Hub : Genes

LSP1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1650	0.0450	1.3e-04	0.048	0.057	0.053	0.063	0.039	1.6e-06	1.5e-07	4.1e-07	3.9e-08	1.3e-05
2	GTEx	Brain Cerebellum	0.2150	0.0870	6.4e-03	0.025	NA	0.005	NA	0.010	6.0e-02	NA	2.2e-01	NA	1.6e-01
3	GTEx	Cells Transformed fibroblasts	0.2130	0.0540	1.0e-04	0.037	NA	0.059	NA	0.042	8.3e-04	NA	3.3e-05	NA	3.8e-04
4	TCGA	Head and Neck Squamous Cell Carcinoma	0.1214	0.0373	1.6e-09	0.079	0.094	0.086	NA	0.097	3.4e-09	1.0e-10	6.3e-10	NA	5.0e-11
5	TCGA	Brain Lower Grade Glioma	0.0574	0.0222	5.2e-04	0.045	0.033	0.038	NA	0.038	7.2e-06	1.0e-04	3.1e-05	NA	3.7e-05
6	TCGA	Lung Squamous Cell Carcinoma	0.0690	0.0326	3.0e-03	0.026	0.029	0.026	NA	0.030	4.9e-04	2.6e-04	5.2e-04	NA	2.4e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.3	0.5	2.1	-0.8	-1.4	0.2	0.0	0.0	0.0
Bipolar Disorder or Schizophrenia	0.3	0.7	1.6	-0.9	-0.4	0.1	-1.3	0.7	-1.0
Depressed Affect (Nagel 2018)	0.5	1.1	2.5	0.2	0.0	-0.4	-1.6	1.2	-1.5
Depression (Nagel 2018)	0.9	1.4	2.2	1.3	1.3	-0.6	-0.5	1.4	-1.5
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.5	1.2	0.1	0.8	-0.1	-0.8	0.5
Neuroticism (Nagel 2018)	0.8	1.9	4.2	1.5	2.1	-1.0	-0.2	1.5	-1.2
Schizophrenia (2018)	0.4	0.8	1.9	-0.5	0.7	-0.3	-1.4	0.9	-1.2
Schizophrenia vs Biploar Disorder	0.1	0.2	0.6	-0.6	0.8	0.1	0.0	0.0	0.0
Worry (Nagel 2018)	0.8	1.6	4.9	1.4	2.2	-1.0	0.3	1.0	-0.8
Alzheimer’s Disease (in mother)	0.9	1.0	2.6	0.0	-0.6	-0.4	-1.0	1.6	-1.5
Alzheimer’s Disease (in father)	0.4	0.5	1.1	-1.1	-0.7	-0.2	0.4	-0.5	0.8
Alzheimer’s Disease (including proxy)	0.3	0.4	1.3	-1.1	-0.1	-0.9	0.1	0.5	0.0
Crohns Disease (2017)	1.8	3.9	6.7	-0.2	1.0	2.4	-2.6	2.0	-2.5
Irritable Bowel Disease (IBD)	5.9	14.2	26.3	2.3	2.4	2.8	-4.0	5.1	-4.9
Ulcerative Colitis (UC)	7.5	14.2	31.7	3.0	2.6	1.7	-3.3	5.6	-4.9
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	0.3	0.5	1.8	-0.8	0.5	1.3	0.5	-0.1	0.4
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.1	0.1	0.0	0.1	0.5	-1.0	0.5
Breast Cancer	11.9	28.6	84.6	-4.2	-1.4	9.2	-7.2	1.2	-3.8
Ovarian Cancer	0.3	0.3	0.9	0.1	-0.4	-1.0	-0.7	-0.6	0.4
Prostate Cancer	3.6	5.0	18.8	-0.2	-4.3	3.0	0.0	-1.2	0.9
Age at First Birth	3.4	4.9	9.9	1.2	0.7	2.3	-2.5	2.5	-3.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.8	1.2	2.7	-0.9	-0.9	0.6	0.3	-1.6	1.4
Coronary Artery Disease (CAD)	0.1	0.1	0.3	0.3	-0.5	-0.4	0.0	0.0	0.0
Crohns Disease (2012)	0.5	0.8	2.4	1.6	1.6	0.4	0.0	0.0	0.0
Mean Putamen Volume	1.7	2.0	7.5	-1.4	0.1	2.7	-1.3	-1.0	-0.3
Fasting Glucose	3.0	3.5	7.3	2.1	2.1	0.6	-2.7	1.3	-1.7
HbA1C	1.5	1.6	4.0	-0.1	0.5	-1.2	0.9	-1.8	2.0
HDL Cholesterol	0.6	1.0	2.6	-0.1	0.6	0.9	-1.1	1.0	-1.6
LDL Cholesterol	0.7	1.1	3.7	-0.1	-0.0	-0.5	0.8	-1.9	1.3
Lupus	0.2	0.3	1.0	-0.2	0.9	0.2	-1.0	-0.5	0.1
Neuroticism (2016)	0.9	1.4	3.4	-0.6	0.1	-1.8	0.6	-1.5	1.4
Primary Biliary Cirrhosis	0.4	0.6	1.8	-0.4	-0.8	1.3	-1.0	0.1	-0.5
Rheumatoid Arthritis	0.5	0.8	2.2	-0.3	1.3	1.5	-0.6	-0.5	0.1
Schizophrenia (2014)	0.4	0.8	2.5	-1.3	-1.6	-0.2	-0.9	0.1	-0.3
Triglycerides	0.6	1.0	2.6	-0.1	0.2	-0.2	1.2	-1.4	1.6
