TWAS hub - TNNT3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.2130	0.0820	9.5e-03	-0.005	NA	-0.004	NA	-0.005	8.7e-01	NA	6.4e-01	NA	8.9e-01
2	GTEx	Brain Cerebellum	0.8760	0.0510	1.9e-05	-0.010	NA	0.050	NA	-0.003	9.5e-01	NA	1.4e-02	NA	4.1e-01
3	GTEx	Skin Not Sun Exposed Suprapubic	0.3280	0.0710	8.2e-07	0.159	NA	0.146	NA	0.166	4.7e-09	NA	2.1e-08	NA	2.0e-09
4	GTEx	Skin Sun Exposed Lower leg	0.6280	0.0810	3.5e-05	0.022	NA	-0.003	NA	0.000	5.5e-03	NA	9.7e-01	NA	3.5e-01
5	NTR	Blood	0.0353	0.0107	6.4e-05	0.022	0.016	0.015	0.014	0.015	7.1e-08	4.3e-06	9.1e-06	1.4e-05	7.9e-06
6	YFS	Blood	0.0156	0.0087	4.3e-02	0.017	0.000	0.009	0.005	0.014	2.6e-06	2.4e-01	4.1e-04	9.2e-03	1.9e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	3	4	5	6
Breast Cancer	23.1	55.5	146.4	-2.9	12.1	3.5	-7.9	-10.2
Systolic Blood Pressure	19.2	96.4	222.0	-7.7	14.9	7.4	-9.2	-12.6
Medication: Amlodipine	17.3	24.3	47.9	-4.6	6.9	3.8	-4.4	-6.6
Medication: Blood pressure	15.9	30.2	59.5	-5.4	7.7	4.9	-4.3	-7.1
High blood pressure	15.4	43.0	83.2	-7.2	9.1	5.6	-5.6	-7.7
Hypertension (Self-reported)	15.4	42.8	82.3	-7.3	9.1	5.9	-5.2	-7.6
Medication: Bendroflumethiazide	14.1	21.4	49.6	-4.1	7.0	3.6	-4.0	-5.7
Vascular/heart problems diagnosed by doctor	13.1	35.7	67.2	6.7	-8.2	-5.0	5.4	6.9
Systolic blood pressure, automated reading	12.3	35.8	84.3	-4.2	9.2	4.5	-5.7	-7.7
Cardiovascular Disease	9.9	32.7	69.2	-5.6	8.3	5.2	-4.6	-6.9
Medication for cholesterol	9.8	14.9	30.9	2.8	-5.2	-3.2	3.7	5.6
High blood pressure (siblings)	7.0	10.1	18.7	-2.6	4.3	2.0	-4.0	-3.9
Medication: Blood pressure	6.2	10.9	21.5	-4.3	4.6	2.8	-2.2	-3.6
High blood pressure (mother)	6.1	8.5	21.9	-0.8	4.7	2.1	-2.9	-4.0
Medication: Ramipril	5.8	7.4	15.4	-3.9	3.9	1.8	-1.4	-3.0
Medication: Atenolol	4.7	5.8	12.9	-1.8	3.5	1.3	-2.2	-3.6
Illnesses of mother	4.3	5.3	11.0	1.2	-3.3	-1.0	3.3	2.8
Diastolic blood pressure, automated reading	4.2	13.1	31.2	-2.2	5.6	2.7	-3.8	-4.6
Medication: Lisinopril	4.0	5.2	10.7	-2.6	2.5	3.3	-1.4	-2.3
Breast cancer (self-reported)	3.7	4.4	12.7	0.2	-2.7	-0.6	3.6	2.4
Birth weight	3.5	7.6	35.2	5.9	-2.2	0.9	-0.7	2.0
Prostate Cancer	3.3	4.7	24.9	5.0	-0.7	-0.6	0.9	1.2
Illnesses of father: High blood pressure	3.3	4.1	8.4	-1.2	2.9	2.0	-1.8	-2.7
Hand grip strength (left)	3.0	7.9	25.9	1.7	2.8	-0.3	-5.1	-3.2
Ever highly irritable/argumentative for 2 days	3.0	3.5	12.7	0.2	1.5	3.6	-2.4	-0.8
Fasting Glucose	2.9	3.5	6.2	-1.3	1.3	2.4	-2.3	-2.5
Friendships satisfaction	2.9	3.6	5.1	-2.2	2.1	2.2	-1.6	-2.3
Illnesses of siblings	2.7	3.9	9.1	3.0	-2.2	-1.4	1.6	2.1
Supplements: Zinc	2.6	2.8	7.0	0.6	2.2	0.4	-2.7	-2.1
Impedance of arm (left)	2.4	11.3	21.0	-2.3	-4.5	-0.7	4.5	4.6
Medication: Ventolin 100micrograms inhaler	2.4	3.1	6.8	1.2	-2.4	0.2	2.6	2.2
Respiratory disease	2.2	4.9	9.7	3.1	-2.6	1.2	1.7	2.9
Loud music exposure frequency	2.2	2.4	5.6	-1.1	2.2	1.4	-1.1	-2.4
