Hub : Genes

TNNT3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.2130 0.0820 9.5e-03 -0.005 NA -0.004 NA -0.005 8.7e-01 NA 6.4e-01 NA 8.9e-01
2 GTEx Brain Cerebellum 0.8760 0.0510 1.9e-05 -0.010 NA 0.050 NA -0.003 9.5e-01 NA 1.4e-02 NA 4.1e-01
3 GTEx Skin Not Sun Exposed Suprapubic 0.3280 0.0710 8.2e-07 0.159 NA 0.146 NA 0.166 4.7e-09 NA 2.1e-08 NA 2.0e-09
4 GTEx Skin Sun Exposed Lower leg 0.6280 0.0810 3.5e-05 0.022 NA -0.003 NA 0.000 5.5e-03 NA 9.7e-01 NA 3.5e-01
5 NTR Blood 0.0353 0.0107 6.4e-05 0.022 0.016 0.015 0.014 0.015 7.1e-08 4.3e-06 9.1e-06 1.4e-05 7.9e-06
6 YFS Blood 0.0156 0.0087 4.3e-02 0.017 0.000 0.009 0.005 0.014 2.6e-06 2.4e-01 4.1e-04 9.2e-03 1.9e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.2 0.3 0.8 0.3 0.0 -0.6 0.9 0.3 0.5
Bipolar Disorder or Schizophrenia 0.3 0.7 2.3 -1.3 0.0 -0.6 1.5 -0.3 -0.2
Depressed Affect (Nagel 2018) 0.1 0.2 0.4 -0.6 0.0 -0.5 -0.1 -0.6 0.3
Depression (Nagel 2018) 0.4 0.7 1.1 -0.7 0.0 -1.0 0.6 1.0 1.0
Intelligence (Savage-Jansen 2018) 0.8 2.3 10.7 3.3 0.0 -0.0 0.8 -1.3 1.0
Neuroticism (Nagel 2018) 0.3 0.6 1.4 -0.8 0.0 -1.2 -0.8 0.5 0.8
Schizophrenia (2018) 0.4 0.8 2.7 -1.7 0.0 -0.2 1.0 -0.6 -0.7
Schizophrenia vs Biploar Disorder 0.3 0.4 1.1 0.8 0.0 -0.9 -1.1 -0.0 0.0
Worry (Nagel 2018) 0.3 0.6 1.9 -0.9 0.0 -0.7 -0.3 1.4 0.6
Alzheimer’s Disease (in mother) 0.6 0.7 2.8 -1.7 0.0 -0.0 1.1 0.5 0.1
Alzheimer’s Disease (in father) 0.5 0.5 2.0 0.2 0.0 0.3 -0.4 -1.0 -1.4
Alzheimer’s Disease (including proxy) 0.3 0.4 1.7 -1.3 0.0 -0.0 0.6 0.5 -0.5
Crohns Disease (2017) 1.0 2.1 4.5 0.4 0.0 2.1 2.1 -0.9 -1.7
Irritable Bowel Disease (IBD) 1.1 2.7 5.3 1.4 0.0 2.1 2.3 -1.2 -1.7
Ulcerative Colitis (UC) 0.8 1.4 2.4 1.5 0.0 1.2 1.4 -1.1 -1.3
Major Depression (MDD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Reaction Time 0.1 0.3 1.2 -1.1 0.0 -0.5 -0.4 -0.0 0.2
Verbal and Numeric Reasoning (VNR) 0.5 1.3 4.8 2.2 0.0 -0.5 -1.1 -0.2 1.2
Breast Cancer 23.1 55.5 146.4 -2.9 0.0 12.1 3.5 -7.9 -10.2
Ovarian Cancer 1.0 1.3 5.6 0.3 0.0 -0.8 0.2 2.4 1.2
Prostate Cancer 3.3 4.7 24.9 5.0 0.0 -0.7 -0.6 0.9 1.2
Age at First Birth 1.0 1.4 3.4 0.1 0.0 1.9 1.5 -0.0 -1.7
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.0 1.3 3.6 1.9 0.0 -0.4 1.6 -1.2 0.5
Coronary Artery Disease (CAD) 0.0 0.0 0.2 -0.4 0.0 0.0 0.0 -0.1 0.0
Crohns Disease (2012) 0.1 0.1 0.5 0.7 0.0 0.0 0.0 0.1 0.0
Mean Putamen Volume 2.1 2.4 4.8 -2.2 0.0 1.8 1.8 -1.3 -1.1
Fasting Glucose 2.9 3.5 6.2 -1.3 0.0 1.3 2.4 -2.3 -2.5
HbA1C 0.4 0.4 1.3 0.3 0.0 -0.2 -1.1 -0.9 -0.4
HDL Cholesterol 0.2 0.4 1.8 0.5 0.0 0.0 -1.3 0.2 0.4
LDL Cholesterol 1.6 2.6 8.8 0.1 0.0 -1.8 -0.9 1.7 3.0
Lupus 0.4 0.6 2.8 0.5 0.0 -0.2 1.7 -0.8 -0.2
Neuroticism (2016) 0.7 1.1 2.8 -0.9 0.0 -1.6 0.4 0.5 1.7
Primary Biliary Cirrhosis 0.7 1.0 2.7 0.6 0.0 1.6 1.1 -0.2 -1.4
Rheumatoid Arthritis 0.4 0.6 1.4 -0.3 0.0 0.9 -0.4 -1.2 -1.1
Schizophrenia (2014) 0.2 0.5 2.3 -0.5 0.0 -0.5 1.5 -0.3 -0.3
Triglycerides 0.2 0.3 0.7 -0.5 0.0 -0.8 0.3 0.5 0.8
