TWAS hub - COL4A3BP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Esophagus Mucosa	0.0950	0.0340	3.5e-05	0.061	NA	0.028	NA	0.047	6.4e-05	NA	0.0051	NA	0.00042
2	GTEx	Muscle Skeletal	0.0919	0.0353	4.1e-04	0.008	NA	0.017	NA	0.020	4.4e-02	NA	0.0069	NA	0.00450

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
LDL Cholesterol	44.0	69.7	136.9	-11.7	1.6
High cholesterol (Self-reported)	35.4	62.7	125.4	-11.2	-0.2
Medication: Atorvastatin	21.2	26.2	48.5	-7.0	-2.0
Cholesterol lowering medication	14.4	21.2	42.1	-6.5	-0.5
Medication: Cholesterol lowering	13.8	21.5	42.9	-6.6	0.1
Medication: Simvastatin	9.4	13.8	27.7	-5.3	-0.1
BMI	9.0	52.3	91.6	9.6	-3.6
Body mass index (BMI)	7.6	32.6	49.8	7.1	-3.9
Leg fat mass (right)	7.5	28.9	46.2	6.8	-3.4
Leg fat mass (left)	7.5	29.3	46.1	6.8	-3.5
Arm fat mass (right)	7.4	30.4	47.2	6.9	-3.7
Hip circumference	7.3	31.3	46.9	6.8	-4.0
Arm fat mass (left)	7.0	28.7	42.9	6.5	-3.8
Weight	6.7	33.0	48.3	7.0	-4.2
Whole body fat mass	6.4	26.9	41.4	6.4	-3.5
Waist circumference	6.1	22.5	28.7	5.4	-4.0
Trunk fat mass	5.5	23.8	35.2	5.9	-3.5
Arm fat percentage (right)	5.4	21.4	35.4	5.9	-2.7
Arm fat percentage (left)	5.2	20.7	33.2	5.8	-2.9
Body fat percentage	5.1	20.0	30.1	5.5	-3.2
Leg fat percentage (left)	5.1	18.5	28.8	5.4	-2.9
Leg fat-free mass (left)	5.0	26.7	42.8	6.5	-3.3
Leg predicted mass (left)	5.0	26.6	41.7	6.5	-3.4
Arm fat-free mass (left)	5.0	25.2	36.0	6.0	-3.8
Leg fat percentage (right)	4.9	17.7	28.7	5.4	-2.6
Basal metabolic rate	4.9	27.3	43.3	6.6	-3.4
Arm predicted mass (left)	4.9	24.8	38.4	6.2	-3.3
Chest pain or discomfort	4.8	6.9	10.8	-1.8	-3.3
Leg fat-free mass (right)	4.8	25.8	40.1	6.3	-3.4
Leg predicted mass (right)	4.8	25.8	40.1	6.3	-3.4
Ulcerative Colitis	4.4	6.3	8.2	2.1	2.9
Exposure to tobacco smoke at home	4.4	4.9	5.7	2.4	2.0
Medication for cholesterol, blood pressure or diabetes	4.4	7.3	14.3	3.8	0.5
Trunk fat percentage	4.3	17.4	24.4	4.9	-3.2
Arm predicted mass (right)	4.2	21.3	32.7	5.7	-3.1
Medication for cholesterol	4.2	6.4	12.0	3.5	0.9
Arm fat-free mass (right)	4.1	21.2	31.8	5.6	-3.2
Whole body fat-free mass	4.0	22.7	37.0	6.1	-2.9
Whole body water mass	4.0	23.0	37.2	6.1	-3.0
Body Mass Index (BMI) (2010)	3.9	5.4	7.5	2.7	-1.8
Heart disease (mother)	3.7	4.5	6.5	-1.6	-2.5
Tinnitus: Yes, now most or all of the time	3.4	3.9	6.5	-1.2	-2.5
Fasting Glucose	3.3	3.9	7.6	2.8	-0.5
Cardiovascular Disease	3.3	11.0	21.7	-4.7	-0.7
Number of treatments/medications taken	3.3	5.9	9.9	-3.1	-1.4
Taking other prescription medications	3.3	5.1	6.1	-2.0	-2.5
