Best TWAS P=3.43e-20 · Best GWAS P=3.58e-20 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | AL133458.1 | 0.11 | 0.02 | enet | 18 | 0.01 | 2.5e-02 | 6.54 | -7.2 | 5.9e-13 | 0.54 | 0.25 | 0.35 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | AL133458.1 | 0.29 | 0.00 | enet | 19 | 0.00 | 3.6e-01 | -7.46 | -8.2 | 1.9e-16 | 0.82 | 0.02 | 0.90 | TRUE |
| 3 | GTEx | Brain Cerebellum | AL133458.1 | 0.42 | 0.32 | lasso | 6 | 0.31 | 1.0e-09 | -9.18 | -9.2 | 3.4e-20 | 0.93 | 0.00 | 1.00 | TRUE |
| 4 | GTEx | Cells Transformed fibroblasts | RNASET2 | 0.29 | 0.30 | enet | 31 | 0.29 | 1.0e-21 | -7.46 | 7.5 | 8.2e-14 | -0.72 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | AL133458.1 | 0.16 | 0.14 | enet | 13 | 0.14 | 1.7e-10 | -7.46 | 6.2 | 5.4e-10 | -0.72 | 0.99 | 0.01 | FALSE |
| 6 | GTEx | Colon Transverse | RNASET2 | 0.21 | 0.02 | enet | 18 | 0.07 | 3.1e-04 | -3.73 | -6.2 | 7.3e-10 | 0.56 | 0.03 | 0.78 | TRUE |
| 7 | GTEx | Esophagus Mucosa | RNASET2 | 0.29 | 0.31 | lasso | 9 | 0.32 | 1.6e-21 | -9.18 | -9.1 | 7.8e-20 | 0.97 | 0.00 | 1.00 | TRUE |
| 8 | GTEx | Esophagus Mucosa | AL133458.1 | 0.15 | 0.01 | enet | 12 | 0.02 | 1.3e-02 | -7.21 | -7.9 | 2.7e-15 | 0.70 | 0.03 | 0.90 | FALSE |
| 9 | GTEx | Esophagus Mucosa | FGFR1OP | 0.10 | 0.07 | lasso | 4 | 0.03 | 4.4e-03 | 7.04 | 7.0 | 1.8e-12 | -0.66 | 0.28 | 0.43 | FALSE |
| 10 | GTEx | Lung | RNASET2 | 0.21 | 0.13 | lasso | 10 | 0.13 | 4.0e-10 | -7.45 | -8.6 | 1.1e-17 | 0.84 | 0.26 | 0.74 | TRUE |
| 11 | GTEx | Lung | AL133458.1 | 0.17 | 0.09 | lasso | 5 | 0.12 | 3.9e-09 | -5.42 | -7.5 | 4.2e-14 | 0.71 | 0.90 | 0.10 | FALSE |
| 12 | GTEx | Nerve Tibial | RNASET2 | 0.19 | 0.07 | lasso | 8 | 0.09 | 4.4e-07 | 6.54 | -7.4 | 1.8e-13 | 0.68 | 0.31 | 0.69 | FALSE |
| 13 | GTEx | Skin Not Sun Exposed Suprapubic | RNASET2 | 0.14 | 0.07 | enet | 25 | 0.08 | 3.6e-05 | 7.35 | -7.0 | 3.4e-12 | 0.64 | 0.08 | 0.91 | FALSE |
| 14 | GTEx | Skin Not Sun Exposed Suprapubic | AL133458.1 | 0.13 | 0.05 | lasso | 2 | 0.01 | 5.4e-02 | 6.54 | -6.5 | 6.1e-11 | 0.54 | 0.10 | 0.72 | FALSE |
| 15 | GTEx | Skin Sun Exposed Lower leg | RNASET2 | 0.32 | 0.23 | enet | 48 | 0.24 | 3.3e-20 | -7.46 | -8.1 | 4.7e-16 | 0.85 | 0.33 | 0.67 | FALSE |
| 16 | GTEx | Skin Sun Exposed Lower leg | AL133458.1 | 0.13 | 0.08 | enet | 10 | 0.03 | 1.0e-03 | -7.45 | -8.1 | 4.5e-16 | 0.79 | 0.14 | 0.86 | FALSE |
| 17 | GTEx | Stomach | RNASET2 | 0.22 | 0.12 | lasso | 6 | 0.16 | 6.5e-08 | -7.61 | -8.4 | 3.9e-17 | 0.89 | 0.00 | 0.99 | FALSE |
| 18 | GTEx | Thyroid | RNASET2 | 0.16 | 0.06 | enet | 33 | 0.04 | 3.8e-04 | 7.00 | -7.0 | 3.7e-12 | 0.59 | 0.88 | 0.09 | TRUE |
| 19 | GTEx | Thyroid | AL133458.1 | 0.09 | 0.07 | lasso | 5 | 0.07 | 2.9e-06 | -5.42 | -6.1 | 1.1e-09 | 0.49 | 0.98 | 0.00 | FALSE |
| 20 | GTEx | Whole Blood | RNASET2 | 0.20 | 0.18 | enet | 23 | 0.18 | 3.4e-16 | -7.47 | -8.5 | 1.9e-17 | 0.84 | 0.99 | 0.01 | FALSE |