Type 2 Diabetes (T2D) (2012) 0.3 0.3 1.4 -0.4 0.0 0.0 -0.3 1.2 0.3
Ulcerative Colitis 1.8 2.6 9.4 3.1 0.0 0.7 2.2 -0.2 -1.0
Blood Eosinophil Count 0.3 2.2 6.8 1.5 0.0 -1.5 0.9 2.6 1.1
Blood Platelet Count 0.6 7.0 17.0 4.1 0.0 -2.7 -1.9 3.3 2.0
Blood Red Count 0.4 3.6 10.1 1.9 0.0 -3.2 -1.2 1.3 2.2
Blood White Count 0.1 0.9 2.3 1.5 0.0 -0.9 1.0 1.1 -0.6
Heel T-Score 0.1 0.7 1.8 1.0 0.0 -0.3 -1.3 0.5 1.1
BMI 0.3 1.8 7.5 2.7 0.0 0.4 -0.3 -1.5 -1.0
Height 0.3 6.1 18.2 0.5 0.0 -4.3 -1.3 -2.1 3.5
Waist Hip Ratio (WHR) 1.8 8.1 14.4 0.7 0.0 -3.7 -2.7 3.8 3.6
Systolic Blood Pressure 19.2 96.4 222.0 -7.7 0.0 14.9 7.4 -9.2 -12.6
Smoking Status 0.0 0.0 0.0 -0.1 0.0 0.2 0.2 0.1 0.0
Allergy or Eczema 0.3 0.8 1.9 1.0 0.0 -1.4 -0.7 0.2 1.2
Cardiovascular Disease 9.9 32.7 69.2 -5.6 0.0 8.3 5.2 -4.6 -6.9
Hypothyroidism (self reported) 0.1 0.3 0.9 -0.6 0.0 -0.1 -0.5 0.9 0.4
Respiratory disease 2.2 4.9 9.7 3.1 0.0 -2.6 1.2 1.7 2.9
Type 2 Diabetes (T2D) (2018) 0.2 0.3 1.2 0.0 0.0 -0.7 0.1 1.1 0.1
Lung FEV1/FVC ratio 0.9 4.7 12.3 1.5 0.0 -1.6 -3.5 2.3 2.5
Lung FVC 0.1 0.7 1.6 -0.1 0.0 1.3 1.2 -0.7 -0.8
Neuroticism 0.0 0.1 0.3 -0.5 0.0 -0.4 -0.3 0.0 -0.3
Chronotype (morning person) 0.2 0.4 0.7 -0.9 0.0 -0.7 -0.4 -0.3 0.9
Hair Pigment 0.1 2.4 7.4 -2.7 0.0 1.7 1.7 -0.1 -1.1
Tanning 0.1 1.0 2.4 1.3 0.0 -1.6 -0.5 -0.1 1.3
Hand grip strength (left) 3.0 7.9 25.9 1.7 0.0 2.8 -0.3 -5.1 -3.2
Number of treatments/medications taken 1.4 2.5 8.2 0.2 0.0 2.0 2.9 -1.0 -1.4
Average weekly spirits intake 0.5 0.6 2.3 1.5 0.0 -0.2 -0.1 1.0 0.7
Sensitivity / hurt feelings 0.3 0.5 0.9 0.9 0.0 -0.9 -0.6 -0.8 -0.3
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.3 -0.3 0.0 -0.5 0.5 0.0 -0.1
Hearing difficulty/problems: Yes 0.2 0.3 0.8 -0.8 0.0 -0.0 -0.5 0.9 0.5
Relative age of first facial hair 0.4 0.8 2.7 -0.7 0.0 1.6 -0.8 -0.3 -0.9
Other serious medical condition/disability diagnosed by doctor 1.3 1.7 5.2 0.1 0.0 2.3 0.8 -1.1 -1.8
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.3 0.5 0.0 -0.1 -0.3 -0.5 0.5
Ever had hysterectomy (womb removed) 0.5 0.6 1.1 -0.6 0.0 0.9 1.0 0.0 -1.1
Systolic blood pressure, automated reading 12.3 35.8 84.3 -4.2 0.0 9.2 4.5 -5.7 -7.7
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 3.3 -1.8 0.0 -1.1 0.2 0.3 1.2
Angina 0.1 0.2 0.4 0.0 0.0 -0.6 0.4 0.5 0.5
Medication for hormone replacement therapy 0.4 0.4 1.4 1.0 0.0 -0.1 -0.4 -1.2 -0.1
Vitamin and mineral supplements 1.0 1.4 3.8 -0.2 0.0 1.2 0.9 -2.0 -1.5
Supplements: Zinc 2.6 2.8 7.0 0.6 0.0 2.2 0.4 -2.7 -2.1
Medication: Co-codamol 2.1 2.5 5.3 0.7 0.0 -2.0 -1.3 1.8 2.3
Medication: Metformin 0.4 0.5 1.0 -0.6 0.0 -0.8 -1.0 1.0 0.2
Diabetes (father) 0.1 0.2 1.0 -1.0 0.0 -0.2 -0.0 0.1 0.1
Diabetes (mother) 1.7 2.1 5.2 -1.0 0.0 2.3 0.9 -0.6 -2.3
Severe depression (siblings) 0.4 0.5 2.2 -1.5 0.0 -0.5 -0.6 0.4 0.1
Pack years adult smoking proportion 1.0 1.5 3.8 0.1 0.0 -1.5 -0.8 2.0 1.5
Impedance of leg (right) 1.4 6.9 15.5 -3.5 0.0 -2.0 -1.6 3.9 2.7
Leg fat-free mass (left) 0.7 3.8 12.4 3.5 0.0 0.0 -0.2 -3.2 -0.6