Coronary Artery Disease (CAD)	3.2	3.8	7.1	-2.7	-0.8
Diabetes (mother)	3.2	4.1	6.6	1.3	-2.6
Impedance of whole body	3.1	15.7	26.6	-5.2	2.2
Trunk fat-free mass	3.0	17.2	29.0	5.4	-2.3
Alcohol intake versus 10 years previously	3.0	4.4	6.7	1.5	-2.6
Trunk predicted mass	3.0	17.2	28.9	5.4	-2.4
Impedance of arm (left)	2.9	13.6	22.9	-4.8	2.1
Ulcerative Colitis (UC)	2.8	5.3	5.5	2.4	2.3
Impedance of leg (right)	2.8	13.5	19.6	-4.4	2.7
Headache pain in last month	2.7	4.6	9.1	-3.0	-0.4
Impedance of leg (left)	2.6	12.7	20.1	-4.5	2.3
Impedance of arm (right)	2.6	11.9	19.1	-4.4	2.2
Falls in the last year	2.5	3.4	4.3	2.1	1.6
Medication: Aspirin	2.5	3.2	6.0	-2.5	-0.7
Smoking status: Previous	2.5	3.7	4.9	-1.6	-2.2
Medication: Gliclazide	2.5	2.9	3.9	2.0	1.4
Blood Platelet Count	2.4	27.9	49.6	-7.0	2.5
Diabetes (father)	2.4	2.9	5.9	2.4	-0.1
Medication: Lansoprazole	2.4	2.8	5.5	2.4	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.4	2.8	3.0	-1.7	-1.6
Ever had bowel cancer screening	2.4	2.8	4.0	1.3	2.0
Medication: Aspirin	2.4	3.2	6.4	-2.5	-0.1
Had other major operations	2.3	2.8	5.6	-0.3	-2.4
Heart attack	2.3	2.9	4.6	-2.1	-1.1
Shortness of breath walking on level ground	2.3	2.7	3.1	1.5	-1.8
Illnesses of father: None of the above (group 1)	2.3	2.9	5.4	-0.6	2.3
Average weekly spirits intake	2.2	2.7	3.9	1.3	2.0
Serious illness, injury or assault of a close relative in last 2 years	2.2	2.5	2.8	1.5	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	2.2	2.9	4.3	2.1	1.2
Supplements: Calcium	2.2	2.4	4.2	0.7	2.1
Diabetes (self-reported)	2.1	3.3	3.7	1.9	-1.7
Pulse wave reflection index	2.1	2.6	5.1	2.3	0.3
Chronic bronchitis/emphysema (mother)	2.1	2.5	4.8	-0.5	-2.2
Qualifications: nursing, teaching	2.1	3.3	6.5	0.2	2.5
Depression (self-reported)	2.0	2.3	3.8	1.9	1.0
Health satisfaction	2.0	2.6	4.2	-1.0	-2.1
Breast cancer (self-reported)	2.0	2.3	2.8	-1.4	-1.7
Heart disease (siblings)	2.0	2.4	2.6	-1.5	-1.6
Medication: Ventolin 100micrograms inhaler	1.9	2.5	4.3	2.1	-0.8
Migraine (self-reported)	1.9	2.4	4.1	-2.0	-0.8
Friendships satisfaction	1.9	2.3	4.5	-2.1	0.2
Medication: Ramipril	1.8	2.3	4.2	-0.6	-2.1
Comparative body size at age 10	1.8	4.9	5.1	2.1	-2.3
Smoking status: Current	1.8	2.9	5.8	2.4	-0.2
Medication: Blood pressure	1.8	3.4	4.0	-1.7	-2.0
Heart attack/myocardial infarction (self-reported)	1.8	2.4	4.2	-2.1	-0.7
Irritable Bowel Disease (IBD)	1.7	4.1	5.1	2.2	1.8
Type 2 Diabetes (T2D) (2018)	1.7	3.1	5.2	2.3	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.2	4.4	0.1	-2.1
Had menopause	1.7	2.2	2.7	-1.3	1.6
