTD4
Systolic blood pressure, automated reading 33.30 2 2 4.4 0 1 FES HECTD4
Angina 19.82 1 1 2.2 0 1 FES
Impedance of leg (right) 4.51 2 1 2.2 0 1 FES HECTD4
Leg fat-free mass (left) 5.62 2 1 2.2 0 1 FES HECTD4
Current tobacco smoking 4.73 1 0 0.0 0 1 FES
Fed-up feelings 6.31 1 0 0.0 0 1 HECTD4
Taking other prescription medications 10.84 1 1 2.2 0 1 HECTD4
High blood pressure 41.61 2 2 4.4 0 1 FES HECTD4
Hayfever, allergic rhinitis or eczema 7.83 2 0 0.0 0 1 FES HECTD4
Diverticular disease/diverticulitis (self-reported) 6.09 1 0 0.0 0 1 HECTD4
Medication: Levothyroxine sodium 49.16 1 1 2.2 0 1 HECTD4
Sitting height 0.91 1 0 0.0 0 1 FES
High blood pressure (mother) 34.36 1 1 2.2 0 1 FES
Body mass index (BMI) 2.54 1 0 0.0 0 1 HECTD4
Impedance of leg (left) 4.35 1 1 2.2 0 1 FES
Leg predicted mass (left) 5.54 2 1 2.2 0 1 FES HECTD4
Trunk fat mass 2.23 1 0 0.0 0 1 HECTD4
Waist circumference 2.55 1 0 0.0 0 1 HECTD4
Number of incorrect matches in round 6.06 1 0 0.0 0 1 FES
Past tobacco smoking 8.32 2 0 0.0 0 1 FES HECTD4
Alcohol usually taken with meals 6.60 1 0 0.0 0 1 FES
Heart attack 15.34 1 1 2.2 0 1 FES
Allergy 6.75 2 0 0.0 0 1 FES HECTD4
Medication: Ramipril 10.06 1 0 0.0 0 1 FES
Medication: Simvastatin 11.71 1 1 2.2 0 1 FES
Illnesses of siblings 15.22 2 1 2.2 0 1 FES HECTD4
Weight 5.06 1 1 2.2 0 1 HECTD4
Impedance of arm (right) 3.11 1 1 2.2 0 1 HECTD4
Trunk fat-free mass 6.71 2 1 2.2 0 1 FES HECTD4
Hip circumference 5.70 1 1 2.2 0 1 HECTD4
Father's age at death 16.49 2 1 2.2 0 1 FES HECTD4
Number of live births 3.92 1 0 0.0 0 1 FES
Asthma 3.28 1 0 0.0 0 1 FES
Medication: Ibuprofen (e.g. Nurofen) 5.08 1 0 0.0 0 1 HECTD4
Medication: Cholesterol lowering 12.91 1 1 2.2 0 1 FES
Medication: Lansoprazole 6.05 1 0 0.0 0 1 HECTD4
Lung cancer (father) 4.79 1 0 0.0 0 1 FES
Illnesses of mother 21.07 1 1 2.2 0 1 FES
Pulse wave Arterial Stiffness index 7.66 1 0 0.0 0 1 FES
Impedance of arm (left) 4.19 1 1 2.2 0 1 HECTD4
Arm fat mass (right) 3.16 1 0 0.0 0 1 HECTD4
Trunk predicted mass 6.76 1 1 2.2 0 1 HECTD4
Standing height 1.73 1 1 2.2 0 1 HECTD4
Breastfed as a baby 6.29 1 0 0.0 0 1 FES
Hair/balding pattern: Pattern 4 3.86 1 0 0.0 0 1 FES
Birth weight of first child 30.01 2 2 4.4 0 1 FES HECTD4
Blood clot in the leg (DVT) 5.17 1 0 0.0 0 1 HECTD4
Headache pain in last month 8.60 2 0 0.0 0 1 FES HECTD4
Medication for cholesterol, blood pressure or diabetes 27.52 2 1 2.2 0 1 FES HECTD4
Gout (self-reported) 6.25 1 0 0.0 0 1 HECTD4
Hypothyroidism/myxoedema (self-reported) 53.87 1 1 2.2 0 1 HECTD4
Medication: Amlodipine 15.65 1 1 2.2 0 1 FES
Birth weight 17.39 2 2 4.4 0 1 FES HECTD4
High blood pressure (siblings) 20.19 2 1 2.2 0 1 FES HECTD4
Arm fat-free mass (right) 6.43 1 1 2.2 0 1 HECTD4
Pulse wave peak to peak time 8.00 1 0 0.0 0 1 FES