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.9	1.4	0.3	0.6	0.0	0.0	0.0
Ulcerative Colitis	4.9	7.1	20.3	3.1	1.8	0.9	-2.9	0.0	-4.5
Blood Eosinophil Count	0.6	4.5	13.5	3.7	-0.2	-2.2	-0.2	2.7	-1.2
Blood Platelet Count	0.6	7.3	16.2	-2.1	0.0	-1.2	2.9	-3.7	4.0
Blood Red Count	0.9	8.5	18.7	1.2	-0.9	-2.0	3.4	-3.8	4.3
Blood White Count	0.9	6.7	19.2	-0.7	-0.8	-0.9	1.2	-4.2	4.4
Heel T-Score	0.2	1.8	9.1	-0.7	-3.0	0.0	0.2	-0.9	0.6
BMI	0.3	1.9	4.7	0.6	-1.4	2.2	-0.7	1.6	-1.1
Height	1.2	23.0	51.6	1.6	1.5	-6.7	7.2	-3.6	4.9
Waist Hip Ratio (WHR)	0.6	2.7	4.8	2.2	2.1	-1.8	1.4	1.2	0.1
Systolic Blood Pressure	20.9	104.8	204.5	-1.1	-1.4	12.1	-14.3	9.8	-13.4
Smoking Status	0.2	0.5	2.2	-0.4	1.5	0.2	0.0	-0.7	0.6
Allergy or Eczema	0.9	2.4	4.7	-1.6	0.7	-0.5	1.9	-1.7	2.2
Cardiovascular Disease	14.3	47.2	85.7	-0.1	-0.7	7.6	-9.1	7.5	-9.3
Hypothyroidism (self reported)	1.4	3.1	5.3	-1.0	-2.1	-0.5	1.7	-2.2	2.3
Respiratory disease	0.7	1.5	2.6	1.3	1.2	-0.8	1.5	-0.3	1.6
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.6	0.9	1.3	-0.2	-0.8	-0.4	0.3
Lung FEV1/FVC ratio	0.8	3.9	10.4	-1.4	-3.2	-0.9	1.5	-2.3	1.5
Lung FVC	1.0	5.2	14.3	-1.1	-3.8	-0.7	-2.0	2.1	-2.6
Neuroticism	0.2	0.4	1.2	-0.2	1.1	-0.7	-0.4	0.5	-0.5
Chronotype (morning person)	0.3	0.6	2.9	-0.5	-1.7	-0.3	-0.7	-0.2	0.2
Hair Pigment	0.1	2.4	7.2	0.0	2.7	0.3	-1.6	1.4	-1.6
Tanning	0.0	0.2	0.4	0.5	-0.6	-0.6	0.1	0.3	0.3
Hand grip strength (left)	1.4	3.7	8.4	-2.3	-2.9	2.8	-0.9	0.2	-0.4
Number of treatments/medications taken	2.2	4.0	9.0	1.3	0.4	1.2	-2.1	2.7	-3.0
Average weekly spirits intake	0.8	1.0	2.2	-0.6	1.5	0.8	0.2	-1.4	0.7
Sensitivity / hurt feelings	0.1	0.1	0.4	0.6	-0.1	-0.2	-0.3	0.1	-0.1
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.6	0.4	-0.0	-0.3	-1.0	1.1	-1.3
Hearing difficulty/problems: Yes	0.7	1.0	3.0	1.0	1.7	-0.5	1.3	-0.2	0.5
Relative age of first facial hair	0.2	0.4	1.4	-1.2	-0.5	0.7	-0.0	-0.6	0.0
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	5.0	0.7	-0.6	1.1	-1.2	2.0	-2.2
Ever used hormone-replacement therapy (HRT)	1.9	2.4	6.0	-1.9	0.4	-0.7	0.8	-2.4	1.8
Ever had hysterectomy (womb removed)	1.0	1.1	3.6	0.1	-1.9	1.2	-0.7	0.4	-0.9
Systolic blood pressure, automated reading	15.4	44.7	94.5	0.0	-0.0	7.1	-9.7	6.5	-9.0
Eye problems/disorders: Diabetes related eye disease	1.0	1.0	1.9	1.1	-0.9	-1.0	-1.4	0.6	-1.0
Angina	0.8	1.0	3.7	1.0	1.9	0.2	0.9	-0.3	0.5
Medication for hormone replacement therapy	0.6	0.7	1.3	-0.8	-1.1	-0.4	0.1	-1.1	0.9
Vitamin and mineral supplements	1.0	1.4	3.3	-0.2	1.4	1.8	-1.5	0.4	-0.7
Supplements: Zinc	2.7	3.0	4.8	-0.7	-2.1	2.2	-2.0	1.0	-1.8
Medication: Co-codamol	1.8	2.1	6.5	0.5	0.6	-2.2	2.5	-0.2	0.8
Medication: Metformin	0.7	1.0	2.6	1.6	1.2	-1.2	-0.5	0.3	-0.4
Diabetes (father)	0.9	1.1	2.1	1.1	0.6	-0.4	-1.4	0.8	-1.5
Diabetes (mother)	1.1	1.4	3.1	-1.0	0.4	1.7	-1.8	0.7	-1.1
Severe depression (siblings)	0.3	0.3	0.6	-0.0	-0.5	0.6	0.4	-0.7	0.8
Pack years adult smoking proportion	0.8	1.2	3.2	1.8	-0.2	0.3	-0.5	1.6	-1.1
Impedance of leg (right)	1.0	5.0	7.5	-1.0	2.7	-2.6	2.7	-2.0	1.9