Number of live births	1.7	2.5	3.0	-1.4	1.7
Ever highly irritable/argumentative for 2 days	1.7	2.0	3.5	1.9	0.8
Leg pain on walking	1.7	2.1	2.4	1.6	-1.4
Illnesses of father: Heart disease	1.7	2.4	2.6	-1.6	-1.5
Commuting to job workplace: Walk	1.7	1.8	3.4	-1.8	0.5
Ever had prostate specific antigen (PSA) test	1.7	2.0	3.1	-0.9	1.8
Hayfever, allergic rhinitis or eczema	1.6	3.5	7.0	0.2	-2.6
Financial difficulties in last 2 years	1.6	2.1	2.7	-1.3	-1.6
Time employed in main current job	1.6	1.8	3.0	-1.7	0.8
Gout (self-reported)	1.6	2.1	2.4	1.5	1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.8	2.0	1.2	1.4
Number of self-reported non-cancer illnesses	1.6	2.8	3.8	-2.0	-1.3
Ever taken oral contraceptive pill	1.6	1.8	2.8	0.9	1.7
Commuting to job workplace: Public transport	1.6	1.9	3.1	-1.7	-0.8
Myopia	1.6	2.3	4.2	0.5	-2.1
Mean Putamen Volume	1.5	1.7	2.2	-1.5	-1.1
Relative age of first facial hair	1.5	3.2	5.2	-2.3	1.1
Age when periods started (menarche)	1.5	3.6	4.1	-2.0	1.8
Qualifications: None of the above	1.5	3.2	5.8	-0.7	-2.4
Fluid intelligence score	1.5	3.1	6.2	-2.5	-0.0
Happiness	1.5	1.8	3.1	-1.8	0.7
Wheeze or whistling in the chest in last year	1.5	2.6	4.7	0.8	-2.2
Angina (self-reported)	1.5	2.0	3.6	-1.9	0.7
Schizophrenia (2014)	1.4	3.1	4.7	-1.2	2.2
Angina	1.4	1.8	3.1	-1.8	0.8
Pack years adult smoking proportion	1.4	2.2	4.3	2.1	0.3
Peak expiratory flow (PEF)	1.4	3.2	5.8	-0.7	-2.4
Eye problems/disorders: Cataract	1.4	1.6	2.7	-0.7	1.7
Financial situation satisfaction	1.4	1.7	2.6	-0.9	-1.6
Worry (Nagel 2018)	1.3	2.7	5.2	-0.5	2.3
Lung FVC	1.3	6.4	8.9	-3.0	-2.0
Current tobacco smoking	1.3	2.2	3.9	2.0	-0.7
Past tobacco smoking	1.3	2.4	4.5	0.5	2.1
Medication: Allopurinol	1.3	1.8	1.8	1.3	1.4
Had major operations	1.3	1.6	2.9	0.4	1.7
Diabetes diagnosed by doctor	1.3	2.2	2.5	1.6	-1.4
Osteoporosis (self-reported)	1.3	1.6	1.7	-1.3	1.2
Average weekly champagne plus white wine intake	1.3	1.8	2.8	0.9	-1.7
Bipolar Disorder or Schizophrenia	1.2	2.9	5.8	-0.2	2.4
Schizophrenia (2018)	1.2	2.5	4.7	-0.4	2.2
Ovarian Cancer	1.2	1.5	2.2	1.5	-0.9
Allergy	1.2	2.7	5.4	0.0	2.3
Alcohol intake frequency.	1.2	2.8	5.7	0.1	-2.4
Mineral and other dietary supplements	1.2	1.7	3.0	0.5	-1.7
Alzheimer’s Disease (in mother)	1.1	1.2	2.1	0.6	1.5
Age at First Birth	1.1	1.7	3.3	0.1	1.8
Type 2 Diabetes (T2D) (2012)	1.1	1.3	1.5	1.0	1.2
Blood White Count	1.1	8.5	16.6	-0.5	-4.1
Hearing difficulty/problems: Yes	1.1	1.7	3.4	-1.9	-0.2
Hearing difficulty/problems with background noise	1.1	1.8	2.1	-1.5	-1.2
