Best TWAS P=1.65e-08 · Best GWAS P=1.04e-07 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Hypothalamus | TIMP4 | 0.24 | 0.10 | lasso | 4 | 0.11 | 1.7e-03 | 5.3 | 5.6 | 1.6e-08 | 0.97 | 0.02 | 0.95 | TRUE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | SYN2 | 0.23 | 0.09 | lasso | 4 | 0.12 | 3.3e-05 | 4.4 | 5.1 | 2.9e-07 | 0.93 | 0.03 | 0.96 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | TIMP4 | 0.07 | 0.05 | lasso | 7 | 0.06 | 5.5e-08 | 4.4 | 5.3 | 1.4e-07 | 0.90 | 0.05 | 0.95 | FALSE |
| 4 | The Cancer Genome Atlas | Lung Adenocarcinoma | SYN2 | 0.03 | 0.02 | enet | 6 | 0.02 | 4.0e-03 | 5.3 | 5.6 | 2.1e-08 | 0.90 | 0.01 | 0.96 | FALSE |