Leg fat-free mass (left)	0.1	0.7	2.1	0.4	-1.4	0.4	0.9	-0.6	0.9
Trunk fat percentage	1.0	3.9	8.6	-0.2	1.7	-2.9	2.7	-1.3	1.9
Hand grip strength (right)	0.9	2.3	6.8	-1.7	-2.6	1.8	-0.9	0.4	-0.5
Townsend deprivation index at recruitment	0.1	0.2	0.4	-0.2	-0.5	0.0	-0.4	0.6	0.2
Current tobacco smoking	0.7	1.2	3.1	-0.7	0.5	-0.5	0.8	-1.8	1.6
Average weekly fortified wine intake	0.1	0.2	0.5	-0.3	-0.5	0.7	-0.3	-0.1	0.1
Maternal smoking around birth	0.3	0.4	2.5	0.3	1.6	-0.0	-0.2	-0.1	0.1
Fed-up feelings	1.2	2.2	6.2	-0.3	0.4	-0.1	-2.5	1.5	-2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.6	0.8	-0.0	-1.1	-0.5	1.2	-1.3
Relative age voice broke	0.4	0.6	2.0	-0.3	-1.4	-0.8	0.4	-0.8	0.5
Taking other prescription medications	0.6	0.9	3.5	0.2	1.9	-0.3	0.1	-1.0	0.8
Age when periods started (menarche)	4.6	11.1	21.9	-1.7	1.2	-3.5	3.1	-4.3	4.7
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	2.1	-0.1	1.5	0.6	-0.0	-0.2	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	3.1	-0.4	-1.8	-0.4	-0.4	-1.0	0.2
Tinnitus: Yes, but not now, but have in the past	1.1	1.1	2.2	1.1	0.1	0.7	-1.1	1.5	-1.3
Qualifications: CSEs or equivalent	1.1	1.5	4.8	-0.8	-2.2	1.0	0.8	-1.0	0.9
Serious illness, injury or assault to yourself	1.1	1.3	5.7	0.8	-2.4	0.0	0.7	1.1	0.1
High blood pressure	16.5	46.1	87.0	-0.6	-0.8	7.4	-9.3	7.0	-9.2
Hayfever, allergic rhinitis or eczema	0.9	2.0	3.6	-1.7	0.7	-0.4	1.6	-1.4	1.9
Multivitamins +/- minerals	2.5	3.1	6.8	0.0	-1.5	-2.6	1.8	-1.9	1.7
Stomach or abdominal pain in last month	0.4	0.5	1.0	-1.0	-0.8	-1.0	0.6	-0.2	0.2
Supplements: Glucosamine	0.7	0.9	2.0	0.1	-1.4	-1.3	1.4	-0.2	0.2
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	4.2	1.6	-0.4	-0.6	-1.0	2.0	-1.9
Medication: Atenolol	4.5	5.6	9.6	-0.1	1.1	2.8	-2.5	3.0	-3.1
Medication: Levothyroxine sodium	0.8	1.3	3.5	0.2	-0.2	-0.5	1.2	-1.6	1.9
Sitting height	0.4	2.6	6.3	-0.9	1.0	0.1	1.8	-2.5	2.1
Chronic bronchitis/emphysema (father)	2.6	3.0	15.5	0.5	3.9	-1.3	-0.4	0.5	-0.6
High blood pressure (mother)	8.0	11.2	25.0	0.7	-0.2	5.0	-4.2	3.3	-3.6
Body mass index (BMI)	0.2	1.0	1.6	0.1	-0.9	1.1	-1.0	1.2	-1.3
Impedance of leg (left)	1.0	4.9	11.0	-0.6	3.3	-2.6	2.4	-1.6	1.6
Leg predicted mass (left)	0.1	0.8	2.2	0.3	-1.5	0.4	0.8	-0.7	1.0
Trunk fat mass	0.5	2.3	4.8	-0.1	1.1	-2.1	2.2	-1.0	1.5
Waist circumference	0.1	0.4	0.9	0.8	0.4	-0.4	0.6	0.9	-0.2
Number of incorrect matches in round	0.4	0.6	2.0	-0.3	-1.4	1.0	-0.9	-0.1	-0.2
Past tobacco smoking	0.5	0.9	2.9	-0.2	-1.7	0.3	1.0	-0.7	0.9
Alcohol usually taken with meals	1.1	1.7	3.4	-0.0	-1.6	1.8	-0.5	1.4	-1.5
Nervous feelings	0.5	1.0	3.2	-0.9	1.8	-0.2	-0.5	-1.1	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.4	0.7	-0.4	-1.0	-0.2	1.1	-1.2
Hearing difficulty/problems with background noise	0.8	1.3	3.9	1.3	2.0	0.5	-0.4	1.0	-0.8
Hair/balding pattern: Pattern 2	0.5	0.6	2.3	-0.4	0.0	0.1	-0.7	1.5	-0.9
Had menopause	0.4	0.5	1.5	-0.2	1.2	0.0	-0.5	0.7	-0.7
Had other major operations	1.2	1.5	2.9	0.3	1.1	-0.6	1.5	-1.7	1.4