Age at first live birth	1.1	2.0	3.8	-0.5	2.0
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.3	4.1	2.0	-0.7
Long-standing illness, disability or infirmity	1.1	1.7	2.3	1.5	-1.0
Pack years of smoking	1.1	1.6	2.8	1.7	0.6
Major Depression (MDD)	1.0	1.2	1.5	1.2	0.9
Chronic bronchitis/emphysema (father)	1.0	1.1	1.7	1.3	-0.8
Exposure to tobacco smoke outside home	1.0	1.3	2.4	0.3	-1.6
Worry too long after embarrassment	1.0	1.7	2.6	-0.8	1.6
Miserableness	1.0	1.8	1.8	-1.3	-1.3
Lupus	0.9	1.4	1.6	-1.3	-1.1
Smoking Status	0.9	2.2	2.8	1.2	-1.7
Maternal smoking around birth	0.9	1.3	1.3	1.2	-1.1
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	1.8	0.5	-1.3
Qualifications: CSEs or equivalent	0.9	1.2	1.2	1.1	1.1
Forced vital capacity (FVC)	0.9	3.6	4.2	-1.7	-2.1
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	2.1	1.4	0.0
Forced expiratory volume in 1-second (FEV1)	0.9	3.1	4.5	-1.3	-2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.9	1.3	1.5	1.2	-1.1
Birth weight	0.9	1.9	2.5	1.6	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	1.3	1.1	-0.9
Guilty feelings	0.9	1.4	2.7	-1.6	0.1
Ever smoked	0.9	1.5	2.9	0.3	-1.7
Average weekly beer plus cider intake	0.9	1.4	2.2	0.7	-1.5
Vascular/heart problems diagnosed by doctor	0.9	2.4	2.9	1.7	1.4
Schizophrenia vs Biploar Disorder	0.8	1.1	2.2	0.1	1.5
Rheumatoid Arthritis	0.8	1.1	2.1	1.5	0.1
Triglycerides	0.8	1.3	1.6	-1.3	-1.0
Neuroticism	0.8	1.9	3.5	-1.9	0.6
Relative age voice broke	0.8	1.3	2.5	-1.6	-0.2
High blood pressure	0.8	2.1	2.5	-1.3	-1.6
Sitting height	0.8	5.4	8.0	1.7	-2.8
Nervous feelings	0.8	1.6	3.1	-0.3	1.7
Worrier / anxious feelings	0.8	1.6	3.1	-1.8	0.3
Tense / ‘highly strung’	0.8	1.3	1.6	-1.0	1.3
Age at last live birth	0.8	1.2	2.0	-0.6	1.4
Fractured/broken bones in last 5 years	0.8	1.0	1.1	-1.1	0.9
Age started oral contraceptive pill	0.8	1.0	1.6	-0.6	1.3
Ever depressed for a whole week	0.8	1.0	1.9	1.4	0.2
Intelligence (Savage-Jansen 2018)	0.7	2.1	4.2	-2.0	0.3
Verbal and Numeric Reasoning (VNR)	0.7	1.7	3.2	-1.8	-0.3
Breast Cancer	0.7	1.6	3.3	1.8	-0.1
Medication for hormone replacement therapy	0.7	0.8	1.4	0.4	1.2
Medication: Co-codamol	0.7	0.8	1.0	1.0	-0.8
Townsend deprivation index at recruitment	0.7	1.0	1.8	0.3	-1.4
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.0	-0.7	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	3.1	1.7	0.1
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.4	-0.7	-1.2
Loud music exposure frequency	0.7	0.8	1.6	1.3	0.0
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	2.0	0.8	-1.4