Trunk fat percentage 1.1 4.4 13.2 0.9 0.0 -3.6 -0.9 1.5 3.1
Hand grip strength (right) 2.0 5.3 20.4 1.7 0.0 1.9 -0.1 -4.5 -2.2
Townsend deprivation index at recruitment 0.5 0.7 2.8 -0.4 0.0 -0.8 1.7 0.7 0.5
Current tobacco smoking 0.4 0.7 2.0 -1.4 0.0 -0.4 -0.5 1.1 0.9
Average weekly fortified wine intake 0.3 0.4 0.8 0.1 0.0 0.9 -0.7 0.5 -0.7
Maternal smoking around birth 0.7 1.0 2.4 -0.3 0.0 -1.6 0.7 1.3 1.1
Fed-up feelings 0.4 0.8 1.8 -1.4 0.0 0.4 0.8 -1.2 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.4 1.1 -0.6 0.0 -0.5 1.1 0.6 0.3
Relative age voice broke 0.1 0.2 0.5 0.1 0.0 0.7 -0.5 0.2 -0.5
Taking other prescription medications 0.6 0.9 3.6 -1.1 0.0 -0.4 1.9 0.3 0.4
Age when periods started (menarche) 1.3 3.1 11.4 0.6 0.0 -3.4 -0.1 1.5 2.1
Bilateral oophorectomy (both ovaries removed) 0.5 0.6 2.3 -1.5 0.0 0.8 -0.5 0.4 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.0 3.3 1.1 0.0 -0.6 -1.8 -0.9 0.8
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 2.8 0.8 0.0 0.3 1.7 0.4 -0.5
Qualifications: CSEs or equivalent 0.3 0.3 1.7 0.2 0.0 -0.0 -1.3 0.5 0.2
Serious illness, injury or assault to yourself 0.1 0.1 0.5 -0.1 0.0 -0.7 -0.2 0.4 0.2
High blood pressure 15.4 43.0 83.2 -7.2 0.0 9.1 5.6 -5.6 -7.7
Hayfever, allergic rhinitis or eczema 0.2 0.5 1.3 1.2 0.0 -0.8 -0.7 0.1 0.7
Multivitamins +/- minerals 1.9 2.4 5.8 0.4 0.0 -1.8 -1.5 2.4 1.6
Stomach or abdominal pain in last month 0.5 0.7 2.1 0.4 0.0 -1.2 0.4 0.4 1.5
Supplements: Glucosamine 1.2 1.6 6.5 2.5 0.0 -0.6 -0.6 0.5 1.5
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 3.5 1.9 0.0 -0.6 0.9 0.3 0.2
Medication: Atenolol 4.7 5.8 12.9 -1.8 0.0 3.5 1.3 -2.2 -3.6
Medication: Levothyroxine sodium 0.8 1.4 6.3 -2.5 0.0 -0.2 1.4 -0.0 0.1
Sitting height 0.7 4.8 25.3 -0.2 0.0 1.2 0.6 -5.0 -1.3
Chronic bronchitis/emphysema (father) 1.6 1.9 4.0 -1.5 0.0 -1.4 -0.6 2.0 1.8
High blood pressure (mother) 6.1 8.5 21.9 -0.8 0.0 4.7 2.1 -2.9 -4.0
Body mass index (BMI) 0.2 1.0 4.2 2.1 0.0 -0.0 0.1 -1.2 -0.2
Impedance of leg (left) 1.3 6.1 13.7 -3.1 0.0 -2.1 -1.3 3.7 2.7
Leg predicted mass (left) 0.7 3.8 12.1 3.5 0.0 0.0 -0.1 -3.2 -0.6
Trunk fat mass 0.6 2.8 8.1 1.5 0.0 -2.9 -1.0 0.2 2.3
Waist circumference 0.4 1.6 3.6 1.5 0.0 -1.9 -1.1 0.5 1.5
Number of incorrect matches in round 0.2 0.4 1.9 -1.4 0.0 0.1 -0.2 -0.5 0.4
Past tobacco smoking 0.3 0.5 2.4 0.9 0.0 -0.2 -1.5 0.2 -0.1
Alcohol usually taken with meals 1.5 2.4 6.2 0.9 0.0 2.5 -1.0 -1.4 -2.1
Nervous feelings 0.8 1.5 6.1 -2.5 0.0 -1.0 0.1 1.1 0.6
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.6 -0.3 0.0 -0.9 1.3 -0.5 0.4
Hearing difficulty/problems with background noise 0.8 1.2 4.9 -2.2 0.0 0.1 1.5 0.3 -0.2
Hair/balding pattern: Pattern 2 0.1 0.1 0.2 -0.1 0.0 -0.1 0.5 -0.4 -0.2
Had menopause 0.2 0.3 0.6 0.2 0.0 0.5 0.6 -0.8 -0.6
Had other major operations 0.3 0.4 0.7 -0.6 0.0 -0.8 0.6 0.5 0.8
Forced vital capacity (FVC) 0.6 2.2 8.1 1.5 0.0 1.1 0.9 -2.9 -0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.2 3.7 1.9 0.0 -0.2 -1.2 -1.1 1.0