Forced vital capacity (FVC)	0.3	1.1	5.1	-0.9	-2.3	-0.2	0.5	0.5	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.4	3.8	-0.6	-1.7	0.3	0.3	-1.9	1.2
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	2.7	1.2	-0.9	-1.3	-1.1	1.6	-1.3
Qualifications: None of the above	0.5	1.1	4.2	0.6	1.2	-2.0	-0.4	0.8	-0.1
Financial difficulties in last 2 years	0.7	1.0	1.8	1.3	-0.7	0.7	-0.7	1.2	-1.1
Mouth/teeth dental problems	1.3	2.0	3.8	1.3	0.6	0.4	-1.4	2.0	-1.9
Heart attack	0.5	0.6	2.8	0.3	1.7	-0.3	-0.6	0.4	-0.6
Allergy	0.5	1.0	2.4	0.4	-0.3	0.7	-1.5	1.0	-1.5
Pain all over the body in last month	0.5	0.6	1.8	0.8	-0.5	0.6	1.3	0.1	0.6
Diabetes (self-reported)	0.6	0.9	2.3	0.5	1.4	0.1	-1.5	0.3	-0.7
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	3.9	-0.6	1.5	2.0	-0.0	-0.2	0.3
Medication: Ramipril	5.5	7.1	18.1	-1.6	-0.3	2.7	-4.3	1.7	-3.4
Medication: Simvastatin	1.0	1.5	2.4	0.6	0.8	1.5	-1.3	1.4	-1.5
Fluid intelligence score	0.1	0.3	0.9	0.5	0.5	0.6	0.3	-0.9	0.2
Illnesses of siblings	2.5	3.5	7.6	0.6	-1.5	-2.8	1.9	-2.0	1.7
Neuroticism score	0.1	0.2	0.6	-0.4	0.7	-0.7	-0.1	-0.4	0.2
Weight	0.1	0.3	1.2	0.2	-0.5	-0.1	1.1	-0.2	0.5
Impedance of arm (right)	3.6	16.8	26.1	-1.1	3.8	-4.7	5.1	-3.9	4.6
Arm fat percentage (right)	0.2	0.8	2.0	-0.1	0.7	-1.2	1.4	-0.4	0.8
Trunk fat-free mass	0.2	1.0	3.4	0.2	-1.6	1.8	-0.6	-0.0	-0.2
Hip circumference	0.0	0.1	0.4	-0.5	0.0	0.6	0.3	-0.0	0.2
Time employed in main current job	2.0	2.3	4.2	1.4	0.8	-1.3	-1.0	2.1	-2.1
Alcohol intake versus 10 years previously	0.6	0.9	3.3	1.8	0.1	-0.6	-0.3	1.1	-0.7
Father’s age at death	1.3	1.7	6.2	-1.0	-2.5	-0.1	-0.1	-1.4	1.1
Worrier / anxious feelings	0.1	0.2	1.2	-0.0	1.1	-0.2	0.0	0.1	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.4	-0.3	-0.6	-1.2	-0.9	0.4	-0.6
Falls in the last year	0.2	0.3	1.1	-1.0	-0.3	0.6	-0.6	-0.0	-0.2
Hair/balding pattern: Pattern 3	0.6	1.0	1.7	1.3	-0.9	0.5	-1.1	0.8	-1.0
Number of live births	0.8	1.1	3.5	-1.9	-0.5	0.8	0.5	-0.9	1.0
Forced expiratory volume in 1-second (FEV1)	0.6	2.0	10.2	-1.0	-3.2	-0.5	0.8	-0.1	-0.1
Pulse rate	0.8	1.4	2.8	1.7	1.3	-0.1	-0.4	1.7	-1.1
Happiness	1.6	2.0	4.6	0.7	1.6	0.7	-2.1	1.0	-1.7
Noisy workplace	0.5	0.7	1.2	-1.1	0.7	0.7	0.4	-0.8	0.9
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.3	0.2	-0.2	1.1	-1.2	-0.3	-0.7
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.8	-0.3	-0.9	-0.1	0.5	0.5	-0.5
Mouth/teeth dental problems: Dentures	2.6	4.3	8.4	-2.4	-0.7	0.7	1.9	-2.7	2.9
Asthma	0.7	1.5	3.6	0.0	0.5	-0.4	1.8	-1.2	1.9
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	8.3	0.9	-2.9	0.8	0.1	0.9	-0.8
Medication: Cholesterol lowering	0.8	1.2	2.2	0.6	1.2	0.5	-1.1	1.2	-1.5
Depression (self-reported)	0.6	0.7	1.9	0.3	-1.4	-0.5	-0.9	0.6	-0.8
Medication: Lansoprazole	1.1	1.2	3.0	1.4	1.7	-0.6	0.4	1.3	-0.5
Prospective memory result	1.0	1.3	3.0	-1.2	-0.9	0.1	-1.0	1.7	-1.1
Lung cancer (father)	0.5	0.6	1.4	-0.4	0.6	1.2	-0.2	1.0	-1.0
Illnesses of mother	5.9	7.3	14.4	-0.6	-0.4	-3.1	3.8	-3.1	3.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	9.2	-1.6	-3.0	-0.8	1.4	-0.9	0.7
Pulse wave Arterial Stiffness index	0.1	0.1	0.3	0.3	-0.5	-0.3	0.6	-0.1	0.3