Mean Putamen Volume	2.1	2.4	4.8	-2.2	1.8	1.8	-1.3	-1.1
Medication: Co-codamol	2.1	2.5	5.3	0.7	-2.0	-1.3	1.8	2.3
Impedance of arm (right)	2.1	10.0	17.6	-2.9	-4.1	-0.8	4.1	4.2
Hand grip strength (right)	2.0	5.3	20.4	1.7	1.9	-0.1	-4.5	-2.2
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.3	6.7	-2.6	1.0	1.2	-1.6	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.2	4.6	1.7	-1.4	-0.7	2.1	1.8
Multivitamins +/- minerals	1.9	2.4	5.8	0.4	-1.8	-1.5	2.4	1.6
Medication for cholesterol, blood pressure or diabetes	1.9	3.2	8.8	3.0	-2.1	-1.8	1.2	1.0
Impedance of whole body	1.9	9.7	19.5	-2.9	-3.6	-1.2	4.4	4.0
Ulcerative Colitis	1.8	2.6	9.4	3.1	0.7	2.2	-0.2	-1.0
Waist Hip Ratio (WHR)	1.8	8.1	14.4	0.7	-3.7	-2.7	3.8	3.6
Tinnitus: Yes, now most or all of the time	1.8	2.2	5.4	-2.3	-1.8	-0.7	-0.2	2.0
Diabetes (mother)	1.7	2.1	5.2	-1.0	2.3	0.9	-0.6	-2.3
Medication: Ibuprofen	1.7	2.1	6.1	2.5	0.8	1.5	-1.7	-0.8
Hearing aid user	1.7	1.9	3.9	0.6	-1.8	-0.5	1.9	2.0
LDL Cholesterol	1.6	2.6	8.8	0.1	-1.8	-0.9	1.7	3.0
Chronic bronchitis/emphysema (father)	1.6	1.9	4.0	-1.5	-1.4	-0.6	2.0	1.8
Alcohol usually taken with meals	1.5	2.4	6.2	0.9	2.5	-1.0	-1.4	-2.1
Qualifications: College or University degree	1.5	4.6	8.8	2.1	2.6	0.4	-3.0	-2.8
Handedness (chirality/laterality): Left-handed	1.5	1.8	3.1	0.4	-1.8	-1.6	1.6	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	4.2	-1.0	-2.0	-0.6	1.7	1.5
Number of treatments/medications taken	1.4	2.5	8.2	0.2	2.0	2.9	-1.0	-1.4
Impedance of leg (right)	1.4	6.9	15.5	-3.5	-2.0	-1.6	3.9	2.7
Lung cancer (father)	1.4	1.7	4.2	-1.4	2.1	-0.1	-0.7	-1.8
Illnesses of father: Heart disease	1.4	1.9	4.1	-1.2	-1.2	-2.0	1.6	1.3
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	5.2	0.1	2.3	0.8	-1.1	-1.8
Age when periods started (menarche)	1.3	3.1	11.4	0.6	-3.4	-0.1	1.5	2.1
Impedance of leg (left)	1.3	6.1	13.7	-3.1	-2.1	-1.3	3.7	2.7
Qualifications: None of the above	1.3	2.8	5.6	-2.4	-2.2	0.2	2.0	1.6
Peak expiratory flow (PEF)	1.3	3.0	9.9	3.1	-1.5	-0.9	0.3	2.2
Emphysema/chronic bronchitis	1.3	1.5	5.5	0.6	-1.3	0.5	2.3	1.2
Supplements: Glucosamine	1.2	1.6	6.5	2.5	-0.6	-0.6	0.5	1.5
Medication: Allopurinol	1.2	1.6	5.7	-0.6	1.2	0.8	-2.4	-1.2
Average weekly beer plus cider intake	1.2	1.8	5.2	-0.8	-1.7	-2.3	0.8	1.1
Pack years of smoking	1.2	1.7	4.4	0.3	-1.7	-0.9	2.1	1.5
Irritable Bowel Disease (IBD)	1.1	2.7	5.3	1.4	2.1	2.3	-1.2	-1.7
Trunk fat percentage	1.1	4.4	13.2	0.9	-3.6	-0.9	1.5	3.1
Happiness	1.1	1.4	2.5	-0.9	1.2	1.6	-1.5	-1.1
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	4.7	2.2	0.8	0.4	-1.5	-0.8
Wheeze or whistling in the chest in last year	1.1	1.9	7.1	0.4	-2.7	0.8	1.1	1.6
Mouth/teeth dental problems: Loose teeth	1.1	1.3	6.0	-1.1	0.5	2.4	-0.3	-0.4
Suffer from ‘nerves’	1.1	1.8	6.2	-0.2	-1.8	-0.4	2.5	1.1
Mother’s age at death	1.1	1.4	3.6	1.9	1.6	0.2	-1.1	-0.9