Medication for pain relief, constipation, heartburn	0.7	1.2	2.3	1.5	0.4
Medication: Omeprazole	0.7	0.9	1.7	-1.3	0.1
Number of full sisters	0.7	0.9	1.7	0.4	1.3
Suffer from ‘nerves’	0.7	1.2	2.3	-0.1	1.5
Overall health rating	0.7	1.6	2.6	0.7	-1.6
Hypertension (Self-reported)	0.7	1.9	2.1	-1.3	-1.5
Back pain experienced in last month	0.7	1.0	1.2	1.1	0.8
Medication: Lisinopril	0.7	0.9	1.7	0.2	-1.3
Risk taking	0.7	1.0	1.8	1.3	-0.4
Bipolar Disorder (2011)	0.6	0.6	1.1	-1.1	0.1
Systolic Blood Pressure	0.6	2.8	4.0	-1.2	-2.0
Ever used hormone-replacement therapy (HRT)	0.6	0.7	0.9	-0.8	0.9
Ever had hysterectomy (womb removed)	0.6	0.7	1.3	0.1	-1.1
Hand grip strength (right)	0.6	1.6	3.1	-0.1	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.4	2.8	1.7	0.0
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.3	-0.8	-1.2
Prospective memory result	0.6	0.7	1.3	0.2	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	3.6	-0.3	-1.9
Pulse wave Arterial Stiffness index	0.6	0.7	0.7	0.8	0.8
Comparative height size at age 10	0.6	3.5	6.9	2.6	0.2
Supplements: Vitamin C	0.6	0.8	1.5	-1.2	-0.0
Mood swings	0.6	1.0	2.0	-1.4	-0.2
Loneliness, isolation	0.6	0.9	1.7	-0.2	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.1	0.9	1.1
Number of operations (self-reported)	0.6	0.9	1.8	-0.0	-1.3
Diastolic blood pressure, automated reading	0.6	1.9	3.6	-1.9	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.5	-1.2	-0.1
Alzheimer’s Disease (including proxy)	0.5	0.8	1.0	-0.8	1.0
HDL Cholesterol	0.5	0.8	1.0	-0.7	1.0
Neuroticism (2016)	0.5	0.7	0.8	-0.7	0.9
Primary Biliary Cirrhosis	0.5	0.7	0.9	0.7	0.9
Heel T-Score	0.5	4.3	8.6	2.9	-0.2
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	0.9	-0.9	-0.4
Medication: Metformin	0.5	0.7	1.1	0.6	-1.0
Supplements: Glucosamine	0.5	0.6	0.9	0.6	0.9
Medication: Levothyroxine sodium	0.5	0.8	1.5	0.2	-1.2
High blood pressure (mother)	0.5	0.7	1.3	-0.4	1.2
Illnesses of siblings	0.5	0.7	1.0	0.6	1.0
Pulse rate	0.5	0.9	1.7	-1.3	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	0.9	1.0	-0.5
Commuting to job workplace: Car/motor vehicle	0.5	0.6	1.1	1.1	0.1
Knee pain experienced in last month	0.5	0.8	0.9	-0.8	-1.0
Bipolar Disorder (2018)	0.4	0.7	1.3	0.2	1.2
Depressed Affect (Nagel 2018)	0.4	0.8	1.0	-1.0	-0.8
Chronotype (morning person)	0.4	0.8	1.4	-1.2	-0.5
Systolic blood pressure, automated reading	0.4	1.2	1.8	-0.8	-1.3
Vitamin and mineral supplements	0.4	0.5	0.9	1.0	-0.2
Supplements: Zinc	0.4	0.5	1.0	-1.0	-0.0
Average weekly fortified wine intake	0.4	0.5	0.9	-0.1	-1.0