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 4.1 -1.3 0.0 -0.6 2.0 0.3 0.1
Qualifications: None of the above 1.3 2.8 5.6 -2.4 0.0 -2.2 0.2 2.0 1.6
Financial difficulties in last 2 years 0.5 0.7 2.8 -1.7 0.0 -0.4 1.0 0.2 -0.1
Mouth/teeth dental problems 0.2 0.4 0.8 0.5 0.0 0.6 -0.1 -0.9 -0.9
Heart attack 0.1 0.2 0.6 -0.8 0.0 -0.3 0.5 -0.0 0.3
Allergy 0.8 1.8 3.6 -1.3 0.0 1.9 0.9 -1.2 -1.8
Pain all over the body in last month 0.1 0.1 0.3 0.1 0.0 0.2 0.3 0.2 -0.5
Diabetes (self-reported) 0.5 0.7 4.0 -2.0 0.0 -0.5 0.2 0.3 0.2
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.4 -0.2 0.0 -0.3 0.4 -0.3 0.7
Medication: Ramipril 5.8 7.4 15.4 -3.9 0.0 3.9 1.8 -1.4 -3.0
Medication: Simvastatin 0.7 1.1 4.8 -1.0 0.0 0.5 2.2 -0.7 -0.2
Fluid intelligence score 0.2 0.4 1.2 1.1 0.0 0.5 -0.3 -0.9 0.2
Illnesses of siblings 2.7 3.9 9.1 3.0 0.0 -2.2 -1.4 1.6 2.1
Neuroticism score 0.2 0.3 0.8 -0.7 0.0 -0.7 -0.1 -0.9 -0.1
Weight 0.4 2.0 6.2 2.5 0.0 -0.9 -0.6 -2.1 0.5
Impedance of arm (right) 2.1 10.0 17.6 -2.9 0.0 -4.1 -0.8 4.1 4.2
Arm fat percentage (right) 0.5 1.9 5.2 1.2 0.0 -2.3 -0.4 0.8 2.0
Trunk fat-free mass 0.8 4.8 16.6 2.6 0.0 1.6 -0.4 -4.1 -1.6
Hip circumference 0.3 1.4 7.3 1.0 0.0 0.1 -0.0 -2.7 -0.4
Time employed in main current job 0.4 0.4 2.0 -0.1 0.0 -0.5 0.1 1.4 0.5
Alcohol intake versus 10 years previously 0.4 0.6 1.7 0.1 0.0 -1.3 0.6 -0.2 1.2
Father’s age at death 0.5 0.7 1.8 0.8 0.0 -0.9 -1.4 0.2 0.9
Worrier / anxious feelings 0.2 0.3 0.9 0.2 0.0 0.3 -0.8 -0.7 -0.9
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 1.3 -1.1 0.0 -0.6 0.1 0.7 0.5
Falls in the last year 0.2 0.2 0.6 -0.8 0.0 0.6 -0.4 -0.2 -0.3
Hair/balding pattern: Pattern 3 0.2 0.3 0.8 0.7 0.0 0.9 0.2 -0.2 -0.6
Number of live births 0.7 0.9 3.8 0.2 0.0 0.5 1.9 -0.3 -1.1
Forced expiratory volume in 1-second (FEV1) 0.6 1.9 6.8 2.6 0.0 0.5 -0.2 -2.1 0.3
Pulse rate 0.5 0.9 3.3 1.8 0.0 0.0 0.7 1.0 -0.6
Happiness 1.1 1.4 2.5 -0.9 0.0 1.2 1.6 -1.5 -1.1
Noisy workplace 0.5 0.6 1.2 -1.0 0.0 0.9 0.1 -1.1 -0.8
Qualifications: A levels/AS levels or equivalent 0.6 1.3 3.2 0.9 0.0 1.8 0.9 -1.1 -1.2
Serious illness, injury or assault of a close relative in last 2 years 0.9 1.0 2.7 -1.2 0.0 -0.2 -1.2 1.6 0.4
Mouth/teeth dental problems: Dentures 0.3 0.5 1.7 -0.4 0.0 -1.3 0.3 0.9 0.6
Asthma 0.9 1.8 3.5 1.2 0.0 -1.7 -0.2 1.8 1.9
Medication: Ibuprofen (e.g. Nurofen) 1.1 1.4 4.7 2.2 0.0 0.8 0.4 -1.5 -0.8
Medication: Cholesterol lowering 0.6 0.9 2.6 -1.6 0.0 0.2 1.6 -0.3 0.5
Depression (self-reported) 0.3 0.4 1.4 -1.2 0.0 -0.5 0.1 -0.0 0.8
Medication: Lansoprazole 0.3 0.4 1.6 0.8 0.0 0.0 1.3 -0.4 -0.1
Prospective memory result 0.2 0.2 0.4 0.6 0.0 -0.6 -0.4 0.2 -0.4
Lung cancer (father) 1.4 1.7 4.2 -1.4 0.0 2.1 -0.1 -0.7 -1.8
Illnesses of mother 4.3 5.3 11.0 1.2 0.0 -3.3 -1.0 3.3 2.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.9 8.0 2.8 0.0 -0.3 -0.9 -1.3 0.8
Pulse wave Arterial Stiffness index 0.2 0.2 0.7 0.6 0.0 0.2 0.5 -0.4 -0.9