Number of operations (self-reported)	1.1	1.6	3.9	-0.3	-1.6	-0.4	2.0	1.7
Alcohol drinker status: Previous	1.1	1.2	4.0	-0.5	-1.1	2.0	1.3	0.5
Crohns Disease (2017)	1.0	2.1	4.5	0.4	2.1	2.1	-0.9	-1.7
Ovarian Cancer	1.0	1.3	5.6	0.3	-0.8	0.2	2.4	1.2
Age at First Birth	1.0	1.4	3.4	0.1	1.9	1.5	-0.0	-1.7
Body Mass Index (BMI) (2010)	1.0	1.3	3.6	1.9	-0.4	1.6	-1.2	0.5
Vitamin and mineral supplements	1.0	1.4	3.8	-0.2	1.2	0.9	-2.0	-1.5
Pack years adult smoking proportion	1.0	1.5	3.8	0.1	-1.5	-0.8	2.0	1.5
Arm predicted mass (right)	1.0	5.0	15.1	3.3	1.4	-0.5	-3.9	-1.5
Loneliness, isolation	1.0	1.4	3.3	-0.9	-1.8	-1.6	-0.2	1.2
Diabetes diagnosed by doctor	1.0	1.7	8.8	-3.0	-0.1	1.0	-0.1	-0.6
Lung FEV1/FVC ratio	0.9	4.7	12.3	1.5	-1.6	-3.5	2.3	2.5
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	3.3	-1.8	-1.1	0.2	0.3	1.2
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.0	2.7	-1.2	-0.2	-1.2	1.6	0.4
Asthma	0.9	1.8	3.5	1.2	-1.7	-0.2	1.8	1.9
Leg pain on walking	0.9	1.1	2.7	1.6	-0.9	-0.4	-0.2	1.6
Leg predicted mass (right)	0.9	4.5	13.5	3.7	0.2	0.2	-3.6	-0.9
Arm fat-free mass (left)	0.9	4.6	16.7	2.6	1.3	0.1	-4.1	-1.6
Ever depressed for a whole week	0.9	1.2	3.0	-1.4	0.6	1.7	-1.0	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	5.5	-0.9	-0.2	2.3	0.2	0.5
Arm predicted mass (left)	0.9	4.7	17.1	2.3	1.7	-0.0	-4.1	-1.8
Intelligence (Savage-Jansen 2018)	0.8	2.3	10.7	3.3	-0.0	0.8	-1.3	1.0
Ulcerative Colitis (UC)	0.8	1.4	2.4	1.5	1.2	1.4	-1.1	-1.3
Medication: Levothyroxine sodium	0.8	1.4	6.3	-2.5	-0.2	1.4	-0.0	0.1
Nervous feelings	0.8	1.5	6.1	-2.5	-1.0	0.1	1.1	0.6
Hearing difficulty/problems with background noise	0.8	1.2	4.9	-2.2	0.1	1.5	0.3	-0.2
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	4.1	-1.3	-0.6	2.0	0.3	0.1
Allergy	0.8	1.8	3.6	-1.3	1.9	0.9	-1.2	-1.8
Trunk fat-free mass	0.8	4.8	16.6	2.6	1.6	-0.4	-4.1	-1.6
Trunk predicted mass	0.8	4.8	16.8	2.6	1.6	-0.3	-4.1	-1.6
Breastfed as a baby	0.8	0.9	2.1	1.0	0.8	0.3	-1.5	-1.3
Arm fat-free mass (right)	0.8	4.1	12.7	3.1	1.0	-0.4	-3.6	-1.1
Comparative body size at age 10	0.8	2.2	6.2	2.5	1.5	0.7	-1.9	-0.8
Migraine (self-reported)	0.8	1.0	2.1	1.1	1.3	-0.5	1.5	-0.8
Medication: Omeprazole	0.8	1.0	4.5	-0.9	-0.2	2.1	0.7	0.3
Family relationship satisfaction	0.8	1.0	1.8	-1.2	0.8	0.8	-1.1	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.8	-0.7	-1.4	0.2	0.2	1.7
Illnesses of siblings: Diabetes	0.8	1.0	3.8	-2.0	0.0	1.4	0.1	0.1
Whole body fat-free mass	0.8	4.7	15.1	3.2	1.1	-0.2	-3.9	-1.3
Leg fat-free mass (right)	0.8	4.5	13.8	3.7	0.2	0.2	-3.5	-0.9
Illnesses of father: None of the above (group 1)	0.8	1.0	3.9	2.0	0.0	0.6	-1.2	-0.7
Whole body water mass	0.8	4.8	16.2	3.1	1.1	-0.1	-4.0	-1.4
Number of self-reported non-cancer illnesses	0.8	1.4	5.7	-0.5	1.0	2.4	-0.8	-0.6
Guilty feelings	0.8	1.1	3.6	0.2	-1.9	-0.6	0.8	1.5