Impedance of arm (left)	3.5	16.2	27.8	-0.7	3.1	-5.1	5.3	-3.7	4.5
Arm fat mass (right)	0.1	0.2	0.8	-0.2	0.0	-0.5	0.9	-0.3	0.5
Trunk predicted mass	0.2	1.0	3.3	0.2	-1.5	1.8	-0.6	-0.1	-0.2
Standing height	0.9	8.8	20.6	0.2	1.0	-2.5	4.5	-3.2	3.9
Length of working week for main job	1.1	1.2	2.4	1.2	-0.7	0.7	-0.8	1.5	-1.2
Exposure to tobacco smoke at home	0.8	0.9	2.1	-1.0	0.1	0.2	1.1	-0.9	1.4
Breastfed as a baby	2.4	3.0	5.5	0.8	-1.9	0.5	-1.5	2.4	-2.3
Tense / ‘highly strung’	0.8	1.4	2.9	0.4	0.8	-1.7	1.4	-1.0	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	2.6	0.2	-1.6	0.9	0.2	-0.4	-0.1
Hair/balding pattern: Pattern 4	0.7	1.7	3.7	0.4	1.3	-1.9	1.4	-1.1	1.2
Birth weight of first child	1.7	3.1	8.7	-2.4	-0.0	-0.3	0.5	-2.9	1.9
Peak expiratory flow (PEF)	1.6	3.6	6.5	0.3	-2.5	-2.4	2.3	-1.4	1.6
Pulse wave reflection index	1.3	1.6	3.5	-1.4	-1.9	0.8	1.4	-0.9	1.0
Ever highly irritable/argumentative for 2 days	4.8	5.8	15.4	0.9	-0.3	1.4	-3.9	2.3	-3.3
Loud music exposure frequency	1.5	1.6	3.9	-2.0	1.3	2.0	-0.5	0.2	0.0
Qualifications: O levels/GCSEs or equivalent	0.6	0.9	5.2	-0.5	0.0	2.3	0.3	-0.3	-0.1
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.7	0.4	-1.3	-1.3	-0.2	0.9	-0.9
Blood clot in the leg (DVT)	0.5	0.7	2.0	0.1	-1.4	-0.5	0.5	-1.0	0.6
Medication: Paracetamol	0.2	0.3	1.3	0.4	1.2	-0.4	0.4	0.2	-0.1
Headache pain in last month	0.6	1.0	2.2	-0.9	0.9	0.9	-1.5	0.4	-1.0
Medication for cholesterol, blood pressure or diabetes	5.0	8.4	17.7	-1.2	-1.4	-2.0	3.6	-3.5	4.2
Glaucoma (self-reported)	0.6	0.7	1.7	0.6	-1.2	-1.3	0.4	0.1	-0.5
Gout (self-reported)	0.6	0.8	1.6	0.2	-0.9	-0.4	-1.0	1.2	-1.0
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	5.4	-0.0	-2.3	-0.6	1.3	-1.4	1.7
Medication: Amlodipine	13.9	19.5	40.8	-0.5	1.0	5.2	-6.4	3.9	-5.7
Medication: Ventolin 100micrograms inhaler	4.1	5.2	9.2	0.5	2.1	-1.7	2.5	-2.9	3.0
Birth weight	2.2	4.9	10.8	-0.6	-1.8	0.9	2.9	-2.3	3.3
Chronic bronchitis/emphysema (mother)	0.6	0.6	3.3	0.0	1.8	0.5	-0.2	-0.3	0.4
High blood pressure (siblings)	5.8	8.4	17.4	-0.4	0.6	4.2	-3.7	2.8	-3.3
Forced vital capacity (FVC), Best measure	0.5	1.9	7.3	-1.6	-2.7	-0.2	0.9	-0.5	0.5
Body fat percentage	0.5	1.8	4.5	0.1	1.3	-2.1	1.8	-0.6	1.0
Leg fat percentage (right)	0.0	0.2	0.4	-0.2	0.4	-0.6	0.3	0.5	-0.3
Arm fat-free mass (right)	0.2	0.8	2.4	0.6	-1.6	1.3	-0.5	0.3	-0.5
Exposure to tobacco smoke outside home	0.5	0.7	1.5	0.5	0.6	-1.2	0.9	-0.3	1.1
Comparative body size at age 10	1.3	3.7	5.9	-0.6	-2.2	1.9	-2.4	1.4	-2.4
Number of full brothers	3.7	4.6	10.0	-1.6	0.8	-0.8	2.4	-2.8	3.2
Worry too long after embarrassment	0.9	1.5	2.9	0.9	1.7	-1.3	1.7	0.1	0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.7	0.5	-1.3	-0.3	0.3	0.6	-0.6
Wheeze or whistling in the chest in last year	0.6	1.0	2.6	1.5	0.8	-1.6	0.3	0.6	0.2
Number of children fathered	0.8	0.9	2.1	-0.2	1.5	-0.0	0.8	-1.3	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.1	-0.7	-0.8	0.9	-1.0	0.6	-0.5
Age at first live birth	0.5	0.9	3.2	1.8	0.7	-0.4	0.2	1.1	-0.7