Medication: Blood pressure 34.20 2 2 4.4 0 1 FES HECTD4
Angina (self-reported) 20.49 1 1 2.2 0 1 FES
Medication: Allopurinol 5.37 1 0 0.0 0 1 HECTD4
Mean time to correctly identify matches 14.78 2 1 2.2 0 1 FES HECTD4
Heart disease (mother) 10.29 2 0 0.0 0 1 FES HECTD4
Whole body fat mass 2.54 1 0 0.0 0 1 HECTD4
Leg fat mass (right) 2.79 1 0 0.0 0 1 HECTD4
Arm predicted mass (right) 6.44 1 1 2.2 0 1 HECTD4
Comparative height size at age 10 5.33 2 1 2.2 0 1 FES HECTD4
Medication: Aspirin 15.48 1 1 2.2 0 1 FES
Hypertension (Self-reported) 40.69 2 2 4.4 0 1 FES HECTD4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 4.74 1 0 0.0 0 1 HECTD4
Illnesses of father: Heart disease 25.58 2 1 2.2 0 1 FES HECTD4
Smoking status: Previous 8.60 1 0 0.0 0 1 HECTD4
Whole body fat-free mass 6.44 2 1 2.2 0 1 FES HECTD4
Leg fat-free mass (right) 5.70 2 1 2.2 0 1 FES HECTD4
Handedness (chirality/laterality): Left-handed 5.88 1 0 0.0 0 1 FES
Loneliness, isolation 5.15 1 0 0.0 0 1 HECTD4
Long-standing illness, disability or infirmity 4.71 1 0 0.0 0 1 HECTD4
Mouth/teeth dental problems: Mouth ulcers 4.63 1 0 0.0 0 1 HECTD4
Medication for cholesterol 15.79 2 0 0.0 0 1 FES HECTD4
Mineral and other dietary supplements 4.36 1 0 0.0 0 1 FES
Asthma (self-reported) 3.20 1 0 0.0 0 1 FES
Medication: Aspirin 16.04 1 1 2.2 0 1 FES
Illnesses of father: None of the above (group 1) 23.29 2 1 2.2 0 1 FES HECTD4
Whole body water mass 6.68 2 1 2.2 0 1 FES HECTD4
Leg predicted mass (right) 5.75 2 1 2.2 0 1 FES HECTD4
Arm fat mass (left) 3.00 1 0 0.0 0 1 HECTD4
Number of self-reported non-cancer illnesses 10.41 1 1 2.2 0 1 HECTD4
Medication: Blood pressure 32.24 2 2 4.4 0 1 FES HECTD4
High cholesterol (Self-reported) 4.30 1 0 0.0 0 1 FES
Medication: Bendroflumethiazide 12.63 1 1 2.2 0 1 FES
Medication: Lisinopril 10.77 2 0 0.0 0 1 FES HECTD4
Illnesses of father: High blood pressure 24.47 1 1 2.2 0 1 FES
Ever smoked 8.26 2 0 0.0 0 1 FES HECTD4
Basal metabolic rate 6.57 2 1 2.2 0 1 FES HECTD4
Arm fat-free mass (left) 7.32 1 1 2.2 0 1 HECTD4
Risk taking 6.76 1 0 0.0 0 1 FES
Age started oral contraceptive pill 4.69 1 0 0.0 0 1 FES
Diastolic blood pressure, automated reading 37.65 2 2 4.4 0 1 FES HECTD4
Vascular/heart problems diagnosed by doctor 45.41 2 2 4.4 0 1 FES HECTD4
Medication: Omeprazole (e.g. Zanprol) 5.12 1 0 0.0 0 1 HECTD4
Pain experienced in last month 6.28 1 0 0.0 0 1 HECTD4
Heart attack/myocardial infarction (self-reported) 15.95 2 1 2.2 0 1 FES HECTD4
Deep venous thrombosis (DVT) (self-reported) 5.12 1 0 0.0 0 1 HECTD4
Heart disease (siblings) 10.55 1 0 0.0 0 1 FES
Impedance of whole body 3.80 2 1 2.2 0 1 FES HECTD4
Leg fat mass (left) 2.78 1 0 0.0 0 1 HECTD4
Arm predicted mass (left) 7.06 1 1 2.2 0 1 HECTD4