Financial situation satisfaction	0.8	0.9	2.0	-1.2	0.5	1.4	-0.8	-1.1
Commuting to job workplace: Public transport	0.8	1.0	2.3	0.9	-1.1	-0.9	1.5	0.8
Fractured/broken bones in last 5 years	0.8	1.0	3.0	0.6	-0.2	1.7	-1.6	-0.1
Myopia	0.8	1.2	2.6	0.5	-1.4	-0.7	1.6	1.5
Neuroticism (2016)	0.7	1.1	2.8	-0.9	-1.6	0.4	0.5	1.7
Primary Biliary Cirrhosis	0.7	1.0	2.7	0.6	1.6	1.1	-0.2	-1.4
Leg fat-free mass (left)	0.7	3.8	12.4	3.5	0.0	-0.2	-3.2	-0.6
Maternal smoking around birth	0.7	1.0	2.4	-0.3	-1.6	0.7	1.3	1.1
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	3.5	1.9	-0.6	0.9	0.3	0.2
Sitting height	0.7	4.8	25.3	-0.2	1.2	0.6	-5.0	-1.3
Leg predicted mass (left)	0.7	3.8	12.1	3.5	0.0	-0.1	-3.2	-0.6
Medication: Simvastatin	0.7	1.1	4.8	-1.0	0.5	2.2	-0.7	-0.2
Number of live births	0.7	0.9	3.8	0.2	0.5	1.9	-0.3	-1.1
Pulse wave reflection index	0.7	0.9	2.3	-0.5	0.9	-1.2	-0.8	-1.5
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	3.2	1.0	1.8	0.3	-0.6	-1.5
Body fat percentage	0.7	2.9	8.7	0.9	-3.0	-0.8	1.2	2.5
Pulse rate, automated reading	0.7	2.2	5.9	2.4	-1.4	-0.2	1.7	1.6
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	4.2	2.1	-1.1	0.7	0.1	0.8
Asthma (self-reported)	0.7	1.4	2.4	1.4	-1.4	-0.1	1.4	1.6
Basal metabolic rate	0.7	3.8	12.5	3.0	0.6	-0.2	-3.5	-0.9
Ever had prostate specific antigen (PSA) test	0.7	0.8	4.2	2.0	-0.5	-0.0	-0.0	0.6
Alzheimer’s Disease (in mother)	0.6	0.7	2.8	-1.7	-0.0	1.1	0.5	0.1
Blood Platelet Count	0.6	7.0	17.0	4.1	-2.7	-1.9	3.3	2.0
Taking other prescription medications	0.6	0.9	3.6	-1.1	-0.4	1.9	0.3	0.4
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	2.8	0.8	0.3	1.7	0.4	-0.5
Trunk fat mass	0.6	2.8	8.1	1.5	-2.9	-1.0	0.2	2.3
Forced vital capacity (FVC)	0.6	2.2	8.1	1.5	1.1	0.9	-2.9	-0.9
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	6.8	2.6	0.5	-0.2	-2.1	0.3
Qualifications: A levels/AS levels or equivalent	0.6	1.3	3.2	0.9	1.8	0.9	-1.1	-1.2
Medication: Cholesterol lowering	0.6	0.9	2.6	-1.6	0.2	1.6	-0.3	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	8.0	2.8	-0.3	-0.9	-1.3	0.8
Headache pain in last month	0.6	1.0	2.2	0.1	1.3	-0.5	-1.5	-1.3
Worry too long after embarrassment	0.6	1.1	3.6	-1.9	-0.8	-1.4	-0.2	0.2
Eye problems/disorders: None of the above	0.6	0.7	1.7	-0.5	1.3	1.1	-0.6	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.2	-0.4	0.8	1.5	-0.7	-0.8
Arm fat percentage (left)	0.6	2.4	6.4	1.5	-2.5	-0.3	1.0	2.1
Ever had bowel cancer screening	0.6	0.7	1.7	-1.0	-0.7	1.3	-0.3	0.8
Back pain experienced in last month	0.6	0.8	2.3	-1.0	-1.5	-0.6	-0.2	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	6.7	2.6	-0.4	0.7	-0.7	0.5
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.3	0.9	-0.9	-0.7	0.4	1.5
Alzheimer’s Disease (in father)	0.5	0.5	2.0	0.2	0.3	-0.4	-1.0	-1.4
Verbal and Numeric Reasoning (VNR)	0.5	1.3	4.8	2.2	-0.5	-1.1	-0.2	1.2
