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chr1:113,236,087-115,222,434

Best TWAS P=9.28e-37 · Best GWAS P=9.02e-84 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
30	The Cancer Genome Atlas	Thyroid Carcinoma	DCLRE1B	0.06	0.04	enet	11	0.04	4.3e-05	12.31	-12.7	9.3e-37	-0.58	0.01	0.99	TRUE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	PTPN22	0.02	0.01	blup	67	0.01	9.6e-03	12.31	10.2	1.7e-24	0.57	0.11	0.37	TRUE
29	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	BCL2L15	0.09	0.00	blup	42	0.04	1.1e-02	8.90	9.4	6.7e-21	0.37	0.02	0.05	TRUE
9	GTEx	Cells Transformed fibroblasts	OLFML3	0.12	0.00	enet	23	0.00	3.0e-01	-4.30	-6.7	1.7e-11	-0.39	0.04	0.49	TRUE
5	GTEx	Artery Tibial	HIPK1	0.13	0.00	enet	39	0.00	1.3e-01	-4.10	5.9	4.7e-09	0.16	0.04	0.40	TRUE
20	METSIM	Adipose	PHTF1	0.10	0.03	blup	517	0.04	1.1e-06	1.29	-5.5	3.0e-08	-0.36	0.83	0.09	TRUE
16	GTEx	Pancreas	PTPN22	0.14	-0.01	enet	28	0.01	8.8e-02	8.90	5.5	3.7e-08	0.21	0.16	0.04	TRUE
11	GTEx	Cells Transformed fibroblasts	DCLRE1B	0.06	0.04	lasso	5	0.02	1.5e-02	6.86	-5.4	6.4e-08	-0.33	0.36	0.02	TRUE
22	ROSMAP	Brain Pre-frontal Cortex	DCLRE1B	0.08	0.04	enet	14	0.05	2.6e-07	12.46	-11.6	3.0e-31	-0.50	0.97	0.03	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	DCLRE1B	0.02	0.00	blup	39	0.01	5.2e-03	10.45	-11.4	2.6e-30	-0.47	0.01	0.44	FALSE
8	GTEx	Breast Mammary Tissue	DCLRE1B	0.19	0.02	lasso	5	0.03	9.1e-03	9.85	-10.5	1.1e-25	-0.39	0.27	0.37	FALSE
28	The Cancer Genome Atlas	Glioblastoma Multiforme	DCLRE1B	0.20	-0.01	blup	39	0.04	3.0e-02	12.46	-10.2	3.1e-24	-0.54	0.00	0.52	FALSE
27	The Cancer Genome Atlas	Esophageal Carcinoma	DCLRE1B	0.13	0.02	blup	39	0.08	1.8e-03	-3.89	-10.0	1.4e-23	-0.46	0.01	0.53	FALSE
17	GTEx	Testis	RSBN1	0.09	0.09	enet	6	0.09	8.9e-05	9.78	-9.9	6.0e-23	-0.37	0.51	0.08	FALSE
14	GTEx	Esophagus Gastroesophageal Junction	AP4B1	0.13	0.00	lasso	4	0.01	2.0e-01	-2.96	-8.6	1.2e-17	-0.47	0.10	0.19	FALSE
12	GTEx	Cells Transformed fibroblasts	AP4B1-AS1	0.12	0.09	lasso	6	0.10	4.1e-08	10.40	-7.7	1.1e-14	-0.27	0.99	0.00	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	OLFML3	0.10	0.02	enet	27	0.04	9.7e-06	8.46	-7.4	1.3e-13	-0.35	0.86	0.05	FALSE
7	GTEx	Brain Cerebellar Hemisphere	AP4B1	0.29	0.22	lasso	5	0.14	1.8e-04	-6.85	7.2	5.9e-13	0.14	0.26	0.04	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	PHTF1	0.05	0.02	enet	7	0.03	3.1e-07	11.27	-7.2	6.3e-13	-0.48	0.22	0.63	FALSE
13	GTEx	Colon Transverse	PTPN22	0.19	0.16	lasso	5	0.21	2.5e-10	8.90	7.2	6.9e-13	0.24	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PHTF1	0.07	0.06	blup	517	0.05	1.2e-06	9.90	-7.1	1.0e-12	-0.32	0.99	0.00	FALSE
18	GTEx	Testis	AP4B1-AS1	0.21	0.19	lasso	5	0.19	5.9e-09	-6.85	7.0	1.9e-12	0.13	1.00	0.00	FALSE
10	GTEx	Cells Transformed fibroblasts	PHTF1	0.22	0.09	lasso	5	0.19	2.2e-14	11.27	-6.9	4.3e-12	-0.47	1.00	0.00	FALSE
6	GTEx	Artery Tibial	AP4B1-AS1	0.14	0.13	lasso	2	0.12	4.9e-10	-6.58	6.6	3.7e-11	0.14	1.00	0.00	FALSE
4	GTEx	Artery Tibial	AP4B1	0.09	0.13	lasso	1	0.13	4.0e-10	-6.58	6.6	4.9e-11	0.14	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	PTPN22	0.09	0.11	lasso	2	0.12	2.7e-14	8.90	6.2	4.2e-10	0.19	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	MAGI3	0.06	0.00	blup	554	0.03	1.9e-04	5.14	-6.2	5.1e-10	-0.33	0.74	0.01	FALSE
15	GTEx	Nerve Tibial	AP4B1-AS1	0.17	0.09	lasso	3	0.07	8.2e-06	-6.58	6.1	9.7e-10	0.12	0.75	0.03	FALSE
23	YFS	Blood	PTPN22	0.17	0.02	bslmm	497	0.10	3.8e-30	0.51	5.8	5.2e-09	0.25	1.00	0.00	FALSE
19	METSIM	Adipose	MAGI3	0.04	0.01	blup	549	0.03	5.5e-05	0.36	-5.1	2.8e-07	-0.31	0.74	0.01	FALSE