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.029 1.3
GTEx Adipose Visceral Omentum 1 0.049 1.3
GTEx Adrenal Gland 0 0.000 1.3
GTEx Artery Aorta 0 0.000 1.3
GTEx Artery Coronary 0 0.000 1.3
GTEx Artery Tibial 2 0.053 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.2
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 0 0.000 1.3
GTEx Brain Cortex 0 0.000 1.3
GTEx Brain Frontal Cortex BA9 0 0.000 1.4
GTEx Brain Hippocampus 0 0.000 1.4
GTEx Brain Hypothalamus 0 0.000 1.3
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.2
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 0 0.000 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.3
GTEx Breast Mammary Tissue (Female) 0 0.000 1.2
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.2
GTEx Cells Transformed fibroblasts 1 0.024 1.3
GTEx Colon Sigmoid 0 0.000 1.3
GTEx Colon Transverse 0 0.000 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 0 0.000 1.3
GTEx Esophagus Muscularis 0 0.000 1.3
GTEx Heart Atrial Appendage 0 0.000 1.3
GTEx Heart Left Ventricle 0 0.000 1.2
GTEx Liver 0 0.000 1.3
GTEx Lung 1 0.035 1.3
GTEx Muscle Skeletal 0 0.000 1.3
GTEx Nerve Tibial 0 0.000 1.3
GTEx Ovary 0 0.000 1.2
GTEx Pancreas 0 0.000 1.3
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.3
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.3
GTEx Skin Sun Exposed Lower leg 1 0.027 1.3
GTEx Small Intestine Terminal Ileum 0 0.000 1.2
GTEx Spleen 0 0.000 1.3
GTEx Stomach 0 0.000 1.3
GTEx Testis 0 0.000 1.3
GTEx Thyroid 1 0.025 1.3
GTEx Uterus 0 0.000 1.3
GTEx Vagina 0 0.000 1.3
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 1 0.022 1.2
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.3
YFS Blood 2 0.043 1.2
CommonMind Brain Pre-frontal Cortex 1 0.019 1.3
The Cancer Genome Atlas Bladder Urothelial Carcinoma 1 0.060 1.1
The Cancer Genome Atlas Breast Invasive Carcinoma 1 0.023 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 1 0.091 1.3
The Cancer Genome Atlas Colon Adenocarcinoma 1 0.048 1.2
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Glioblastoma Multiforme 1 0.098 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 1 0.037 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 1 0.024 1.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Adenocarcinoma 1 0.034 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 1 0.040 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 1 0.063 1.3
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 1 0.022 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.3
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 1 0.059 1.3
The Cancer Genome Atlas Testicular Germ Cell Tumors 1 0.078 1.2
The Cancer Genome Atlas Thyroid Carcinoma 1 0.019 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.3