Average weekly spirits intake	0.5	0.6	2.3	1.5	-0.2	-0.1	1.0	0.7
Ever had hysterectomy (womb removed)	0.5	0.6	1.1	-0.6	0.9	1.0	0.0	-1.1
Townsend deprivation index at recruitment	0.5	0.7	2.8	-0.4	-0.8	1.7	0.7	0.5
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.3	-1.5	0.8	-0.5	0.4	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.0	3.3	1.1	-0.6	-1.8	-0.9	0.8
Stomach or abdominal pain in last month	0.5	0.7	2.1	0.4	-1.2	0.4	0.4	1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	3.7	1.9	-0.2	-1.2	-1.1	1.0
Financial difficulties in last 2 years	0.5	0.7	2.8	-1.7	-0.4	1.0	0.2	-0.1
Diabetes (self-reported)	0.5	0.7	4.0	-2.0	-0.5	0.2	0.3	0.2
Arm fat percentage (right)	0.5	1.9	5.2	1.2	-2.3	-0.4	0.8	2.0
Father’s age at death	0.5	0.7	1.8	0.8	-0.9	-1.4	0.2	0.9
Pulse rate	0.5	0.9	3.3	1.8	0.0	0.7	1.0	-0.6
Noisy workplace	0.5	0.6	1.2	-1.0	0.9	0.1	-1.1	-0.8
Hair/balding pattern: Pattern 4	0.5	1.1	3.2	-0.3	-1.4	-1.8	0.9	0.8
Glaucoma (self-reported)	0.5	0.6	1.5	1.2	-0.6	-0.4	0.7	0.9
Forced vital capacity (FVC), Best measure	0.5	1.9	5.8	2.2	0.5	0.1	-2.4	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.8	-0.2	-0.8	1.3	0.2	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.6	0.4	-0.6	-1.3	0.5	1.1
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.1	-1.0	-0.4	-0.3	1.0	1.0
Smoking status: Previous	0.5	0.7	4.2	-0.4	0.2	2.0	0.1	0.1
Mineral and other dietary supplements	0.5	0.7	2.9	-1.7	0.2	0.6	-0.2	-1.0
Osteoarthritis (self-reported)	0.5	0.6	2.6	-0.2	-0.3	-0.9	1.6	0.6
Average weekly champagne plus white wine intake	0.5	0.8	2.5	-0.9	0.9	-0.1	-1.6	-0.6
Depression (Nagel 2018)	0.4	0.7	1.1	-0.7	-1.0	0.6	1.0	1.0
Schizophrenia (2018)	0.4	0.8	2.7	-1.7	-0.2	1.0	-0.6	-0.7
HbA1C	0.4	0.4	1.3	0.3	-0.2	-1.1	-0.9	-0.4
Lupus	0.4	0.6	2.8	0.5	-0.2	1.7	-0.8	-0.2
Rheumatoid Arthritis	0.4	0.6	1.4	-0.3	0.9	-0.4	-1.2	-1.1
Blood Red Count	0.4	3.6	10.1	1.9	-3.2	-1.2	1.3	2.2
Relative age of first facial hair	0.4	0.8	2.7	-0.7	1.6	-0.8	-0.3	-0.9
Medication for hormone replacement therapy	0.4	0.4	1.4	1.0	-0.1	-0.4	-1.2	-0.1
Medication: Metformin	0.4	0.5	1.0	-0.6	-0.8	-1.0	1.0	0.2
Severe depression (siblings)	0.4	0.5	2.2	-1.5	-0.5	-0.6	0.4	0.1
Current tobacco smoking	0.4	0.7	2.0	-1.4	-0.4	-0.5	1.1	0.9
Fed-up feelings	0.4	0.8	1.8	-1.4	0.4	0.8	-1.2	-0.6
Waist circumference	0.4	1.6	3.6	1.5	-1.9	-1.1	0.5	1.5
Weight	0.4	2.0	6.2	2.5	-0.9	-0.6	-2.1	0.5
Time employed in main current job	0.4	0.4	2.0	-0.1	-0.5	0.1	1.4	0.5
Alcohol intake versus 10 years previously	0.4	0.6	1.7	0.1	-1.3	0.6	-0.2	1.2
Tense / ‘highly strung’	0.4	0.7	1.7	-1.2	-1.3	-0.3	0.7	0.5
Leg fat percentage (right)	0.4	1.4	3.5	0.1	-1.9	-1.1	0.9	1.7
Exposure to tobacco smoke outside home	0.4	0.6	2.0	0.1	-1.4	-0.6	0.5	0.9
Neck or shoulder pain in last month	0.4	0.6	1.4	-0.8	-0.8	0.5	0.9	1.2
Medication: Seretide 50 evohaler	0.4	0.4	1.4	0.8	0.1	0.5	1.2	0.5