Number of incorrect matches in round	0.4	0.6	0.9	0.6	0.9
Neuroticism score	0.4	0.8	1.6	-1.3	0.1
Father’s age at death	0.4	0.6	1.2	1.1	0.1
Noisy workplace	0.4	0.5	0.9	0.4	-0.9
Illnesses of mother	0.4	0.6	0.7	0.6	0.8
Length of working week for main job	0.4	0.5	0.9	-0.2	-1.0
High blood pressure (siblings)	0.4	0.6	0.9	-0.5	-0.9
Forced vital capacity (FVC), Best measure	0.4	1.4	1.9	-1.0	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	0.4	-0.6	0.7
Mouth/teeth dental problems: Loose teeth	0.4	0.4	0.9	-0.9	-0.0
Mean time to correctly identify matches	0.4	0.7	1.3	-1.1	-0.2
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.6	-0.6	-0.8
Illnesses of father: High blood pressure	0.4	0.5	0.9	0.1	-0.9
Alcohol drinker status: Never	0.4	0.5	0.7	-0.8	0.5
Commuting to job workplace: Cycle	0.4	0.4	0.7	0.4	0.8
Pain experienced in last month	0.4	0.6	1.2	1.1	0.2
Neuroticism (Nagel 2018)	0.3	0.7	0.8	-0.7	0.9
Alzheimer’s Disease (in father)	0.3	0.3	0.6	-0.8	-0.2
Crohns Disease (2017)	0.3	0.7	1.5	1.2	0.0
Prostate Cancer	0.3	0.4	0.8	0.9	0.1
HbA1C	0.3	0.3	0.6	0.2	0.8
Waist Hip Ratio (WHR)	0.3	1.3	1.7	-1.3	-0.9
Allergy or Eczema	0.3	0.8	1.5	-0.5	-1.2
Hypothyroidism (self reported)	0.3	0.7	0.7	0.8	-0.8
Lung FEV1/FVC ratio	0.3	1.5	1.7	1.3	-1.1
Severe depression (siblings)	0.3	0.3	0.5	0.7	0.3
Fed-up feelings	0.3	0.5	1.1	0.0	-1.0
Stomach or abdominal pain in last month	0.3	0.4	0.5	-0.7	-0.5
Mouth/teeth dental problems	0.3	0.5	0.7	0.9	-0.4
Hair/balding pattern: Pattern 3	0.3	0.4	0.6	0.4	0.8
Qualifications: A levels/AS levels or equivalent	0.3	0.8	1.2	-1.1	-0.6
Lung cancer (father)	0.3	0.4	0.8	0.9	0.1
Breastfed as a baby	0.3	0.4	0.5	0.7	-0.6
Number of children fathered	0.3	0.4	0.7	-0.2	-0.8
Pulse wave peak to peak time	0.3	0.4	0.5	-0.5	-0.7
Qualifications: College or University degree	0.3	1.1	1.6	-0.7	1.3
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.4	-0.5	-0.6
Hearing aid user	0.3	0.3	0.4	-0.5	-0.6
Medication: Bendroflumethiazide	0.3	0.5	1.0	0.0	-1.0
Depression (Nagel 2018)	0.2	0.3	0.5	-0.7	-0.2
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.5	-0.2	-0.7
Multivitamins +/- minerals	0.2	0.2	0.3	0.4	0.6
Alcohol usually taken with meals	0.2	0.3	0.4	-0.6	-0.3
Mouth/teeth dental problems: Dentures	0.2	0.3	0.4	0.3	0.6
Hair/balding pattern: Pattern 4	0.2	0.6	0.7	-0.7	0.8
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.4	-0.7	0.3
Medication: Paracetamol	0.2	0.4	0.7	-0.8	-0.3
Medication: Amlodipine	0.2	0.2	0.4	-0.6	-0.3
Eye problems/disorders: None of the above	0.2	0.2	0.4	0.1	-0.7
