Best TWAS P=4.44e-12 · Best GWAS P=4.15e-12 conditioned to 0.149
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | LSP1 | 0.21 | 0.04 | enet | 28 | 0.06 | 3.4e-05 | 6.9 | 5.2 | 1.7e-07 | 0.68 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Skin Not Sun Exposed Suprapubic | TNNT3 | 0.33 | 0.16 | lasso | 7 | 0.17 | 2.0e-09 | 6.7 | 6.9 | 4.4e-12 | 0.87 | 0.00 | 1.00 | TRUE |
| 3 | YFS | Blood | TNNT3 | 0.02 | 0.02 | lasso | 3 | 0.01 | 1.9e-05 | 6.7 | -6.6 | 5.2e-11 | -0.79 | 0.01 | 0.99 | FALSE |
| 4 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LSP1 | 0.12 | 0.08 | lasso | 5 | 0.10 | 5.0e-11 | -6.1 | -6.4 | 1.7e-10 | -0.61 | 0.29 | 0.71 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | LSP1 | 0.07 | 0.03 | lasso | 4 | 0.03 | 2.4e-04 | 4.4 | -5.7 | 1.1e-08 | -0.35 | 0.09 | 0.23 | TRUE |