Impedance of arm (left) 2.4 11.3 21.0 -2.3 0.0 -4.5 -0.7 4.5 4.6
Arm fat mass (right) 0.3 1.1 3.3 1.8 0.0 -1.4 -0.1 -0.5 1.1
Trunk predicted mass 0.8 4.8 16.8 2.6 0.0 1.6 -0.3 -4.1 -1.6
Standing height 0.2 2.2 4.2 1.3 0.0 -1.7 -1.4 -2.1 1.5
Length of working week for main job 0.3 0.3 0.7 0.8 0.0 0.8 -0.4 -0.1 -0.7
Exposure to tobacco smoke at home 0.2 0.2 0.5 0.7 0.0 -0.6 -0.2 0.4 0.2
Breastfed as a baby 0.8 0.9 2.1 1.0 0.0 0.8 0.3 -1.5 -1.3
Tense / ‘highly strung’ 0.4 0.7 1.7 -1.2 0.0 -1.3 -0.3 0.7 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 1.7 0.1 0.0 0.7 0.2 -1.3 -0.2
Hair/balding pattern: Pattern 4 0.5 1.1 3.2 -0.3 0.0 -1.4 -1.8 0.9 0.8
Birth weight of first child 0.2 0.4 0.9 0.7 0.0 -0.5 -0.9 0.1 0.7
Peak expiratory flow (PEF) 1.3 3.0 9.9 3.1 0.0 -1.5 -0.9 0.3 2.2
Pulse wave reflection index 0.7 0.9 2.3 -0.5 0.0 0.9 -1.2 -0.8 -1.5
Ever highly irritable/argumentative for 2 days 3.0 3.5 12.7 0.2 0.0 1.5 3.6 -2.4 -0.8
Loud music exposure frequency 2.2 2.4 5.6 -1.1 0.0 2.2 1.4 -1.1 -2.4
Qualifications: O levels/GCSEs or equivalent 0.7 1.2 3.2 1.0 0.0 1.8 0.3 -0.6 -1.5
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 0.9 -0.9 0.0 0.4 0.9 0.2 0.2
Blood clot in the leg (DVT) 0.1 0.1 0.4 0.2 0.0 -0.4 0.2 0.3 0.6
Medication: Paracetamol 0.2 0.3 0.7 0.3 0.0 -0.1 0.4 0.8 0.8
Headache pain in last month 0.6 1.0 2.2 0.1 0.0 1.3 -0.5 -1.5 -1.3
Medication for cholesterol, blood pressure or diabetes 1.9 3.2 8.8 3.0 0.0 -2.1 -1.8 1.2 1.0
Glaucoma (self-reported) 0.5 0.6 1.5 1.2 0.0 -0.6 -0.4 0.7 0.9
Gout (self-reported) 0.2 0.3 1.2 0.4 0.0 0.0 1.1 -0.7 -0.0
Hypothyroidism/myxoedema (self-reported) 0.3 0.7 2.3 -0.9 0.0 -0.6 0.2 1.5 0.7
Medication: Amlodipine 17.3 24.3 47.9 -4.6 0.0 6.9 3.8 -4.4 -6.6
Medication: Ventolin 100micrograms inhaler 2.4 3.1 6.8 1.2 0.0 -2.4 0.2 2.6 2.2
Birth weight 3.5 7.6 35.2 5.9 0.0 -2.2 0.9 -0.7 2.0
Chronic bronchitis/emphysema (mother) 0.3 0.3 1.5 -0.4 0.0 -0.2 -0.5 -1.2 -0.2
High blood pressure (siblings) 7.0 10.1 18.7 -2.6 0.0 4.3 2.0 -4.0 -3.9
Forced vital capacity (FVC), Best measure 0.5 1.9 5.8 2.2 0.0 0.5 0.1 -2.4 -0.7
Body fat percentage 0.7 2.9 8.7 0.9 0.0 -3.0 -0.8 1.2 2.5
Leg fat percentage (right) 0.4 1.4 3.5 0.1 0.0 -1.9 -1.1 0.9 1.7
Arm fat-free mass (right) 0.8 4.1 12.7 3.1 0.0 1.0 -0.4 -3.6 -1.1
Exposure to tobacco smoke outside home 0.4 0.6 2.0 0.1 0.0 -1.4 -0.6 0.5 0.9
Comparative body size at age 10 0.8 2.2 6.2 2.5 0.0 1.5 0.7 -1.9 -0.8
Number of full brothers 0.3 0.4 1.6 -0.0 0.0 -1.3 0.2 0.8 0.6
Worry too long after embarrassment 0.6 1.1 3.6 -1.9 0.0 -0.8 -1.4 -0.2 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 1.8 -0.2 0.0 -0.8 1.3 0.2 1.1
Wheeze or whistling in the chest in last year 1.1 1.9 7.1 0.4 0.0 -2.7 0.8 1.1 1.6
Number of children fathered 0.1 0.1 0.4 0.0 0.0 -0.6 0.7 -0.1 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 2.0 2.3 6.7 -2.6 0.0 1.0 1.2 -1.6 -1.5
Age at first live birth 0.2 0.3 1.2 -1.1 0.0 0.4 0.2 0.6 -0.2
Pulse wave peak to peak time 0.3 0.4 1.2 -0.2 0.0 -0.6 -0.7 0.5 1.1