Number of full sisters	0.4	0.5	0.9	-1.0	-0.5	-0.7	1.0	0.4
Overall health rating	0.4	0.9	3.9	-2.0	0.0	1.1	0.3	-0.4
Chest pain or discomfort	0.4	0.6	1.7	-0.6	-0.8	0.7	0.7	1.3
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.6	0.3	0.8	0.2	-1.3	-0.8
Medication: Aspirin	0.4	0.5	2.1	-0.1	-0.2	0.3	1.4	0.9
Supplements: Vitamin C	0.4	0.5	2.5	1.6	-0.4	-0.2	-0.3	0.5
Knee pain experienced in last month	0.4	0.6	1.7	0.9	-1.3	-0.4	0.3	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	2.1	1.4	-0.7	-0.7	0.6	1.0
Osteoporosis (self-reported)	0.4	0.4	2.1	0.4	0.2	-0.5	1.4	-0.4
Miserableness	0.4	0.7	2.0	-1.1	-0.7	0.9	-1.4	0.0
Ever taken oral contraceptive pill	0.4	0.4	1.0	-0.5	0.8	-0.2	-1.0	-0.9
Alcohol drinker status: Never	0.4	0.5	1.0	0.8	-0.9	-1.0	0.5	0.6
Leg fat percentage (left)	0.4	1.3	3.8	0.5	-2.0	-0.8	0.8	1.6
Age started oral contraceptive pill	0.4	0.6	0.9	-0.8	0.9	-0.3	0.9	-0.9
Unable to work because of sickness or disability	0.4	0.6	2.1	-0.5	-0.3	0.9	1.4	0.1
Bipolar Disorder or Schizophrenia	0.3	0.7	2.3	-1.3	-0.6	1.5	-0.3	-0.2
Neuroticism (Nagel 2018)	0.3	0.6	1.4	-0.8	-1.2	-0.8	0.5	0.8
Schizophrenia vs Biploar Disorder	0.3	0.4	1.1	0.8	-0.9	-1.1	-0.0	0.0
Worry (Nagel 2018)	0.3	0.6	1.9	-0.9	-0.7	-0.3	1.4	0.6
Alzheimer’s Disease (including proxy)	0.3	0.4	1.7	-1.3	-0.0	0.6	0.5	-0.5
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.4	-0.4	0.0	-0.3	1.2	0.3
Blood Eosinophil Count	0.3	2.2	6.8	1.5	-1.5	0.9	2.6	1.1
BMI	0.3	1.8	7.5	2.7	0.4	-0.3	-1.5	-1.0
Height	0.3	6.1	18.2	0.5	-4.3	-1.3	-2.1	3.5
Allergy or Eczema	0.3	0.8	1.9	1.0	-1.4	-0.7	0.2	1.2
Sensitivity / hurt feelings	0.3	0.5	0.9	0.9	-0.9	-0.6	-0.8	-0.3
Average weekly fortified wine intake	0.3	0.4	0.8	0.1	0.9	-0.7	0.5	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.1	-0.6	-0.5	1.1	0.6	0.3
Qualifications: CSEs or equivalent	0.3	0.3	1.7	0.2	-0.0	-1.3	0.5	0.2
Past tobacco smoking	0.3	0.5	2.4	0.9	-0.2	-1.5	0.2	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.6	-0.3	-0.9	1.3	-0.5	0.4
Had other major operations	0.3	0.4	0.7	-0.6	-0.8	0.6	0.5	0.8
Hip circumference	0.3	1.4	7.3	1.0	0.1	-0.0	-2.7	-0.4
Mouth/teeth dental problems: Dentures	0.3	0.5	1.7	-0.4	-1.3	0.3	0.9	0.6
Depression (self-reported)	0.3	0.4	1.4	-1.2	-0.5	0.1	-0.0	0.8
Medication: Lansoprazole	0.3	0.4	1.6	0.8	0.0	1.3	-0.4	-0.1
Arm fat mass (right)	0.3	1.1	3.3	1.8	-1.4	-0.1	-0.5	1.1
Length of working week for main job	0.3	0.3	0.7	0.8	0.8	-0.4	-0.1	-0.7
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	2.3	-0.9	-0.6	0.2	1.5	0.7
Chronic bronchitis/emphysema (mother)	0.3	0.3	1.5	-0.4	-0.2	-0.5	-1.2	-0.2
Number of full brothers	0.3	0.4	1.6	-0.0	-1.3	0.2	0.8	0.6
Pulse wave peak to peak time	0.3	0.4	1.2	-0.2	-0.6	-0.7	0.5	1.1
Health satisfaction	0.3	0.4	0.7	-0.8	-0.7	0.8	0.5	0.6
Mean time to correctly identify matches	0.3	0.6	1.2	-1.1	-1.1	-0.0	0.8	0.7
