Best TWAS P=2.88e-29 · Best GWAS P=2.12e-29 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Lung | VAV3 | 0.25 | 0.23 | lasso | 2 | 0.23 | 2.4e-17 | 9.9 | 9.7 | 2.2e-22 | 0.90 | 0.98 | 0.02 | FALSE |
| 2 | GTEx | Nerve Tibial | VAV3 | 0.20 | 0.07 | lasso | 5 | 0.09 | 8.8e-07 | 6.6 | 6.3 | 2.2e-10 | 0.77 | 0.12 | 0.87 | TRUE |
| 3 | GTEx | Thyroid | VAV3 | 0.36 | 0.27 | lasso | 5 | 0.29 | 2.7e-22 | 11.3 | 11.2 | 2.9e-29 | 1.00 | 0.00 | 1.00 | TRUE |
| 4 | NTR | Blood | VAV3 | 0.03 | 0.01 | lasso | 4 | 0.01 | 3.6e-03 | 9.9 | 9.4 | 5.6e-21 | 0.82 | 0.10 | 0.72 | FALSE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | VAV3 | 0.09 | 0.02 | enet | 13 | 0.05 | 1.3e-05 | 10.2 | 8.5 | 2.5e-17 | 0.87 | 0.01 | 0.99 | FALSE |