Best TWAS P=2.12e-14 · Best GWAS P=3.15e-14 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | GTF3C2 | 0.06 | 0.09 | lasso | 8 | 0.08 | 7.2e-10 | -3.9 | 5.2 | 2.2e-07 | 0.72 | 0.28 | 0.72 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | IFT172 | 0.06 | 0.09 | enet | 16 | 0.09 | 3.9e-11 | -4.1 | -5.4 | 8.5e-08 | -0.75 | 0.48 | 0.52 | FALSE |
3 | GTEx | Esophagus Mucosa | AC074117.10 | 0.12 | 0.14 | lasso | 8 | 0.14 | 2.1e-09 | -5.2 | 5.9 | 3.9e-09 | 0.74 | 0.94 | 0.06 | FALSE |
4 | GTEx | Esophagus Muscularis | NRBP1 | 0.07 | 0.04 | lasso | 6 | 0.04 | 1.3e-03 | -5.2 | 6.0 | 2.2e-09 | 0.82 | 0.01 | 0.97 | FALSE |
5 | GTEx | Ovary | AC074117.10 | 0.16 | 0.04 | enet | 9 | 0.05 | 2.0e-02 | -4.1 | 5.5 | 3.0e-08 | 0.77 | 0.04 | 0.80 | FALSE |
6 | GTEx | Testis | NRBP1 | 0.16 | 0.09 | lasso | 3 | 0.06 | 1.8e-03 | -5.2 | 6.0 | 1.5e-09 | 0.80 | 0.03 | 0.96 | FALSE |
7 | GTEx | Testis | AC074117.10 | 0.14 | 0.08 | lasso | 6 | 0.12 | 4.5e-06 | -4.4 | 6.2 | 6.0e-10 | 0.85 | 0.05 | 0.94 | FALSE |
8 | GTEx | Thyroid | FNDC4 | 0.24 | 0.10 | enet | 23 | 0.16 | 2.2e-12 | -2.2 | -5.3 | 1.2e-07 | -0.69 | 0.67 | 0.33 | FALSE |
9 | GTEx | Vagina | AC074117.10 | 0.14 | 0.04 | enet | 13 | 0.06 | 1.4e-02 | -3.6 | 5.4 | 7.7e-08 | 0.72 | 0.08 | 0.57 | FALSE |
10 | METSIM | Adipose | NRBP1 | 0.06 | 0.09 | lasso | 3 | 0.08 | 1.6e-12 | -5.2 | 5.2 | 1.9e-07 | 0.67 | 1.00 | 0.00 | FALSE |
11 | The Cancer Genome Atlas | Glioblastoma Multiforme | NRBP1 | 0.15 | 0.10 | lasso | 2 | 0.10 | 5.8e-04 | -5.2 | 5.2 | 2.6e-07 | 0.67 | 0.02 | 0.10 | FALSE |
12 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FNDC4 | 0.13 | 0.06 | lasso | 2 | 0.05 | 1.1e-03 | 7.6 | -7.6 | 2.1e-14 | -0.99 | 0.00 | 0.96 | TRUE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | FNDC4 | 0.24 | 0.09 | enet | 9 | 0.17 | 1.9e-16 | -2.6 | -5.3 | 1.2e-07 | -0.70 | 0.41 | 0.59 | FALSE |