Whole body fat mass	0.3	1.4	3.8	1.5	-1.9	-0.6	-0.5	1.5
Leg fat mass (right)	0.3	1.1	2.1	1.4	-1.5	-0.8	-0.4	1.2
Average weekly red wine intake	0.3	0.5	1.2	0.7	1.1	-0.8	0.7	-0.4
Long-standing illness, disability or infirmity	0.3	0.5	0.9	-0.9	-0.9	0.3	1.0	0.3
Medication: Aspirin	0.3	0.4	1.4	-0.3	-0.2	0.4	1.2	0.8
Smoking status: Current	0.3	0.4	1.9	-1.4	-0.2	-0.4	0.5	0.6
Arm fat mass (left)	0.3	1.0	3.1	1.8	-1.3	-0.0	-0.7	1.0
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.7	-0.3	0.1	-0.8	1.3	0.4
Medication: Paracetamol	0.3	0.4	1.0	0.6	-0.4	-0.0	1.0	1.0
Cholesterol lowering medication	0.3	0.5	2.0	-0.6	0.4	0.6	0.0	-1.4
Basal cell carcinoma (self-reported)	0.3	0.4	1.5	-0.7	0.2	-1.2	-0.4	-0.4
Heart disease (siblings)	0.3	0.4	1.3	-1.1	-0.6	-0.2	0.6	0.5
Leg fat mass (left)	0.3	1.0	2.6	1.6	-1.4	-0.6	-0.5	1.1
Bipolar Disorder (2018)	0.2	0.3	0.8	0.3	-0.6	0.9	0.3	0.5
HDL Cholesterol	0.2	0.4	1.8	0.5	0.0	-1.3	0.2	0.4
Schizophrenia (2014)	0.2	0.5	2.3	-0.5	-0.5	1.5	-0.3	-0.3
Triglycerides	0.2	0.3	0.7	-0.5	-0.8	0.3	0.5	0.8
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.2	0.0	-0.7	0.1	1.1	0.1
Chronotype (morning person)	0.2	0.4	0.7	-0.9	-0.7	-0.4	-0.3	0.9
Hearing difficulty/problems: Yes	0.2	0.3	0.8	-0.8	-0.0	-0.5	0.9	0.5
Hayfever, allergic rhinitis or eczema	0.2	0.5	1.3	1.2	-0.8	-0.7	0.1	0.7
Body mass index (BMI)	0.2	1.0	4.2	2.1	-0.0	0.1	-1.2	-0.2
Number of incorrect matches in round	0.2	0.4	1.9	-1.4	0.1	-0.2	-0.5	0.4
Had menopause	0.2	0.3	0.6	0.2	0.5	0.6	-0.8	-0.6
Mouth/teeth dental problems	0.2	0.4	0.8	0.5	0.6	-0.1	-0.9	-0.9
Fluid intelligence score	0.2	0.4	1.2	1.1	0.5	-0.3	-0.9	0.2
Neuroticism score	0.2	0.3	0.8	-0.7	-0.7	-0.1	-0.9	-0.1
Worrier / anxious feelings	0.2	0.3	0.9	0.2	0.3	-0.8	-0.7	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.3	-1.1	-0.6	0.1	0.7	0.5
Falls in the last year	0.2	0.2	0.6	-0.8	0.6	-0.4	-0.2	-0.3
Hair/balding pattern: Pattern 3	0.2	0.3	0.8	0.7	0.9	0.2	-0.2	-0.6
Prospective memory result	0.2	0.2	0.4	0.6	-0.6	-0.4	0.2	-0.4
Pulse wave Arterial Stiffness index	0.2	0.2	0.7	0.6	0.2	0.5	-0.4	-0.9
Standing height	0.2	2.2	4.2	1.3	-1.7	-1.4	-2.1	1.5
Exposure to tobacco smoke at home	0.2	0.2	0.5	0.7	-0.6	-0.2	0.4	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.7	0.1	0.7	0.2	-1.3	-0.2
Birth weight of first child	0.2	0.4	0.9	0.7	-0.5	-0.9	0.1	0.7
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.9	-0.9	0.4	0.9	0.2	0.2
Medication: Paracetamol	0.2	0.3	0.7	0.3	-0.1	0.4	0.8	0.8
Gout (self-reported)	0.2	0.3	1.2	0.4	0.0	1.1	-0.7	-0.0
Age at first live birth	0.2	0.3	1.2	-1.1	0.4	0.2	0.6	-0.2
Angina (self-reported)	0.2	0.3	0.7	-0.2	-0.8	0.3	0.7	0.6
Heart disease (mother)	0.2	0.3	1.0	-1.0	-0.5	-0.1	-0.0	0.6
Alcohol intake frequency.	0.2	0.5	1.5	0.1	-1.0	0.6	1.2	0.3
Comparative height size at age 10	0.2	1.1	6.6	0.1	0.1	-0.0	-2.6	0.2
