Best TWAS P=1.01e-14 · Best GWAS P=2.13e-12 conditioned to 0.746
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | COL4A3BP | 0.09 | 0.06 | lasso | 5 | 0.05 | 0.00042 | 6.9 | -7.0 | 3.3e-12 | -0.69 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Spleen | POLK | 0.18 | -0.01 | lasso | 16 | 0.03 | 0.05110 | 6.2 | 5.4 | 5.9e-08 | 0.60 | 0.14 | 0.31 | FALSE |
| 3 | GTEx | Thyroid | CTC-366B18.2 | 0.06 | 0.03 | lasso | 9 | 0.02 | 0.00618 | 4.5 | 5.4 | 5.4e-08 | 0.57 | 0.30 | 0.18 | FALSE |
| 4 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | HMGCR | 0.04 | 0.02 | enet | 4 | 0.03 | 0.00600 | 7.0 | 7.7 | 1.0e-14 | 0.89 | 0.00 | 0.92 | TRUE |
| 5 | The Cancer Genome Atlas | Prostate Adenocarcinoma | POLK | 0.03 | 0.01 | blup | 53 | 0.01 | 0.01610 | 5.5 | -5.7 | 1.0e-08 | -0.63 | 0.04 | 0.93 | FALSE |