| 21 | GTEx | Whole Blood | AL133458.1 | 0.20 | 0.14 | enet | 7 | 0.18 | 1.4e-16 | -7.21 | -7.9 | 2.6e-15 | 0.79 | 1.00 | 0.00 | FALSE |
| 22 | METSIM | Adipose | CCR6 | 0.06 | 0.02 | lasso | 3 | 0.04 | 5.6e-07 | 6.02 | 5.5 | 4.6e-08 | -0.43 | 0.93 | 0.01 | FALSE |
| 23 | METSIM | Adipose | FGFR1OP | 0.05 | 0.00 | blup | 606 | 0.02 | 1.5e-03 | -0.56 | 5.6 | 2.1e-08 | -0.57 | 0.06 | 0.84 | FALSE |
| 24 | METSIM | Adipose | RNASET2 | 0.09 | 0.09 | lasso | 4 | 0.12 | 8.7e-18 | -7.45 | -8.5 | 2.5e-17 | 0.86 | 0.14 | 0.86 | FALSE |
| 25 | NTR | Blood | RNASET2 | 0.28 | 0.42 | lasso | 13 | 0.43 | 5.3e-155 | -7.46 | -8.1 | 5.3e-16 | 0.83 | 1.00 | 0.00 | FALSE |
| 26 | YFS | Blood | RNASET2 | 0.45 | 0.60 | enet | 24 | 0.61 | 1.8e-260 | -7.47 | -7.7 | 1.9e-14 | 0.82 | 1.00 | 0.00 | FALSE |
| 27 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | RNASET2 | 0.08 | 0.05 | enet | 12 | 0.07 | 2.0e-06 | -9.20 | -8.7 | 3.0e-18 | 0.85 | 0.00 | 1.00 | FALSE |
| 28 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RNASET2 | 0.07 | 0.05 | lasso | 4 | 0.04 | 5.1e-09 | -9.18 | -9.2 | 4.7e-20 | 1.00 | 0.00 | 1.00 | FALSE |
| 29 | The Cancer Genome Atlas | Colon Adenocarcinoma | RNASET2 | 0.12 | 0.05 | enet | 7 | 0.08 | 2.4e-05 | -9.20 | -7.1 | 1.6e-12 | 0.84 | 0.00 | 0.98 | FALSE |
| 30 | The Cancer Genome Atlas | Esophageal Carcinoma | RNASET2 | 0.17 | 0.11 | lasso | 3 | 0.09 | 8.7e-04 | -9.18 | -9.0 | 1.7e-19 | 0.97 | 0.00 | 0.98 | FALSE |
| 31 | The Cancer Genome Atlas | Glioblastoma Multiforme | GPR31 | 0.17 | 0.06 | enet | 10 | 0.09 | 1.3e-03 | -4.01 | 5.3 | 1.1e-07 | -0.29 | 0.02 | 0.24 | TRUE |
| 32 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RNASET2 | 0.09 | 0.08 | lasso | 2 | 0.08 | 2.9e-09 | -9.20 | -9.2 | 5.5e-20 | 0.99 | 0.00 | 1.00 | FALSE |
| 33 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RNASET2 | 0.05 | 0.03 | lasso | 3 | 0.03 | 9.2e-05 | -7.46 | -8.9 | 4.1e-19 | 0.91 | 0.00 | 0.99 | FALSE |
| 34 | The Cancer Genome Atlas | Lung Adenocarcinoma | RNASET2 | 0.06 | 0.04 | lasso | 2 | 0.03 | 2.6e-04 | -9.20 | -9.2 | 4.9e-20 | 0.99 | 0.00 | 0.99 | FALSE |
| 35 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | RNASET2 | 0.13 | 0.09 | lasso | 9 | 0.10 | 1.4e-11 | -9.20 | -9.0 | 3.3e-19 | 0.93 | 0.00 | 1.00 | FALSE |
| 36 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RNASET2 | 0.08 | 0.00 | enet | 8 | 0.01 | 6.5e-02 | -3.98 | -7.8 | 4.2e-15 | 0.73 | 0.01 | 0.70 | TRUE |
| 37 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RNASET2 | 0.24 | 0.15 | lasso | 3 | 0.14 | 5.6e-15 | -9.20 | -8.9 | 6.9e-19 | 0.97 | 0.00 | 1.00 | FALSE |
| 38 | The Cancer Genome Atlas | Rectum Adenocarcinoma | RNASET2 | 0.14 | 0.19 | lasso | 3 | 0.15 | 2.1e-04 | -9.20 | -9.2 | 3.6e-20 | 1.00 | 0.00 | 0.93 | FALSE |