Pulse wave peak to peak time	0.0	0.0	0.1	-0.1	0.3	-0.0	-0.2	-0.0	-0.0
Health satisfaction	2.5	3.3	6.8	2.5	0.7	-0.5	-0.8	2.6	-2.3
Shortness of breath walking on level ground	0.3	0.3	1.4	0.3	-0.1	-1.2	-0.0	0.5	0.3
Qualifications: College or University degree	0.8	2.5	4.4	1.0	-1.3	1.3	-1.6	1.9	-2.1
Eye problems/disorders: None of the above	1.5	1.7	3.8	-1.9	0.4	1.4	-0.4	-1.6	1.2
Mouth/teeth dental problems: Loose teeth	0.4	0.5	0.9	0.4	0.2	0.9	-1.0	0.7	-0.7
Emphysema/chronic bronchitis	0.7	0.8	2.1	0.4	-0.8	-0.9	-0.3	1.4	-1.0
Medication for pain relief, constipation, heartburn	0.9	1.5	4.1	-2.0	-0.8	-0.1	0.2	-1.5	1.4
Neck or shoulder pain in last month	1.3	1.9	4.1	1.5	-0.2	-2.0	0.2	1.6	-1.5
Medication: Blood pressure	9.6	16.9	33.4	0.1	0.2	4.0	-5.8	4.4	-5.7
Angina (self-reported)	0.7	0.9	3.6	1.0	1.9	-0.0	0.9	-0.2	0.3
Migraine (self-reported)	0.8	1.0	3.8	-1.0	-1.9	0.8	-0.7	0.1	-0.0
Medication: Ibuprofen	1.9	2.2	11.8	0.4	-3.4	0.5	-0.5	0.6	-0.8
Medication: Allopurinol	0.7	1.0	2.2	-1.5	-1.1	1.2	-0.9	-0.3	0.2
Medication: Omeprazole	0.3	0.4	1.4	0.8	1.2	-0.4	-0.4	0.1	-0.1
Medication: Seretide 50 evohaler	0.3	0.4	1.0	-1.0	-0.2	-0.4	0.5	-0.7	0.5
Mean time to correctly identify matches	0.2	0.3	1.7	-0.5	1.3	0.2	-0.1	-0.1	0.1
Heart disease (mother)	0.5	0.6	1.4	1.2	1.1	-0.9	-0.3	0.2	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	3.3	0.7	1.8	1.1	-0.8	0.1	-0.1
Whole body fat mass	0.2	0.8	1.9	-0.1	0.9	-1.1	1.4	-0.6	0.9
Leg fat mass (right)	0.0	0.1	0.2	0.3	0.1	-0.3	0.5	0.2	-0.1
Arm predicted mass (right)	0.2	1.2	3.1	0.5	-1.5	1.8	-0.8	0.4	-0.7
Pulse rate, automated reading	0.3	0.8	2.0	1.2	1.4	-0.4	0.7	0.9	-0.3
Alcohol intake frequency.	0.4	0.9	2.3	1.5	-0.1	-0.6	1.0	-0.4	1.3
Comparative height size at age 10	0.2	1.1	4.1	2.0	1.1	0.3	-0.3	0.7	-0.7
Number of full sisters	0.7	0.9	3.9	0.8	-0.5	-0.1	0.1	2.0	-0.8
Suffer from ‘nerves’	1.2	1.8	6.2	1.4	0.8	-2.5	1.0	0.9	-0.5
Overall health rating	1.1	2.3	5.8	0.3	-0.4	0.7	-2.0	1.8	-2.4
Chest pain or discomfort	1.1	1.6	4.7	0.2	-2.2	-0.4	-0.8	1.4	-1.4
Had major operations	1.0	1.2	3.3	1.8	0.0	0.1	1.8	0.3	0.6
Age at last live birth	0.4	0.6	2.4	1.6	0.5	-0.4	-0.3	0.5	-0.5
Family relationship satisfaction	0.9	1.1	3.8	0.5	-1.0	1.9	-0.3	1.1	-0.7
Leg pain on walking	0.5	0.6	1.8	0.1	-0.2	-0.0	1.2	-0.5	1.4
Qualifications: NVQ or HND or HNC or equivalent	1.5	1.8	4.1	-0.6	0.3	-0.3	1.7	-2.0	1.8
Commuting to job workplace: Car/motor vehicle	1.0	1.1	4.0	-0.4	-0.7	-0.7	2.0	-1.0	0.8
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	3.2	0.7	1.8	-0.9	-0.6	0.6	-0.5
Medication: Aspirin	2.5	3.3	5.8	2.2	1.6	0.2	-1.3	2.3	-2.4
Supplements: Vitamin C	0.6	0.8	3.7	-0.7	-1.9	0.4	0.2	-0.3	0.2
Knee pain experienced in last month	0.4	0.6	1.4	1.2	-0.2	-1.1	0.5	0.7	-0.1
Hypertension (Self-reported)	17.1	47.4	92.5	-0.3	-0.4	7.3	-9.6	7.1	-9.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.9	0.6	0.2	-1.4	0.9	0.2	0.3
Illnesses of father: Heart disease	2.2	3.0	6.9	2.6	-1.3	-0.8	0.5	2.5	-1.5
Illnesses of siblings: Diabetes	0.2	0.2	0.4	0.2	0.5	-0.1	-0.6	0.6	-0.6
