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chr6:166,651,581-167,841,508

Best TWAS P=3.43e-20 · Best GWAS P=3.58e-20 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Brain Cerebellum	AL133458.1	0.42	0.32	lasso	6	0.31	1.0e-09	-9.18	-9.2	3.4e-20	0.93	0.00	1.00	TRUE
7	GTEx	Esophagus Mucosa	RNASET2	0.29	0.31	lasso	9	0.32	1.6e-21	-9.18	-9.1	7.8e-20	0.97	0.00	1.00	TRUE
10	GTEx	Lung	RNASET2	0.21	0.13	lasso	10	0.13	4.0e-10	-7.45	-8.6	1.1e-17	0.84	0.26	0.74	TRUE
2	GTEx	Brain Cerebellar Hemisphere	AL133458.1	0.29	0.00	enet	19	0.00	3.6e-01	-7.46	-8.2	1.9e-16	0.82	0.02	0.90	TRUE
36	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RNASET2	0.08	0.00	enet	8	0.01	6.5e-02	-3.98	-7.8	4.2e-15	0.73	0.01	0.70	TRUE
18	GTEx	Thyroid	RNASET2	0.16	0.06	enet	33	0.04	3.8e-04	7.00	-7.0	3.7e-12	0.59	0.88	0.09	TRUE
6	GTEx	Colon Transverse	RNASET2	0.21	0.02	enet	18	0.07	3.1e-04	-3.73	-6.2	7.3e-10	0.56	0.03	0.78	TRUE
31	The Cancer Genome Atlas	Glioblastoma Multiforme	GPR31	0.17	0.06	enet	10	0.09	1.3e-03	-4.01	5.3	1.1e-07	-0.29	0.02	0.24	TRUE
38	The Cancer Genome Atlas	Rectum Adenocarcinoma	RNASET2	0.14	0.19	lasso	3	0.15	2.1e-04	-9.20	-9.2	3.6e-20	1.00	0.00	0.93	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	RNASET2	0.07	0.05	lasso	4	0.04	5.1e-09	-9.18	-9.2	4.7e-20	1.00	0.00	1.00	FALSE
34	The Cancer Genome Atlas	Lung Adenocarcinoma	RNASET2	0.06	0.04	lasso	2	0.03	2.6e-04	-9.20	-9.2	4.9e-20	0.99	0.00	0.99	FALSE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RNASET2	0.09	0.08	lasso	2	0.08	2.9e-09	-9.20	-9.2	5.5e-20	0.99	0.00	1.00	FALSE
30	The Cancer Genome Atlas	Esophageal Carcinoma	RNASET2	0.17	0.11	lasso	3	0.09	8.7e-04	-9.18	-9.0	1.7e-19	0.97	0.00	0.98	FALSE
35	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RNASET2	0.13	0.09	lasso	9	0.10	1.4e-11	-9.20	-9.0	3.3e-19	0.93	0.00	1.00	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	RNASET2	0.05	0.03	lasso	3	0.03	9.2e-05	-7.46	-8.9	4.1e-19	0.91	0.00	0.99	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	RNASET2	0.24	0.15	lasso	3	0.14	5.6e-15	-9.20	-8.9	6.9e-19	0.97	0.00	1.00	FALSE
27	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	RNASET2	0.08	0.05	enet	12	0.07	2.0e-06	-9.20	-8.7	3.0e-18	0.85	0.00	1.00	FALSE
20	GTEx	Whole Blood	RNASET2	0.20	0.18	enet	23	0.18	3.4e-16	-7.47	-8.5	1.9e-17	0.84	0.99	0.01	FALSE
24	METSIM	Adipose	RNASET2	0.09	0.09	lasso	4	0.12	8.7e-18	-7.45	-8.5	2.5e-17	0.86	0.14	0.86	FALSE
17	GTEx	Stomach	RNASET2	0.22	0.12	lasso	6	0.16	6.5e-08	-7.61	-8.4	3.9e-17	0.89	0.00	0.99	FALSE
16	GTEx	Skin Sun Exposed Lower leg	AL133458.1	0.13	0.08	enet	10	0.03	1.0e-03	-7.45	-8.1	4.5e-16	0.79	0.14	0.86	FALSE
15	GTEx	Skin Sun Exposed Lower leg	RNASET2	0.32	0.23	enet	48	0.24	3.3e-20	-7.46	-8.1	4.7e-16	0.85	0.33	0.67	FALSE
25	NTR	Blood	RNASET2	0.28	0.42	lasso	13	0.43	5.3e-155	-7.46	-8.1	5.3e-16	0.83	1.00	0.00	FALSE
21	GTEx	Whole Blood	AL133458.1	0.20	0.14	enet	7	0.18	1.4e-16	-7.21	-7.9	2.6e-15	0.79	1.00	0.00	FALSE
8	GTEx	Esophagus Mucosa	AL133458.1	0.15	0.01	enet	12	0.02	1.3e-02	-7.21	-7.9	2.7e-15	0.70	0.03	0.90	FALSE
26	YFS	Blood	RNASET2	0.45	0.60	enet	24	0.61	1.8e-260	-7.47	-7.7	1.9e-14	0.82	1.00	0.00	FALSE
11	GTEx	Lung	AL133458.1	0.17	0.09	lasso	5	0.12	3.9e-09	-5.42	-7.5	4.2e-14	0.71	0.90	0.10	FALSE
4	GTEx	Cells Transformed fibroblasts	RNASET2	0.29	0.30	enet	31	0.29	1.0e-21	-7.46	7.5	8.2e-14	-0.72	1.00	0.00	FALSE
12	GTEx	Nerve Tibial	RNASET2	0.19	0.07	lasso	8	0.09	4.4e-07	6.54	-7.4	1.8e-13	0.68	0.31	0.69	FALSE
1	GTEx	Adipose Subcutaneous	AL133458.1	0.11	0.02	enet	18	0.01	2.5e-02	6.54	-7.2	5.9e-13	0.54	0.25	0.35	FALSE
29	The Cancer Genome Atlas	Colon Adenocarcinoma	RNASET2	0.12	0.05	enet	7	0.08	2.4e-05	-9.20	-7.1	1.6e-12	0.84	0.00	0.98	FALSE
9	GTEx	Esophagus Mucosa	FGFR1OP	0.10	0.07	lasso	4	0.03	4.4e-03	7.04	7.0	1.8e-12	-0.66	0.28	0.43	FALSE
13	GTEx	Skin Not Sun Exposed Suprapubic	RNASET2	0.14	0.07	enet	25	0.08	3.6e-05	7.35	-7.0	3.4e-12	0.64	0.08	0.91	FALSE
14	GTEx	Skin Not Sun Exposed Suprapubic	AL133458.1	0.13	0.05	lasso	2	0.01	5.4e-02	6.54	-6.5	6.1e-11	0.54	0.10	0.72	FALSE
5	GTEx	Cells Transformed fibroblasts	AL133458.1	0.16	0.14	enet	13	0.14	1.7e-10	-7.46	6.2	5.4e-10	-0.72	0.99	0.01	FALSE
19	GTEx	Thyroid	AL133458.1	0.09	0.07	lasso	5	0.07	2.9e-06	-5.42	-6.1	1.1e-09	0.49	0.98	0.00	FALSE
23	METSIM	Adipose	FGFR1OP	0.05	0.00	blup	606	0.02	1.5e-03	-0.56	5.6	2.1e-08	-0.57	0.06	0.84	FALSE
22	METSIM	Adipose	CCR6	0.06	0.02	lasso	3	0.04	5.6e-07	6.02	5.5	4.6e-08	-0.43	0.93	0.01	FALSE