Health satisfaction 0.3 0.4 0.7 -0.8 0.0 -0.7 0.8 0.5 0.6
Shortness of breath walking on level ground 0.1 0.1 0.3 0.0 0.0 -0.5 0.5 0.4 0.3
Qualifications: College or University degree 1.5 4.6 8.8 2.1 0.0 2.6 0.4 -3.0 -2.8
Eye problems/disorders: None of the above 0.6 0.7 1.7 -0.5 0.0 1.3 1.1 -0.6 -1.0
Mouth/teeth dental problems: Loose teeth 1.1 1.3 6.0 -1.1 0.0 0.5 2.4 -0.3 -0.4
Emphysema/chronic bronchitis 1.3 1.5 5.5 0.6 0.0 -1.3 0.5 2.3 1.2
Medication for pain relief, constipation, heartburn 0.1 0.1 0.3 -0.6 0.0 -0.1 -0.4 -0.1 -0.2
Neck or shoulder pain in last month 0.4 0.6 1.4 -0.8 0.0 -0.8 0.5 0.9 1.2
Medication: Blood pressure 6.2 10.9 21.5 -4.3 0.0 4.6 2.8 -2.2 -3.6
Angina (self-reported) 0.2 0.3 0.7 -0.2 0.0 -0.8 0.3 0.7 0.6
Migraine (self-reported) 0.8 1.0 2.1 1.1 0.0 1.3 -0.5 1.5 -0.8
Medication: Ibuprofen 1.7 2.1 6.1 2.5 0.0 0.8 1.5 -1.7 -0.8
Medication: Allopurinol 1.2 1.6 5.7 -0.6 0.0 1.2 0.8 -2.4 -1.2
Medication: Omeprazole 0.8 1.0 4.5 -0.9 0.0 -0.2 2.1 0.7 0.3
Medication: Seretide 50 evohaler 0.4 0.4 1.4 0.8 0.0 0.1 0.5 1.2 0.5
Mean time to correctly identify matches 0.3 0.6 1.2 -1.1 0.0 -1.1 -0.0 0.8 0.7
Heart disease (mother) 0.2 0.3 1.0 -1.0 0.0 -0.5 -0.1 -0.0 0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 2.2 -0.4 0.0 0.8 1.5 -0.7 -0.8
Whole body fat mass 0.3 1.4 3.8 1.5 0.0 -1.9 -0.6 -0.5 1.5
Leg fat mass (right) 0.3 1.1 2.1 1.4 0.0 -1.5 -0.8 -0.4 1.2
Arm predicted mass (right) 1.0 5.0 15.1 3.3 0.0 1.4 -0.5 -3.9 -1.5
Pulse rate, automated reading 0.7 2.2 5.9 2.4 0.0 -1.4 -0.2 1.7 1.6
Alcohol intake frequency. 0.2 0.5 1.5 0.1 0.0 -1.0 0.6 1.2 0.3
Comparative height size at age 10 0.2 1.1 6.6 0.1 0.0 0.1 -0.0 -2.6 0.2
Number of full sisters 0.4 0.5 0.9 -1.0 0.0 -0.5 -0.7 1.0 0.4
Suffer from ‘nerves’ 1.1 1.8 6.2 -0.2 0.0 -1.8 -0.4 2.5 1.1
Overall health rating 0.4 0.9 3.9 -2.0 0.0 0.0 1.1 0.3 -0.4
Chest pain or discomfort 0.4 0.6 1.7 -0.6 0.0 -0.8 0.7 0.7 1.3
Had major operations 0.1 0.1 0.3 -0.4 0.0 0.5 -0.1 -0.1 -0.5
Age at last live birth 0.2 0.3 1.2 0.3 0.0 0.5 1.1 0.4 -0.5
Family relationship satisfaction 0.8 1.0 1.8 -1.2 0.0 0.8 0.8 -1.1 -1.3
Leg pain on walking 0.9 1.1 2.7 1.6 0.0 -0.9 -0.4 -0.2 1.6
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.6 0.4 0.0 -0.6 -1.3 0.5 1.1
Commuting to job workplace: Car/motor vehicle 0.5 0.6 1.1 -1.0 0.0 -0.4 -0.3 1.0 1.0
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.6 0.3 0.0 0.8 0.2 -1.3 -0.8
Medication: Aspirin 0.4 0.5 2.1 -0.1 0.0 -0.2 0.3 1.4 0.9
Supplements: Vitamin C 0.4 0.5 2.5 1.6 0.0 -0.4 -0.2 -0.3 0.5
Knee pain experienced in last month 0.4 0.6 1.7 0.9 0.0 -1.3 -0.4 0.3 1.0
Hypertension (Self-reported) 15.4 42.8 82.3 -7.3 0.0 9.1 5.9 -5.2 -7.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 2.8 -0.7 0.0 -1.4 0.2 0.2 1.7
Illnesses of father: Heart disease 1.4 1.9 4.1 -1.2 0.0 -1.2 -2.0 1.6 1.3
Illnesses of siblings: Diabetes 0.8 1.0 3.8 -2.0 0.0 0.0 1.4 0.1 0.1
Smoking status: Previous 0.5 0.7 4.2 -0.4 0.0 0.2 2.0 0.1 0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.7 2.1 1.4 0.0 -0.7 -0.7 0.6 1.0