Smoking status: Previous	0.9	1.3	3.5	0.7	1.9	-0.4	-0.9	1.3	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.8	6.1	-1.0	-0.9	-0.5	1.9	-2.5	2.2
Whole body fat-free mass	0.1	0.7	2.3	0.5	-1.5	1.4	-0.1	-0.1	0.1
Leg fat-free mass (right)	0.1	0.6	2.1	0.5	-1.4	0.5	0.6	-0.5	0.7
Arm fat percentage (left)	0.2	0.7	1.9	0.1	0.4	-1.3	1.4	-0.1	0.7
Average weekly red wine intake	0.5	0.7	1.2	0.5	-1.0	0.8	-1.1	0.4	-1.1
Handedness (chirality/laterality): Left-handed	1.2	1.4	4.6	1.8	0.3	-2.2	0.8	0.4	0.1
Mood swings	0.2	0.4	0.8	-0.6	0.1	-0.9	-0.5	-0.8	0.3
Loneliness, isolation	0.9	1.3	4.4	0.1	-1.0	-2.1	1.5	0.0	0.4
Long-standing illness, disability or infirmity	1.6	2.5	4.0	2.0	0.5	-1.6	-1.3	1.6	-2.0
Ever had bowel cancer screening	0.6	0.8	4.0	0.1	0.3	-2.0	-0.6	-0.0	-0.2
Diabetes diagnosed by doctor	1.1	1.7	6.0	0.5	2.4	0.1	-1.9	0.4	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.1	2.7	0.2	1.6	-0.4	1.3	-1.1	1.0
Friendships satisfaction	1.2	1.5	3.2	-0.0	-0.2	1.8	-1.7	1.0	-1.4
Qualifications: nursing, teaching	0.2	0.3	1.4	0.1	-0.3	0.3	1.2	-0.3	0.3
Commuting to job workplace: Walk	0.4	0.5	1.6	-0.1	0.9	0.5	-1.2	-0.6	0.1
Eye problems/disorders: Cataract	0.7	0.9	4.0	0.8	2.0	-0.5	0.3	0.4	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	2.2	0.5	0.0	-1.5	0.2	-0.4	0.8
Medication for cholesterol	9.3	14.0	25.7	0.2	0.3	-5.0	5.1	-3.7	4.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.1	1.4	0.1	-1.3	1.4	1.2	0.3
Back pain experienced in last month	1.8	2.6	8.0	2.5	-0.3	-2.8	0.7	0.9	-0.4
Mineral and other dietary supplements	0.7	0.9	2.4	-0.9	1.1	1.5	-0.9	-0.5	0.4
Breast cancer (self-reported)	2.5	3.0	9.5	1.4	0.8	-3.1	2.2	0.2	1.0
Asthma (self-reported)	0.8	1.5	4.3	0.1	0.5	-0.1	1.7	-1.3	2.1
Osteoporosis (self-reported)	0.8	1.0	2.1	1.4	-0.3	0.7	1.1	1.2	-0.7
Osteoarthritis (self-reported)	1.0	1.3	5.3	-0.8	-2.3	1.1	0.7	0.5	0.0
Medication: Aspirin	2.3	3.0	5.4	2.1	1.6	0.0	-1.1	2.0	-2.3
Medication: Gliclazide	1.0	1.2	2.2	-1.4	-1.1	0.5	-0.2	-1.2	1.5
Illnesses of father: None of the above (group 1)	2.1	2.6	6.4	-1.6	-0.1	-0.8	1.1	-2.5	2.2
Smoking status: Current	1.0	1.6	4.4	-1.2	0.6	-0.3	0.6	-2.1	1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	6.2	-0.6	-2.5	-0.4	-1.1	0.1	-0.9
Whole body water mass	0.1	0.8	2.2	0.4	-1.5	1.4	-0.3	-0.1	-0.0
Leg predicted mass (right)	0.1	0.6	2.0	0.4	-1.4	0.5	0.6	-0.6	0.8
Arm fat mass (left)	0.0	0.1	0.6	-0.1	-0.1	-0.4	0.8	-0.1	0.3
Number of self-reported non-cancer illnesses	3.2	5.6	10.8	1.8	0.3	1.7	-2.7	3.1	-3.3
Average weekly champagne plus white wine intake	0.2	0.2	0.8	-0.4	-0.5	0.9	0.2	-0.2	0.2
Miserableness	0.2	0.3	0.5	0.5	-0.5	-0.5	-0.7	0.6	-0.4
Guilty feelings	1.2	1.8	5.2	1.4	2.3	-1.4	1.1	-0.1	0.5
Wears glasses or contact lenses	0.5	0.5	2.5	0.3	1.6	0.2	-0.2	0.4	-0.5
Ever taken oral contraceptive pill	1.8	2.0	3.9	-2.0	1.8	0.5	-0.4	-1.6	1.4
Hearing aid user	1.4	1.5	3.5	1.2	1.9	-1.3	1.5	-0.4	0.6
Mother’s age at death	1.0	1.3	4.0	-0.6	-2.0	0.8	-1.4	0.2	-0.9
Financial situation satisfaction	3.7	4.5	8.8	1.8	-0.6	1.0	-2.5	3.0	-2.8
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.1	0.8	0.6	-0.5	1.0	-0.6	0.5