Age at last live birth	0.2	0.3	1.2	0.3	0.5	1.1	0.4	-0.5
Commuting to job workplace: Walk	0.2	0.2	0.7	-0.4	0.3	-0.2	-0.9	-0.5
Eye problems/disorders: Cataract	0.2	0.2	0.9	1.0	-0.2	0.0	0.5	-0.1
Medication: Gliclazide	0.2	0.3	1.1	0.1	-0.1	-1.0	-0.5	-0.4
Eye problems/disorders: Glaucoma	0.2	0.3	0.8	0.9	0.1	0.6	-0.6	-0.2
Ever smoked	0.2	0.3	1.3	-1.1	0.6	0.4	-0.5	-0.3
Irritability	0.2	0.4	1.6	0.4	0.5	-0.3	-1.3	-0.3
Risk taking	0.2	0.2	0.4	0.6	-0.3	-0.6	-0.5	-0.5
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	-0.6	-0.5	-0.1	-0.6	0.3
Reaction Time	0.1	0.3	1.2	-1.1	-0.5	-0.4	-0.0	0.2
Crohns Disease (2012)	0.1	0.1	0.5	0.7	0.0	0.0	0.1	0.0
Blood White Count	0.1	0.9	2.3	1.5	-0.9	1.0	1.1	-0.6
Heel T-Score	0.1	0.7	1.8	1.0	-0.3	-1.3	0.5	1.1
Hypothyroidism (self reported)	0.1	0.3	0.9	-0.6	-0.1	-0.5	0.9	0.4
Lung FVC	0.1	0.7	1.6	-0.1	1.3	1.2	-0.7	-0.8
Hair Pigment	0.1	2.4	7.4	-2.7	1.7	1.7	-0.1	-1.1
Tanning	0.1	1.0	2.4	1.3	-1.6	-0.5	-0.1	1.3
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	-0.3	-0.5	0.5	0.0	-0.1
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.3	0.5	-0.1	-0.3	-0.5	0.5
Angina	0.1	0.2	0.4	0.0	-0.6	0.4	0.5	0.5
Diabetes (father)	0.1	0.2	1.0	-1.0	-0.2	-0.0	0.1	0.1
Relative age voice broke	0.1	0.2	0.5	0.1	0.7	-0.5	0.2	-0.5
Serious illness, injury or assault to yourself	0.1	0.1	0.5	-0.1	-0.7	-0.2	0.4	0.2
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.1	-0.1	0.5	-0.4	-0.2
Heart attack	0.1	0.2	0.6	-0.8	-0.3	0.5	-0.0	0.3
Pain all over the body in last month	0.1	0.1	0.3	0.1	0.2	0.3	0.2	-0.5
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.4	-0.2	-0.3	0.4	-0.3	0.7
Blood clot in the leg (DVT)	0.1	0.1	0.4	0.2	-0.4	0.2	0.3	0.6
Number of children fathered	0.1	0.1	0.4	0.0	-0.6	0.7	-0.1	-0.1
Shortness of breath walking on level ground	0.1	0.1	0.3	0.0	-0.5	0.5	0.4	0.3
Medication for pain relief, constipation, heartburn	0.1	0.1	0.3	-0.6	-0.1	-0.4	-0.1	-0.2
Had major operations	0.1	0.1	0.3	-0.4	0.5	-0.1	-0.1	-0.5
Mood swings	0.1	0.2	0.7	-0.0	-0.8	0.2	-0.1	0.5
Qualifications: nursing, teaching	0.1	0.1	0.6	-0.0	0.3	-0.8	0.1	0.4
Wears glasses or contact lenses	0.1	0.1	0.6	0.8	-0.2	0.3	0.3	0.2
High cholesterol (Self-reported)	0.1	0.1	0.6	0.1	0.3	-0.0	0.7	-0.5
Medication: Atorvastatin	0.1	0.1	0.2	-0.0	-0.2	-0.5	0.4	-0.2
Commuting to job workplace: Cycle	0.1	0.1	0.4	0.7	0.2	0.3	0.2	-0.1
Pain experienced in last month	0.1	0.2	0.5	0.6	-0.1	0.0	0.7	-0.0
Supplements: Calcium	0.1	0.1	0.4	-0.1	0.5	-0.0	-0.2	-0.7
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.7	-0.8	-0.1	0.6	-0.1	0.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.2	-0.4	0.0	0.0	-0.1	0.0
Smoking Status	0.0	0.0	0.0	-0.1	0.2	0.2	0.1	0.0
Neuroticism	0.0	0.1	0.3	-0.5	-0.4	-0.3	0.0	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.1	0.0	0.0	0.3	-0.3	0.3

Hub : Genes

TNNT3

Models

Trait associations