Whole body fat-free mass 0.8 4.7 15.1 3.2 0.0 1.1 -0.2 -3.9 -1.3
Leg fat-free mass (right) 0.8 4.5 13.8 3.7 0.0 0.2 0.2 -3.5 -0.9
Arm fat percentage (left) 0.6 2.4 6.4 1.5 0.0 -2.5 -0.3 1.0 2.1
Average weekly red wine intake 0.3 0.5 1.2 0.7 0.0 1.1 -0.8 0.7 -0.4
Handedness (chirality/laterality): Left-handed 1.5 1.8 3.1 0.4 0.0 -1.8 -1.6 1.6 1.6
Mood swings 0.1 0.2 0.7 -0.0 0.0 -0.8 0.2 -0.1 0.5
Loneliness, isolation 1.0 1.4 3.3 -0.9 0.0 -1.8 -1.6 -0.2 1.2
Long-standing illness, disability or infirmity 0.3 0.5 0.9 -0.9 0.0 -0.9 0.3 1.0 0.3
Ever had bowel cancer screening 0.6 0.7 1.7 -1.0 0.0 -0.7 1.3 -0.3 0.8
Diabetes diagnosed by doctor 1.0 1.7 8.8 -3.0 0.0 -0.1 1.0 -0.1 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 2.0 2.2 4.6 1.7 0.0 -1.4 -0.7 2.1 1.8
Friendships satisfaction 2.9 3.6 5.1 -2.2 0.0 2.1 2.2 -1.6 -2.3
Qualifications: nursing, teaching 0.1 0.1 0.6 -0.0 0.0 0.3 -0.8 0.1 0.4
Commuting to job workplace: Walk 0.2 0.2 0.7 -0.4 0.0 0.3 -0.2 -0.9 -0.5
Eye problems/disorders: Cataract 0.2 0.2 0.9 1.0 0.0 -0.2 0.0 0.5 -0.1
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 4.2 2.1 0.0 -1.1 0.7 0.1 0.8
Medication for cholesterol 9.8 14.9 30.9 2.8 0.0 -5.2 -3.2 3.7 5.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.5 1.8 4.2 -1.0 0.0 -2.0 -0.6 1.7 1.5
Back pain experienced in last month 0.6 0.8 2.3 -1.0 0.0 -1.5 -0.6 -0.2 1.1
Mineral and other dietary supplements 0.5 0.7 2.9 -1.7 0.0 0.2 0.6 -0.2 -1.0
Breast cancer (self-reported) 3.7 4.4 12.7 0.2 0.0 -2.7 -0.6 3.6 2.4
Asthma (self-reported) 0.7 1.4 2.4 1.4 0.0 -1.4 -0.1 1.4 1.6
Osteoporosis (self-reported) 0.4 0.4 2.1 0.4 0.0 0.2 -0.5 1.4 -0.4
Osteoarthritis (self-reported) 0.5 0.6 2.6 -0.2 0.0 -0.3 -0.9 1.6 0.6
Medication: Aspirin 0.3 0.4 1.4 -0.3 0.0 -0.2 0.4 1.2 0.8
Medication: Gliclazide 0.2 0.3 1.1 0.1 0.0 -0.1 -1.0 -0.5 -0.4
Illnesses of father: None of the above (group 1) 0.8 1.0 3.9 2.0 0.0 0.0 0.6 -1.2 -0.7
Smoking status: Current 0.3 0.4 1.9 -1.4 0.0 -0.2 -0.4 0.5 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.3 6.7 2.6 0.0 -0.4 0.7 -0.7 0.5
Whole body water mass 0.8 4.8 16.2 3.1 0.0 1.1 -0.1 -4.0 -1.4
Leg predicted mass (right) 0.9 4.5 13.5 3.7 0.0 0.2 0.2 -3.6 -0.9
Arm fat mass (left) 0.3 1.0 3.1 1.8 0.0 -1.3 -0.0 -0.7 1.0
Number of self-reported non-cancer illnesses 0.8 1.4 5.7 -0.5 0.0 1.0 2.4 -0.8 -0.6
Average weekly champagne plus white wine intake 0.5 0.8 2.5 -0.9 0.0 0.9 -0.1 -1.6 -0.6
Miserableness 0.4 0.7 2.0 -1.1 0.0 -0.7 0.9 -1.4 0.0
Guilty feelings 0.8 1.1 3.6 0.2 0.0 -1.9 -0.6 0.8 1.5
Wears glasses or contact lenses 0.1 0.1 0.6 0.8 0.0 -0.2 0.3 0.3 0.2
Ever taken oral contraceptive pill 0.4 0.4 1.0 -0.5 0.0 0.8 -0.2 -1.0 -0.9
Hearing aid user 1.7 1.9 3.9 0.6 0.0 -1.8 -0.5 1.9 2.0
Mother’s age at death 1.1 1.4 3.6 1.9 0.0 1.6 0.2 -1.1 -0.9
Financial situation satisfaction 0.8 0.9 2.0 -1.2 0.0 0.5 1.4 -0.8 -1.1
Tinnitus: Yes, now most or all of the time 1.8 2.2 5.4 -2.3 0.0 -1.8 -0.7 -0.2 2.0