Medication: Blood pressure	0.2	0.4	0.7	0.1	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.3	0.4	0.6
Illnesses of siblings: Diabetes	0.2	0.2	0.2	0.5	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.6	-0.6	-0.8
Medication: Paracetamol	0.2	0.4	0.7	-0.9	-0.1
Irritability	0.2	0.3	0.6	-0.3	-0.8
Alcohol drinker status: Previous	0.2	0.2	0.3	-0.6	-0.4
Reaction Time	0.1	0.2	0.5	-0.2	-0.7
Crohns Disease (2012)	0.1	0.1	0.3	-0.1	-0.5
Blood Eosinophil Count	0.1	1.1	2.2	0.1	-1.5
Blood Red Count	0.1	1.2	1.9	-1.4	-0.6
Height	0.1	1.5	2.9	-0.1	-1.7
Respiratory disease	0.1	0.1	0.2	0.5	-0.3
Hair Pigment	0.1	2.0	3.1	-1.8	0.9
Hand grip strength (left)	0.1	0.3	0.6	0.2	-0.8
Sensitivity / hurt feelings	0.1	0.2	0.4	0.1	0.6
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.1	-0.2	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	0.5	0.4
Hair/balding pattern: Pattern 2	0.1	0.1	0.1	0.2	0.3
Asthma	0.1	0.1	0.1	0.2	-0.4
Standing height	0.1	0.6	0.9	0.6	-1.0
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	-0.6	-0.1
Blood clot in the leg (DVT)	0.1	0.1	0.2	-0.5	0.1
Glaucoma (self-reported)	0.1	0.1	0.2	0.2	-0.5
Number of full brothers	0.1	0.2	0.3	-0.0	-0.6
Neck or shoulder pain in last month	0.1	0.1	0.2	-0.5	0.1
Medication: Ibuprofen	0.1	0.1	0.1	-0.3	-0.3
Medication: Seretide 50 evohaler	0.1	0.1	0.1	0.3	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.1	-0.2	-0.3
Asthma (self-reported)	0.1	0.1	0.2	0.2	-0.5
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	-0.1	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	-0.4	0.1
Tanning	0.0	0.1	0.1	0.2	-0.3
Other serious medical condition/disability diagnosed by doctor	0.0	0.1	0.1	-0.3	-0.1
Serious illness, injury or assault to yourself	0.0	0.0	0.1	-0.3	-0.1
Medication: Atenolol	0.0	0.0	0.0	0.0	0.1
Pain all over the body in last month	0.0	0.0	0.1	0.2	0.0
Birth weight of first child	0.0	0.1	0.2	-0.4	0.0
Emphysema/chronic bronchitis	0.0	0.0	0.1	0.0	0.2
Pulse rate, automated reading	0.0	0.1	0.2	-0.2	0.5
Family relationship satisfaction	0.0	0.1	0.1	0.3	0.1
Average weekly red wine intake	0.0	0.0	0.0	-0.1	0.0
Osteoarthritis (self-reported)	0.0	0.0	0.0	-0.0	-0.1
Wears glasses or contact lenses	0.0	0.0	0.0	0.0	0.0
Mother’s age at death	0.0	0.0	0.0	-0.0	0.1
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.0	-0.1	-0.2
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.1	-0.2	0.2
Unable to work because of sickness or disability	0.0	0.0	0.0	0.0	0.1
Basal cell carcinoma (self-reported)	0.0	0.1	0.1	-0.2	-0.3

Hub : Genes

COL4A3BP

Models

Trait associations