Commuting to job workplace: Public transport	0.8	1.0	2.3	-0.5	-0.5	-0.8	1.4	-0.8	1.5
Eye problems/disorders: Glaucoma	0.5	0.6	3.0	-0.5	-1.7	-0.2	-0.4	-0.0	-0.4
Medication: Blood pressure	18.3	34.8	64.1	-0.1	-0.6	7.0	-8.0	6.0	-7.7
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.9	-0.3	-1.4	-0.8	1.2	0.1	0.2
Supplements: Fish oil (including cod liver oil)	1.0	1.4	4.5	1.0	-0.8	-2.1	1.4	0.1	0.1
High cholesterol (Self-reported)	1.0	1.8	4.8	0.9	-0.1	1.1	-0.8	2.2	-1.8
Medication: Bendroflumethiazide	20.4	31.0	62.0	-0.7	-0.4	6.2	-7.9	5.4	-7.4
Medication: Paracetamol	0.1	0.2	0.4	0.0	0.6	-0.5	0.6	-0.0	0.0
Medication: Lisinopril	8.9	11.5	23.0	1.1	1.4	3.0	-4.8	3.6	-4.6
Medication: Atorvastatin	0.2	0.2	0.6	0.1	0.7	-0.1	-0.8	0.3	-0.3
Illnesses of father: High blood pressure	7.5	9.3	15.0	0.7	-0.2	3.7	-3.8	3.4	-3.9
Alcohol drinker status: Never	0.5	0.6	1.7	0.2	-0.6	-0.8	0.3	-1.3	1.0
Ever smoked	0.4	0.7	1.4	0.6	1.2	0.2	-0.2	1.2	-0.8
Basal metabolic rate	0.1	0.5	1.6	0.4	-1.2	1.1	0.2	-0.2	0.2
Leg fat percentage (left)	0.1	0.4	0.9	0.2	0.7	-0.6	0.1	0.9	-0.6
Arm fat-free mass (left)	0.2	0.9	2.7	0.2	-1.3	1.6	-0.7	0.2	-0.5
Number of operations (self-reported)	1.7	2.5	6.4	1.1	0.8	-1.7	2.5	-1.3	1.7
Average weekly beer plus cider intake	1.4	2.0	6.2	-2.5	-0.2	-1.3	1.4	-1.2	1.0
Irritability	0.2	0.4	0.9	0.2	0.9	0.0	-0.3	0.7	-0.9
Risk taking	0.8	1.2	5.0	-1.0	-2.2	-0.1	0.7	-0.2	0.9
Ever had prostate specific antigen (PSA) test	1.9	2.2	3.8	1.3	-1.5	-0.8	-1.0	2.0	-1.9
Fractured/broken bones in last 5 years	0.8	1.0	1.6	1.3	0.8	-0.8	-0.7	1.2	-1.2
Age started oral contraceptive pill	0.5	0.7	1.2	-0.5	-0.9	-0.3	-0.6	1.1	-1.1
Diastolic blood pressure, automated reading	7.9	24.4	47.6	-1.0	-1.8	4.8	-6.8	5.1	-6.9
Ever depressed for a whole week	0.9	1.1	2.5	0.9	-0.7	0.4	-1.2	1.6	-1.1
Unable to work because of sickness or disability	0.3	0.4	1.0	1.0	0.6	-0.4	0.8	0.4	-0.1
Commuting to job workplace: Cycle	1.7	2.1	4.6	-1.5	-0.5	0.4	1.1	-2.1	2.0
Myopia	0.3	0.4	1.8	1.4	-0.1	0.3	0.3	0.3	-0.4
Vascular/heart problems diagnosed by doctor	14.0	38.3	75.5	0.4	-0.4	-6.6	8.7	-6.3	8.4
Cholesterol lowering medication	0.3	0.4	1.8	-0.3	0.3	1.4	-0.5	0.1	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.8	0.9	2.6	1.0	1.6	-0.0	-1.0	0.5	-0.8
Pain experienced in last month	0.2	0.4	1.3	-0.3	0.2	1.2	-0.7	-0.4	0.4
Supplements: Calcium	0.8	0.9	2.3	1.1	0.0	0.0	-0.4	1.5	-1.4
Basal cell carcinoma (self-reported)	0.8	0.9	2.2	-1.1	-1.5	-0.5	-0.3	0.7	-1.1
Heart attack/myocardial infarction (self-reported)	0.6	0.7	3.6	0.3	1.9	-0.1	-0.6	0.4	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.5	-0.2	-1.6	0.0	0.5	-1.3	0.7
Heart disease (siblings)	0.7	0.9	2.3	-0.5	0.2	-0.2	1.2	-1.0	1.5
Alcohol drinker status: Previous	0.1	0.1	0.3	0.4	-0.4	-0.4	0.5	0.2	0.3
Pack years of smoking	0.9	1.3	2.8	1.7	-0.1	-0.0	-0.7	1.7	-1.2
Impedance of whole body	2.5	13.0	20.6	-0.8	3.6	-4.4	4.5	-3.3	3.7
Leg fat mass (left)	0.0	0.1	0.2	0.3	0.2	-0.2	0.3	0.5	-0.3
Arm predicted mass (left)	0.2	1.0	3.1	0.1	-1.3	1.8	-0.9	0.2	-0.6