Commuting to job workplace: Public transport 0.8 1.0 2.3 0.9 0.0 -1.1 -0.9 1.5 0.8
Eye problems/disorders: Glaucoma 0.2 0.3 0.8 0.9 0.0 0.1 0.6 -0.6 -0.2
Medication: Blood pressure 15.9 30.2 59.5 -5.4 0.0 7.7 4.9 -4.3 -7.1
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.7 -0.3 0.0 0.1 -0.8 1.3 0.4
Supplements: Fish oil (including cod liver oil) 0.6 0.8 2.3 0.9 0.0 -0.9 -0.7 0.4 1.5
High cholesterol (Self-reported) 0.1 0.1 0.6 0.1 0.0 0.3 -0.0 0.7 -0.5
Medication: Bendroflumethiazide 14.1 21.4 49.6 -4.1 0.0 7.0 3.6 -4.0 -5.7
Medication: Paracetamol 0.3 0.4 1.0 0.6 0.0 -0.4 -0.0 1.0 1.0
Medication: Lisinopril 4.0 5.2 10.7 -2.6 0.0 2.5 3.3 -1.4 -2.3
Medication: Atorvastatin 0.1 0.1 0.2 -0.0 0.0 -0.2 -0.5 0.4 -0.2
Illnesses of father: High blood pressure 3.3 4.1 8.4 -1.2 0.0 2.9 2.0 -1.8 -2.7
Alcohol drinker status: Never 0.4 0.5 1.0 0.8 0.0 -0.9 -1.0 0.5 0.6
Ever smoked 0.2 0.3 1.3 -1.1 0.0 0.6 0.4 -0.5 -0.3
Basal metabolic rate 0.7 3.8 12.5 3.0 0.0 0.6 -0.2 -3.5 -0.9
Leg fat percentage (left) 0.4 1.3 3.8 0.5 0.0 -2.0 -0.8 0.8 1.6
Arm fat-free mass (left) 0.9 4.6 16.7 2.6 0.0 1.3 0.1 -4.1 -1.6
Number of operations (self-reported) 1.1 1.6 3.9 -0.3 0.0 -1.6 -0.4 2.0 1.7
Average weekly beer plus cider intake 1.2 1.8 5.2 -0.8 0.0 -1.7 -2.3 0.8 1.1
Irritability 0.2 0.4 1.6 0.4 0.0 0.5 -0.3 -1.3 -0.3
Risk taking 0.2 0.2 0.4 0.6 0.0 -0.3 -0.6 -0.5 -0.5
Ever had prostate specific antigen (PSA) test 0.7 0.8 4.2 2.0 0.0 -0.5 -0.0 -0.0 0.6
Fractured/broken bones in last 5 years 0.8 1.0 3.0 0.6 0.0 -0.2 1.7 -1.6 -0.1
Age started oral contraceptive pill 0.4 0.6 0.9 -0.8 0.0 0.9 -0.3 0.9 -0.9
Diastolic blood pressure, automated reading 4.2 13.1 31.2 -2.2 0.0 5.6 2.7 -3.8 -4.6
Ever depressed for a whole week 0.9 1.2 3.0 -1.4 0.0 0.6 1.7 -1.0 -0.9
Unable to work because of sickness or disability 0.4 0.6 2.1 -0.5 0.0 -0.3 0.9 1.4 0.1
Commuting to job workplace: Cycle 0.1 0.1 0.4 0.7 0.0 0.2 0.3 0.2 -0.1
Myopia 0.8 1.2 2.6 0.5 0.0 -1.4 -0.7 1.6 1.5
Vascular/heart problems diagnosed by doctor 13.1 35.7 67.2 6.7 0.0 -8.2 -5.0 5.4 6.9
Cholesterol lowering medication 0.3 0.5 2.0 -0.6 0.0 0.4 0.6 0.0 -1.4
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 5.5 -0.9 0.0 -0.2 2.3 0.2 0.5
Pain experienced in last month 0.1 0.2 0.5 0.6 0.0 -0.1 0.0 0.7 -0.0
Supplements: Calcium 0.1 0.1 0.4 -0.1 0.0 0.5 -0.0 -0.2 -0.7
Basal cell carcinoma (self-reported) 0.3 0.4 1.5 -0.7 0.0 0.2 -1.2 -0.4 -0.4
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.7 -0.8 0.0 -0.1 0.6 -0.1 0.2
Deep venous thrombosis (DVT) (self-reported) 0.0 0.0 0.1 0.0 0.0 0.0 0.3 -0.3 0.3
Heart disease (siblings) 0.3 0.4 1.3 -1.1 0.0 -0.6 -0.2 0.6 0.5
Alcohol drinker status: Previous 1.1 1.2 4.0 -0.5 0.0 -1.1 2.0 1.3 0.5
Pack years of smoking 1.2 1.7 4.4 0.3 0.0 -1.7 -0.9 2.1 1.5
Impedance of whole body 1.9 9.7 19.5 -2.9 0.0 -3.6 -1.2 4.4 4.0
Leg fat mass (left) 0.3 1.0 2.6 1.6 0.0 -1.4 -0.6 -0.5 1.1
Arm predicted mass (left) 0.9 4.7 17.1 2.3 0.0 1.7 -0.0 -4.1 -1.8